Kaelyn Sumigray, PhD
Assistant Professor of GeneticsDownloadHi-Res Photo
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Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
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Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
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About
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Assistant Professor of Genetics
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Biography
Kaelyn Sumigray earned her B.S. from Union College in 2006. She obtained her Ph.D. in 2011 from the Department of Cell Biology at Duke University. She was a postdoctoral fellow first at the University of North Carolina at Chapel Hill, from 2012-2013, where she was awarded an NIH Kirschstein postdoctoral fellowship, followed by a postdoctoral fellow at Duke University with Terry Lechler from 2013-2019, where she was awarded a Dermatology Foundation Research Grant. She joined the Yale faculty in 2019.
Last Updated on April 19, 2025.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral associate
- Duke University (2019)
- Postdoctoral Fellow
- University of North Carolina at Chapel Hill (2013)
- PhD
- Duke University, Cell Biology (2011)
- BS
- Union College, Biology (2006)
Research
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Overview
Medical Research Interests
Actin Cytoskeleton; Cell Adhesion; Cell Polarity; Cell Shape; Cytoskeleton; Intestinal Polyps; Intestine, Small; Morphogenesis; Organogenesis; Stem Cell Niche; Stem Cells
ORCID
0000-0002-1267-7559- View Lab Website
Sumigray lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Kaelyn Sumigray's published research.
Publications Timeline
A big-picture view of Kaelyn Sumigray's research output by year.
Research Interests
Research topics Kaelyn Sumigray is interested in exploring.
Nadia Ameen, MBBS
Zachary Smith, PhD
Maria Figetakis
Timothy Nottoli, PhD
Andrea Barbieri, MD
Bluma Lesch, MD, PhD
39Publications
1,248Citations
Cell Adhesion
Stem Cells
Intestine, Small
Morphogenesis
Cell Polarity
Cell Shape
Publications
2025
Nkx2-3 defines the splenic vascular patterning in a lineage-and-dose-dependent manner 9187
Balogh P, Balogh P, Váradi K, Berta G, Heidt D, Figetakis M, Sumigray K, Kellermayer Z. Nkx2-3 defines the splenic vascular patterning in a lineage-and-dose-dependent manner 9187. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2624.Peer-Reviewed Original ResearchConceptsLineage-restricted expressionLYVE-1Vascular patternMarginal sinusImpaired humoral immune responseRed pulpGene dosageSplenic vasculatureLymphatic capillariesVE-cadherin-CreMarginal reticular cellsHumoral immune responsePeripheral maintenanceExpression of Nkx2KO miceEctopic inductionLymphocyte differentiationSplenic structureEndothelial venulesImmune responseMAdCAM-1Lymphatic vesselsNKX2Lymphatic circulationMiceEpidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions
He H, Boraas L, Bell J, Gong X, Iannaccone S, Wen Z, Mak M, Carlson M, Sumigray K, Nicoli S. Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions. Nature Communications 2025, 16: 8967. PMID: 41073376, PMCID: PMC12514158, DOI: 10.1038/s41467-025-64040-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSuperficial epidermal cellsAdherens junctionsEpidermal stem cellsIntegrin-mediated adhesionExtracellular matrixRegulating adhesion moleculesRegions of collagenLaminin deficiencyIn vivoFin foldEpidermal cellsGenetic reductionDesmosome formationStem cellsWound healing capacitySpecialized junctionsCell contactJunctional specializationsIntercellular junctionsSkin-healing propertiesDesmosomesAdhesion moleculesHuman keratinocyte modelCellsLamininCFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease
Dos Reis D, Jin J, Santos A, Dastoor P, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen N. CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease. American Journal Of Physiology - Cell Physiology 2025, 329: c1411-c1428. PMID: 41005986, DOI: 10.1152/ajpcell.00082.2025.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsMeSH KeywordsAnimalsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDuodenumEnterocytesGene Knockout TechniquesGuanylate Cyclase-Activating ProteinsHumansHydrogen-Ion ConcentrationIon ChannelsJejunumMaleMyosin Type INatriuretic PeptidesNeuronsOrganoidsRatsRats, Sprague-DawleyReceptors, EnterotoxinSingle-Cell Gene Expression AnalysisConceptsCHE cellsNeuropod cellsGuanylyl cyclase-CApical domainHigh-expressing cellsProximal small intestineRat jejunumScRNA-seq studiesHuman intestineSingle-cell RNA sequencingCystic fibrosisCF rat modelsSmall intestineSubpopulation of epithelial cellsLuminal pH regulationAcid-sensing receptorsWild-type animalsCystic fibrosis diseaseRNA sequencingProtein immunolocalizationIntestinal physiologyRostrocaudal axisRelevant mRNAsWild-typeRat modelPROTAMINE 2 DEFICIENT SPERM CAUSE ABNORMAL EMBRYOGENESIS IN MICE
Rainsford S, Sumigray K, Smith Z, Lesch B. PROTAMINE 2 DEFICIENT SPERM CAUSE ABNORMAL EMBRYOGENESIS IN MICE. Fertility And Sterility 2025, 124: e10. DOI: 10.1016/j.fertnstert.2025.05.012.Peer-Reviewed Original ResearchEvidence of secondary Notch signaling within the rat small intestine.
