Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease
Chiasseu M, Fesharaki A, Saito T, Saido T, Strittmatter S. Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047623.Peer-Reviewed Original ResearchMild traumatic brain injuryChronic head injuryHead injuryMorris water maze testAmyloid-beta pathologyAccumulation of amyloidAge-matched miceWater maze testTraumatic brain injuryNovel object recognitionProtein gene mutationsEnvironmental risk factorsAlzheimer's disease symptomsIba1 expressionCortical AβAlzheimer pathologyPhospho-tauClinical manifestationsAD pathologyCortical impactorAD pathogenesisRisk factorsBrain injuryApp NLMaze testGene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in
Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology Of Disease 2020, 145: 105059. PMID: 32858147, PMCID: PMC7572902, DOI: 10.1016/j.nbd.2020.105059.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryTraumatic brain injuryAlzheimer's diseaseBrain injuryGene-environment interactionsMild closed head injuryMorris water maze testAge-matched wild-type controlsStrong unmet needAccumulation of amyloidAge-matched miceClosed head injuryWater maze testNovel object recognitionPersistent cognitive deficitsProtein gene mutationsIba1 expressionWild-type controlsPhospho-tauClinical manifestationsAD pathologyAD symptomsHead injuryAD pathogenesisRisk factors