2012
Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes
Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes. Journal Of Neuroscience 2012, 32: 14080-14086. PMID: 23055476, PMCID: PMC3576841, DOI: 10.1523/jneurosci.3359-12.2012.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorType 2 diabetes mellitusNeurotrophic signaling pathwaysFrontotemporal lobar degenerationNon-neuronal cellsPathogenesis of neurodegenerationGenetic risk factorsBDNF levelsDiabetes mellitusFamily of receptorsNeurotrophic factorRisk factorsParkinson's diseaseTrk receptorsAcute responseAutosomal dominant formAlzheimer's diseaseNeurodegenerative diseasesDiseaseCell surface receptorsReceptorsSignaling pathwaysSurface receptorsPleiotropic functionsIntracellular responses
2000
Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway
Fryer H, Wolf D, Knox R, Strittmatter S, Pennica D, O'Leary R, Russell D, Kalb R. Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway. Journal Of Neurochemistry 2000, 74: 582-595. PMID: 10646509, DOI: 10.1046/j.1471-4159.2000.740582.x.Peer-Reviewed Original ResearchConceptsHerpes simplex virusBrain-derived neurotrophic factorNeurotrophic factorMotor neuronsGlial-derived neurotrophic factorRat spinal motor neuronsEffects of BDNFRat motor neuronsSpinal motor neuronsActivation of TrkBPI3K pathwayExcitotoxic deathNeurotrophin-3Receptor p75NTRBDNFSimplex virusIntracellular Ca2Cardiotrophin-1NeuronsReceptor-mediated cell deathK pathwayPI3KDominant negative p85 subunitTrkBCell death