Dustin Scheinost, PhD, BS
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
Featured Publications
Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences
Rodriguez R, Noble S, Camp C, Scheinost D. Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences. Nature Neuroscience 2025, 28: 2601-2611. PMID: 41184631, PMCID: PMC12641774, DOI: 10.1038/s41593-025-02099-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResting-state functional magnetic resonance imagingResting-state dataCoactivation patternsFunctional connectivityResting-state signalsBrain's intrinsic functional architectureResting-state functional connectivityIntrinsic functional architectureTask activation patternsTask fMRI dataHigh identifiersFMRI dataLarge-scale neuroimaging datasetsConnectomeFunctional architectureNeuroimaging datasetsActivity patternsTask dataMagnetic resonance imagingTaskResonance imagingPhenotypic measurementsConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkBrain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectomeThe tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research
Noble S, Curtiss J, Pessoa L, Scheinost D. The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research. Imaging Neuroscience 2024, 2: imag-2-00138. PMID: 40740614, PMCID: PMC12247580, DOI: 10.1162/imag_a_00138.Peer-Reviewed Original Research
2026
Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting
Samardzija A, Shen X, Luo W, Greene A, Mehta S, Tokoglu F, Arora J, Woods S, Katz R, Sanacora G, Srihari V, Scheinost D, Constable R. Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting. Nature Communications 2026 PMID: 42303975, DOI: 10.1038/s41467-026-73941-0.Peer-Reviewed Original ResearchBrain systemsConnectome-based predictive modelingBrain-behavior modelsCognitive constructsBrain circuitsBrain networksBrain metricsFMRI dataNetwork contributionComposite scoreTest scoresCognitive networksScore relationshipsConnectivity networksBrainStandardized testsDiverse participantsSubtestsFMRIPredictive powerExternal testScoresKernel ridge regressionFeed-forward approachClinical symptomsNeuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity
Honhar P, Tinaz S, Ebrahimian Sadabad F, Dias M, Yang Y, Henry S, Hillmer A, Zakiniaeiz Y, Radhakrishnan R, Comley R, Zhang X, Hooker B, Zhang Y, Finnema S, Carson R, Scheinost D, Matuskey D. Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity. Npj Parkinson's Disease 2026 PMID: 42248873, DOI: 10.1038/s41531-026-01411-x.Peer-Reviewed Original ResearchPD motor severityMotor severityDopamine transporterPrecentral gyrusParkinson's diseaseMotor cortexBrain microstructural alterationsDAT availabilityEarly-stage Parkinson's diseaseNeuroimaging evidenceDiffusion tensor imagingWhite matter regionsParietal lobeSub-corticalDopaminergic lossTensor imagingMatter regionsMean diffusivityMid-brainGyrusCortexMicrostructural alterationsMRI measurementsParkinson's disease severityNeurite orientation dispersionExternal validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging
Rosenblatt M, Foster M, Adkinson B, Tejavibulya L, Khaitova M, Ye J, Sun H, Rodriguez R, Camp C, Chinta A, McCusker M, Han L, Fields C, Mehta S, Scheinost D. External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging. Nature Methods 2026, 1-11. PMID: 42203860, DOI: 10.1038/s41592-026-03115-9.Peer-Reviewed Original ResearchWhat effect sizes can we expect in functional neuroimaging?
Shearer H, Rosenblatt M, Ye J, Jiang R, Tejavibulya L, Foster M, Liang Q, Dadashkarimi J, Westwater M, Cheng I, Rolison M, Peterson H, Adkinson B, Mehta S, Camp C, Fischbach A, Cravo F, Meija A, Nichols T, Curtiss J, Scheinost D, Noble S. What effect sizes can we expect in functional neuroimaging? JoCN Forum 2026 DOI: 10.21428/8e6ba8ef.af9f794c.Peer-Reviewed Original ResearchThe metabolomic signatures mediate associations between physical frailty and metabolic dysfunction–associated steatotic liver disease
Jiang R, Rosenblatt M, Qi S, Calhoun V, Wang Q, Wang P, Wu J, Scheinost D, Sui J. The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction–associated steatotic liver disease. Science Advances 2026, 12: eaeg4939. PMID: 42127175, PMCID: PMC13170646, DOI: 10.1126/sciadv.aeg4939.Peer-Reviewed Original ResearchConceptsPotential causal effectPhysical frailtyMetabolic syndromeEffect of physical frailtyUK Biobank participantsModifiable risk factorsLiver diseaseEffect of metabolic syndromeSteatotic liver diseaseHigh-risk individualsMetabolome-wide association analysisMendelian randomizationBiobank participantsFrailty screeningAdverse effectsFrail peopleLipoprotein biomarkersMetabolomic signaturesAdverse effects of metabolic syndromeFrailtyEarly preventionMetabolomic mechanismFollow-upRisk factorsAssociation analysisShared Brain Networks Support Neural Flexibility Across Transdiagnostic Populations
Ye J, Mehta S, Khaitova M, Arora J, Tokoglu F, Hahn C, Lacadie C, Greene A, Constable R, Scheinost D. Shared Brain Networks Support Neural Flexibility Across Transdiagnostic Populations. Biological Psychiatry 2026, 99: s15-s16. DOI: 10.1016/j.biopsych.2026.03.046.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Connectivity While Coming of Age
IRB ID2000028368RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 yearsBrain Imaging Study of Emotion Regulation in Children
IRB ID2000031303RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsGenderBothAge5 years - 15 yearsStudying the Adult Brain
IRB ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsGenomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
IRB ID2000020449RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge8+ yearsLinks Between Newborn Brain Connectivity and Social Development
IRB ID2000021541RoleSub InvestigatorPrimary Completion Date08/31/2023Recruiting ParticipantsGenderBothAgeUp to 1 year 9 months
News
News
- April 15, 2026
Overlooked Brain Connections Hold Clues to Cognition and Mental Health
- January 13, 2026
More Than Just Fear: A New Profile of Post-traumatic Stress Disorder
- December 01, 2025
From the Journals
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
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