2022
Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma
Sekine Y, Kannan R, Wang X, Strittmatter SM. Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma. Experimental Neurology 2022, 353: 114070. PMID: 35398339, PMCID: PMC9555232, DOI: 10.1016/j.expneurol.2022.114070.Peer-Reviewed Original ResearchConceptsAxon regenerationModerate spinal cord contusion injurySpinal cord contusion injuryTraumatic spinal cord injuryAdult mammalian central nervous systemGrowth conesRetinal ganglion cell axonsOptic nerve crushSpinal cord crush injuryGanglion cell axonsSpinal cord injuryMammalian central nervous systemCentral nervous systemCorticospinal axon regenerationContusion injuryAxonal sproutingCrush injuryNerve crushAxonal growth conesCord injuryAxon sproutingCell axonsProximal bodyNervous systemNeural repair
2008
The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism
Hu F, Strittmatter SM. The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism. Journal Of Neuroscience 2008, 28: 1262-1269. PMID: 18234903, PMCID: PMC2856844, DOI: 10.1523/jneurosci.1068-07.2008.Peer-Reviewed Original ResearchConceptsCell adhesionFocal adhesion kinase activationN-terminal domainAxonal outgrowthInhibits cell adhesionAxonal growth conesCNS axon regenerationKinase activationCertain integrinsIntegrin activatorIntegrin beta1Widespread expressionExtracellular matrixSecond domainAlpha5 integrinUnknown mechanismIntegrinsGrowth conesNogo-A proteinCell linesAlpha6 integrinNogo-66 receptorAxonal growthAdult brainOutgrowth
2000
Transduction of Inhibitory Signals by the Axonal Growth Cone
Wang L, Fournier A, Nakamura F, Takahashi T, Kalb R, Strittmatter S. Transduction of Inhibitory Signals by the Axonal Growth Cone. Contemporary Neuroscience 2000, 131-153. DOI: 10.1007/978-1-59259-200-5_6.Peer-Reviewed Original Research
1995
Neuronal Guidance Molecules: Inhibitory and Soluble Factors
Strittmatter S. Neuronal Guidance Molecules: Inhibitory and Soluble Factors. The Neuroscientist 1995, 1: 255-258. DOI: 10.1177/107385849500100502.Peer-Reviewed Original ResearchCell-surface adhesive proteinsMatrix-bound factorsGuidance moleculesImportance of moleculesAxonal guidance factorsAxonal growth conesExtracellular matrix componentsNeural developmentSoluble factorsPhysiological roleSemaphorin familyMolecular levelNeuronal guidance moleculesAdhesive proteinsGrowth conesGuidance factorsMatrix componentsGrowth inhibitorCentral roleAxonal outgrowthCNS myelinAxonal growth inhibitorsAxonal guidance moleculesRegenerationMolecules