2017
Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia
Bazazi AR, Wickersham JA, Wegman MP, Culbert GJ, Pillai V, Shrestha R, Al-Darraji H, Copenhaver MM, Kamarulzaman A, Altice FL. Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia. Contemporary Clinical Trials 2017, 59: 1-12. PMID: 28479216, PMCID: PMC5557499, DOI: 10.1016/j.cct.2017.05.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyHIV transmission risk behaviorsMaintenance therapyTransmission risk behaviorsEvidence-based behavioral interventionsOpioid dependencePoor HIV treatment outcomesRisk behaviorsBehavioral interventionsHIV treatment outcomesProspective clinical trialsEvidence-based treatmentsHealth-related outcomesOpioid useTreatment receiptClinical trialsTreatment outcomesIncarcerated peopleTherapyStudy participantsFactorial trialHIVTrialsInterventionOutcomes
2016
Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study
Wegman MP, Altice FL, Kaur S, Rajandaran V, Osornprasop S, Wilson D, Wilson DP, Kamarulzaman A. Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study. The Lancet Global Health 2016, 5: e198-e207. PMID: 27964869, PMCID: PMC5657487, DOI: 10.1016/s2214-109x(16)30303-5.Peer-Reviewed Original ResearchConceptsVoluntary drug treatment centresCompulsory drug detention centersOpioid-dependent individualsProspective observational studyOpioid relapseTwo-armObservational studyTreatment centersEvidence-based pharmacological therapyHazard ratio reductionUrinary drug testingDrug testsOpioid agonist treatmentDoris Duke Charitable FoundationOpioid use disorderUrine drug testsMethadone treatment centersAssessed individualsDrug treatment centersNational InstituteEvidence-based treatmentsSubstance use disordersMedical Research CouncilAustralian National HealthVTC participantsPretreatment Drug use Characteristics and Experiences among Patients in a Voluntary Substance Abuse Treatment Center in Malaysia: A Mixed-Methods Approach
Krishnan A, Brown SE, Ghani MA, Khan F, Kamarulzaman A, Altice FL. Pretreatment Drug use Characteristics and Experiences among Patients in a Voluntary Substance Abuse Treatment Center in Malaysia: A Mixed-Methods Approach. Substance Use & Addiction Journal 2016, 37: 542-549. PMID: 26914230, PMCID: PMC5551393, DOI: 10.1080/08897077.2016.1146648.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMalaysiaMaleNeedle SharingPeer GroupRisk-TakingSubstance Abuse Treatment CentersSubstance Abuse, IntravenousSubstance-Related DisordersYoung AdultConceptsCompulsory drug detention centersDrug use characteristicsDrug useAmphetamine useTreatment centersDrug usersVoluntary drug treatment centresIllicit amphetamine useInjection drug useDrug treatment centersSubstance abuse treatment centersDrug use patternsDrug use profilesHigh-risk behaviorsSignificant public healthDrug initiationCare centerHigh prevalencePolysubstance useNortheast MalaysiaAddiction severityPatientsBehavioral interventionsAddiction treatmentConvenience samplePublic health and international drug policy
Csete J, Kamarulzaman A, Kazatchkine M, Altice F, Balicki M, Buxton J, Cepeda J, Comfort M, Goosby E, Goulão J, Hart C, Kerr T, Lajous AM, Lewis S, Martin N, Mejía D, Camacho A, Mathieson D, Obot I, Ogunrombi A, Sherman S, Stone J, Vallath N, Vickerman P, Zábranský T, Beyrer C. Public health and international drug policy. The Lancet 2016, 387: 1427-1480. PMID: 27021149, PMCID: PMC5042332, DOI: 10.1016/s0140-6736(16)00619-x.Peer-Reviewed Original Research
2015
Treatment Readiness, Attitudes Toward, and Experiences with Methadone and Buprenorphine Maintenance Therapy Among People Who Inject Drugs in Malaysia
