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Project HARAPAN was a 2x2 randomized, controlled trial of a prison-based, pre-release methadone program and an evidence-based behavioral intervention (HHRP) for HIV-infected, opioid dependent prisoners in Malaysia. Participants were randomized to one of four study arms:
  1. methadone only
  2. HHRP only
  3. methadone and HHRP
  4. control/standard of care. Participants were interviewed at baseline, day of release from prison, and then monthly for 12 months post-release.

Primary outcomes included retention in HIV care, retention in substance dependence treatment, time to relapse to drugs, and time to re-incarceration.

Principal Investigator:
Frederick L Altice, MD

Funding provided by:
National Institute on Drug Abuse

Project Period:
June 2008 – August 2013

Link to Report:


  • Principal Investigator

    Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases); Affiliated Faculty, Yale Institute for Global Health; Director, Yale Center for Clinical and Community Research, Department of Medicine; Director, HIV in Prisons Program, Infectious Diseases; Director, Community Health Care Van, Intersection of Infectious Diseases and Substance Use Disorders/Addiction Medicine; Academic Icon Professor of Medicine, University of Malaya-Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine