Featured Publications
Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients
Han L, McCusker J, Cole M, Abrahamowicz M, Primeau F, Elie M. Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients. JAMA Internal Medicine 2001, 161: 1099-1105. PMID: 11322844, DOI: 10.1001/archinte.161.8.1099.Peer-Reviewed Original ResearchConceptsDelirium severityACH medicationsMedication exposureDelirium symptomsMedical inpatientsInpatients 65 yearsModifiable risk factorsOlder medical inpatientsUse of medicationsPresence of dementiaElderly medical inpatientsMixed linear regression modelsAnticholinergic medicationsACh effectsAnticholinergic effectsMedication usePrevalent deliriumDelirium IndexRisk factorsClinical severityMedicationsDeliriumSymptom severityLongitudinal associationsSeverity
2011
Antidepressant Use and Cognitive Functioning in Older Medical Patients With Major or Minor Depression
Han L, McCusker J, Cole M, apek R, Abrahamowicz M. Antidepressant Use and Cognitive Functioning in Older Medical Patients With Major or Minor Depression. Journal Of Clinical Psychopharmacology 2011, 31: 429-435. PMID: 21694621, PMCID: PMC3558972, DOI: 10.1097/jcp.0b013e318221b2f8.Peer-Reviewed Original ResearchConceptsOlder medical patientsAntidepressant useMinor depressionMedical patientsAntidepressant medicationMini-Mental State Examination scoreHamilton Depression Rating ScaleMini-Mental State ExaminationProvincial prescription databasePsychotropic drug useDepression Rating ScaleAcute care hospitalsState Examination scoreComplex medical conditionsLong-term cognitive effectsSignificant cognitive impairmentSmall cognitive improvementsAntidepressant prescriptionsCare hospitalConcomitant benzodiazepinesMedical inpatientsPrescription databaseAntidepressant agentsDepression diagnosisMajor depression
2008
12-Month Cognitive Outcomes of Major and Minor Depression in Older Medical Patients
Han L, McCusker J, Cole M, Abrahamowicz M, Čapek R. 12-Month Cognitive Outcomes of Major and Minor Depression in Older Medical Patients. American Journal Of Geriatric Psychiatry 2008, 16: 742-751. PMID: 18757768, DOI: 10.1097/jgp.0b013e31817c6ad7.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationOlder medical patientsMinor depressionPoor cognitive functionMedical patientsDepression diagnosisCognitive functionStudy entryIndependent risk factorProspective cohort studyApparent cognitive impairmentFourth Edition criteriaAcute care hospitalsDiagnostic Interview ScheduleMixed effects regression modelsAntidepressant treatmentCohort studyCare hospitalHospital admissionMedical inpatientsRegression modelsPhysical functionRisk factorsCardiovascular diseaseEdition criteria
2003
The Course of Delirium in Older Medical Inpatients
McCusker J, Cole M, Dendukuri N, Han L, Belzile É. The Course of Delirium in Older Medical Inpatients. Journal Of General Internal Medicine 2003, 18: 696-704. PMID: 12950477, PMCID: PMC1494920, DOI: 10.1046/j.1525-1497.2003.20602.x.Peer-Reviewed Original ResearchConceptsOutcome of deliriumClinical courseMedical inpatientsCourse of deliriumHospital clinical courseProspective cohort studyOlder medical inpatientsTime of diagnosisSeverity of illnessSubgroup of patientsNursing home residencePost-discharge outcomesAcute care hospitalsRole of dementiaHospital courseInitial hospitalizationCohort studyPersistent symptomsCare hospitalHospital recoveryMedical wardsFunctional outcomeAdmission levelsDaily livingDeliriumThe Prognostic Significance of Subsyndromal Delirium in Elderly Medical Inpatients
Cole M, McCusker J, Dendukuri N, Han L. The Prognostic Significance of Subsyndromal Delirium in Elderly Medical Inpatients. Journal Of The American Geriatrics Society 2003, 51: 754-760. PMID: 12757560, DOI: 10.1046/j.1365-2389.2003.51255.x.Peer-Reviewed Original ResearchConceptsElderly medical inpatientsMedical inpatientsPrognostic significanceLonger acute care hospital staysAcute care hospital stayCore symptomsAcute care hospitalsPostdischarge mortalityRevised (DSM-III-R) criteriaHospital stayCohort studyCare hospitalRisk factorsSubsyndromal deliriumDementia statusImportant syndromeDeliriumPhysiological severityMore symptomsAdmissionMental disordersSymptomsPatientsFirst weekInpatients
2002
Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia
Cole MG, McCusker J, Dendukuri N, Han L. Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia. Journal Of Neuropsychiatry 2002, 14: 167-175. PMID: 11983791, DOI: 10.1176/jnp.14.2.167.Peer-Reviewed Original Research