Marc Schneeberger Pane, PhD
Assistant Professor in Cellular and Molecular Physiology
Research & Publications
Biography
Research Summary
The Schneeberger Pané Laboratory is interested in the neurobiology of homeostasis. In particular we are interested in understanding how structural-molecular-functional crosstalk exists between the neuronal vascular and immune systems in the brain to permit behaviour and as a result life. We are taking an unbiased approach trying to understand first at the whole mount level how shifts in homeostasis shift the different systems to transition from physiology to pathophysiology. By doing so, we aim at deciphering the adaptive processes that the neurovascular unit engages with to counteract the initial shift. Uncovering the molecular mechanisms responsible for such transitions and how to override them might result into new effective therapeutics for complex disorders.
Hence, the outstanding questions of research span in the intersection between the fields of neurobiology, metabolism, behaviour and genetics. First, how is energy homeostasis (both energy intake and expenditure) regulated centrally? Second, which neural circuits are essential for energy homeostasis to happen?
The long-term goal of the laboratory is to understand how homeostatically driven neurovascular impairments can shape centrally mediated behaviours and underlie complex disorders such as obesity, Alzheimer's disease, anorexia nervosa, Parkinson's disease, etc.
Coauthors
Research Interests
Cardiovascular Diseases; Nervous System Diseases; Nutritional and Metabolic Diseases
Research Image
neurobiology of energy homeostasis interpretation
Selected Publications
- Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction.Schneeberger M, Brice NL, Pellegrino K, Parolari L, Shaked JT, Page KJ, Marchildon F, Barrows DW, Carroll TS, Topilko T, Mulligan VM, Newman R, Doyle K, Bürli R, Barker DF, Glen A, Ortuño MJ, Nectow AR, Renier N, Cohen P, Carlton M, Heintz N, Friedman JM. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nat Metab 2022, 4: 1495-1513. PMID: 36411386, DOI: 10.1038/s42255-022-00677-8.
- Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM. Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biol 2022, 54: 102353. PMID: 35777200, DOI: 10.1016/j.redox.2022.102353.
- Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure.Ortuño MJ, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman JM, Ducy P. Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal Of Clinical Investigation 2021, 131 PMID: 34673574, PMCID: PMC8670849, DOI: 10.1172/JCI151976.
- Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis.Al-Massadi O, Dieguez C, Schneeberger M, López M, Schwaninger M, Prevot V, Nogueiras R. Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis. Nature Reviews. Endocrinology 2021, 17: 745-755. PMID: 34608277, DOI: 10.1038/s41574-021-00559-1.
- Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice.Parolari L, Schneeberger M, Heintz N, Friedman JM. Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice. Molecular Psychiatry 2021, 26: 7029-7046. PMID: 34099874, DOI: 10.1038/s41380-021-01162-6.
- Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysisGómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D’Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis Cell Metabolism 2021, 33: 1820-1835.e9. PMID: 34343501, PMCID: PMC8432968, DOI: 10.1016/j.cmet.2021.07.008.
- Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.Ito K, Schneeberger M, Gerber A, Jishage M, Marchildon F, Maganti AV, Cohen P, Friedman JM, Roeder RG. Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes & Development 2021, 35: 729-748. PMID: 33888560, PMCID: PMC8091968, DOI: 10.1101/gad.346791.120.
- Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.Muller PA, Matheis F, Schneeberger M, Kerner Z, Jové V, Mucida D. Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose. Science (New York, N.Y.) 2020, 370: 314-321. PMID: 32855216, PMCID: PMC7886298, DOI: 10.1126/science.abd6176.
- A limbic circuit selectively links active escape to food suppression.Azevedo EP, Tan B, Pomeranz LE, Ivan V, Fetcho R, Schneeberger M, Doerig KR, Liston C, Friedman JM, Stern SA. A limbic circuit selectively links active escape to food suppression. ELife 2020, 9 PMID: 32894221, PMCID: PMC7476759, DOI: 10.7554/eLife.58894.
- Author Correction: Microbiota modulate sympathetic neurons via a gut-brain circuit.Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Del Mármol J, Castro TBR, Furuichi M, Perkins M, Han W, Rao A, Pickard AJ, Cross JR, Honda K, de Araujo I, Mucida D. Author Correction: Microbiota modulate sympathetic neurons via a gut-brain circuit. Nature 2020, 585: E2. PMID: 32814907, DOI: 10.1038/s41586-020-2657-2.