Zagoren E, Dias N, Santos A, Smith Z, Ameen N, Sumigray K. Evidence of secondary Notch signaling within the rat small intestine. Development 2025, 152 PMID: 40371707, PMCID: PMC12188240, DOI: 10.1242/dev.204277.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSecretory lineageRegulate luminal pHSecretory cellsNotch signalingSecretory cell typesSmall intestinal epithelial cellsRNA sequencing dataIntestinal epithelial cellsIntestinal stem cellsSmall intestineFate in vivoFibrosis pathophysiologyRat small intestineCrypt progenitorsTranscription factorsEpithelial cellsRat jejunumStem cellsPseudotime trajectory analysisRare populationLuminal pHRatsHigher expressionIntestinal functionIn vitroCFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease
dos Reis D, Jin J, Santos A, Nogueira C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, Mc Carron A, Smith Z, Sumigray K, Ameen N. CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease. Physiology 2025, 40: 1127. DOI: 10.1152/physiol.2025.40.s1.1127.Peer-Reviewed Original ResearchConceptsCHE cellsGuanylyl cyclase-CNeuropod cellsApical domainRat jejunumHuman intestineSingle-cell RNA sequencingCystic fibrosisLuminal pH regulationSubpopulation of epithelial cellsLong basal processesScRNA-seqRNA sequencingAcid-sensing receptorsWild-type animalsCystic fibrosis diseaseIncreased abundanceHigh-expressing cellsProtein immunolocalizationIntestinal physiologyMorphological coreWild-typeBasal processesHCO3- secretionCFTRSex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase
Aladelokun O, Benitez K, Wang Y, Jain A, Berardi D, Maroun G, Shen X, Roper J, Gibson J, Sumigray K, Khan S, Johnson C. Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase. Pharmacological Research 2025, 215: 107736. PMID: 40228761, PMCID: PMC12100670, DOI: 10.1016/j.phrs.2025.107736.Peer-Reviewed Original ResearchCitationsConceptsTumor-specific survivalColorectal cancerTumor growthR2G2 miceIncreased serum estradiol levelsSerum estradiol levelsSub-populations of macrophagesAssociated with cancer prognosisSuppressed tumor growthColorectal tumor growthExogenous asparagineColorectal cancer developmentColorectal cancer cellsNegative feed-back effectEstradiol levelsGlutamate levelsSex-related differencesSex-specific effectsMale miceCancer prognosisAsparagine supplementationCancer progressionMiceDecreased numberTumorShaping the intestine: The role of cell morphology and spatial dynamics in development
Wang Y, Wen Z, Sumigray K. Shaping the intestine: The role of cell morphology and spatial dynamics in development. Current Topics In Developmental Biology 2025 DOI: 10.1016/bs.ctdb.2025.10.002.Peer-Reviewed Original ResearchConceptsCell fate specificationCell shape changesExtracellular matrix interactionsActomyosin dynamicsCrypt-villus axisCytoskeletal reorganizationFate specificationLate embryogenesisVillus morphogenesisSpatiotemporal regulationEpithelial-mesenchymal signalingIntestinal morphogenesisMatrix interactionsTube elongationMicrobial threatsCell morphologyNutrient absorptionIn vitro organoid systemsFunctional specializationMorphogenesisEpithelial cellsEmbryogenesisEpithelial turnoverAbsorptive surface areaSpatial dynamics
2024
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins
Seabrook L, Franco C, Loy C, Osman J, Fredlender C, Zimak J, Campos M, Nguyen S, Watson R, Levine S, Khalil M, Sumigray K, Trader D, Albrecht L. Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. Nature Chemical Biology 2024, 20: 1566-1576. PMID: 39414979, DOI: 10.1038/s41589-024-01741-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProtein arginine methyltransferasesTarget proteinsLoss-of-function phenotypesDegradation of intracellular proteinsUbiquitin-proteasome pathwayHistone deacetylase 6Bromodomain-containing protein 4Discovery of small moleculesTargeted Protein DegradationDegrade target proteinsTargeting chimerasArginine methylationArginine methyltransferasesProtein methylationPathogenic proteinsLysosomal deliveryLysosomal pathwayIntracellular proteinsLysosomal degradationHeterobifunctional small moleculesProtein degradationSmall-molecule degradersLysosomal proteolysisSubstrate degradationSmall molecules313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine
Jin J, dos Reis D, Muiler C, Zagoren E, Donnelley M, Parsons D, Sumigray K, Ameen N. 313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine. Journal Of Cystic Fibrosis 2024, 23: s167. DOI: 10.1016/s1569-1993(24)01153-6.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity American Heart Association
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity eLife
2022 - PresentJournal ServiceRevieweractivity Science
2023 - PresentJournal ServiceRevieweractivity Nature Cell Biology
2021 - PresentJournal ServiceRevieweractivity Journal of Clinical Investigation
2022 - PresentJournal ServiceReviewer
Honors
honor Chen Innovation Award
03/01/2022Yale School of Medicine AwardYale Stem Cell CenterDetailsUnited Stateshonor Basic Research Award
03/03/2014National AwardDermatology Foundation
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