2022
Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia
Ouellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia. Journal Of The American Geriatrics Society 2022, 71: 561-568. PMID: 36310367, PMCID: PMC9957933, DOI: 10.1111/jgs.18108.Peer-Reviewed Original ResearchConceptsNursing home residentsAtrial fibrillationAdvanced dementiaHome residentsStroke riskLong-stay nursing home residentsMedicare Part D claimsDementia-related mortalityGuideline-recommended thresholdHarms of anticoagulationRetrospective cohort studyMultivariable survival analysisValvular heart diseaseRisk of deathPart D claimsMonths of lifeMinimum Data SetAnticoagulant discontinuationAnticoagulated individualsMean CHAVASc scoreCause mortalityMultivariable adjustmentOral anticoagulantsCohort studyThe association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias
Gilstrap L, Cohen A, Ouellet GM, Goyal P, Gladders B, Flint D, Skinner J. The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias. Journal Of The American Geriatrics Society 2022, 71: 404-413. PMID: 36240493, DOI: 10.1111/jgs.18086.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAlzheimer DiseaseHeart FailureHospitalizationHumansMedicareStroke VolumeUnited StatesConceptsHigh riskBB useHeart failureAlzheimer's diseaseLong-term mortality ratesConcurrent Alzheimer's diseaseBeta-blocker useReduced ejection fractionMedicare Part ARisk/benefitBB therapyEjection fractionContemporary patientsHFrEFHigh prevalenceSimilar riskMortality ratePatientsCognitive impairmentMortalityDiseaseADRDRiskTherapyOutcomes
2021
Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization dataAnticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life
Ouellet GM, Fried TR, Gilstrap LG, O’Leary J, Austin AM, Skinner JS, Cohen AB. Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life. JAMA Internal Medicine 2021, 181: 1121-1123. PMID: 33970197, PMCID: PMC8111560, DOI: 10.1001/jamainternmed.2021.1819.Peer-Reviewed Original Research
2020
Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes
Cohen AB, Han L, OʼLeary JR, Fried TR. Guardianship and End‐of‐Life Care for Veterans with Dementia in Nursing Homes. Journal Of The American Geriatrics Society 2020, 69: 342-348. PMID: 33170957, PMCID: PMC7902349, DOI: 10.1111/jgs.16900.Peer-Reviewed Original ResearchConceptsDays of lifeHospital deathHigh-intensity treatmentMechanical ventilationTube placementHome residentsCardiopulmonary resuscitationNursing homesIntensive care unit admissionMinimum Data Set assessmentsCare unit admissionRetrospective cohort studyNursing home residentsHigh-intensity endMore nursing homesUnit admissionICU admissionCohort studySecondary outcomesPrimary outcomeHospital transferLife hospitalizationsSevere dementiaLife careDementia severityOlder Adults without Desired Surrogates in a Nationally Representative Sample
Cohen AB, Costello DM, OʼLeary JR, Fried TR. Older Adults without Desired Surrogates in a Nationally Representative Sample. Journal Of The American Geriatrics Society 2020, 69: 114-121. PMID: 32898285, PMCID: PMC7854949, DOI: 10.1111/jgs.16813.Peer-Reviewed Original ResearchConceptsNuclear familiesOlder adultsNational Social LifeNationally Representative SampleSocial lifeCommunity-dwelling older adultsRepresentative sampleSocial connectednessCross-sectional studyHealth care agentCare agentsCognitive impairmentLogistic regressionLow indicatorsAdultsRespondentsConfidantsIntact capacityMedical decisions
2019
End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians
Cohen AB, Benjamin AZ, Fried TR. End‐of‐Life Decision Making and Treatment for Patients with Professional Guardians. Journal Of The American Geriatrics Society 2019, 67: 2161-2166. PMID: 31301189, PMCID: PMC6800801, DOI: 10.1111/jgs.16072.Peer-Reviewed Original ResearchConceptsHigh-intensity treatmentPatient preferencesHospice careVeterans Affairs Connecticut Healthcare SystemUnderwent cardiopulmonary resuscitationRetrospective cohort studyIntensive care unitLast monthAdvance care planningLife decisionsDecedent patientsLife decision makingChart reviewCohort studyCare unitTreatment outcomesCardiopulmonary resuscitationOutpatient facilitiesLife careCare planningVA recordsVA facilitiesProfessional guardiansPatientsOlder adultsCharacteristics of Patients With Professional Guardians in the Department of Veterans Affairs Health Care System.
