2023
Receipt of Smoking Cessation Medications Among People With and Without Human Immunodeficiency Virus in the Veterans Aging Cohort Study (2003–2018)
Shahrir S, Crothers K, McGinnis K, Chan K, Baeten J, Wilson S, Butt A, Pisani M, Baldassarri S, Justice A, Williams E. Receipt of Smoking Cessation Medications Among People With and Without Human Immunodeficiency Virus in the Veterans Aging Cohort Study (2003–2018). Open Forum Infectious Diseases 2023, 10: ofad089. PMID: 36968969, PMCID: PMC10034589, DOI: 10.1093/ofid/ofad089.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyAging Cohort StudyHuman immunodeficiency virusCessation medicationsCohort studyCurrent smokersCurrent smokingHIV statusImmunodeficiency virusRelative riskHuman immunodeficiency virus statusSmoking cessation medicationsNicotine replacement therapyRates of receiptDangers of smokingOutpatient prescriptionsReplacement therapyPharmacy dataVirus statusTobacco useAnnual rateMedicationsSmokingPWHStatistical difference
2022
Using the biomarker cotinine and survey self-report to validate smoking data from United States Veterans Health Administration electronic health records
McGinnis K, Skanderson M, Justice A, Tindle H, Akgün K, Wrona A, Freiberg M, Goetz M, Rodriguez-Barradas M, Brown S, Crothers K. Using the biomarker cotinine and survey self-report to validate smoking data from United States Veterans Health Administration electronic health records. JAMIA Open 2022, 5: ooac040. PMID: 37252267, PMCID: PMC9154288, DOI: 10.1093/jamiaopen/ooac040.Peer-Reviewed Original ResearchICD-10 codesClinical remindersCurrent smokingSmoking dataSelf-reported smoking statusVeterans Health Administration electronic health recordsCohort Study participantsElectronic health record dataHealth record dataElectronic health recordsSmoking informationSmoking statusSalivary cotinineEpidemiologic studiesInternational ClassificationSmokingCotinineStudy participantsICD-10Health systemHealth recordsRecord dataKappa statisticsAfrican AmericansReminders
2021
Brief original report: Does smoking status provide information relevant to screening for other substance use among US adults?
Khan MR, Ban K, Caniglia EC, Edelman JE, Gaither J, Crystal S, Chichetto NE, Young KE, Tate J, Justice AC, Braithwaite RS. Brief original report: Does smoking status provide information relevant to screening for other substance use among US adults? Preventive Medicine Reports 2021, 23: 101483. PMID: 34345578, PMCID: PMC8319511, DOI: 10.1016/j.pmedr.2021.101483.Peer-Reviewed Original ResearchInjection drug useUnhealthy alcohol useTobacco screeningDrug useSubstance useOpioid useStimulant useAlcohol useCrack/cocaine useIllicit opioid useCrack/cocaineTest performance characteristicsFormer smokersCurrent smokingSmoking statusUS adultsLifetime smokingCocaine useSmokingScreening resultsFour-fold decreaseNegative resultsMarijuana usePositive resultsTwo-fold decrease
2020
Receipt and predictors of smoking cessation pharmacotherapy among veterans with and without HIV
Shahrir S, Crothers K, McGinnis KA, Chan KCG, Baeten JM, Wilson SM, Butt AA, Pisani MA, Baldassarri SR, Justice A, Williams EC. Receipt and predictors of smoking cessation pharmacotherapy among veterans with and without HIV. Progress In Cardiovascular Diseases 2020, 63: 118-124. PMID: 31987807, PMCID: PMC7251937, DOI: 10.1016/j.pcad.2020.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-HIV AgentsCardiovascular DiseasesFemaleHealth StatusHIV InfectionsHIV Long-Term SurvivorsHumansLongitudinal StudiesMaleMiddle AgedPreventive Health ServicesProspective StudiesProtective FactorsRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokersSmokingSmoking CessationSmoking Cessation AgentsTime FactorsTreatment OutcomeUnited StatesVeterans HealthViral LoadConceptsNicotine replacement therapyVeterans Aging Cohort StudyMultivariable log-linear regression modelsPotential treatment disparitiesSmoking cessation pharmacotherapyPatient-level factorsAging Cohort StudyMental health disordersRates of receiptUninfected participantsUninfected patientsCardiovascular riskCessation pharmacotherapyCohort studyCurrent smokingHIV statusMultivariable analysisTreatment disparitiesReplacement therapyRelative riskHealth disordersPharmacotherapyPLWHSmokingHIV