Vijay A, Bazazi AR, Yee I, Kamarulzaman A, Altice FL. Treatment Readiness, Attitudes Toward, and Experiences with Methadone and Buprenorphine Maintenance Therapy Among People Who Inject Drugs in Malaysia. Journal Of Substance Use And Addiction Treatment 2015, 54: 29-36. PMID: 25841703, PMCID: PMC4758679, DOI: 10.1016/j.jsat.2015.01.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAge of OnsetAgedAttitudeBuprenorphineEthnicityFemaleHumansMalaysiaMaleMethadoneMiddle AgedNarcoticsNeedle SharingNeedle-Exchange ProgramsOpiate Substitution TreatmentPatient Acceptance of Health CareStress, PsychologicalSubstance Abuse Treatment CentersSubstance Abuse, IntravenousYoung AdultConceptsOpioid maintenance therapyBuprenorphine maintenance therapyMaintenance therapyTreatment readinessNeedle/syringe exchange programsSharing of needlesMultivariable linear regressionSyringe exchange programsCompulsory drug detention centersMajority of subjectsReadiness scoresOpioid dependencePatients' attitudesPrimary careMethadoneTreatment settingsStress symptom severityBuprenorphineIndian ethnicityAdult populationSymptom severityOlder agePast monthTherapyDrugs
2014
Buprenorphine Maintenance Treatment Retention Improves Nationally Recommended Preventive Primary Care Screenings when Integrated into Urban Federally Qualified Health Centers
Haddad MS, Zelenev A, Altice FL. Buprenorphine Maintenance Treatment Retention Improves Nationally Recommended Preventive Primary Care Screenings when Integrated into Urban Federally Qualified Health Centers. Journal Of Urban Health 2014, 92: 193-213. PMID: 25550126, PMCID: PMC4338126, DOI: 10.1007/s11524-014-9924-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCohort StudiesConnecticutFemaleHumansMaintenance ChemotherapyMaleMass ScreeningMiddle AgedOpioid-Related DisordersPrimary Health CareSubstance Abuse Treatment CentersUrban PopulationYoung AdultConceptsBuprenorphine maintenance therapyPrimary care providersPrimary health care settingsHealth care screeningQualified health centersHealth care settingsOpioid dependenceHealth centersPsychiatric specialistsUrban Federally Qualified Health CenterFederally Qualified Health CentersOpioid-dependent womenPrimary care screeningObservational cohort studyOpioid-dependent patientsHuman immunodeficiency virusProportion of subjectsHealth care indicatorsHealth care outcomesImproved health outcomesElectronic health recordsUrban FQHCsHepatitis CMaintenance therapyCohort studyAn exploratory qualitative assessment of self-reported treatment outcomes and satisfaction among patients accessing an innovative voluntary drug treatment centre in Malaysia
Ghani MA, Brown SE, Khan F, Wickersham JA, Lim SH, Dhaliwal SK, Kamarulzaman A, Altice FL. An exploratory qualitative assessment of self-reported treatment outcomes and satisfaction among patients accessing an innovative voluntary drug treatment centre in Malaysia. International Journal Of Drug Policy 2014, 26: 175-182. PMID: 25577322, PMCID: PMC4291539, DOI: 10.1016/j.drugpo.2014.10.002.Peer-Reviewed Original ResearchConceptsCompulsory drug detention centersVoluntary drug treatment centresDrug treatment centersTreatment centersTreatment-based approachExploratory qualitative assessmentDrug treatment programsPositive patient experienceSelf-reported treatment outcomesAcute detoxificationAddiction needsMethadone treatmentCare centerTreatment successTreatment outcomesPatient's perspectivePatient experienceDrug usersHealthcare accessExplorative qualitative studyTreatment programPatientsAddiction rehabilitationConvenience samplePsychosocial programsCorrelates of Having Never Been HIV Tested among Entrants to Substance Abuse Treatment Clinics: Empiric Findings from Real-World New England Settings
