Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang X. Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. Frontiers In Immunology 2024, 15: 1346587. PMID: 38690261, PMCID: PMC11058222, DOI: 10.3389/fimmu.2024.1346587.Peer-Reviewed Original ResearchConceptsTumor-derived extracellular vesiclesTumor developmentBreast carcinomaLung carcinomaExtracellular vesiclesM2 phenotypeMacrophage polarizationM2 polarizationPromote tumor developmentStimulate macrophage polarizationAnti-tumor activityM2 to M1 macrophagesAnti-inflammatory effectsInduced M2 polarizationPancreatic carcinomaPro-tumorColorectal carcinomaTumor progressionHepatocellular carcinomaCarcinomaColorectal cancerRegulating tumor developmentCell ratioM1 macrophagesPromote M2 polarization