Clancy Mullan, MD
Hospital ResidentAbout
Research
Publications
2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024 PMID: 39302113, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translationTHE U.S. NATIONAL LANDSCAPE OF TEMPORARY MECHANICAL CIRCULATORY SUPPORT
Morrison A, Mullan C, Chouairi F, Waldron C, Carnicelli A, Houston B, Ahmad T, Miller P. THE U.S. NATIONAL LANDSCAPE OF TEMPORARY MECHANICAL CIRCULATORY SUPPORT. Journal Of The American College Of Cardiology 2024, 83: 2537. DOI: 10.1016/s0735-1097(24)04527-3.Peer-Reviewed Original Research
2023
Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantation
2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatientsRedo mitral valve surgery: A totally endoscopic, robotic-assisted approach for adhesiolysis and complex repair.
Amabile A, LaLonde M, Hameed I, Mullan C, Degife E, Morrison A, Shang M, Komlo C, Krane M, Geirsson A. Redo mitral valve surgery: A totally endoscopic, robotic-assisted approach for adhesiolysis and complex repair. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36367136, DOI: 10.1510/mmcts.2022.061.Peer-Reviewed Case Reports and Technical NotesTotally endoscopic, robotic-assisted tricuspid valve repair with neochords.
Amabile A, LaLonde MR, Mullan CW, Hameed I, Degife E, Krane M, Geirsson A, Agrawal A. Totally endoscopic, robotic-assisted tricuspid valve repair with neochords. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36314718, DOI: 10.1510/mmcts.2022.056.Peer-Reviewed Case Reports and Technical NotesDouble Papillary Muscle Relocation: A Totally Endoscopic, Robotic-Assisted Approach.
Amabile A, LaLonde MR, Komlo CMK, Mullan CW, Shang M, Agrawal A, Geirsson A, Krane M. Double Papillary Muscle Relocation: A Totally Endoscopic, Robotic-Assisted Approach. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36314585, DOI: 10.1510/mmcts.2022.058.Peer-Reviewed Case Reports and Technical NotesSurvival After Heart Transplantation From SARS-CoV-2–Positive Donors
Mullan CW, Komlo C, Clark KAA, Sen S, Anwer M, Geirsson A, Ahmad T, Davis RP. Survival After Heart Transplantation From SARS-CoV-2–Positive Donors. JACC Heart Failure 2022, 10: 874-876. PMID: 36328657, PMCID: PMC9555312, DOI: 10.1016/j.jchf.2022.08.006.Peer-Reviewed Original ResearchMembrane attack complexes, endothelial cell activation, and direct allorecognition
Song G, Wang S, Barkestani MN, Mullan C, Fan M, Jiang B, Jiang Q, Li X, Jane-wit D. Membrane attack complexes, endothelial cell activation, and direct allorecognition. Frontiers In Immunology 2022, 13: 1020889. PMID: 36211400, PMCID: PMC9539657, DOI: 10.3389/fimmu.2022.1020889.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionIschemia-reperfusion injuryDonor-derived endothelial cellsAlloreactive T cellsT cellsDirect allorecognitionInflammatory mediatorsMembrane attack complexEndothelial cellsTissue allograftsCell activationEC activationComplement cascadeAlloimmune T cell responsesT cell-mediated inflammationSolid organ transplant rejectionCell-mediated inflammationRecipient T cellsSolid organ transplantationT cell infiltrationT cell responsesDonor endothelial cellsImmune cell activationEndothelial cell activationOrgan transplant rejectionInstitution representation in publications reporting mitral valve repair durability: A scoping review
Komlo CM, Brooks C, Amabile A, Mori M, Najem M, Mullan C, Weininger G, Krane M, Vallabhajosyula P, Geirsson A. Institution representation in publications reporting mitral valve repair durability: A scoping review. Journal Of Cardiac Surgery 2022, 37: 2163-2165. PMID: 35506749, DOI: 10.1111/jocs.16498.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- April 26, 2024
Clancy Mullan Named 2024 Surgeon Scientist Training Program Scholar for Yale Department of Surgery
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- November 03, 2022Source: Medscape
Heart Transplant Outcomes Similar With COVID-19–Positive Donors
- October 12, 2022Source: Healio
Hearts from SARS-CoV-2-positive donors safe for transplant