Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 2173-2177. PMID: 3872460, PMCID: PMC397515, DOI: 10.1073/pnas.82.7.2173.Peer-Reviewed Original ResearchConceptsDopamine neuronsCortical synaptosomesParkinsonism-inducing neurotoxinNigrostriatal dopamine neuronsCerebral cortical synaptosomesMetabolite N-methylNorepinephrine uptake systemMetabolite of MPTPPotency of drugsIdiopathic parkinsonismStriatal synaptosomesClinical abnormalitiesMonoamine oxidase BNucleus accumbensRat brainRat striatumDopamine uptakeMPTPN-methylSelective destructionSynaptosomesNeuronsOxidase BTetrahydropyridineSelective toxicity