2004
Blockade of Nogo-66, Myelin-Associated Glycoprotein, and Oligodendrocyte Myelin Glycoprotein by Soluble Nogo-66 Receptor Promotes Axonal Sprouting and Recovery after Spinal Injury
Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Li W, Jirik A, Rabacchi S, Choi E, Worley D, Sah DW, Pepinsky B, Lee D, Relton J, Strittmatter SM. Blockade of Nogo-66, Myelin-Associated Glycoprotein, and Oligodendrocyte Myelin Glycoprotein by Soluble Nogo-66 Receptor Promotes Axonal Sprouting and Recovery after Spinal Injury. Journal Of Neuroscience 2004, 24: 10511-10520. PMID: 15548666, PMCID: PMC6730300, DOI: 10.1523/jneurosci.2828-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsEvoked Potentials, MotorFemaleGPI-Linked ProteinsInjections, SpinalMotor ActivityMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNogo ProteinsNogo Receptor 1OligodendrogliaPeptide FragmentsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, PeptideRecombinant Fusion ProteinsSerotoninSolubilitySpinal CordSpinal Cord InjuriesConceptsAxonal sproutingTraumatic spinal cord injurySpinal-injured ratsSpinal cord injuryAdult mammalian CNSNogo-66 receptorOligodendrocyte myelin glycoproteinMyelin associated glycoproteinRaphespinal fibersLocomotor recoveryCord injurySpinal injuryMammalian CNSNgR functionTherapeutic potentialAxonal growthNogo-66Myelin glycoproteinInjuryMyelin proteinsImproved locomotionViral blockadeBlockadeFc proteinSproutingA Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin*
Li W, Walus L, Rabacchi SA, Jirik A, Chang E, Schauer J, Zheng BH, Benedetti NJ, Liu BP, Choi E, Worley D, Silvian L, Mo W, Mullen C, Yang W, Strittmatter SM, Sah DW, Pepinsky B, Lee DH. A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin*. Journal Of Biological Chemistry 2004, 279: 43780-43788. PMID: 15297463, DOI: 10.1074/jbc.m401803200.Peer-Reviewed Original ResearchConceptsOligodendrocyte myelin glycoproteinRat dorsal root ganglion neuronsDorsal root ganglion neuronsMonoclonal antibodiesMyelin glycoproteinNeurite outgrowthMyelin proteinsUseful therapeutic approachCNS myelin substrateNogo66 receptorCentral nervous system myelinGanglion neuronsTherapeutic approachesCNS repairMyelin substrateCentral nervous system myelin proteinsInhibitory effectNgR1AntibodiesNeurite growthMyelinSystem myelinReverses inhibitionMolecular epitopes
2002
Chapter 25 Nogo and the Nogo-66 receptor
Fournier AE, GrandPré T, Gould G, Wang X, Strittmatter SM. Chapter 25 Nogo and the Nogo-66 receptor. Progress In Brain Research 2002, 137: 361-369. PMID: 12440378, DOI: 10.1016/s0079-6123(02)37027-4.Peer-Reviewed Original ResearchConceptsNogo-66 receptorAxonal regenerationNogo-66Oligodendrocyte myelin glycoproteinAxonal inhibitionAdult vertebrate CNSUnresponsive neuronsChondroitin sulfate proteoglycanCentral nervous system myelinCNS injuryReceptor expressionAxon regenerationMyelin inhibitionMyelin glycoproteinReceptor componentsNogoReceptorsSystem myelinAxonal surfaceSulfate proteoglycanNeuronsInhibitionMyelinVertebrate CNSHigh affinity