Alzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition
Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH, Strittmatter SM. Alzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition. Journal Of Neuroscience 2006, 26: 1386-1395. PMID: 16452662, PMCID: PMC2846286, DOI: 10.1523/jneurosci.3291-05.2006.Peer-Reviewed Original ResearchConceptsAmyloid precursor proteinAlzheimer's diseaseAbeta levelsDystrophic neuritesPlaque depositionAmyloid-β plaque depositionCourse of ADAbeta plaque depositionTransgenic AD modelBrain Abeta levelsAD brain samplesAdult CNS axonsAxonal sprouting responseNgR expressionAbeta depositsAxonal dysfunctionPathophysiologic hypothesesSecretase processingTraumatic injuryAbeta productionDisease processAD modelBrain samplesCNS axonsPlaque deposits