DownloadHi-Res Photo

Li Wen, MD, PhD

Professor of Medicine (Endocrinology); Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)

Research & Publications
Biography
News

Research Summary

Our research interest lies mainly in autoimmunity, in particular the immunology of type 1 diabetes. Using different animal models, my research group has been trying to understand why immune cells attack insulin producing islet beta cells and how we can prevent this attack and if we can reverse the autoimmune destruction after the disease onset. Our current research topics include 1) the role of innate immunity in type 1 diabetes; 2) the role of gut microbiota in diabetes; 3) the role of B lymphocytes in diabetes; 4) the role of dendritic cells and innate immunity in obesity and diabetes; 5) the role of the inflammasome in diabetes; 6) the role of innate and adaptive immunity in skin allergy; 7) the role of innate and adaptive immunity in liver immunology.

Coauthors

Research Interests

Antigen-Presenting Cells; Autoimmune Diseases; Diabetes Mellitus, Type 1; Hypersensitivity; Immune Tolerance; Immunity, Innate; Islets of Langerhans; Liver; Obesity; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Antigens, CD20; T-Lymphocytes, Regulatory; Toll-Like Receptors; Immunity, Humoral; Inflammasomes; Microbiota

Selected Publications

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid miceChen D, Kakabadse D, Fishman S, Weinstein-Marom H, Davies J, Boldison J, Thayer T, Wen L, Gross G, Wong F. Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice. Frontiers In Immunology 2023, 14: 1227133. PMID: 37731505, PMCID: PMC10507356, DOI: 10.3389/fimmu.2023.1227133.
Assessing Obstetric Anal Sphincter InjuriesZhao B, Li Y, Tang Y, Guo Y, Yang Y, Wen L, Dietz H. Assessing Obstetric Anal Sphincter Injuries. Journal Of Ultrasound In Medicine 2023, 42: 2031-2038. PMID: 36916688, DOI: 10.1002/jum.16221.
NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD micePearson J, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell R, Zhao H, Wong F, Wen L. NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD mice. Frontiers In Immunology 2023, 14: 1147925. PMID: 36911699, PMCID: PMC9995752, DOI: 10.3389/fimmu.2023.1147925.
Correction: Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammationDing P, Tan Q, Wei Z, Chen Q, Wang C, Qi L, Wen L, Zhang C, Yao C. Correction: Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation. Bone Research 2022, 10: 47. PMID: 35798700, PMCID: PMC9263109, DOI: 10.1038/s41413-022-00221-0.
Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity.Yang ML, Connolly SE, Gee RJ, Lam TT, Kanyo J, Peng J, Guyer P, Syed F, Tse HM, Clarke SG, Clarke CF, James EA, Speake C, Evans-Molina C, Arvan P, Herold KC, Wen L, Mamula MJ. Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. Diabetes 2022, 71: 1979-1993. PMID: 35730902, PMCID: PMC9450849, DOI: 10.2337/db21-0989.
Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammationDing P, Tan Q, Wei Z, Chen Q, Wang C, Qi L, Wen L, Zhang C, Yao C. Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation. Bone Research 2022, 10: 42. PMID: 35624094, PMCID: PMC9142495, DOI: 10.1038/s41413-022-00210-3.
IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humansPearson JA, Ding H, Hu C, Peng J, Galuppo B, Wong FS, Caprio S, Santoro N, Wen L. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 2022, 65: 1398-1411. PMID: 35587276, PMCID: PMC9283171, DOI: 10.1007/s00125-022-05711-8.
Obesity aggravates contact hypersensitivity reaction in miceMajewska‐Szczepanik M, Kowalczyk P, Marcińska K, Strzępa A, Lis GJ, Wong FS, Szczepanik M, Wen L. Obesity aggravates contact hypersensitivity reaction in mice. Contact Dermatitis 2022, 87: 28-39. PMID: 35234303, PMCID: PMC9949724, DOI: 10.1111/cod.14088.
Editorial: Immunopathology of Type 1 DiabetesGreen EA, Cooke AC, Piganelli JD, Richardson SJ, Wen L, Wong FS. Editorial: Immunopathology of Type 1 Diabetes. Frontiers In Immunology 2022, 13: 852963. PMID: 35359940, PMCID: PMC8960371, DOI: 10.3389/fimmu.2022.852963.