Chadwick JJ, Andrade LF, Altice FL, Petry NM. Correlates of Having Never Been HIV Tested among Entrants to Substance Abuse Treatment Clinics: Empiric Findings from Real-World New England Settings. Journal Of Psychoactive Drugs 2014, 46: 208-214. PMID: 25052879, PMCID: PMC4780256, DOI: 10.1080/02791072.2014.915363.Peer-Reviewed Original ResearchMeSH KeywordsAdultChi-Square DistributionDrug UsersEmploymentFemaleHealth Knowledge, Attitudes, PracticeHealth StatusHIV InfectionsHumansLogistic ModelsMaleMiddle AgedNew EnglandOdds RatioPatient Acceptance of Health CarePredictive Value of TestsRisk FactorsSerologic TestsSex FactorsSubstance Abuse Treatment CentersSubstance-Related DisordersConceptsSubstance abuse treatment patientsSubstance abuse treatment clinicsSubstance abuse patientsSubstance abuse treatmentHIV testingTreatment patientsMale genderTreatment clinicsAbuse patientsHIVPatientsMedical problemsAbuse treatmentRoutine testingClinicSignificant minorityReal-world evaluationEmpiric findingsTesting strategiesTreatmentTestingAccessibility and utilization patterns of a mobile medical clinic among vulnerable populations
Gibson BA, Ghosh D, Morano JP, Altice FL. Accessibility and utilization patterns of a mobile medical clinic among vulnerable populations. Health & Place 2014, 28: 153-166. PMID: 24853039, PMCID: PMC4475348, DOI: 10.1016/j.healthplace.2014.04.008.Peer-Reviewed Original Research
2013
Tuberculosis screening in a novel substance abuse treatment center in Malaysia: Implications for a comprehensive approach for integrated care
Al-Darraji HA, Wong KC, Yeow DG, Fu JJ, Loeliger K, Paiji C, Kamarulzaman A, Altice FL. Tuberculosis screening in a novel substance abuse treatment center in Malaysia: Implications for a comprehensive approach for integrated care. Journal Of Substance Use And Addiction Treatment 2013, 46: 144-149. PMID: 24074846, PMCID: PMC5189907, DOI: 10.1016/j.jsat.2013.08.023.Peer-Reviewed Original ResearchConceptsLatent TB infectionTuberculin skin testingDrug treatment centersSubstance abuse treatment centersTreatment centersKey high‐risk groupsVoluntary drug treatment centresCross-sectional convenience surveyHigh-risk groupComplex treatment needsArrest/incarcerationActive diseaseTB infectionTB screeningTST positivitySkin testingRisk groupsTreatment needsHeroin useStandardized questionnaireTreatment entryIntegrated careTreatment programTuberculosisPrevalenceIntegrating buprenorphine maintenance therapy into federally qualified health centers: Real-world substance abuse treatment outcomes
Haddad MS, Zelenev A, Altice FL. Integrating buprenorphine maintenance therapy into federally qualified health centers: Real-world substance abuse treatment outcomes. Drug And Alcohol Dependence 2013, 131: 127-135. PMID: 23332439, PMCID: PMC3674170, DOI: 10.1016/j.drugalcdep.2012.12.008.Peer-Reviewed Original ResearchConceptsQualified health centersSubstance abuse counselingHealth centersBuprenorphine maintenance treatment programCocaine useBuprenorphine maintenance therapyConcomitant cocaine useOpioid-dependent patientsMaintenance treatment programReal-world effectivenessSubstance abuse treatment outcomesElectronic health recordsHCV infectionMaintenance therapyPsychiatric comorbidityMean ageDependent patientsPsychiatric medicationsClinical trialsTreatment outcomesMood disordersFamily practitionersMore weeksTreatment programBMT
2011
Integration of Buprenorphine/Naloxone Treatment into HIV Clinical Care: Lessons From the BHIVES Collaborative
