2018
Diltiazem Promotes Regenerative Axon Growth
Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Diltiazem Promotes Regenerative Axon Growth. Molecular Neurobiology 2018, 56: 3948-3957. PMID: 30232777, PMCID: PMC6424671, DOI: 10.1007/s12035-018-1349-5.Peer-Reviewed Original ResearchConceptsL-type calcium channel blockerDorsal root gangliaCentral nervous systemChondroitin sulfate proteoglycanAxon regenerationMouse dorsal root gangliaAdult central nervous systemHuman sensory neuronsCalcium channel blockersSpinal cord injuryRat cortical culturesCord injuryAxonal regrowthRoot gangliaCortical culturesChannel blockersRegenerative propensityRegenerative axon growthSensory neuronsNervous systemPharmacological enhancersAxon growthPermanent lossSulfate proteoglycanAxotomy
2010
Chapter 240 Semaphorins and their Receptors in Vertebrates and Invertebrates
Schmidt E, Togashi H, Strittmatter S. Chapter 240 Semaphorins and their Receptors in Vertebrates and Invertebrates. 2010, 1961-1966. DOI: 10.1016/b978-0-12-374145-5.00240-0.Peer-Reviewed Original ResearchExpression of Sema4DDorsal root gangliaTypes of neuronsNon-neuronal cellsT lymphocyte activationCentral nervous system developmentMalignant lung cellsNeuronal cell migrationAxon guidance factorsRoot gangliaNervous system developmentCardiovascular abnormalitiesImmune responseNerve bundlesAxoplasmic transportNervous systemImmune systemCardiovascular systemLung cellsAdult animalsAxonsReduced levelsSemaphorinsGuidance factorsCell migration
2007
Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals
Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T. Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals. Journal Of Neuroscience 2007, 27: 13033-13041. PMID: 18032677, PMCID: PMC4313565, DOI: 10.1523/jneurosci.4290-06.2007.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Functional toll-like receptor 3Poly IActivation of TLR3Nervous systemInnate immunityReceptor 3Pattern recognition receptor functionAxonal growthDorsal root gangliaFunction of TLRsToll-like receptorsPeripheral nervous systemMammalian Toll-like receptorsPattern recognition receptorsViral double-stranded RNAClasses of receptorsNuclear factor kappaB.Sensorimotor deficitsRoot gangliaNeonatal miceNeurodegenerative effectsGrowth cone collapseCNS regenerationRecognition receptors
1994
GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth
Strittmatter S, Igarashi M, Fishman M. GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth. Journal Of Neuroscience 1994, 14: 5503-5513. PMID: 8083750, PMCID: PMC6577098, DOI: 10.1523/jneurosci.14-09-05503.1994.Peer-Reviewed Original ResearchConceptsGAP-43G-protein activityPertussis toxinNeuronal growth-associated protein GAP-43Neurite outgrowthGrowth-associated protein GAP-43Dorsal root ganglion cellsG protein-mediated eventsGrowth cone membraneDorsal root gangliaProtein GAP-43N1E-115 neuroblastoma cellsChick dorsal root ganglion cellsChick dorsal root gangliaNeurite extensionCone membraneEmbryonic chick dorsal root gangliaRoot gangliaGanglion cellsRetinal neuronsPeptide stimulationGrowth cone collapseGrowth cone morphologyNeuroblastoma cellsPotential modulators