2021
NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates
Boghdadi AG, Spurrier J, Teo L, Li M, Skarica M, Cao B, Kwan WC, Merson TD, Nilsson SK, Sestan N, Strittmatter SM, Bourne JA. NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates. Nature Communications 2021, 12: 6906. PMID: 34824275, PMCID: PMC8617297, DOI: 10.1038/s41467-021-27245-0.Peer-Reviewed Original ResearchConceptsBrain injuryPeripheral macrophage infiltrationIschemic brain injuryAnti-inflammatory responseMajority of astrocytesNeurite outgrowth inhibitory proteinIschemic strokePeripheral macrophagesReactive astrocytesMacrophage infiltrationStroke recoveryAstrocyte clustersMarmoset monkeysVisual cortexAstrocytesNogoASingle-nucleus transcriptomicsInhibitory proteinInjuryStrokeHuman brainInfiltrationCritical rolePrecise functionOligodendrocytes
2005
Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury
Li S, Kim JE, Budel S, Hampton TG, Strittmatter SM. Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury. Molecular And Cellular Neuroscience 2005, 29: 26-39. PMID: 15866044, PMCID: PMC3246391, DOI: 10.1016/j.mcn.2004.12.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAxonal sproutingSpinal injuryLumbar spinal cordNogo-66 receptorRecovery of locomotionHemisection injuryCord injurySpinal cordAdult CNSMice exhibitTherapeutic meansAxonal growthReceptor functionNgR ligandsInjuryNogo-66Improved locomotionTransgenic inhibitionMiceSproutingAstrocytesCordCNSOMgp