Featured Publications
TOP CITED PAPERS IN INTERNATIONAL PSYCHOGERIATRICS: 6c. TRACKING COGNITIVE DECLINE IN ALZHEIMER'S DISEASE USING THE MINI-MENTAL STATE EXAMINATION: A META-ANALYSIS (“MINI” IS NOT NECESSARILY TRIVIAL!)
Han L, Ames D. TOP CITED PAPERS IN INTERNATIONAL PSYCHOGERIATRICS: 6c. TRACKING COGNITIVE DECLINE IN ALZHEIMER'S DISEASE USING THE MINI-MENTAL STATE EXAMINATION: A META-ANALYSIS (“MINI” IS NOT NECESSARILY TRIVIAL!). International Psychogeriatrics 2009, 21: 1037-1040. PMID: 19747422, DOI: 10.1017/s1041610209990883.Peer-Reviewed Original Research
2017
Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes
Liu Z, Han L, Gahbauer EA, Allore HG, Gill TM. Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes. Journal Of The American Medical Directors Association 2017, 19: 304-309.e2. PMID: 29146224, PMCID: PMC6054444, DOI: 10.1016/j.jamda.2017.10.010.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesNursing home admissionException of hospitalizationMini-Mental State ExaminationFrailty groupHome admissionCumulative burdenSlower cognitive declineCognitive frailtyCognitive declineProgressive frailtyCommunity-living older personsGreater burdenJoint trajectory groupsHigh cumulative burdenCommunity-living personsIncidence density rateLow physical activitySlow walking speedTrajectory groupsEquation Poisson modelsRapid cognitive declineDistinct joint trajectoriesFried phenotypeMuscle weakness
2012
Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons.
Gill TM, Gahbauer EA, Murphy TE, Han L, Allore HG. Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons. Annals Of Internal Medicine 2012, 156: 131-40. PMID: 22250144, PMCID: PMC3278794, DOI: 10.7326/0003-4819-156-2-201201170-00009.Peer-Reviewed Original ResearchConceptsLong-term disabilityRisk factorsOlder personsCohort studyCommunity mobilityShort Physical Performance BatteryMultivariate hazard ratiosProspective cohort studyPhysical Performance BatteryMultiple risk factorsCandidate risk factorsSpecific risk factorsNational InstituteLong-term mobility disabilityHazard ratioAbsolute riskPerformance BatteryPotential precipitantsMobility disabilityRestricted activityOlder ageObserved associationsInitial onsetStrong associationQuarter mile
2011
Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods
Han L, Kim N, Brandt C, Allore HG. Antidepressant Use and Cognitive Deficits in Older Men: Addressing Confounding by Indications with Different Methods. Annals Of Epidemiology 2011, 22: 9-16. PMID: 22037381, PMCID: PMC4054866, DOI: 10.1016/j.annepidem.2011.10.004.Peer-Reviewed Original ResearchConceptsDepression-related diagnosisAntidepressant useDepression symptomsOlder personsPropensity scoreHopkins Verbal Learning TestHypertensive menAntidepressant medicationIndication biasVerbal Learning TestMedical recordsPotential confoundingCumulative exposureOlder menCognitive impairmentMemory deficitsCognitive deficitsMultiple linear regressionLinear regressionLearning TestApparent associationScoresSymptomsDiagnosisIndicationsAntidepressant Use and Cognitive Functioning in Older Medical Patients With Major or Minor Depression
Han L, McCusker J, Cole M, apek R, Abrahamowicz M. Antidepressant Use and Cognitive Functioning in Older Medical Patients With Major or Minor Depression. Journal Of Clinical Psychopharmacology 2011, 31: 429-435. PMID: 21694621, PMCID: PMC3558972, DOI: 10.1097/jcp.0b013e318221b2f8.Peer-Reviewed Original ResearchConceptsOlder medical patientsAntidepressant useMinor depressionMedical patientsAntidepressant medicationMini-Mental State Examination scoreHamilton Depression Rating ScaleMini-Mental State ExaminationProvincial prescription databasePsychotropic drug useDepression Rating ScaleAcute care hospitalsState Examination scoreComplex medical conditionsLong-term cognitive effectsSignificant cognitive impairmentSmall cognitive improvementsAntidepressant prescriptionsCare hospitalConcomitant benzodiazepinesMedical inpatientsPrescription databaseAntidepressant agentsDepression diagnosisMajor depression