2018
Using DNA methylation to validate an electronic medical record phenotype for smoking
McGinnis KA, Justice AC, Tate JP, Kranzler HR, Tindle HA, Becker WC, Concato J, Gelernter J, Li B, Zhang X, Zhao H, Crothers K, Xu K, Group F. Using DNA methylation to validate an electronic medical record phenotype for smoking. Addiction Biology 2018, 24: 1056-1065. PMID: 30284751, PMCID: PMC6541538, DOI: 10.1111/adb.12670.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyAging Cohort StudyStrong associationDNA methylation sitesSmoking metricsCohort studyCurrent smokingSmoking statusSpearman correlation coefficientBiomarker cohortBlood samplesSmoking behaviorCriterion standardLogistic regressionSmokingSmoking phenotypesCurve analysisGroup assignmentText notesAssociationDescriptive statisticsPhenotypeCorrelation coefficientGenetic discoveriesPercent
2016
What are the Patterns Between Depression, Smoking, Unhealthy Alcohol Use, and Other Substance Use Among Individuals Receiving Medical Care? A Longitudinal Study of 5479 Participants
Ruggles KV, Fang Y, Tate J, Mentor SM, Bryant KJ, Fiellin DA, Justice AC, Braithwaite RS. What are the Patterns Between Depression, Smoking, Unhealthy Alcohol Use, and Other Substance Use Among Individuals Receiving Medical Care? A Longitudinal Study of 5479 Participants. AIDS And Behavior 2016, 21: 2014-2022. PMID: 27475945, PMCID: PMC5542002, DOI: 10.1007/s10461-016-1492-9.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useVeterans Aging Cohort StudyAlcohol useSubstance useTreatment strategiesIntegrated screeningCurrent depressionMedical careHIV-negative subgroupsAging Cohort StudyPatterns of depressionCohort studyCurrent smokingOpioid useNegative subgroupSmokingDepressionLongitudinal studyHIVMarijuana useSubgroupsCareCurrent useScreeningStatus
2015
Do Alcohol Misuse, Smoking, and Depression Vary Concordantly or Sequentially? A Longitudinal Study of HIV-Infected and Matched Uninfected Veterans in Care
Braithwaite RS, Fang Y, Tate J, Mentor SM, Bryant KJ, Fiellin DA, Justice AC. Do Alcohol Misuse, Smoking, and Depression Vary Concordantly or Sequentially? A Longitudinal Study of HIV-Infected and Matched Uninfected Veterans in Care. AIDS And Behavior 2015, 20: 566-572. PMID: 26187007, PMCID: PMC5009622, DOI: 10.1007/s10461-015-1117-8.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol misuseCurrent smokingVeterans Aging Cohort StudyAlcohol useAging Cohort StudyUninfected veteransCohort studyHIV statusDepression variesChronic diseasesCommon syndromePrior depressionSmokingUninfected individualsCurrent depressionHIVDepressionLongitudinal studyRegression analysisCareVeteransMisuseSame surveyNumber of years
2013
Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans
Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.Peer-Reviewed Original ResearchConceptsVACS Index scoreMedical intensive care unit admissionIntensive care unit admissionVeterans Aging Cohort StudyCare unit admissionMICU admissionIndex scoreRisk factorsHazardous alcohol useVACS IndexUnit admissionCurrent smokingChronic obstructive pulmonary diseaseAlcohol useNon-AIDS diseasesVA administrative databasesMultivariable Cox regressionSurvival of HIVObstructive pulmonary diseaseAging Cohort StudyElectronic medical recordsAntiretroviral therapyCause mortalityPrior AIDSPrior cancer
2012
HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clinical Infectious Diseases 2012, 55: 126-136. PMID: 22534147, PMCID: PMC3493182, DOI: 10.1093/cid/cis406.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationVeterans Aging Cohort StudyAltered coagulationMonocyte activationUninfected veteransCardiovascular diseaseElevated biomarkersComorbid conditionsHigh prevalenceCD4 cell countElevated IL-6Aging Cohort StudyOngoing HIV replicationPrevalent cardiovascular diseaseHIV-1 RNAHuman immunodeficiency virusCopies/mLElevated sCD14More dyslipidemiaCD4 countHepatitis CCohort studyComorbid diseasesCurrent smokingHIV infection
2010
Decreased Serum Antibody Responses to Recombinant Pneumocystis Antigens in HIV-Infected and Uninfected Current Smokers
Crothers K, Daly KR, Rimland D, Goetz MB, Gibert CL, Butt AA, Justice AC, Djawe K, Levin L, Walzer PD. Decreased Serum Antibody Responses to Recombinant Pneumocystis Antigens in HIV-Infected and Uninfected Current Smokers. MSphere 2010, 18: 380-386. PMID: 21191078, PMCID: PMC3067379, DOI: 10.1128/cvi.00421-10.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusChronic obstructive pulmonary diseaseAntibody responseEnzyme-linked immunosorbent assayP. jiroveciiCurrent smokersSerum antibodiesHIV-negative subjectsObstructive pulmonary diseaseInjection drug useSerum antibody responseMultivariate Tobit regression modelsHazardous alcohol useCross-sectional analysisUninfected patientsCurrent smokingHIV infectionIndependent predictorsPulmonary diseaseSyncytial virusImmunosuppressive effectsSerologic studiesSubsequent riskPneumocystis jiroveciiDrug use
2009
Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans.
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Goetz MB, Crystal S, Leaf DA, Butt AA, Braithwaite RS, Peck R, Justice AC. Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans. AIDS Education And Prevention 2009, 21: 40-53. PMID: 19537953, PMCID: PMC3118467, DOI: 10.1521/aeap.2009.21.3_supp.40.Peer-Reviewed Original ResearchConceptsHIV-negative veteransIncidence rate ratiosSmoking statusHIV-negative patientsSimilar mortality riskHIV-positive veteransComorbid diseasesCurrent smokingOverall mortalityCigarette smokingPoor outcomeMortality riskHIVPoisson regressionMortalitySmokingRate ratioVeteransDiseaseStudy of mechanismsLow levelsStatusSmokersPatientsCessation
2008
Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study
Rodriguez-Barradas MC, Goulet J, Brown S, Goetz MB, Rimland D, Simberkoff MS, Crothers K, Justice AC. Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study. Clinical Infectious Diseases 2008, 46: 1093-1100. PMID: 18444830, PMCID: PMC3115628, DOI: 10.1086/529201.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccineVeterans Aging CohortPPV vaccinationIncidence of pneumoniaAging CohortCox proportional hazards regression methodsLow CD4 cell countsProportional hazards regression methodsCD4 cell countHIV infection statusRisk of pneumoniaLower hemoglobin levelsBenefits of vaccinationHuman immunodeficiency virusOngoing prospective studyElectronic medical recordsPneumococcal vaccinationPneumonia eventsUnvaccinated patientsCurrent smokingPneumococcal diseasePolysaccharide vaccineVaccination statusHIV infectionRetrospective review
2007
Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Butt AA, Braithwaite RS, Peck R, Justice AC. Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans. Journal Of General Internal Medicine 2007, 22: 749-754. PMID: 17503106, PMCID: PMC2219870, DOI: 10.1007/s11606-007-0158-8.Peer-Reviewed Original ResearchConceptsHIV providersCurrent smokingSmoking cessationCough/dyspneaHIV-negative patientsHIV-negative veteransCombination antiretroviral therapyHIV-positive patientsHIV viral suppressionPatient's HIV statusImportant risk factorHealth care providersElectronic medical recordsBackgroundCigarette smokingAntiretroviral therapyComorbid illnessesViral suppressionComorbid diseasesCurrent smokersIndependent predictorsProvider questionnairesHIV statusVA databasesPatient populationImmune competence