Circadian Rhythm Modulation of Microbes During Health and InfectionPearson JA, Voisey AC, Boest-Bjerg K, Wong FS, Wen L. Circadian Rhythm Modulation of Microbes During Health and Infection. Frontiers In Microbiology 2021, 12: 721004. PMID: 34512600, PMCID: PMC8430216, DOI: 10.3389/fmicb.2021.721004.
IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD MiceHuang J, Tan Q, Tai N, Pearson JA, Li Y, Chao C, Zhang L, Peng J, Xing Y, Zhang L, Hu Y, Zhou Z, Wong FS, Wen L. IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice. Frontiers In Immunology 2021, 12: 702955. PMID: 34394099, PMCID: PMC8362616, DOI: 10.3389/fimmu.2021.702955.
Innate immunity in latent autoimmune diabetes in adultsHuang J, Pearson JA, Wong FS, Wen L, Zhou Z. Innate immunity in latent autoimmune diabetes in adults. Diabetes/Metabolism Research And Reviews 2021, 38: e3480. PMID: 34156143, PMCID: PMC8813511, DOI: 10.1002/dmrr.3480.
Inflammasomes and Type 1 DiabetesPearson JA, Wong FS, Wen L. Inflammasomes and Type 1 Diabetes. Frontiers In Immunology 2021, 12: 686956. PMID: 34177937, PMCID: PMC8219953, DOI: 10.3389/fimmu.2021.686956.
Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and functionHuang J, Peng J, Pearson JA, Efthimiou G, Hu Y, Tai N, Xing Y, Zhang L, Gu J, Jiang J, Zhao H, Zhou Z, Wong FS, Wen L. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular & Molecular Immunology 2021, 18: 328-338. PMID: 33432061, PMCID: PMC8027372, DOI: 10.1038/s41423-020-00590-8.
Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes.Thayer TC, Davies J, Pearson JA, Hanna SJ, Wen L, Wong FS. Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes. Diabetes 2020, 70: 529-537. PMID: 33122391, PMCID: PMC8176215, DOI: 10.2337/db19-1050.
Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD MicePearson JA, Li Y, Majewska-Szczepanik M, Guo J, Zhang L, Liu Y, Wong FS, Wen L. Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice. Frontiers In Immunology 2020, 11: 585886. PMID: 33262765, PMCID: PMC7688534, DOI: 10.3389/fimmu.2020.585886.
TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model.Sha S, Pearson JA, Peng J, Hu Y, Huang J, Xing Y, Zhang L, Zhu Y, Zhao H, Wong FS, Chen L, Wen L. TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model. Diabetes 2020, 70: 504-515. PMID: 33154070, PMCID: PMC7881860, DOI: 10.2337/db20-0373.
Crosstalk between circadian rhythms and the microbiotaPearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunology 2020, 161: 278-290. PMID: 33090484, PMCID: PMC7692254, DOI: 10.1111/imm.13278.
Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes.Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: e4616-e4625. PMID: 32860693, PMCID: PMC7549925, DOI: 10.1210/clinem/dgaa590.
Gut microbial metabolites alter IgA immunity in type 1 diabetesHuang J, Pearson JA, Peng J, Hu Y, Sha S, Xing Y, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Wong F, Zhou Z, Wen L. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 2020, 5 PMID: 32298241, PMCID: PMC7259536, DOI: 10.1172/jci.insight.135718.
Mouse Models of Autoimmune Diabetes: The Nonobese Diabetic (NOD) MouseChen D, Thayer TC, Wen L, Wong FS. Mouse Models of Autoimmune Diabetes: The Nonobese Diabetic (NOD) Mouse. 2020, 2128: 87-92. PMID: 32180187, PMCID: PMC8253669, DOI: 10.1007/978-1-0716-0385-7_6.
A predictive CD8+ T cell phenotype for T1DM progressionWong FS, Wen L. A predictive CD8+ T cell phenotype for T1DM progression. Nature Reviews Endocrinology 2020, 16: 198-199. PMID: 32051538, PMCID: PMC8258660, DOI: 10.1038/s41574-020-0330-3.
Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell FunctionsPearson JA, Tai N, Ekanayake-Alper DK, Peng J, Hu Y, Hager K, Compton S, Wong FS, Smith PC, Wen L. Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions. Frontiers In Immunology 2019, 10: 2654. PMID: 31798584, PMCID: PMC6863139, DOI: 10.3389/fimmu.2019.02654.
Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD miceHu Y, Jin P, Peng J, Zhang X, Wong FS, Wen L. Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice. Journal Of Autoimmunity 2016, 72: 47-56. PMID: 27178773, PMCID: PMC4958594, DOI: 10.1016/j.jaut.2016.05.001.
The Gut Microbiome in the NOD MousePeng J, Hu Y, Wong FS, Wen L. The Gut Microbiome in the NOD Mouse. 2016, 1433: 169-177. PMID: 27032947, DOI: 10.1007/7651_2016_331.
Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a productionMajewska-Szczepanik M, Askenase PW, Lobo FM, Marcińska K, Wen L, Szczepanik M. Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production. Journal Of Allergy And Clinical Immunology 2016, 138: 262-273.e6. PMID: 26810716, PMCID: PMC5278675, DOI: 10.1016/j.jaci.2015.11.018.
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCsHu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS, Wen L. Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. The Journal Of Immunology 2015, 195: 4176-4184. PMID: 26401004, PMCID: PMC4765177, DOI: 10.4049/jimmunol.1500884.
NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic isletsHu C, Ding H, Li Y, Pearson JA, Zhang X, Flavell RA, Wong FS, Wen L. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 11318-11323. PMID: 26305961, PMCID: PMC4568693, DOI: 10.1073/pnas.1513509112.
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesityTai N, Wong FS, Wen L. The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Reviews In Endocrine And Metabolic Disorders 2015, 16: 55-65. PMID: 25619480, PMCID: PMC4348024, DOI: 10.1007/s11154-015-9309-0.
Toll-Like Receptor 3 Is Critical for Coxsackievirus B4-Induced Type 1 Diabetes in Female NOD MiceMcCall K, Thuma J, Courreges M, Benencia F, James C, Malgor R, Kantake N, Mudd W, Denlinger N, Nolan B, Wen L, Schwartz F. Toll-Like Receptor 3 Is Critical for Coxsackievirus B4-Induced Type 1 Diabetes in Female NOD Mice. Endocrinology 2014, 156: 453-461. PMID: 25422874, PMCID: PMC4298321, DOI: 10.1210/en.2013-2006.
Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet AutoantigensKleffel S, Vergani A, Tezza S, Nasr M, Niewczas MA, Wong S, Bassi R, D’Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O’Connor K, Fiorina P. Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens. Diabetes 2014, 64: 158-171. PMID: 25187361, PMCID: PMC4274804, DOI: 10.2337/db13-1639.
IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD MiceTan Q, Majewska-Szczepanik M, Zhang X, Szczepanik M, Zhou Z, Wong FS, Wen L. IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice. Diabetes 2014, 63: 2761-2775. PMID: 24696448, PMCID: PMC4113073, DOI: 10.2337/db13-1504.
Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17AMajewska-Szczepanik M, Strzepa A, Marcińska K, Wen L, Szczepanik M. Epicutaneous Immunization with TNP-Ig and Zymosan Induces TCRαβ+ CD4+ Contrasuppressor Cells That Reverse Skin-Induced Suppression via IL-17A. International Archives Of Allergy And Immunology 2014, 164: 122-136. PMID: 24993442, PMCID: PMC4141016, DOI: 10.1159/000363446.
Long term effect of gut microbiota transfer on diabetes developmentPeng J, Narasimhan S, Marchesi JR, Benson A, Wong FS, Wen L. Long term effect of gut microbiota transfer on diabetes development. Journal Of Autoimmunity 2014, 53: 85-94. PMID: 24767831, PMCID: PMC4361177, DOI: 10.1016/j.jaut.2014.03.005.
TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic MiceTai N, Wong FS, Wen L. TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice. The Journal Of Immunology 2013, 191: 2926-2937. PMID: 23956420, PMCID: PMC3788667, DOI: 10.4049/jimmunol.1300547.
Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune DiabetesHu C, Ding H, Zhang X, Wong FS, Wen L. Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes. Diabetes 2013, 62: 2849-2858. PMID: 23447122, PMCID: PMC3717853, DOI: 10.2337/db12-1175.
Immunotherapy for T1DM—targeting innate immunityWong F, Wen L. Immunotherapy for T1DM—targeting innate immunity. Nature Reviews Endocrinology 2013, 9: 384-385. PMID: 23732280, PMCID: PMC4048745, DOI: 10.1038/nrendo.2013.103.
