Featured Publications
Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortalityContribution of Individual Diseases to Death in Older Adults with Multiple Diseases
Tinetti ME, McAvay GJ, Murphy TE, Gross CP, Lin H, Allore HG. Contribution of Individual Diseases to Death in Older Adults with Multiple Diseases. Journal Of The American Geriatrics Society 2012, 60: 1448-1456. PMID: 22734792, PMCID: PMC3419332, DOI: 10.1111/j.1532-5415.2012.04077.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCause of DeathComorbidityFemaleGeriatricsHumansLongitudinal StudiesMaleConceptsOlder adultsSingle underlying causeRespiratory diseaseMedicare Current Beneficiary Survey participantsChronic lower respiratory diseasesUnderlying causeAcute kidney injuryLower respiratory diseaseAverage attributable fractionKidney injuryHazard ratioHeart failureLiver diseaseAcute eventMyocardial infarctionUnintentional injuriesAcute diseaseAttributable fractionNational representative sampleMedicare beneficiariesOlder adults' experiencesDiseaseIndividual diseasesDeathConfidence intervalsContribution of Multiple Chronic Conditions to Universal Health Outcomes
Tinetti ME, McAvay GJ, Chang SS, Newman AB, Fitzpatrick AL, Fried TR, Peduzzi PN. Contribution of Multiple Chronic Conditions to Universal Health Outcomes. Journal Of The American Geriatrics Society 2011, 59: 1686-1691. PMID: 21883118, PMCID: PMC3622699, DOI: 10.1111/j.1532-5415.2011.03573.x.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseUniversal health outcomesHeart failureSelf-rated healthCognitive impairmentHealth outcomesChronic conditionsObstructive pulmonary diseaseCardiovascular Health StudyCommunity-living participantsMultiple chronic conditionsPulmonary diseaseBurden ScaleInstrumental activitiesDaily livingCox modelHealth StudyCare prioritiesMore symptomsIADLsDepressionImpairmentOutcomesOsteoarthritisADLs
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic disease
2012
Designing Health Care for the Most Common Chronic Condition—Multimorbidity
Tinetti ME, Fried TR, Boyd CM. Designing Health Care for the Most Common Chronic Condition—Multimorbidity. JAMA 2012, 307: 2493-2494. PMID: 22797447, PMCID: PMC4083627, DOI: 10.1001/jama.2012.5265.Peer-Reviewed Original Research
2009
Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents
Quagliarello V, Juthani‐Mehta M, Ginter S, Towle V, Allore H, Tinetti M. Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents. Journal Of The American Geriatrics Society 2009, 57: 1226-1231. PMID: 19558483, PMCID: PMC2779042, DOI: 10.1111/j.1532-5415.2009.02311.x.Peer-Reviewed Original ResearchConceptsNursing home residentsChlorhexidine oral rinseOral brushingHome residentsOral hygieneStaff adherenceOral rinseIntervention protocolImproved oral hygienePneumonia risk factorsRisk factor reductionPlaque score reductionPrevent PneumoniaChlorhexidine rinseProspective studyRisk factorsScore reductionNursing homesSwallowing techniquesAdherenceBrushingFactor reductionPneumoniaHygieneMonths
1999
Alcohol Use and Functional Disability Among Cognitively Impaired Adults
Reid M, Concaio J, Towle V, Williams C, Tinetti M. Alcohol Use and Functional Disability Among Cognitively Impaired Adults. Journal Of The American Geriatrics Society 1999, 47: 854-859. PMID: 10404931, DOI: 10.1111/j.1532-5415.1999.tb03844.x.Peer-Reviewed Original ResearchConceptsFunctional disabilityIADL scoresHeavy drinkersFormer drinkersMini-Mental Status Examination scoreRetrospective medical record reviewImpaired adultsPotential dose-response effectAlcohol useLower IADL scoresMedical record reviewDose-response effectRecord reviewAlcohol intakeProspective studyConsecutive participantsFunctional statusAlcohol exposureInstrumental activitiesDaily livingIADL functionModerate drinkersCognitive impairmentBADLAlcohol effects