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Lloyd Friedman, MD

Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine); Director of Inpatient Quality and Safety, Internal Medicine

Contact Information

Lloyd Friedman, MD

Mailing Address

  • Pulmonary, Critical Care & Sleep Medicine

    333 Cedar St

    New Haven, CT 06510

    United States

Yale Medicine

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Research Summary

Dr. Lloyd Friedman recently published the results of a multicenter trial investigating the incidence of reversion of latent tuberculosis infection through the use of skin tests and interferon gamma release assays. He has been following a cohort of welfare patients in New York to assess the incidence of tuberculosis, AIDS, and death. His major focus currently is an experimental project on the association of a tuberculosis and asthma. His critical care efforts include participation as a study site principal investigator in a recently reported study on the use of drotrecogin alpha (activated) in early sepsis. He also has an interest in the improvement of medical care through the use of electronic medical records.

Specialized Terms: tuberculosis; AIDS; asthma

Extensive Research Description

Follow up of a cohort of NYC drug and alcohol users for the development of TB AIDS and death.

The ability of chitinase to protect against tuberculosis

Coauthors

Research Interests

Acquired Immunodeficiency Syndrome; Asthma; Lung; Respiration; Tuberculosis; Pulmonary Medicine; Electronic Health Records

Selected Publications

  • Clinical TuberculosisFriedman, LN, Dedicoat M, Davies P, editors. Clinical Tuberculosis, 6th edition. Boca Raton: CRC Press, Inc. 2020
  • Guidelines for the treatment of tuberculosis disease and infectionSosa L, Friedman LN. In: Friedman LN, Dedicoat M, Davies P, editors. Guidelines for the treatment of tuberculosis disease and infection. In Clinical Tuberculosis, 6th ed. Boca Raton: CRC Press, Inc. 2020
  • Tuberculosis and Biologic Therapies: Anti-Tumor Necrosis Factor-α and Beyond.Godfrey MS, Friedman LN. Tuberculosis and Biologic Therapies: Anti-Tumor Necrosis Factor-α and Beyond. Clinics In Chest Medicine 2019, 40: 721-739. PMID: 31731980, DOI: 10.1016/j.ccm.2019.07.003.
  • Tuberculosis and biologic therapies: anti-tumor necrosis factor-alpha and beyondGodfrey MS, Friedman LN. Tuberculosis and biologic therapies: anti-tumor necrosis factor-alpha and beyond. In Lewinsohn DM, Daley CL, editors. Clinics in Chest Medicine, Amsterdam: Elsevier, Inc. 2019
  • Connecticut Tuberculosis Risk AssessmentConnecticut Tuberculosis Risk Assessment . Connecticut Department of Public Health. 2019
  • Tuberculosis in PregnancyFriedman LN, Tanoue LT. Tuberculosis in Pregnancy. UpToDate, Inc., Waltham, Mass
  • Standards of care for patients with suspected and confirmed drug-susceptible tuberculosis in Connecticut: reporting, diagnosis and treatment.Connecticut Department of Public Health
  • Electronic DOT (eDOT): Guidelines and ProceduresElectronic DOT (eDOT): Guidelines and Procedures. Connecticut Department of Public Health. 2016
  • Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence SettingCummings KJ, Smith TS, Shogren ES, Khakoo R, Nanda S, Bunner L, Smithmyer A, Soccorsi D, Kashon ML, Mazurek GH, Friedman LN, Weissman DN. Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting Infection Control And Hospital Epidemiology 2009, 30: 1123-1126. PMID: 19803719, DOI: 10.1086/644754.
  • Tuberculin Skin Test Versus QuantiFERON-TB Gold In-Tube Assay in Healthcare Workers.Cummings K, Smith T, Shogren E, Khakoo R, Nanda S, Bunner L, Smithmyer A, Soccorsi D, Kashon M, Mazurek G, Friedman L, Weissman D. Tuberculin Skin Test Versus QuantiFERON-TB Gold In-Tube Assay in Healthcare Workers. 2009, a4103. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4103.
  • Implementing an Electronic Medical RecordFriedman LN, Halpern NA, Fackler JC. Implementing an Electronic Medical Record Critical Care Clinics 2007, 23: 347-381. PMID: 17900476, DOI: 10.1016/j.ccc.2007.05.001.
  • International Standards for Tuberculosis Care (ISTC)International Standards for Tuberculosis Care (ISTC). The Hague. 2007
  • High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test ResultsFriedman LN, Nash ER, Bryant J, Henry S, Shi J, D'Amato J, Khaled GH, Russi MB, O'Connor PG, Edberg SC, Pisani MA, Cain HC, Tanoue L, Weissman DN. High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results Infection Control And Hospital Epidemiology 2006, 27: 436-441. PMID: 16671022, DOI: 10.1086/503690.
  • American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of AmericaBlumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America American Journal Of Respiratory And Critical Care Medicine 2003, 167: 603-662. PMID: 12588714, DOI: 10.1164/rccm.167.4.603.
  • Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society.. Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society. MMWR Recomm Rep 2000, 49:1-51.
  • Tuberculosis: Current Concepts and TreatmentFriedman LN, editor. Tuberculosis: Current Concepts and Treatment. 2nd ed. Boca Raton: CRC Press, Inc., 2000.
  • Tuberculosis chemoprophylaxis using a liquid isoniazid‐methadone admixture for drug users in methadone maintenanceO'Connor PG, Shi JM, Henry S, Durante AJ, Friedman L, Selwyn PA. Tuberculosis chemoprophylaxis using a liquid isoniazid‐methadone admixture for drug users in methadone maintenance Addiction 1999, 94: 1071-1075. PMID: 10707445, DOI: 10.1046/j.1360-0443.1999.947107112.x.
  • Tuberculosis, AIDS, and Death among Substance Abusers on Welfare in New York CityFriedman L, Williams M, Singh T, Frieden T. Tuberculosis, AIDS, and Death among Substance Abusers on Welfare in New York City New England Journal Of Medicine 1996, 334: 828-833. PMID: 8596549, DOI: 10.1056/nejm199603283341304.
  • ELISA analysis of BACTEC bottles for the earlier diagnosis of tuberculosis.Friedman LN, Filderman AE, D'Aquila TG, Reynolds HY. ELISA analysis of BACTEC bottles for the earlier diagnosis of tuberculosis. The American Review Of Respiratory Disease 1989, 140: 668-71. PMID: 2506783, DOI: 10.1164/ajrccm/140.3.668.
  • Tuberculosis screening in alcoholics and drug addicts.Friedman LN, Sullivan GM, Bevilaqua RP, Loscos R. Tuberculosis screening in alcoholics and drug addicts. The American Review Of Respiratory Disease 1987, 136: 1188-92. PMID: 3674581, DOI: 10.1164/ajrccm/136.5.1188.
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