2013
Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease
Um JW, Strittmatter SM. Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. Prion 2013, 7: 37-41. PMID: 22987042, PMCID: PMC3609048, DOI: 10.4161/pri.22212.Peer-Reviewed Original ResearchConceptsCellular prion proteinPrion proteinSignal transduction downstreamTransduction downstreamAlzheimer's diseaseFyn kinaseFunctional consequencesAβ oligomersAmyloid-β OligomersNeuronal surfaceHigh-affinity receptorOligomer complexesAD-related phenotypesCentral roleProteinAD pathogenesisRecent evidencePrevalent causeTherapeutic interventionsFynKinaseOligomersPhenotypeDiseaseDownstream
2007
ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases
Schmandke A, Schmandke A, Strittmatter SM. ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases. The Neuroscientist 2007, 13: 454-469. PMID: 17901255, PMCID: PMC2849133, DOI: 10.1177/1073858407303611.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCentral Nervous SystemCytoskeletonHumansLipoproteinsMyelin ProteinsNerve Tissue ProteinsNeuronsNogo ProteinsProtein Processing, Post-TranslationalReceptor Protein-Tyrosine KinasesReceptors, G-Protein-CoupledReceptors, ImmunologicRho GTP-Binding ProteinsRho-Associated KinasesSignal TransductionConceptsProtein kinaseRho-Associated Protein KinaseSignal transduction mechanismsNeuronal functionDiverse neuronal functionsActin cytoskeletonRho familyExtracellular signalsROCK functionSignaling pathwaysBiochemical knowledgeCell survivalTransduction mechanismsCell migrationAxonal guidanceDendritic spine morphologyKinaseROCK pathwayPathwayNeuronal regenerationSpine morphologyRhoBrain developmentKey rolePotential sites