2009
An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers
Linhoff MW, Laurén J, Cassidy RM, Dobie FA, Takahashi H, Nygaard HB, Airaksinen MS, Strittmatter SM, Craig AM. An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers. Neuron 2009, 61: 734-749. PMID: 19285470, PMCID: PMC2746109, DOI: 10.1016/j.neuron.2009.01.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCloning, MolecularCricetinaeCricetulusDisks Large Homolog 4 ProteinEmbryo, MammalianGene ExpressionGene Expression RegulationGene LibraryGenetic TestingGuanylate KinasesHippocampusHumansIntracellular Signaling Peptides and ProteinsLuminescent ProteinsMembrane PotentialsMembrane ProteinsMiceMice, KnockoutNeuronsPatch-Clamp TechniquesPDZ DomainsPresynaptic TerminalsRatsSynapsesTransfectionVesicular Glutamate Transport Protein 1ConceptsExpression screenSynaptogenic proteinsTrans-synaptic signalingDomain proteinsProtein familyTransmembrane proteinCDNA libraryMolecular basisSynaptogenic activityPresynaptic differentiationVesicular glutamate transporter VGLUT1Postsynaptic differentiationSynaptic organizersSynapse developmentPositive clonesCocultures of neuronsReported linkageLRRTMsCellular basisProteinGlutamate transporter VGLUT1LRRTM1Synaptic functionCurrent understandingAltered distribution
1999
Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro
Fryer HJ, Knox RJ, Strittmatter SM, Kalb RG. Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro. Journal Of Neurochemistry 1999, 72: 500-513. PMID: 9930721, DOI: 10.1046/j.1471-4159.1999.0720500.x.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalciumCalcium ChannelsCalcium Channels, L-TypeCell Culture TechniquesCell DeathCells, CulturedDizocilpine MaleateDose-Response Relationship, DrugExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFemaleGlutamic AcidGlutamineGlycineKainic AcidMembrane PotentialsMotor NeuronsN-MethylaspartateNerve Tissue ProteinsNeurotoxinsPotassiumPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSpinal CordConceptsGlutamate receptor agonistsMotor neuronsReceptor agonistNon-NMDA glutamate receptor agonistsIntracellular Ca2Agonist-evoked intracellular Ca2Specific glutamate receptor agonistsIonotropic glutamate receptor activationReceptor subtype-specific antagonistsSpinal cord motor neuronsSubtype-specific antagonistsCultured motor neuronsGlutamate receptor expressionRat motor neuronsMost motor neuronsGlutamate receptor activationL-type Ca2Subunit-specific antibodiesTime-dependent mannerReceptor phenotypeChannel antagonistsReceptor expressionNeurotoxic effectsRoute of entryExtracellular Ca2
1996
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
Nakamura F, Strittmatter SM. P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 10465-10470. PMID: 8816824, PMCID: PMC38408, DOI: 10.1073/pnas.93.19.10465.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApyraseChickensFemaleGanglia, SpinalMembrane PotentialsMolecular Sequence DataNerve FibersNeurons, AfferentOocytesPhysical StimulationPurinergic P2 Receptor AgonistsPyridoxal PhosphateRatsReceptors, Purinergic P2Receptors, Purinergic P2X3Receptors, Purinergic P2Y1RNA, MessengerSciatic NerveSkinSuraminTime FactorsTranscription, GeneticXenopus laevisConceptsNerve endingsPurinergic receptorsSensory neuronsAction potentialsSmall fiber sensory neuronsDorsal root ganglion neuronsDistal nerve endingsSensory action potentialsPeripheral nerve endingsSensory nerve fibersP2 receptor agonistsP2Y1 purinergic receptorRelease of ATPP2 antagonistsGanglion neuronsReceptor agonistNerve fibersLight touchNeuronsXenopus laevis oocytesSomatic sensationsReceptorsImpulse generationExtracellular spaceLaevis oocytes
1993
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes.
Strittmatter SM, Cannon SC, Ross EM, Higashijima T, Fishman MC. GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5327-5331. PMID: 7685122, PMCID: PMC46709, DOI: 10.1073/pnas.90.11.5327.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsCalciumCattleChloride ChannelsFemaleGAP-43 ProteinGrowth SubstancesGTP-Binding ProteinsHumansInositol 1,4,5-TrisphosphateIon Channel GatingIon ChannelsKineticsMembrane GlycoproteinsMembrane PotentialsMembrane ProteinsNerve Tissue ProteinsOocytesReceptors, MuscarinicRecombinant ProteinsSignal TransductionXenopus laevisConceptsGAP-43Receptor transductionG protein-coupled receptor agonistsCalcium-activated chloride channelXenopus laevis oocytesProtein GAP-43Neuronal protein GAP-43Receptor agonistInjection of inositolLaevis oocytesReceptor stimulationOocyte responseGrowth cone motilityChloride channelsSignal transductionIntracellular regulatorsIntracellular signalsMolecular mechanismsTransductionOocytesHigh levelsAgonists