2024
Supervised Disulfiram Should Be Considered First-line Treatment for Alcohol Use Disorder
Holt S. Supervised Disulfiram Should Be Considered First-line Treatment for Alcohol Use Disorder. Journal Of Addiction Medicine 2024, 18: 614-616. PMID: 39150091, DOI: 10.1097/adm.0000000000001345.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSupervised disulfiramUse disorderAlcohol use disorder treatmentPrevalence of alcohol use disordersFDA-approved medicationsRandomized controlled trialsFirst-line interventionBehavioral interventionsDouble-blind randomized controlled trialApproved medicationsDisulfiramOpen-label randomized controlled trialSecond-line optionFirst-line treatmentNational treatment guidelinesDisordersTherapeutic resourcesEfficacy dataMedicationTreatment guidelinesAddictionControlled trialsInterventionPatient preferences
2019
A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders
Ahmed OM, Mao JA, Holt SR, Hawk K, D'Onofrio G, Martel S, Melnick ER. A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders. Journal Of Substance Use And Addiction Treatment 2019, 102: 47-52. PMID: 31202288, PMCID: PMC6578846, DOI: 10.1016/j.jsat.2019.05.006.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersCommunity providersCommunity sitesEmergency department-initiated buprenorphineTreatment referral programNeeds assessmentStakeholder meetingsKey stakeholder meetingsED referralsED cliniciansEmergency departmentWarm handoffsMOUDReferral systemReferral processSite referralTrials NetworkPatient identifiersReferral programReferralMedicationsPatientsHIPAA-compliant mannerDisordersUnhealthy Alcohol Use
Holt S, Donroe J. Unhealthy Alcohol Use. DeckerMed Psychiatry 2019 DOI: 10.2310/psych.13106.Peer-Reviewed Original Research
2018
Pharmacotherapy for Alcohol Use Disorder
Holt SR, Tobin DG. Pharmacotherapy for Alcohol Use Disorder. Medical Clinics Of North America 2018, 102: 653-666. PMID: 29933821, DOI: 10.1016/j.mcna.2018.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol use disorderUse disordersNondrug therapiesUndertreated diseaseTreatment optionsPharmacotherapeutic agentsDrug interactionsTreatment goalsUS FoodDrug AdministrationSpecific patientDrug availabilityDisordersPatientsCounseling strategiesComorbiditiesMedicationsPharmacotherapyOptionsTherapyDiseaseAdministrationCareAddressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder
Holt SR, Donroe JH, Cavallo DA, Tetrault JM. Addressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder. Drug And Alcohol Dependence 2018, 186: 171-174. PMID: 29579725, DOI: 10.1016/j.drugalcdep.2017.12.040.Peer-Reviewed Original ResearchConceptsOngoing illicit drug usePatient-provider relationshipOpioid use disorderIllicit drug useUse disordersUrine adulterationTreatment planDrug useQuantitative urine testingMethadone treatment programsSubstance use disordersNorbuprenorphine levelsUrine buprenorphineUrine testingPatientsTreatment programNonjudgmental approachUrine samplesTherapeutic allianceDiscordant levelsBuprenorphineDisordersUrineNorbuprenorphineLevels
2016
Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital
Donroe JH, Holt SR, Tetrault JM. Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital. Canadian Medical Association Journal 2016, 188: cmaj.160290. PMID: 27647616, PMCID: PMC5135493, DOI: 10.1503/cmaj.160290.Peer-Reviewed Original Research