Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury
Kopp MA, Liebscher T, Niedeggen A, Laufer S, Brommer B, Jungehulsing GJ, Strittmatter SM, Dirnagl U, Schwab JM. Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury. Cell And Tissue Research 2012, 349: 119-132. PMID: 22350947, PMCID: PMC3744771, DOI: 10.1007/s00441-012-1334-7.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemAxonal plasticityCord injuryAcute spinal cord injuryExperimental spinal cord injuryNon-steroid anti-inflammatory drugsRelevant SCI modelGrowth-inhibitory environmentCNS injury modelsAnti-inflammatory drugsOligodendrocyte myelin glycoproteinRhoA inhibitionRepulsive guidance moleculeMotor recoveryAxonal sproutingPreclinical evidenceFunctional recoveryLocomotor recoverySCI modelChondroitin sulfate proteoglycanCNS injuryNeurofunctional outcomeGrowth cone collapsePossible clinical translation