Abhishek Kumar, MBBS, FASN, FAST
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Research
Publications
2024
Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz M. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. The EMBO Journal 2024, 1-17. PMID: 38886581, DOI: 10.1038/s44318-024-00142-0.Peer-Reviewed Original ResearchLatrophilin-2Affinity purification methodCell-cell junctionsHuman genetic dataPECAM-1SiRNA screenGenetic dataEndothelial cell response to fluid shear stressGA proteinsDownstream eventsEndothelial-specific knockoutG-proteinActivity assayShear stress mechanotransductionPlexin-D1Endothelial signalingJunctional complexesPurification methodVE-cadherinResponse to fluid shear stressVascular developmentGA residuesEndothelial junctionsGPCRsVEGF receptorsKidney after Liver Transplantation for All: Are You Kidneying Me?
Kumar A, Wadei HM. Kidney after Liver Transplantation for All: Are You Kidneying Me? Clin J Am Soc Nephrol 2024 PMID: 38265809, DOI: 10.2215/CJN.0000000000000409.Peer-Reviewed Original Research
2023
A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization
Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.Peer-Reviewed Original ResearchArterial intimal fibrosisGraft lossOrgan utilizationIntimal fibrosisSclerotic glomeruliLarge-scale retrospective studyGlomerular filtration rateDeceased donor kidneysPathologist scoresTransplant outcomesBiopsy findingsSurvival prediction modelWedge biopsyRisk stratificationRetrospective studyFiltration ratePathological assessmentDonor biopsiesNeedle biopsySimilar survivalHistological scoringUnnecessary organsDiscovery setKidneyLesion scores
2022
The Transplant Kidney Biopsy: In Whose Hands?
Virmani S, Kumar A. The Transplant Kidney Biopsy: In Whose Hands? Kidney360 2022, 3: 1662-1663. PMID: 36514728, PMCID: PMC9717671, DOI: 10.34067/kid.0005382022.Peer-Reviewed Original ResearchSeverely Reduced Kidney Function Assessed by a Single eGFR Determination at the Time of an Isolated Heart Transplant Does Not Predict Inevitable Posttransplant ESKD.
Kumar A, Bonnell LN, Thomas CP. Severely Reduced Kidney Function Assessed by a Single eGFR Determination at the Time of an Isolated Heart Transplant Does Not Predict Inevitable Posttransplant ESKD. Transplantation 2022 PMID: 36223634, DOI: 10.1097/TP.0000000000004350.Peer-Reviewed Original ResearchThe U-shaped association of post-lung transplant mortality with pretransplant eGFR underscores possible limitations of creatinine-based estimation equations for risk stratification.
Kumar A, Bonnell LN, Eberlein M, Thomas CP. The U-shaped association of post-lung transplant mortality with pretransplant eGFR underscores possible limitations of creatinine-based estimation equations for risk stratification. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2022, 41: 1277-1284. PMID: 35778259, DOI: 10.1016/j.healun.2022.05.018.Peer-Reviewed Original ResearchThe evolution of performing a kidney biopsy: a single center experience comparing native and transplant kidney biopsies performed by interventional radiologists and nephrologists
Emelianova D, Prikis M, Morris CS, Gibson PC, Solomon R, Scriver G, Smith ZT, Bhave A, Shields J, DeSarno M, Kumar A. The evolution of performing a kidney biopsy: a single center experience comparing native and transplant kidney biopsies performed by interventional radiologists and nephrologists. BMC Nephrology 2022, 23: 226. PMID: 35752759, PMCID: PMC9233823, DOI: 10.1186/s12882-022-02860-1.Peer-Reviewed Original ResearchConceptsKidney biopsyComplication rateNative biopsiesInterventional radiologistsCovariates of interestBiopsy procedureSingle-center retrospective analysisSignificant differencesCenter retrospective analysisSingle-center experienceMultivariable logistic regressionTransplant kidney biopsiesLikelihood of complicationsReal-time ultrasoundHemoglobin checkBaseline characteristicsCenter experienceFrequent complicationMicroscopic hematuriaPost biopsyBlood pressureEntire cohortGeneral anesthesiaBlood countKidney disease
2021
Impact of changing renal function, while waiting for a heart transplant, on post-transplant mortality and development of end stage kidney disease.
Kumar A, Bonnell LN, Thomas CP. Impact of changing renal function, while waiting for a heart transplant, on post-transplant mortality and development of end stage kidney disease. Transplant International : Official Journal Of The European Society For Organ Transplantation 2021 PMID: 33884675, DOI: 10.1111/tri.13889.Peer-Reviewed Original ResearchImpact of age mismatch between donor and recipient on heart transplant mortality.
Kumar A, Bonnell LN, Prikis M, Solomon R. Impact of age mismatch between donor and recipient on heart transplant mortality. Clinical Transplantation 2021, 35: e14194. PMID: 33336373, DOI: 10.1111/ctr.14194.Peer-Reviewed Original Research
2020
Estimated Glomerular Filtration Rate at Transplant Listing and Other Predictors of Post-Heart Transplant Mortality and the Development of ESRD.
Kumar A, Howard A, Thomas CP. Estimated Glomerular Filtration Rate at Transplant Listing and Other Predictors of Post-Heart Transplant Mortality and the Development of ESRD. Transplantation 2020, 104: 2444-2452. PMID: 32028343, DOI: 10.1097/TP.0000000000003159.Peer-Reviewed Original Research
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Nephrology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2015
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