Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease
Chiasseu M, Fesharaki A, Saito T, Saido T, Strittmatter S. Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047623.Peer-Reviewed Original ResearchMild traumatic brain injuryChronic head injuryHead injuryMorris water maze testAmyloid-beta pathologyAccumulation of amyloidAge-matched miceWater maze testTraumatic brain injuryNovel object recognitionProtein gene mutationsEnvironmental risk factorsAlzheimer's disease symptomsIba1 expressionCortical AβAlzheimer pathologyPhospho-tauClinical manifestationsAD pathologyCortical impactorAD pathogenesisRisk factorsBrain injuryApp NLMaze test