- A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.Wang P, Loh KH, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman J. A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue. Nature 2020, 583: 839-844. PMID: 32699414, DOI: 10.1038/s41586-020-2527-y.
- Regulation of Energy Expenditure by Brainstem GABA Neurons.Schneeberger M, Parolari L, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, Engel EA, Cohen P, Renier N, Friedman JM, Nectow AR. Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell 2019, 178: 672-685.e12. PMID: 31257028, PMCID: PMC7481042, DOI: 10.1016/j.cell.2019.05.048.
- A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake.Azevedo EP, Pomeranz L, Cheng J, Schneeberger M, Vaughan R, Stern SA, Tan B, Doerig K, Greengard P, Friedman JM. A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake. Neuron 2019, 102: 873-886.e5. PMID: 30930044, DOI: 10.1016/j.neuron.2019.03.011.
- Irx3, a new leader on obesity genetics.Schneeberger M. Irx3, a new leader on obesity genetics. EBioMedicine 2019, 39: 19-20. PMID: 30541683, PMCID: PMC6354703, DOI: 10.1016/j.ebiom.2018.12.005.
- Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons.Schneeberger M, Tan K, Nectow AR, Parolari L, Caglar C, Azevedo E, Li Z, Domingos A, Friedman JM. Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons. Molecular Metabolism 2018, 13: 83-89. PMID: 29843980, PMCID: PMC6026325, DOI: 10.1016/j.molmet.2018.05.001.
- Identification of a Brainstem Circuit Controlling Feeding.Nectow AR, Schneeberger M, Zhang H, Field BC, Renier N, Azevedo E, Patel B, Liang Y, Mitra S, Tessier-Lavigne M, Han MH, Friedman JM. Identification of a Brainstem Circuit Controlling Feeding. Cell 2017, 170: 429-442.e11. PMID: 28753423, DOI: 10.1016/j.cell.2017.06.045.
- Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release ControlRamírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control Cell Metabolism 2017, 25: 1390-1399.e6. PMID: 28591639, DOI: 10.1016/j.cmet.2017.05.010.
- Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice.Schneeberger M, Everard A, Gómez-Valadés AG, Matamoros S, Ramírez S, Delzenne NM, Gomis R, Claret M, Cani PD. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports 2015, 5: 16643. PMID: 26563823, PMCID: PMC4643218, DOI: 10.1038/srep16643.
- Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis.Schneeberger M, Gómez-Valadés AG, Altirriba J, Sebastián D, Ramírez S, Garcia A, Esteban Y, Drougard A, Ferrés-Coy A, Bortolozzi A, Garcia-Roves PM, Jones JG, Manadas B, Zorzano A, Gomis R, Claret M. Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis. Cell Reports 2015, 12: 361-70. PMID: 26166568, DOI: 10.1016/j.celrep.2015.06.041.
- Hypothalamic miRNAs: emerging roles in energy balance control.Schneeberger M, Gomez-Valadés AG, Ramirez S, Gomis R, Claret M. Hypothalamic miRNAs: emerging roles in energy balance control. Frontiers In Neuroscience 2015, 9: 41. PMID: 25729348, PMCID: PMC4325937, DOI: 10.3389/fnins.2015.00041.
- Corrigendum: Hypothalamic miRNAs: emerging roles in energy balance control.Schneeberger M, Gómez-Valadés AG, Ramírez S, Gomis R, Claret M. Corrigendum: Hypothalamic miRNAs: emerging roles in energy balance control. Frontiers In Neuroscience 2015, 9: 96. PMID: 25852465, PMCID: PMC4367163, DOI: 10.3389/fnins.2015.00096.
- Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.Schneeberger M, Gomis R, Claret M. Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. The Journal Of Endocrinology 2014, 220: T25-46. PMID: 24222039, DOI: 10.1530/JOE-13-0398.
- Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy ImbalanceSchneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M. Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance Cell 2013, 155: 172-187. PMID: 24074867, PMCID: PMC3839088, DOI: 10.1016/j.cell.2013.09.003.
- Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.Schneeberger M, Altirriba J, García A, Esteban Y, Castaño C, García-Lavandeira M, Alvarez CV, Gomis R, Claret M. Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Molecular Metabolism 2012, 2: 74-85. PMID: 24199146, PMCID: PMC3817393, DOI: 10.1016/j.molmet.2012.10.001.