2021
Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports 2021, 34: 108777. PMID: 33657370, PMCID: PMC8009559, DOI: 10.1016/j.celrep.2021.108777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCRISPR-Cas SystemsDependovirusFemaleGene EditingGene Expression RegulationGenetic Association StudiesHEK293 CellsHumansInterleukinsMaleMAP Kinase Kinase KinasesMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionSTAT3 Transcription FactorConceptsOptic nerve crushRetinal ganglion cellsRegeneration-associated genesShort hairpin RNAIL-22Neural repairCentral nervous system traumaNeurological deficits persistNervous system traumaNerve crushAxonal damageAxonal regenerationGanglion cellsSystem traumaInflammatory responseCNS regenerationDeficits persistAxonal growthHairpin RNAConcurrent activationTranscription 3Cell-autonomous factorsKinase pathwaySignal transducerRepair
2006
Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
Harel NY, Strittmatter SM. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nature Reviews Neuroscience 2006, 7: 603-616. PMID: 16858389, PMCID: PMC2288666, DOI: 10.1038/nrn1957.Peer-Reviewed Original ResearchConceptsCNS regenerationNervous systemCentral pattern generatorImmature nervous systemSpinal cord injuryRegeneration-associated genesMammalian CNS regenerationContext of injuryExperience-dependent plasticityFurther plastic changesInflammatory cellsCord injuryVoluntary inputNervous system developmentRegenerating axonsSensory feedbackInhibitory barrierPlastic changesInhibitory moleculesRegenerative responseGuidance moleculesAltered distributionNeuronal branchesInjuryGuidance factors