2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associations
2022
Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort
Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Ferrante L. Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort. Journal Of The American Geriatrics Society 2022, 71: 832-844. PMID: 36544250, PMCID: PMC9877652, DOI: 10.1111/jgs.18146.Peer-Reviewed Original ResearchConceptsPatient-centered outcomesCOVID-19 hospitalizationCognitive impairmentPhysical functionOlder COVID-19 survivorsCOVID-19-related symptomsCOVID-19Older adultsIntensive care unitCOVID-19 survivorsPersistent cognitive impairmentSix-month followMost older adultsThird of participantsElectronic health recordsStepdown unitAcute illnessBurdensome symptomsCare unitSupplemental oxygenMedian lengthProspective studyMean ageBlack raceBaseline interviewBenefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort studyEmergency department‐to‐community care transition barriers: A qualitative study of older adults
Gettel CJ, Serina PT, Uzamere I, Hernandez‐Bigos K, Venkatesh AK, Rising KL, Goldberg EM, Feder SL, Cohen AB, Hwang U. Emergency department‐to‐community care transition barriers: A qualitative study of older adults. Journal Of The American Geriatrics Society 2022, 70: 3152-3162. PMID: 35779278, PMCID: PMC9669106, DOI: 10.1111/jgs.17950.Peer-Reviewed Original ResearchConceptsCare transitionsOlder adultsClinical careImmediate post-discharge periodED discharge processEmergency clinical careEmergency department visitsPost-discharge periodAdverse health outcomesOutpatient clinical careDepartment visitsIntact patientsEmergency departmentHealth outcomesOlder adults' willingnessU.S. healthcare systemBaseline activityEffective interventionsIntervention developmentHealthcare systemAdultsCareAdults' willingnessSymptom explanationsEDAssociations between hospitalist physician workload, length of stay, and return to the hospital
Djulbegovic M, Chen K, Cohen AB, Heacock D, Canavan M, Cushing W, Agarwal R, Simonov M, Chaudhry SI. Associations between hospitalist physician workload, length of stay, and return to the hospital. Journal Of Hospital Medicine 2022, 17: 445-455. PMID: 35662410, PMCID: PMC9248905, DOI: 10.1002/jhm.12847.Peer-Reviewed Original ResearchConceptsLength of stayEmergency departmentPhysician workloadYale-New Haven HospitalMedian patient ageSeverity of illnessElectronic health record dataNumber of patientsHealth record dataWeekend admissionHospital daysPatient ageClinical outcomesObservational studyHospitalist serviceMAIN OUTCOMEPatient complexityHospitalist workloadSociodemographic factorsPatient encountersPatientsLogistic regressionMultilevel PoissonRecord dataOutcomes
2021
Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization dataAnticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life
Ouellet GM, Fried TR, Gilstrap LG, O’Leary J, Austin AM, Skinner JS, Cohen AB. Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life. JAMA Internal Medicine 2021, 181: 1121-1123. PMID: 33970197, PMCID: PMC8111560, DOI: 10.1001/jamainternmed.2021.1819.Peer-Reviewed Original ResearchDemographic Characteristics Driving Disparities in Receipt of Long-term Services and Supports in the Community Setting
Travers JL, Naylor MD, Coe NB, Meng C, Li F, Cohen AB. Demographic Characteristics Driving Disparities in Receipt of Long-term Services and Supports in the Community Setting. Medical Care 2021, 59: 537-542. PMID: 33827107, PMCID: PMC8119333, DOI: 10.1097/mlr.0000000000001544.Peer-Reviewed Original ResearchConceptsMinority older adultsWhite older adultsOlder adultsFunctional limitation scoresLimitation scoresUnadjusted analysesDaily livingFunctional limitationsNH careAlzheimer's diseaseCommunity settingsMarital statusAdultsAdult nursingFunctional needsRetirement StudyCareNursingMinority groupsGroupDisparitiesLong-term serviceDifferencesDementiaDisease
2020
Cognitively Impaired Older Persons' and Caregivers' Perspectives on Dementia‐Specific Advance Care Planning
Fried TR, Cohen AB, Harris JE, Moreines L. Cognitively Impaired Older Persons' and Caregivers' Perspectives on Dementia‐Specific Advance Care Planning. Journal Of The American Geriatrics Society 2020, 69: 932-937. PMID: 33216955, PMCID: PMC8300881, DOI: 10.1111/jgs.16953.Peer-Reviewed Original ResearchGuardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes
Cohen AB, Han L, OʼLeary JR, Fried TR. Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes. Journal Of The American Geriatrics Society 2020, 69: 342-348. PMID: 33170957, PMCID: PMC7902349, DOI: 10.1111/jgs.16900.Peer-Reviewed Original ResearchConceptsDays of lifeHospital deathHigh-intensity treatmentMechanical ventilationTube placementHome residentsCardiopulmonary resuscitationNursing homesIntensive care unit admissionMinimum Data Set assessmentsCare unit admissionRetrospective cohort studyNursing home residentsHigh-intensity endMore nursing homesUnit admissionICU admissionCohort studySecondary outcomesPrimary outcomeHospital transferLife hospitalizationsSevere dementiaLife careDementia severityOlder Adults without Desired Surrogates in a Nationally Representative Sample
Cohen AB, Costello DM, OʼLeary JR, Fried TR. Older Adults without Desired Surrogates in a Nationally Representative Sample. Journal Of The American Geriatrics Society 2020, 69: 114-121. PMID: 32898285, PMCID: PMC7854949, DOI: 10.1111/jgs.16813.Peer-Reviewed Original ResearchConceptsNuclear familiesOlder adultsNational Social LifeNationally Representative SampleSocial lifeCommunity-dwelling older adultsRepresentative sampleSocial connectednessCross-sectional studyHealth care agentCare agentsCognitive impairmentLogistic regressionLow indicatorsAdultsRespondentsConfidantsIntact capacityMedical decisions
2019
End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians
Cohen AB, Benjamin AZ, Fried TR. End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians. Journal Of The American Geriatrics Society 2019, 67: 2161-2166. PMID: 31301189, PMCID: PMC6800801, DOI: 10.1111/jgs.16072.Peer-Reviewed Original ResearchConceptsHigh-intensity treatmentPatient preferencesHospice careVeterans Affairs Connecticut Healthcare SystemUnderwent cardiopulmonary resuscitationRetrospective cohort studyIntensive care unitLast monthAdvance care planningLife decisionsDecedent patientsLife decision makingChart reviewCohort studyCare unitTreatment outcomesCardiopulmonary resuscitationOutpatient facilitiesLife careCare planningVA recordsVA facilitiesProfessional guardiansPatientsOlder adultsCharacteristics of Patients With Professional Guardians in the Department of Veterans Affairs Health Care System.
