2021
The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation
D'Onofrio G, Hawk KF, Herring AA, Perrone J, Cowan E, McCormack RP, Dziura J, Taylor RA, Coupet E, Edelman EJ, Pantalon MV, Owens PH, Martel SH, O'Connor PG, Van Veldhuisen P, DeVogel N, Huntley K, Murphy SM, Lofwall MR, Walsh SL, Fiellin DA. The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation. Contemporary Clinical Trials 2021, 104: 106359. PMID: 33737199, PMCID: PMC9153252, DOI: 10.1016/j.cct.2021.106359.Peer-Reviewed Original ResearchConceptsOpioid use disorderRandomized clinical trialsPrimary outcomeFormal addiction treatmentOpioid withdrawalClinical trialsAncillary studiesUse disordersSelf-reported opioid useAddiction treatmentEmergency department initiationIncremental cost-effectiveness ratioReceipt of medicationEmergency department studyHealth service utilizationCost-effectiveness ratioOpioid useSecondary outcomesService utilizationTreatment accessEligibility criteriaImplementation facilitationBuprenorphineOverdose eventsDepartment study
2002
Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome
Fiellin D, O'Connor P, Holmboe E, Horwitz R. Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome. Substance Use & Addiction Journal 2002, 23: 83-94. DOI: 10.1023/a:1015350005418.Peer-Reviewed Original ResearchAdverse clinical featuresDelirium tremensComplicated withdrawalBlood pressureClinical featuresComplicated alcohol withdrawalElevated blood pressureAlcohol withdrawal syndromeSystolic blood pressureCase-control studyDSM-IV criteriaComorbidity scoreMedical comorbiditiesAlcohol withdrawalWithdrawal syndromeDetoxification unitEligibility criteriaTremensWithdrawalRiskComorbiditiesPatientsAdmissionHospitalSyndromeRisk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1
Fiellin DA, O'Connor PG, Holmboe ES, Horwitz RI. Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1. Substance Use & Addiction Journal 2002, 23: 83-94. PMID: 12444353, DOI: 10.1080/08897070209511478.Peer-Reviewed Original ResearchConceptsAdverse clinical featuresDelirium tremensComplicated withdrawalBlood pressureAlcohol withdrawalClinical featuresComplicated alcohol withdrawalElevated blood pressureSystolic blood pressureCase-control studyDSM-IV criteriaComorbidity scoreMedical comorbiditiesDetoxification unitEligibility criteriaTremensWithdrawalRiskComorbiditiesPatientsAdmissionHospitalCasesControl