1989
Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye.
Strittmatter SM, Braas KM, Snyder SH. Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye. Investigative Ophthalmology & Visual Science 1989, 30: 2209-14. PMID: 2551838.Peer-Reviewed Original ResearchConceptsCiliary epitheliumRat eyesLocalization of angiotensinAnti-ACE antibodiesAqueous humor productionACE immunoreactivityACE inhibitorsPotent ACE inhibitorPosterior chamberChoroid plexusImmunocytochemical stainingMonoclonal antibodiesChoroidal epitheliumVentricular surfaceEpitheliumAngiotensinHumor productionEyesMajor siteACEAntibodiesLow levelsHigh levelsPlexusImmunoreactivity
1988
Enkephalin convertase: characterization and localization using [3H]guanidinoethylmercaptosuccinic acid
Lynch D, Venable J, Strittmatter S, Snyder S. Enkephalin convertase: characterization and localization using [3H]guanidinoethylmercaptosuccinic acid. Biochimie 1988, 70: 57-64. PMID: 3135843, DOI: 10.1016/0300-9084(88)90158-7.Peer-Reviewed Original Research
1987
Enkephalin Convertase in the Gastrointestinal Tract and Associated Organs Characterized and Localized with [3H]Guanidinoethylmercaptosuccinic Acid*
LYNCH D, STRITTMATTER S, VENABLE J, SNYDER S. Enkephalin Convertase in the Gastrointestinal Tract and Associated Organs Characterized and Localized with [3H]Guanidinoethylmercaptosuccinic Acid*. Endocrinology 1987, 121: 116-126. PMID: 3109877, DOI: 10.1210/endo-121-1-116.Peer-Reviewed Original ResearchAngiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization
Strittmatter SM, Snyder SH. Angiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization. Neuroscience 1987, 21: 407-420. PMID: 3039401, DOI: 10.1016/0306-4522(87)90131-x.Peer-Reviewed Original ResearchConceptsAngiotensin converting enzymeSubstantia nigraRat brainChoroid plexusPituitary glandPosterior pituitaryConverting enzymePituitary stalk sectionEntopeduncular nucleusSubfornical organCaudate putamenGlobus pallidusEnzyme immunoreactivityParaventricular nucleusAnterior pituitaryAngiotensinEnzyme inhibitorsPosterior lobeIntense stainingCell bodiesMonoclonal antibodiesDiffuse stainingEndothelial cellsEnzyme immunohistochemistryAntibody specificity
1986
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
Strittmatter SM, Lynch DR, Snyder SH. Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 394: 207-15. PMID: 3021286, DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAutoradiographyBrainCarboxypeptidase HCarboxypeptidasesGestational AgePeptidyl-Dipeptidase ARatsConceptsBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRatsEnkephalin convertase: localization to specific neuronal pathways
Lynch DR, Strittmatter SM, Venable JC, Snyder SH. Enkephalin convertase: localization to specific neuronal pathways. Journal Of Neuroscience 1986, 6: 1662-1675. PMID: 3086516, PMCID: PMC6568706, DOI: 10.1523/jneurosci.06-06-01662.1986.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBrainCarboxypeptidase HCarboxypeptidasesHippocampusMaleNeuronsRatsRats, Inbred StrainsSuccinatesTritiumConceptsSpecific neuronal pathwaysPyramidal cellsDentate gyrusStria terminalisNeuronal pathwaysAcid lesionsBed nucleusCaudate nucleusGranule cellsSubstantia nigra pars reticulataDentate gyrus granule cellsKnife-cut lesionsGyrus granule cellsQuinolinic acid lesionsHypothalamic magnocellular nucleiIbotenic acid lesionsWhite matter tractsBrain tissue sectionsPars reticulataTrigeminal ganglionKainic acidEnkephalinergic pathwaysLateral septumSensory neuronsMedian eminenceAngiotensin-Converting Enzyme Localized in the Rat Pituitary and Adrenal Glands by [3H]Captopril Autoradiography*
STRITTMATTER S, DE SOUZA E, LYNCH D, SNYDER S. Angiotensin-Converting Enzyme Localized in the Rat Pituitary and Adrenal Glands by [3H]Captopril Autoradiography*. Endocrinology 1986, 118: 1690-1699. PMID: 3004925, DOI: 10.1210/endo-118-4-1690.Peer-Reviewed Original ResearchConceptsFmol/Adrenal medullaReserpine treatmentAdrenal glandAnterior pituitaryAngiotensin-converting enzymeRat pituitary glandAngiotension-converting enzymeAdrenal cortexDexamethasone treatmentPituitary glandPosterior pituitaryBrattleboro ratsMedullaBovine adrenal medullaPituitaryRatsIntermediate pituitaryGlandHypophysectomyAutoradiographyTreatmentChromaffin granulesAdrenalectomyAngiotensin
1985
Angiotensin-Converting Enzyme in the Testis and Epididymis: Differential Development and Pituitary Regulation of Isozymes*
STRITTMATTER S, THIELE E, DE SOUZA E, SNYDER S. Angiotensin-Converting Enzyme in the Testis and Epididymis: Differential Development and Pituitary Regulation of Isozymes*. Endocrinology 1985, 117: 1374-1379. PMID: 2992911, DOI: 10.1210/endo-117-4-1374.Peer-Reviewed Original ResearchEnkephalin Convertase Demonstrated in the Pituitary and Adrenal Gland by 3HGuanidinoethylmercaptosuccinic Acid Autoradiography: Dehydration Decreases Neurohypophyseal Levels*