Weiss L, Netherland J, Egan JE, Flanigan TP, Fiellin DA, Finkelstein R, Altice FL. Integration of Buprenorphine/Naloxone Treatment into HIV Clinical Care: Lessons From the BHIVES Collaborative. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 56: s68-s75. PMID: 21317597, DOI: 10.1097/qai.0b013e31820a8226.Peer-Reviewed Original ResearchMeSH KeywordsAmbulatory CareAnti-HIV AgentsBuprenorphineBuprenorphine, Naloxone Drug CombinationDelivery of Health Care, IntegratedHealth ResourcesHealth Services Needs and DemandHIV InfectionsHumansNaloxoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPrimary Health CareSubstance Abuse Treatment CentersUnited StatesConceptsBUP/NXHIV clinical careBup/HIV evaluationClinical careBuprenorphine/naloxone treatmentGeneral internal medicine physiciansHospital-based clinicsInternal medicine physiciansSite principal investigatorsExperiences of physiciansMental health issuesPrincipal investigatorHIV providersMultisubstance useNX treatmentHIV careIntegrated HIVNaloxone treatmentUrine toxicologyMultiple prescribersHIV treatmentMedicine physiciansTreatment servicesProvider experience
2007
HIV treatment access and scale-up for delivery of opiate substitution therapy with buprenorphine for IDUs in Ukraine—programme description and policy implications
Bruce RD, Dvoryak S, Sylla L, Altice FL. HIV treatment access and scale-up for delivery of opiate substitution therapy with buprenorphine for IDUs in Ukraine—programme description and policy implications. International Journal Of Drug Policy 2007, 18: 326-328. PMID: 17689382, PMCID: PMC2084072, DOI: 10.1016/j.drugpo.2006.12.011.Peer-Reviewed Original ResearchConceptsBuprenorphine maintenance therapyInjection drug useAnti-retroviral therapySubstitution therapyDrug useAddition of methadoneAdministration of buprenorphineHIV-1 seropositivityOpiate substitution therapyOverall health outcomesIllicit drug useCost of buprenorphineHIV treatment accessMaintenance therapyOpioid dependenceHIV casesEntry criteriaTreatment accessBuprenorphineDrug usersHealth outcomesMultidisciplinary teamTherapyGlobal Fund resourcesAdministrationBehavioral Counseling Content for Optimizing the Use of Buprenorphine for Treatment of Opioid Dependence in Community-Based Settings: A Review of the Empirical Evidence
Copenhaver MM, Bruce RD, Altice FL. Behavioral Counseling Content for Optimizing the Use of Buprenorphine for Treatment of Opioid Dependence in Community-Based Settings: A Review of the Empirical Evidence. The American Journal Of Drug And Alcohol Abuse 2007, 33: 643-654. PMID: 17891657, PMCID: PMC2274830, DOI: 10.1080/00952990701522674.Peer-Reviewed Original Research
2006
The Potential Role of Buprenorphine in the Treatment of Opioid Dependence in HIV-Infected Individuals and in HIV Infection Prevention
Altice FL, Sullivan LE, Smith-Rohrberg D, Basu S, Stancliff S, Eldred L. The Potential Role of Buprenorphine in the Treatment of Opioid Dependence in HIV-Infected Individuals and in HIV Infection Prevention. Clinical Infectious Diseases 2006, 43: s178-s183. PMID: 17109304, DOI: 10.1086/508181.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHumansIncidenceMaleNarcotic AntagonistsOpioid-Related DisordersRisk AssessmentSeverity of Illness IndexSubstance Abuse DetectionSubstance Abuse Treatment CentersSurvival AnalysisTreatment OutcomeUnited StatesConceptsHIV clinical care settingsHIV treatment outcomesClinical care settingsRole of buprenorphineOpioid dependenceTreatment outcomesCare settingsHuman immunodeficiency virus (HIV) infectionStudies of buprenorphineImmunodeficiency virus infectionHIV infection preventionUntreated opioid dependenceAntiretroviral therapyHIV carePreventive therapySecondary preventionAntiretroviral treatmentBuprenorphine treatmentHIV infectionOpportunistic infectionsSuccessful treatmentInfection preventionVirus infectionBuprenorphineInfected individuals