2015
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models*
Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models*. Journal Of Biological Chemistry 2015, 290: 17415-17438. PMID: 26018073, PMCID: PMC4498078, DOI: 10.1074/jbc.m115.643577.Peer-Reviewed Original ResearchAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBehavior, AnimalDisease Models, AnimalFemaleHumansMaleMemory DisordersMiceMice, Inbred C57BLMice, Mutant StrainsMice, TransgenicMiddle AgedMolecular WeightPrefrontal CortexPresenilin-1PrionsProtein Structure, QuaternaryPrPC ProteinsRecombinant Proteins
2003
Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury
Li S, Strittmatter SM. Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury. Journal Of Neuroscience 2003, 23: 4219-4227. PMID: 12764110, PMCID: PMC6741116, DOI: 10.1523/jneurosci.23-10-04219.2003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsAxotomyBehavior, AnimalCornified Envelope Proline-Rich ProteinsFemaleGanglia, SpinalGPI-Linked ProteinsInjections, SubcutaneousIntralaminar Thalamic NucleiMembrane ProteinsMiceMice, Inbred C57BLMolecular Sequence DataMolecular WeightMotor ActivityMyelin ProteinsNerve FibersNerve RegenerationNogo Receptor 1Peptide FragmentsProtein BiosynthesisProteinsPyramidal TractsReceptors, Cell SurfaceSerotoninSpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCord injuryCorticospinal axonsThoracic spinal cord injuryTherapeutic time windowSpinal cord hemisectionSpinal cord traumaCorticospinal tract axonsAdult mammalian CNSNogo-66 receptorOligodendrocyte myelin glycoproteinCNS axonal injuryCord lesionsSubcutaneous treatmentSystemic therapyCord hemisectionCord traumaIntrathecal applicationLocal therapyLocomotor recoveryFunctional recoverySerotonergic fibersAxonal injuryReceptor antagonistAxon sprouting
1990
G0 is a major growth cone protein subject to regulation by GAP-43
Strittmatter S, Valenzuela D, Kennedy T, Neer E, Fishman M. G0 is a major growth cone protein subject to regulation by GAP-43. Nature 1990, 344: 836-841. PMID: 2158629, DOI: 10.1038/344836a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBrain ChemistryCell MembraneGAP-43 ProteinGrowth SubstancesGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)Guanosine TriphosphateMembrane GlycoproteinsMolecular Sequence DataMolecular WeightNerve Tissue ProteinsPeptide FragmentsProtein BindingRatsReceptors, Cell SurfaceReceptors, NeurotransmitterSequence Homology, Nucleic AcidSignal TransductionThionucleotidesConceptsTransmembrane receptorsNeuronal growth cone membraneAmino-terminal domainGTP-binding proteinsGrowth cone membraneExtracellular signalsGrowth cone proteinGAP-43Cone membraneGrowth conesCone proteinNeuronal growthProteinS bindingMajor componentG0ReceptorsGTPRegulationIntracellularBindingMembraneDomain
1988
Characterization of a neutral, divalent cation-sensitive endopeptidase: a possible role in neuropeptide processing.
Supattapone S, Strittmatter SM, Fricker LD, Snyder SH. Characterization of a neutral, divalent cation-sensitive endopeptidase: a possible role in neuropeptide processing. Brain Research 1988, 427: 173-81. PMID: 3382941, DOI: 10.1016/0169-328x(88)90063-0.Peer-Reviewed Original ResearchConceptsCorpus striatumBrain regionsTissue distributionBovine adrenal chromaffin granulesAdrenal chromaffin granulesHomogeneous tissue distributionPossible roleNeuropeptide processingDensity gradient fractionationSucrose density gradient fractionationEndopeptidaseLeu-ArgChromaffin granulesHigh levelsBasic amino acidsTrypsin-like endopeptidaseEnzyme activityHippocampusStriatum
1985
A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates.
Strittmatter SM, Thiele EA, Kapiloff MS, Snyder SH. A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. Journal Of Biological Chemistry 1985, 260: 9825-9832. PMID: 2991265, DOI: 10.1016/s0021-9258(17)39310-9.Peer-Reviewed Original ResearchConceptsBrain ACESubstance PLung ACERat brain corpus striatumSubstance KMet-NH2Substance P 5Hormone-releasing hormoneLung enzymeThyrotropin-releasing hormoneAngiotensin-converting enzymeSubstance P 1Striatonigral pathwayCorpus striatumRat lungAmidated peptidesLungStriatal enzymeACE isozymeGly-LeuBrain enzymeBrain isozymeSimilar extentImmunological propertiesACE
1984
Monoclonal antibody production by receptor-mediated electrically induced cell fusion
Lo M, Tsong T, Conrad M, Strittmatter S, Hester L, Snyder S. Monoclonal antibody production by receptor-mediated electrically induced cell fusion. Nature 1984, 310: 792-794. PMID: 6088990, DOI: 10.1038/310792a0.Peer-Reviewed Original Research