Ashwani Kumar, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchConceptsROCK activitySmall molecule inhibitorsSHROOM3Wild typeAssociated with renal fibrosisCo-expressionRisk allelesTransgenic toolsPleiotropic effectsROCK inhibitionRho-kinaseOverexpressionCell linesPrecision therapeuticsFibroblast linesProfibrotic functionProfibrotic signalingMotifKidney diseaseEnhanced variantRenal fibrosisTubular cellsAlbuminuriaIn vivoMiceDesign and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx.
Kumar A, Barsotti G, Yi Z, Sun Z, Reghuvaran A, Tanvir EM, Pell J, Shi H, Perincheri S, Shaw M, Kent C, Javed D, Leite P, Jayaram D, Turner J, Meliambro K, Luciano R, He JC, Moledina D, Wilson P, Zhang W, Menon MC. Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx. MedRxiv 2025 PMID: 41282816, DOI: 10.1101/2025.10.31.25338655.Peer-Reviewed Original ResearchAPOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection
Pell J, Tanvir E, Sun Z, Azzi J, Murakami N, Reghuvaran A, Kumar A, Barsotti G, Ishibe S, Heeger P, Menon M. APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kn5bktfx. DOI: 10.1681/asn.2025kn5bktfx.Peer-Reviewed Original ResearchUrine mRNA Assay to Measure Compartment-Specific Kidney Injury
Barsotti G, Kumar A, Yi Z, Pell J, Tanvir E, Moledina D, Luciano R, Reghuvaran A, Meliambro K, Perincheri S, Zhang W, He J, Menon M. Urine mRNA Assay to Measure Compartment-Specific Kidney Injury. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025c7mvzqgd. DOI: 10.1681/asn.2025c7mvzqgd.Peer-Reviewed Original ResearchVincristine in FSGS: Rediscovering an Old Therapeutic for FSGS
Kumar A, Prasad P, Menon M. Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS. Kidney International Reports 2025, 10: 3727-3729. PMID: 41278331, PMCID: PMC12640027, DOI: 10.1016/j.ekir.2025.09.018.Peer-Reviewed Original ResearchA T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
Pell J, Tanvir E, Sun Z, Reghuvaran A, Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188.Peer-Reviewed Original ResearchA T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection.
Pell J, Tanvir EM, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Chaar SA, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, Kumar B, Song W, He C, Pober JS, Somlo S, Gibson IW, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon MC. A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. BioRxiv 2025 PMID: 40791557, DOI: 10.1101/2025.07.14.664793.Peer-Reviewed Original ResearchAuthor Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.Peer-Reviewed Original ResearchLILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, PMCID: PMC12527113, DOI: 10.1038/s41591-025-03568-z.Peer-Reviewed Original ResearchSingle-nucelotide polymorphismsAssociated with death-censored graft lossDeath-censored graft lossGenetic variationGraft lossImmunoreceptor tyrosine-based inhibitory motifTyrosine-based inhibitory motifAA individualsApolipoprotein L1Rate of graft lossEnd-stage renal diseaseMissense mutationsInhibitory motifRNA sequencingKidney transplant outcomesKidney transplant failureMultiomics analysisImmune-related diseasesAmino acidsAfrican American recipientsTransplant cohortTransplant failureTransplant outcomesAnalysis of bloodProspective study
2024
Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele
Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.Peer-Reviewed Original Research
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Yale School of Medicine
Internal Medicine-Nephrology, The Anlyan Center, 1 Gilbert Street
New Haven, Connecticut 06519
United States