2009
Axon Regeneration in the Peripheral and Central Nervous Systems
Huebner EA, Strittmatter SM. Axon Regeneration in the Peripheral and Central Nervous Systems. Results And Problems In Cell Differentiation 2009, 48: 305-360. PMID: 19582408, PMCID: PMC2846285, DOI: 10.1007/400_2009_19.Peer-Reviewed Original ResearchConceptsCentral nervous systemPeripheral nervous systemSpinal cord injuryNervous systemAxon regenerationLong-distance axon regenerationMature mammalian central nervous systemMammalian peripheral nervous systemSubstantial functional recoveryMammalian central nervous systemTraumatic brain injuryIntrinsic growth capacityFunctional recoveryCord injuryAxonal disconnectionFunctional deficitsBrain injuryRelated conditionsInjuryRegenerative successExtracellular moleculesGrowth capacityStroke
2007
Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals
Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T. Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals. Journal Of Neuroscience 2007, 27: 13033-13041. PMID: 18032677, PMCID: PMC4313565, DOI: 10.1523/jneurosci.4290-06.2007.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Functional toll-like receptor 3Poly IActivation of TLR3Nervous systemInnate immunityReceptor 3Pattern recognition receptor functionAxonal growthDorsal root gangliaFunction of TLRsToll-like receptorsPeripheral nervous systemMammalian Toll-like receptorsPattern recognition receptorsViral double-stranded RNAClasses of receptorsNuclear factor kappaB.Sensorimotor deficitsRoot gangliaNeonatal miceNeurodegenerative effectsGrowth cone collapseCNS regenerationRecognition receptors
2001
Nogo: A Molecular Determinant of Axonal Growth and Regeneration
Grandpré T, Strittmatter S. Nogo: A Molecular Determinant of Axonal Growth and Regeneration. The Neuroscientist 2001, 7: 377-386. PMID: 11597097, DOI: 10.1177/107385840100700507.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS environmentNervous systemAdult mammalian central nervous systemEnhanced axonal regenerationPersistent functional deficitsMammalian central nervous systemPeripheral nervous systemNeurite outgrowth inhibitorIntegral membrane proteinsCNS traumaFunctional recoveryReactive astrocytesVivo neutralizationCNS injuryAxonal regenerationFunctional deficitsGlial scarNonpermissive natureOutgrowth inhibitorCNS axonsAxonal growthAxonal elongationMembrane proteinsAxon elongation
2000
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
GrandPré T, Nakamura F, Vartanian T, Strittmatter S. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403: 439-444. PMID: 10667797, DOI: 10.1038/35000226.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsCattleCell DivisionCell LineCentral Nervous SystemChick EmbryoCloning, MolecularConsensus SequenceEscherichia coliGrowth InhibitorsHumansMembrane ProteinsMolecular Sequence DataMyelin ProteinsNerve RegenerationNogo ProteinsOligodendrogliaPC12 CellsRatsRecombinant ProteinsSequence Homology, Amino AcidConceptsCentral nervous systemPeripheral nervous systemCNS white matterAxonal regenerationAxon regenerationNervous systemWhite matterAdult central nervous systemMammalian axon regenerationIN-1 antibodiesReticulon 1Dorsal root ganglion growth conesFunctional recoverySpinal cordSchwann cellsCNS axonsExtracellular domainAxonal extensionNogoAxon extensionGrowth conesOligodendrocytesInhibitory activityReticulon 4Moderate degree