2020
A Randomized Controlled Trial Protocol for Engaging Distress Tolerance and Working Memory to Aid Smoking Cessation in Low Socioeconomic Status (SES) Adults
Otto MW, Zvolensky MJ, Rosenfield D, Hoyt DL, Witkiewitz K, McKee SA, Bickel WK, Smits JAJ. A Randomized Controlled Trial Protocol for Engaging Distress Tolerance and Working Memory to Aid Smoking Cessation in Low Socioeconomic Status (SES) Adults. Health Psychology 2020, 39: 815-825. PMID: 32833483, PMCID: PMC8489738, DOI: 10.1037/hea0000858.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedFemaleHumansMaleMemory, Short-TermMiddle AgedPovertySmoking CessationYoung AdultConceptsDistress toleranceMindfulness interventionLow distress toleranceCessation attemptsLow socioeconomic contextExperimental medicine approachRandomized clinical trial designWorking memoryLow socioeconomic status adultsMemory capacitySmoking lapseTarget of treatmentHeightened stressTreatment refinementNicotine useQuit attemptsControlled Trial ProtocolMechanistic targetStrongest predictorSpecific vulnerabilitiesClinical trial designLow educational attainmentEducational attainmentLapseTherapeutic gain
2018
Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes
Roberts W, McKee SA. Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes. Experimental And Clinical Psychopharmacology 2018, 26: 49-57. PMID: 29389170, PMCID: PMC5797996, DOI: 10.1037/pha0000161.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive functioningCognitive assessment batteryContinuous performance taskAdult heavy drinkersSignificant indirect effectUse disordersReaction timeEffects of vareniclinePerformance taskHeavy drinkersCognitive outcomesAssessment BatteryHuman laboratory experimentsCognitive functionMediation analysisDrinking outcomesMemoryLess drinkingAlcohol useDrinking behaviorIndirect effectsLaboratory sessionsDrinking taskVarenicline dose
2016
Effect of Varenicline Combined with High‐Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings
Verplaetse TL, Pittman BP, Shi JM, Tetrault JM, Coppola S, McKee SA. Effect of Varenicline Combined with High‐Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings. Alcohol Clinical And Experimental Research 2016, 40: 1567-1576. PMID: 27246567, PMCID: PMC4930423, DOI: 10.1111/acer.13110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationAlcohol-Related DisordersAssociation LearningBlood PressureCravingDose-Response Relationship, DrugDouble-Blind MethodEthanolExecutive FunctionFemaleHeart RateHumansMaleMemory, Short-TermNicotinic AgonistsPsychological TestsPsychomotor PerformanceVareniclineYoung AdultConceptsPerceptual-motor functionAlcohol use disorderExecutive cognitive functionCognitive functionDose of alcoholSubjective reactivitySubjective intoxicationHigh-dose alcoholNonalcoholic control beverageAlcohol-motivated behaviorsUse disordersEffects of vareniclineAssociative learningAversive eventsLaboratory paradigmDiastolic blood pressureAlcohol cravingControl beverageMotor responsePhysiologic reactivityAlcohol-related increasesLaboratory sessionsMotor functionBlood pressurePreliminary investigation
2012
Effects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers
Ashare RL, McKee SA. Effects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers. Experimental And Clinical Psychopharmacology 2012, 20: 63-70. PMID: 21942262, PMCID: PMC3640636, DOI: 10.1037/a0025594.Peer-Reviewed Original ResearchConceptsNicotine deprivationCognitive processesMeasures of attentionNicotine-deprived smokersMeasures of cravingEffects of vareniclineNegative affectOvernight abstinenceCurrent data highlightMemoryReduced accuracyDaily smokersCurrent sampleDifficulty concentratingLaboratory sessionsEffects of bupropionFuture researchReaction timeSex differencesRecent researchAbstinence ratesDeficitsNew pharmacological treatmentsParticipantsSmoking cessation