Skip to Main Content

Zeyan Liew, PhD, MPH

Assistant Professor of Epidemiology (Environmental Health)

Research Summary

Fetal programming theory suggests that there are critical vulnerable periods in pre or early postnatal life during which not only development, but also future health may be impacted dramatically. My research has been focusing on employing large longitudinal pregnancy cohorts to evaluate potential adverse effects from fetal exposures to endocrine disrupting chemicals in critical time windows, including persistent organic pollutants and pesticides, and pharmaceutical agent such as acetaminophen. Over the years, I have studied a broad range of neurodevelopmental endpoints including attention-deficit/hyperactivity disorders (ADHD), autism spectrum disorders (ASD), cerebral palsy (CP), and functional brain measures such as intelligence, executive function, motor function, and social and behavioral problems. Recently, I also started to investigate early life risk factors associated with asthma and obesity in childhood. My team utilizes some unique and large-scale population-based cohorts and register data for research, which include (1) the Danish National Birth Cohort (DNBC), a prospective pregnancy cohort of approximately 100,000 women and their offspring currently in its 18 years follow up, (2) Danish and other Nordic medical registers and biobank data that span up to three decades and two generations, (3) statewide birth records and disease registers in California, and recently (4) mental health outcomes among children enrolled in the U.S. Nurses’ Health Study collaborating with Weisskopf’s lab. Finally, I also contributed to methodological research specifically in causal inference and bias analyses.

Coauthors

Research Interests

Acetaminophen; Attention Deficit Disorder with Hyperactivity; Cerebral Palsy; Child Development; Environmental Pollutants; Models, Statistical; Causality; Pharmacoepidemiology; Endocrine Disruptors; Pediatric Obesity; Autism Spectrum Disorder

Public Health Interests

Aging; Environmental Health; Epidemiology Methods; Genetics, Genomics, Epigenetics; Global Health; Maternal & Child Health; Perinatal/Prenatal Health; Pharmacoepidemiology

Selected Publications

  • Paracetamol Use During Pregnancy—A Call for Precautionary ActionBauer A, Swan S, Kriebel D, Liew Z, Taylor H, Bornehag C, Andrade A, Olsen J, Jensen R, Mitchell R, Skakkebaek N, Jégou B, Kristensen D. Paracetamol Use During Pregnancy—A Call for Precautionary Action Obstetrical & Gynecological Survey 2022, 77: 133-134. DOI: 10.1097/ogx.0000000000001019.
  • Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish PopulationXia Y, Xiao J, Yu Y, Tseng W, Lebowitz E, DeWan A, Pedersen L, Olsen J, Li J, Liew Z. Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population Obstetrical & Gynecological Survey 2021, 76: 719-721. DOI: 10.1097/01.ogx.0000802660.47978.73.
  • Non-targeted metabolomics in evaluating alterations associated with per-fluoroalkyl and polyfluoroalkyl substances (PFAS) exposure in human studies: a scoping reviewGuo P, Furnary T, Vasiliou V, Yan Q, Jones D, Johnson C, Liew Z. Non-targeted metabolomics in evaluating alterations associated with per-fluoroalkyl and polyfluoroalkyl substances (PFAS) exposure in human studies: a scoping review ISEE Conference Abstracts 2021, 2021 DOI: 10.1289/isee.2021.p-608.
  • Prenatal Exposure to Perfluoroalkyl Substances and Mental Health in ChildhoodLuo J, Ramlau Hansen C, Olsen J, Strandberg Larsen K, Liew Z. Prenatal Exposure to Perfluoroalkyl Substances and Mental Health in Childhood ISEE Conference Abstracts 2021, 2021 DOI: 10.1289/isee.2021.o-lt-076.
  • Prenatal Exposure to Perfluoroalkyl Substances and Dysmorphic Facial Features at age 5Luo J, Xiao J, Ramlau-Hansen C, Kesmodel U, Olsen J, Liew Z. Prenatal Exposure to Perfluoroalkyl Substances and Dysmorphic Facial Features at age 5 ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.o-os-543.
  • Associations between preterm birth and low birth weight in parents and autism spectrum disorder (ASD) risk in their offspring: A population-based multigenerational cohort study in DenmarkXiao J, Gao Y, Yu Y, Toft G, Zhang Y, Luo J, Xia Y, Chawarska K, Olsen J, Li J, Liew Z. Associations between preterm birth and low birth weight in parents and autism spectrum disorder (ASD) risk in their offspring: A population-based multigenerational cohort study in Denmark ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-0708.
  • Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 yearsLuo J, Xiao J, Gao Y, Ramlau-Hansen C, Toft G, Li J, Obel C, Andersen S, Deziel N, Tseng W, Inoue K, Bonefeld-Jørgensen C, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-0872.
  • Solid fuel-related indoor air pollution and poor sleep quality in the elderly: a national longitudinal study in ChinaYu H, Luo J, Pollitt K, Liew Z. Solid fuel-related indoor air pollution and poor sleep quality in the elderly: a national longitudinal study in China ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1303.
  • Maternal Diabetes During Pregnancy and Early Onset of Cardiovascular Disease in Offspring: Population Based Cohort Study With 40 Years of Follow UpYu Y, Arah O, Liew Z, Cnattingius S, Olsen J, Sørensen H, Qin G, Li J. Maternal Diabetes During Pregnancy and Early Onset of Cardiovascular Disease in Offspring: Population Based Cohort Study With 40 Years of Follow Up Obstetrical & Gynecological Survey 2020, 75: 277-279. DOI: 10.1097/01.ogx.0000666220.44880.94.
  • Perfluoroalkyl Substances and thyroid hormones in early pregnancy; findings in the Danish National Birth Cohort (DNBC)Z L, K I, B R, S A, C R, B H, B B, T H, E B, J O. Perfluoroalkyl Substances and thyroid hormones in early pregnancy; findings in the Danish National Birth Cohort (DNBC) Environmental Epidemiology 2019, 3: 240. DOI: 10.1097/01.ee9.0000608512.83637.07.
  • The Maternal Serum Metabolome and Ambient Air Pollution Exposure during PregnancyQ Y, O V, C L, X C, D W, D J, K U, Z L. The Maternal Serum Metabolome and Ambient Air Pollution Exposure during Pregnancy Environmental Epidemiology 2019, 3: 334. DOI: 10.1097/01.ee9.0000609680.03465.2e.
  • The association of short-term effects of air pollution and sleep disorders among elderly residents in ChinaM T, D L, Z L, K C, B R. The association of short-term effects of air pollution and sleep disorders among elderly residents in China Environmental Epidemiology 2019, 3: 390. DOI: 10.1097/01.ee9.0000610344.17339.a4.
  • Air Pollution and Metabolomics in Maternal SerumYan Q, Liew Z, Uppal K, Jones D, Ritz B. Air Pollution and Metabolomics in Maternal Serum ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.p01.0780.
  • Perfluoroalkyl Substances and Birth Outcomes: A Pool Analysis in the Danish National Birth CohortMeng Q, Ritz B, Olsen J, Liew Z. Perfluoroalkyl Substances and Birth Outcomes: A Pool Analysis in the Danish National Birth Cohort ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.p01.2300.
  • A Population-Based Study of Traffic-Related and Outdoor Air Pollution during Pregnancy and Autism in DenmarkYan Q, Ritz B, Liew Z, Cui X, Matthias M, Virk J, Raaschou-Nielsen O. A Population-Based Study of Traffic-Related and Outdoor Air Pollution during Pregnancy and Autism in Denmark ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.p02.1250.
  • Bias from Conditioning on Live Birth in Pregnancy Cohorts: An Illustration Based on Neurodevelopment in Children after Prenatal Exposure to Organic PollutantsLiew Z, Olsen J, Ritz B, Arah O. Bias from Conditioning on Live Birth in Pregnancy Cohorts: An Illustration Based on Neurodevelopment in Children after Prenatal Exposure to Organic Pollutants ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.s02.01.12.
  • Ambient Pesticide Exposure during Pregnancy and Risk of Cerebral Palsy: A California Statewide StudyLiew Z, Yuan Y, Ling C, Cui X, Park A, Cockburn M, Ehrenstein O, Ritz B. Ambient Pesticide Exposure during Pregnancy and Risk of Cerebral Palsy: A California Statewide Study ISEE Conference Abstracts 2018, 2017: 922. DOI: 10.1289/isee.2017.2017-922.
  • Maternal socioeconomic status and infant mortality with low birth weight as a mediator: an inter-country comparison between Scotland and Denmark using administrative dataYu Y, Verfuerden M, Hardelid P, Zylbersztejn A, Liew Z, Olsen J, Gilbert R, Li J, Fu B. Maternal socioeconomic status and infant mortality with low birth weight as a mediator: an inter-country comparison between Scotland and Denmark using administrative data International Journal For Population Data Science 2017, 1: 368. PMCID: PMC9351277, DOI: 10.23889/ijpds.v1i1.368.
  • Maternal levels of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and executive function in the offspringBach* C, Liew Z, Matthiesen N, Henriksen T, Nohr E, Bech B, Ritz B, Olsen J. Maternal levels of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and executive function in the offspring ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.3070.
  • Air pollution and fetal growth- a study on ultrasound measures of Swedish childrenMalmqvist* E, Liew Z, Rylander L, Ritz B. Air pollution and fetal growth- a study on ultrasound measures of Swedish children ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.3194.
  • Exposure misclassification using a Geographical Information System (GIS)-based assessment of long-term ambient pesticide exposures: residential mobility and changes in pesticide use in a study of Parkinson’s diseaseCui* X, Liew Z, Ling C, Paul K, Ritz B. Exposure misclassification using a Geographical Information System (GIS)-based assessment of long-term ambient pesticide exposures: residential mobility and changes in pesticide use in a study of Parkinson’s disease ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.3243.
  • Maternal Perfluoroalkyl Substances Levels in Pregnancy and Child IQ: a Danish National Birth Cohort Study.Liew* Z, Ritz B, Bech B, Nohr E, Bossi R, Henriksen T, Bonefeld-Jørgensen E, Olsen J. Maternal Perfluoroalkyl Substances Levels in Pregnancy and Child IQ: a Danish National Birth Cohort Study. ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.3303.
  • Maternal levels of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and attention in the offspringBach* C, Liew Z, Matthiesen N, Henriksen T, Nohr E, Bech B, Ritz B, Olsen J. Maternal levels of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and attention in the offspring ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.3315.
  • Occupational Pesticide Exposures and Risk of Depression in Central CaliforniaLiew* Z, Paul K, Narayan S, Lee P, Ritz B. Occupational Pesticide Exposures and Risk of Depression in Central California ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.4020.
  • Occupational Pesticide Use and Parkinson’s Disease in Central CaliforniaNarayan S, Liew* Z, Bronstein J, Ritz B. Occupational Pesticide Use and Parkinson’s Disease in Central California ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.4062.
  • Prenatal Exposure to Perfluorinated Chemicals and Risk of Congenital Cerebral Palsy in Children.Liew Z, Ritz B, Bonefeld-Jørgensen E, Henriksen T, Nohr E, Bech B, Fei C, Bossi R, von Ehrenstein O, Streja E, Uldall P, Olsen J. Prenatal Exposure to Perfluorinated Chemicals and Risk of Congenital Cerebral Palsy in Children. International Journal Of Epidemiology 2015, 44: i158-i158. DOI: 10.1093/ije/dyv096.202.
  • PS-252 Infantile Colic, Hyperkinetic Disorder, And Emotional And Behavioural Problems In Childhood - The Danish National BirthcohortMilidou I, Søndergaard C, Jensen, Liew Z, Olesen J, Henriksen T. PS-252 Infantile Colic, Hyperkinetic Disorder, And Emotional And Behavioural Problems In Childhood - The Danish National Birthcohort Archives Of Disease In Childhood 2014, 99: a203. DOI: 10.1136/archdischild-2014-307384.551.
  • Job Exposure Matrix (JEM) derived estimates of life-time occupational pesticide exposure and the risk of Parkinson’s DiseaseLiew Z, Wang A, Bronstein J, Ritz B. Job Exposure Matrix (JEM) derived estimates of life-time occupational pesticide exposure and the risk of Parkinson’s Disease ISEE Conference Abstracts 2013, 2013: 4440. DOI: 10.1289/isee.2013.p-2-23-14.
  • Household Organophosphorus Pesticide Use and Parkinson's DiseaseNarayan S, Liew Z, Paul K, Lee P, Sinsheimer J, Bronstein J, Ritz B. Household Organophosphorus Pesticide Use and Parkinson's Disease ISEE Conference Abstracts 2013, 2013: 4083. DOI: 10.1289/isee.2013.p-3-23-13.