Role of IRAK-M in Alcohol Induced Liver InjuryWang Y, Hu Y, Chao C, Yuksel M, Colle I, Flavell RA, Ma Y, Yan H, Wen L. Role of IRAK-M in Alcohol Induced Liver Injury. PLOS ONE 2013, 8: e57085. PMID: 23437317, PMCID: PMC3578822, DOI: 10.1371/journal.pone.0057085.
Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes.Wong F, Wen L. Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes. The Review Of Diabetic Studies 2012, 9: 289-304. PMID: 23804267, PMCID: PMC3740697, DOI: 10.1900/rds.2012.9.289.
TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetesDong B, Qi D, Yang L, Huang Y, Xiao X, Tai N, Wen L, Wong F. TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. AJP Heart And Circulatory Physiology 2012, 303: h732-h742. PMID: 22842069, PMCID: PMC3468457, DOI: 10.1152/ajpheart.00948.2011.
The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD MiceXiang Y, Peng J, Tai N, Hu C, Zhou Z, Wong FS, Wen L. The Dual Effects of B Cell Depletion on Antigen-Specific T Cells in BDC2.5NOD Mice. The Journal Of Immunology 2012, 188: 4747-4758. PMID: 22490442, PMCID: PMC4361183, DOI: 10.4049/jimmunol.1103055.
Correction: The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic MiceHu C, Du W, Zhang X, Wong F, Wen L. Correction: The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice. The Journal Of Immunology 2012, 188: 3552-3552. DOI: 10.4049/jimmunol.1290005.
Epicutaneous immunization with DNP‐BSA induces CD4+ CD25+ Treg cells that inhibit Tc1‐mediated CSMajewska‐Szczepanik M, Zemelka‐Wiącek M, Ptak W, Wen L, Szczepanik M. Epicutaneous immunization with DNP‐BSA induces CD4+ CD25+ Treg cells that inhibit Tc1‐mediated CS. Immunology And Cell Biology 2012, 90: 784-795. PMID: 22290507, DOI: 10.1038/icb.2012.1.
The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic MiceHu C, Du W, Zhang X, Wong FS, Wen L. The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice. The Journal Of Immunology 2012, 188: 294-301. PMID: 22140261, PMCID: PMC4361178, DOI: 10.4049/jimmunol.1101590.
Insulinoma-Released Exosomes or Microparticles Are Immunostimulatory and Can Activate Autoreactive T Cells Spontaneously Developed in Nonobese Diabetic MiceSheng H, Hassanali S, Nugent C, Wen L, Hamilton-Williams E, Dias P, Dai Y. Insulinoma-Released Exosomes or Microparticles Are Immunostimulatory and Can Activate Autoreactive T Cells Spontaneously Developed in Nonobese Diabetic Mice. The Journal Of Immunology 2011, 187: 1591-1600. PMID: 21734072, PMCID: PMC3150365, DOI: 10.4049/jimmunol.1100231.
Combined antibody therapy for type 1 diabetes (107.2)Hu C, Ding H, Wong F, Wen L. Combined antibody therapy for type 1 diabetes (107.2). The Journal Of Immunology 2011, 186: 107.2-107.2. DOI: 10.4049/jimmunol.186.supp.107.2.
IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 miceTai N, Yasuda H, Xiang Y, Zhang L, Rodriguez-Pinto D, Yokono K, Sherwin R, Wong FS, Nagata M, Wen L. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clinical Immunology 2011, 139: 336-349. PMID: 21458378, DOI: 10.1016/j.clim.2011.03.003.
To B or not to B—pathogenic and regulatory B cells in autoimmune diabetesWong F, Hu C, Xiang Y, Wen L. To B or not to B—pathogenic and regulatory B cells in autoimmune diabetes. Current Opinion In Immunology 2010, 22: 723-731. PMID: 21050736, DOI: 10.1016/j.coi.2010.10.002.
Immunotargeting of insulin reactive CD8 T cells to prevent DiabetesScott G, Fishman S, Siew L, Margalit A, Chapman S, Chervonsky A, Wen L, Gross G, Wong F. Immunotargeting of insulin reactive CD8 T cells to prevent Diabetes. Journal Of Autoimmunity 2010, 35: 390-397. PMID: 20850948, DOI: 10.1016/j.jaut.2010.08.005.
Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigensBurton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, Cooke A, Zaccone P. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. European Journal Of Immunology 2010, 40: 2221-2229. PMID: 20480503, DOI: 10.1002/eji.200939998.
The role of TLR3 in protection of diabetes by PolyI:C in NOD mice (136.31)Xiang Y, Wen L, Zhou Z, Wong F. The role of TLR3 in protection of diabetes by PolyI:C in NOD mice (136.31). The Journal Of Immunology 2010, 184: 136.31-136.31. DOI: 10.4049/jimmunol.184.supp.136.31.