Cohen AB, Trentalange M, Benjamin AZ, Fried TR. Characteristics of Patients With Professional Guardians in the Department of Veterans Affairs Health Care System. JAMA Internal Medicine 2019, 179: 107-108. PMID: 30398533, PMCID: PMC6500761, DOI: 10.1001/jamainternmed.2018.4849.Peer-Reviewed Original Research
2017
Guideline‐Recommended Medications and Physical Function in Older Adults with Multiple Chronic Conditions
McAvay G, Allore HG, Cohen AB, Gnjidic D, Murphy TE, Tinetti ME. Guideline‐Recommended Medications and Physical Function in Older Adults with Multiple Chronic Conditions. Journal Of The American Geriatrics Society 2017, 65: 2619-2626. PMID: 28905359, PMCID: PMC5729049, DOI: 10.1111/jgs.15065.Peer-Reviewed Original ResearchConceptsGuideline-recommended medicationsMultiple chronic conditionsCoronary artery diseasePhysical functionChronic conditionsHeart failureAtrial fibrillationSelf-reported declineOlder adultsArtery diseaseDiabetes mellitusRenin-angiotensin system blockersAngiotensin system blockersProspective observational cohortCommunity-dwelling adultsHealth risk factorsOverall sampleLess polypharmacyPolypharmacy exposureSystem blockersObservational cohortSingle medicationRisk factorsMedicationsLower riskDo‐Not‐Hospitalize Orders in Nursing Homes: “Call the Family Instead of Calling the Ambulance”
Cohen AB, Knobf MT, Fried TR. Do‐Not‐Hospitalize Orders in Nursing Homes: “Call the Family Instead of Calling the Ambulance”. Journal Of The American Geriatrics Society 2017, 65: 1573-1577. PMID: 28369740, PMCID: PMC5507729, DOI: 10.1111/jgs.14879.Peer-Reviewed Original ResearchAvoiding Hospitalizations From Nursing Homes for Potentially Burdensome Care: Results of a Qualitative Study
Cohen AB, Knobf MT, Fried TR. Avoiding Hospitalizations From Nursing Homes for Potentially Burdensome Care: Results of a Qualitative Study. JAMA Internal Medicine 2017, 177: 137-139. PMID: 27893891, PMCID: PMC5345121, DOI: 10.1001/jamainternmed.2016.7128.Peer-Reviewed Original Research
2016
Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions
Allore HG, Zhan Y, Cohen AB, Tinetti ME, Trentalange M, McAvay G. Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions. The Journals Of Gerontology Series A 2016, 71: 1113-1116. PMID: 26748093, PMCID: PMC4945884, DOI: 10.1093/gerona/glv223.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCardiovascular DiseasesDrug PrescriptionsDrug Therapy, CombinationFemaleFollow-Up StudiesHumansMaleMedicareMultiple Chronic ConditionsPractice Guidelines as TopicRetrospective StudiesSurveys and QuestionnairesSurvival RateThiazidesTreatment OutcomeUnited StatesConceptsMultiple chronic conditionsAverage attributable fractionChronic conditionsAttributable fractionCardiovascular conditionsHeart failureMedicare Current Beneficiary Survey participantsRenin-angiotensin system blockersGuideline-recommended medicationsMore chronic conditionsAge-stratified modelsSystem blockersBeta blockersCardiovascular medicationsOral medicationsAtrial fibrillationMedication effectsMedicationsAge strataParticipant characteristicsOlder adultsSurvivalThiazidesBlockersAge
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic diseaseSurrogate Decision Making for Patients Without Nuclear Family
Cohen AB, Trentalange M, Fried T. Surrogate Decision Making for Patients Without Nuclear Family. JAMA 2015, 314: 408-408. PMID: 26219065, DOI: 10.1001/jama.2015.7253.Peer-Reviewed Original Research