Cohen AB, Trentalange M, Benjamin AZ, Fried TR. Characteristics of Patients With Professional Guardians in the Department of Veterans Affairs Health Care System. JAMA Internal Medicine 2019, 179: 107-108. PMID: 30398533, PMCID: PMC6500761, DOI: 10.1001/jamainternmed.2018.4849.Peer-Reviewed Original Research
2017
Avoiding Hospitalizations From Nursing Homes for Potentially Burdensome Care: Results of a Qualitative Study
Cohen AB, Knobf MT, Fried TR. Avoiding Hospitalizations From Nursing Homes for Potentially Burdensome Care: Results of a Qualitative Study. JAMA Internal Medicine 2017, 177: 137-139. PMID: 27893891, PMCID: PMC5345121, DOI: 10.1001/jamainternmed.2016.7128.Peer-Reviewed Original Research
2016
Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions
Allore HG, Zhan Y, Cohen AB, Tinetti ME, Trentalange M, McAvay G. Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions. The Journals Of Gerontology Series A 2016, 71: 1113-1116. PMID: 26748093, PMCID: PMC4945884, DOI: 10.1093/gerona/glv223.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCardiovascular DiseasesDrug PrescriptionsDrug Therapy, CombinationFemaleFollow-Up StudiesHumansMaleMedicareMultiple Chronic ConditionsPractice Guidelines as TopicRetrospective StudiesSurveys and QuestionnairesSurvival RateThiazidesTreatment OutcomeUnited StatesConceptsMultiple chronic conditionsAverage attributable fractionChronic conditionsAttributable fractionCardiovascular conditionsHeart failureMedicare Current Beneficiary Survey participantsRenin-angiotensin system blockersGuideline-recommended medicationsMore chronic conditionsAge-stratified modelsSystem blockersBeta blockersCardiovascular medicationsOral medicationsAtrial fibrillationMedication effectsMedicationsAge strataParticipant characteristicsOlder adultsSurvivalThiazidesBlockersAge
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic diseaseGuardianship and End-of-Life Decision Making
Cohen AB, Wright MS, Cooney L, Fried T. Guardianship and End-of-Life Decision Making. JAMA Internal Medicine 2015, 175: 1687-1691. PMID: 26258634, PMCID: PMC4683611, DOI: 10.1001/jamainternmed.2015.3956.Peer-Reviewed Original ResearchConceptsLegal casesProfessional guardiansLife decisionsRecent legal casesImpaired decision-making capacityDecision-making capacityLife-sustaining treatmentJudicial reviewGuardian's authoritySurrogate decision makersVulnerable personsComprehensive standardsGuardiansAuthoritiesStatutesBroader frameworkPreexisting relationshipDecisionsLife treatmentMedical decisionsSuch situationsCourtGuardianshipLawRights
2014
Nascher's Geriatrics at 100
Cohen AB. Nascher's Geriatrics at 100. Journal Of The American Geriatrics Society 2014, 62: 2428-2429. PMID: 25516038, PMCID: PMC4270078, DOI: 10.1111/jgs.13155.Commentaries, Editorials and LettersMeSH KeywordsGeriatricsHistory, 20th CenturyHistory, 21st CenturyHumansTextbooks as TopicUnited StatesConceptsGeriatrics
2013
Medicare and the 3‐Day Rule
Cohen AB. Medicare and the 3‐Day Rule. Journal Of The American Geriatrics Society 2013, 61: 2266-2267. PMID: 24329847, PMCID: PMC3869097, DOI: 10.1111/jgs.12579.Commentaries, Editorials and Letters