2015
Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury
Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM. Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. Journal Of Neuroscience 2015, 35: 10429-10439. PMID: 26203138, PMCID: PMC4510284, DOI: 10.1523/jneurosci.1718-15.2015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsDisease Models, AnimalGene Knockdown TechniquesImmunohistochemistryInositol Polyphosphate 5-PhosphatasesMiceMice, Inbred C57BLMice, KnockoutNerve RegenerationPhosphoric Monoester HydrolasesRecovery of FunctionReverse Transcriptase Polymerase Chain ReactionSpinal Cord InjuriesConceptsSpinal cord injuryCord injuryEndogenous suppressorAxon regenerationNonoverlapping substrate specificityGenome-wide scaleHigh-throughput functional screensFunctional recoveryAxonal regenerationCNS axon repairSpinal cord injury researchDorsal hemisection injuryMammalian genesPI3K/AKT/mTOR pathwayCNS axon growthAKT/mTOR pathwayLipid phosphataseCorticospinal tract axonsCNS axon regenerationAdult mammalian CNSFunctional screenSubstrate specificityNovel suppressorShRNA resultsINPP5F
2008
The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism
Hu F, Strittmatter SM. The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism. Journal Of Neuroscience 2008, 28: 1262-1269. PMID: 18234903, PMCID: PMC2856844, DOI: 10.1523/jneurosci.1068-07.2008.Peer-Reviewed Original ResearchConceptsCell adhesionFocal adhesion kinase activationN-terminal domainAxonal outgrowthInhibits cell adhesionAxonal growth conesCNS axon regenerationKinase activationCertain integrinsIntegrin activatorIntegrin beta1Widespread expressionExtracellular matrixSecond domainAlpha5 integrinUnknown mechanismIntegrinsGrowth conesNogo-A proteinCell linesAlpha6 integrinNogo-66 receptorAxonal growthAdult brainOutgrowth
2001
Repulsive factors and axon regeneration in the CNS
Fournier A, Strittmatter S. Repulsive factors and axon regeneration in the CNS. Current Opinion In Neurobiology 2001, 11: 89-94. PMID: 11179877, DOI: 10.1016/s0959-4388(00)00178-1.Peer-Reviewed Original Research