Project HARAPAN was a 2x2 randomized, controlled trial of a prison-based, pre-release methadone program and an evidence-based behavioral intervention (HHRP) for HIV-infected, opioid dependent prisoners in Malaysia. Participants were randomized to one of four study arms:
  1. methadone only
  2. HHRP only
  3. methadone and HHRP
  4. control/standard of care. Participants were interviewed at baseline, day of release from prison, and then monthly for 12 months post-release. 

Primary outcomes included retention in HIV care, retention in substance dependence treatment, time to relapse to drugs, and time to re-incarceration.

Bio Profile

Frederick Altice, MD

Principal Investigator

Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases)

Director, Clinical and Community Research

Director, HIV in Prisons Program

Director, Community Health Care Van

Academic Icon Professor of Medicine, University of Malaya-Centre of Excellence for Research in AIDS (CERiA)

Frederick L. Altice is a professor of Medicine, Epidemiology and Public Health and is a clinician, clinical epidemiologist, intervention and implementation science researcher at Yale University School of Medicine and School of Public Health. Dr. Altice’s primary research project focuses on the interface between infectious diseases and substance use disorders and he has a special interest in Global Health. He also has a number of projects working in the criminal justice system, including...

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Principal Investigator:
Frederick L Altice, MD 

Funding provided by:
National Institute on Drug Abuse 

Project Period:
June 2008 – August 2013

Link to Report: