Yang Liu, PhD

Spatial omics techniques have greatly expanded our understanding of biology on the omics level within the tissue context. Our techniques (DBiT-seq, Spatial-CITE-seq) were demonstrated to be a highly flexible platform, capable of working on multiple omics at the same time. The long-term goal will be to focus on the development of highly innovative enabling techniques for omics studies and the applications and adoptions of techniques to biological studies.

Yang Liu, PhD, was appointed Assistant Professor in the Department of Pathology effective August 1, 2022. Dr. Yang Liu received his PhD degree from the University of California Riverside, working in quite a few different fields, including engineering, chemistry, toxicology, and computer science. He has been a Postdoctoral Research Associate at Yale since 2018 working with Dr. Rong Fan in the Department of Biomedical Engineering at Yale. During the Postdoc training, he developed a high spatial resolution multi-omics sequencing technique, named DBiT-seq, which can achieve near single-cell spatial resolution (10 µm) sequencing of RNA and protein on the same tissue section. He also developed Spatial-CITE-seq (High plex spatial epitome sequencing) and DBiT-seq FFPE technology (spatial transcriptome and epitome of banked FFPE samples). Dr. Liu received the SITC-SU2C Convergence Scholar Awards in 2019 and NIH Hubmap Jumpstart award. His Lab in Yale Pathology will focus on development of spatial based omics techniques (Transcriptome, proteome, epigenome, etc..) and the application of spatial omics techniques to study tumor microenvironments, neurological disease, heart and vascular disease, development and microbiome.