STRITTMATTER S, LYNCH D, DE SOUZA E, SNYDER S. Enkephalin Convertase Demonstrated in the Pituitary and Adrenal Gland by 3HGuanidinoethylmercaptosuccinic Acid Autoradiography: Dehydration Decreases Neurohypophyseal Levels*. Endocrinology 1985, 117: 1667-1674. PMID: 3928337, DOI: 10.1210/endo-117-4-1667.Peer-Reviewed Original ResearchConceptsPituitary lobeBrattleboro ratsPmol/Acid autoradiographyAdrenal glandAdrenal medullaEnkephalin convertaseArginine vasopressin treatmentAnterior pituitary lobeIntermediate pituitary lobePosterior pituitary lobeNeurohypophyseal levelsSplanchnic denervationHaloperidol treatmentParaventricular nucleusAdrenal cortexMagnocellular portionControl animalsSupraoptic nucleusIntermediate lobeRatsVasopressin treatmentBovine adrenal medullaAdrenal medullary enzymesLobeDifferential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography
Javitch JA, Strittmatter SM, Snyder SH. Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography. Journal Of Neuroscience 1985, 5: 1513-1521. PMID: 4009243, PMCID: PMC6565258, DOI: 10.1523/jneurosci.05-06-01513.1985.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBrainCorpus StriatumDesipramineDopamineIndolesMaleMazindolNorepinephrineRatsRats, Inbred StrainsTritiumConceptsDA uptake sitesNE uptake sitesUptake sitesRat brainSubstantia nigra pars compactaAnterior olfactory nucleusVentral tegmental areaIbotenic acid lesionsAnteroventral thalamusNoradrenergic terminalsOlfactory nucleusSolitary tractMazindol bindingPars compactaSomatodendritic regionOlfactory tubercleDopaminergic axonsLocus coeruleusNorepinephrine uptakeTegmental areaPeriventricular nucleusSubthalamic nucleusIbotenic acidStria terminalisAcid lesionsParkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 2173-2177. PMID: 3872460, PMCID: PMC397515, DOI: 10.1073/pnas.82.7.2173.Peer-Reviewed Original ResearchConceptsDopamine neuronsCortical synaptosomesParkinsonism-inducing neurotoxinNigrostriatal dopamine neuronsCerebral cortical synaptosomesMetabolite N-methylNorepinephrine uptake systemMetabolite of MPTPPotency of drugsIdiopathic parkinsonismStriatal synaptosomesClinical abnormalitiesMonoamine oxidase BNucleus accumbensRat brainRat striatumDopamine uptakeMPTPN-methylSelective destructionSynaptosomesNeuronsOxidase BTetrahydropyridineSelective toxicity
1984
Angiotensin-Converting Enzyme in the Male Rat Reproductive System: Autoradiographic Visualization with [3H]Captopril*
STRITTMATTER S, SNYDER S. Angiotensin-Converting Enzyme in the Male Rat Reproductive System: Autoradiographic Visualization with [3H]Captopril*. Endocrinology 1984, 115: 2332-2341. PMID: 6094156, DOI: 10.1210/endo-115-6-2332.Peer-Reviewed Original ResearchConceptsACE activityMale rat reproductive systemRat reproductive systemSoluble ACE activityAutoradiographic silver grainsStages I-VIIIInitial segmentMale ratsAutoradiographic visualizationPharmacological profileTesticular slicesBasal epitheliumSilver grainsLuminal labellingReproductive tractInterstitial tissueMonoclonal antibodiesVas deferensSeminiferous tubulesLevel of bindingReproductive systemLuminal surfaceEpitheliumEnkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons.
Lynch DR, Strittmatter SM, Snyder SH. Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6543-6547. PMID: 6436816, PMCID: PMC391961, DOI: 10.1073/pnas.81.20.6543.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBrainBrain MappingCarboxypeptidase HCarboxypeptidasesEnkephalinsRatsSuccinatesConceptsEnkephalin convertaseSpinal trigeminal tractDorsal parabrachial nucleusTrigeminal tractSolitary tractAcid autoradiographySubstantia gelatinosaParabrachial nucleusDentate gyrusLocus coeruleusPreoptic hypothalamusInterpeduncular nucleusLateral septumBed nucleusRat brainStria terminalisMedian eminenceMagnocellular nucleusCentral nucleusImmunocytochemical localizationHypothalamusEnkephalin biosynthesisEnkephalinTractGuanidinoethylmercaptosuccinic acidAutoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1599-1603. PMID: 6324207, PMCID: PMC344885, DOI: 10.1073/pnas.81.5.1599.Peer-Reviewed Original ResearchConceptsCaudate putamenSubstantia nigraStriatonigral pathwayRat brainAngiotensin II involvementIpsilateral caudate putamenTrans-synaptic changesIpsilateral substantia nigraMedian preoptic areaAngiotensin-converting enzymeLack of effectStriatal interneuronsAngiotensin IIEntopeduncular nucleusNeuronal perikaryaSubfornical organZona reticulataGlobus pallidusACE activityLocus coeruleusParaventricular nucleusPreoptic areaIbotenic acidMedial habenulaNeuronal pathways