2008
12-Month Cognitive Outcomes of Major and Minor Depression in Older Medical Patients
Han L, McCusker J, Cole M, Abrahamowicz M, Čapek R. 12-Month Cognitive Outcomes of Major and Minor Depression in Older Medical Patients. American Journal Of Geriatric Psychiatry 2008, 16: 742-751. PMID: 18757768, DOI: 10.1097/jgp.0b013e31817c6ad7.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationOlder medical patientsMinor depressionPoor cognitive functionMedical patientsDepression diagnosisCognitive functionStudy entryIndependent risk factorProspective cohort studyApparent cognitive impairmentFourth Edition criteriaAcute care hospitalsDiagnostic Interview ScheduleMixed effects regression modelsAntidepressant treatmentCohort studyCare hospitalHospital admissionMedical inpatientsRegression modelsPhysical functionRisk factorsCardiovascular diseaseEdition criteria
2006
The Temporal Relationship Between Depression Symptoms and Cognitive Functioning in Older Medical Patients—Prospective or Concurrent?
Han L, McCusker J, Abrahamowicz M, Cole M, Capek R. The Temporal Relationship Between Depression Symptoms and Cognitive Functioning in Older Medical Patients—Prospective or Concurrent? The Journals Of Gerontology Series A 2006, 61: 1319-1323. PMID: 17234828, DOI: 10.1093/gerona/61.12.1319.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitionCognition DisordersDepressionFemaleFollow-Up StudiesHumansMaleTime FactorsConceptsMini-Mental State ExaminationHamilton Depression Rating ScaleHDRS scoresDepression symptomsCognitive impairmentInpatients 65 yearsIndependent risk factorTime pointsOlder medical patientsDepression Rating ScaleOld-age depressionLower MMSE scoresSame time pointsCognitive functioningSubsequent time pointsOne-point increaseTemporal relationshipCardiovascular riskMMSE changeIllness severityMedical patientsRisk factorsMMSE scoresDepressive symptomsEpidemiological studiesRecoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness
Inouye SK, Zhang Y, Han L, Leo‐Summers L, Jones R, Marcantonio E. Recoverable Cognitive Dysfunction at Hospital Admission in Older Persons During Acute Illness. Journal Of General Internal Medicine 2006, 21: 1276-1281. PMID: 16965558, PMCID: PMC1924736, DOI: 10.1111/j.1525-1497.2006.00613.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAgedAged, 80 and overCognition DisordersCohort StudiesDeliriumDementiaEducational StatusFemaleHospitalizationHumansIncidenceMalePredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecovery of FunctionSeverity of Illness IndexConceptsMini-Mental State ExaminationCognitive dysfunctionAcute illnessOlder personsProspective cohort studyAdjusted odds ratioHigher illness severityPotential clinical implicationsMajority of casesHigher educational levelCohort studyHospital admissionPrimary outcomeIllness severityMultivariable analysisConsecutive admissionsOdds ratioAcademic hospitalFunctional impairmentMMSE scoresState ExaminationDeliriumMMSE impairmentDysfunctionPatients
2000
Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis
Han L, Cole M, Bellavance F, McCusker J, Primeau F. Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis. International Psychogeriatrics 2000, 12: 231-247. PMID: 10937543, DOI: 10.1017/s1041610200006359.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseCognition DisordersHumansNeuropsychological TestsPrognosisSeverity of Illness IndexConceptsMini-Mental State ExaminationAD patientsAlzheimer's diseaseCognitive declineInclusion criteriaStudy populationMMSE scoresState ExaminationCourse of ADPathological diagnostic criteriaEffect sizeInitial MMSE scoreNumber of assessmentsLongitudinal study designOutcome measuresDiagnostic criteriaPopulation characteristicsFollowing keywordsMeta-AnalysisPatientsStudy designDiseaseChange scoresRandom effects regression modelsSignificant heterogeneity