2023
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Stoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter S. Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein. Alzheimer's Research & Therapy 2023, 15: 201. PMID: 37968719, PMCID: PMC10647125, DOI: 10.1186/s13195-023-01345-z.Peer-Reviewed Original ResearchConceptsSynapse lossDKI miceTau accumulationBrain immune activationNeural network dysfunctionPhospho-tau accumulationAccumulation of tauNeuronal genesInflammatory markersAD miceAβ levelsPrion proteinDystrophic neuritesImmune activationTau pathologyNeuronal gene expressionAmyloid-β OligomersGliotic reactionNetwork dysfunctionBehavioral deficitsSynaptic failureAD modelMemory impairmentAlzheimer's diseaseFunction of age
2022
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Science Translational Medicine 2022, 14: eabi8593. PMID: 35648810, PMCID: PMC9554345, DOI: 10.1126/scitranslmed.abi8593.Peer-Reviewed Original ResearchConceptsPositron emission tomographySilent allosteric modulatorsAlzheimer's diseaseMouse modelPhospho-tau accumulationAged mouse modelAlzheimer mouse modelImmune-mediated attackSAM treatmentMicroglial mediatorsSynaptic engulfmentSynaptic lossAD miceComplement component C1qSynapse lossGlutamate responseSynaptic densityDrug washoutSynaptic localizationTherapeutic benefitCognitive impairmentAllosteric modulatorsEmission tomographyNonhuman primatesComponent C1q
2019
VEGF/VEGFR2 signaling regulates hippocampal axon branching during development
Luck R, Urban S, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. ELife 2019, 8: e49818. PMID: 31868583, PMCID: PMC6927742, DOI: 10.7554/elife.49818.Peer-Reviewed Original ResearchConceptsVEGF/VEGFR2Hippocampal axonsAxon branchingVEGF/VEGFR2 signalingHippocampal neurons resultsMouse hippocampal neuronsCA1 neuronsFunctional synapsesCA3 regionHippocampal neuronsNeurons resultsAngiogenic factorsHippocampus developmentAxonsReceptor VEGFR2NeuronsVEGFR2Neuronal networksVEGFNumber of filopodiaVEGFR2 signalingEphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
Harde E, Nicholson L, Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, de Almodóvar C, Acker-Palmer A. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. ELife 2019, 8: e49819. PMID: 31868584, PMCID: PMC6927743, DOI: 10.7554/elife.49819.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorLong-term potentiationDendritic arborizationCircuitry developmentSpine morphogenesisSpine head sizeEndothelial growth factorVEGFR2 internalizationCA3 synapsesCA3 regionDendritic arborsSpine maturationCompound miceHippocampal neuronsDendritic branchingNervous systemAngiogenic factorsEndothelial cellsGrowth factorNeuronsVEGFR2ArborizationMiceFunctional crosstalkEphrinB2