Inflammatory Regulation by TLR3 in Acute HepatitisXiao X, Zhao P, Rodriguez-Pinto D, Qi D, Henegariu O, Alexopoulou L, Flavell RA, Wong FS, Wen L. Inflammatory Regulation by TLR3 in Acute Hepatitis. The Journal Of Immunology 2009, 183: 3712-3719. PMID: 19710451, PMCID: PMC3787866, DOI: 10.4049/jimmunol.0901221.
Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic MiceHamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA. Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice. The Journal Of Immunology 2009, 183: 1533-1541. PMID: 19592648, PMCID: PMC2733871, DOI: 10.4049/jimmunol.0900428.
Translational Mini‐Review Series on B Cell‐Directed Therapies: B cell‐directed therapy for autoimmune diseasesHu C, Wong F, Wen L. Translational Mini‐Review Series on B Cell‐Directed Therapies: B cell‐directed therapy for autoimmune diseases. Clinical & Experimental Immunology 2009, 157: 181-190. PMID: 19604257, PMCID: PMC2730843, DOI: 10.1111/j.1365-2249.2009.03977.x.
Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune DiabetesWong FS, Siew LK, Scott G, Thomas IJ, Chapman S, Viret C, Wen L. Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes. Diabetes 2009, 58: 1156-1164. PMID: 19208910, PMCID: PMC2671054, DOI: 10.2337/db08-0800.
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD miceXiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.
Innate and adaptive immune responses are highly interconnected at many levels.Wong F, Wen L. Innate and adaptive immune responses are highly interconnected at many levels. 2009, 9: 1-3. PMID: 19199936, DOI: 10.2174/156652409787314462.
IFN‐α Can Both Protect against and Promote the Development of Type 1 DiabetesWong F, Wen L. IFN‐α Can Both Protect against and Promote the Development of Type 1 Diabetes. Annals Of The New York Academy Of Sciences 2008, 1150: 187-189. PMID: 19120292, DOI: 10.1196/annals.1447.031.
Developing a Novel Model System to Target Insulin‐Reactive CD8 T CellsScott G, Fishman S, Margalit A, Siew L, Chapman S, Wen L, Gross G, Wong F. Developing a Novel Model System to Target Insulin‐Reactive CD8 T Cells. Annals Of The New York Academy Of Sciences 2008, 1150: 54-58. PMID: 19120267, DOI: 10.1196/annals.1447.040.
The Role of Toll‐Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD MiceWong FS, Hu C, Zhang L, Du W, Alexopoulou L, Flavell RA, Wen L. The Role of Toll‐Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice. Annals Of The New York Academy Of Sciences 2008, 1150: 146-148. PMID: 19120284, DOI: 10.1196/annals.1447.039.
Toll‐Like Receptors and DiabetesWong F, Wen L. Toll‐Like Receptors and Diabetes. Annals Of The New York Academy Of Sciences 2008, 1150: 123-132. PMID: 19120280, DOI: 10.1196/annals.1447.063.
Innate immunity and intestinal microbiota in the development of Type 1 diabetesWen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008, 455: 1109-1113. PMID: 18806780, PMCID: PMC2574766, DOI: 10.1038/nature07336.
The human T cell receptor Vβ repertoire of normal peripheral blood lymphocytes before and after mitogen stimulationWONG F, HIBBERD M, WEN L, MILLWARD B, DEMAINF A. The human T cell receptor Vβ repertoire of normal peripheral blood lymphocytes before and after mitogen stimulation. Clinical & Experimental Immunology 2008, 92: 361-366. PMID: 8387412, PMCID: PMC1554814, DOI: 10.1111/j.1365-2249.1993.tb03405.x.
Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunityMERINO J, SCHURMANS S, WEN L, BRIGHOUSE G, LUZUY S, LAMBERT P. Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity. Clinical & Experimental Immunology 2008, 79: 273-278. PMID: 1968797, PMCID: PMC1534764, DOI: 10.1111/j.1365-2249.1990.tb05190.x.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infectionMA Y, PEAKMAN M, LOBO‐YEO A, WEN L, LENZI M, GÄKEN J, FARZANEH F, MIELI‐VERGANI G, BIANCHI F, VERGANI D. Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. Clinical & Experimental Immunology 2008, 97: 94-99. PMID: 8033426, PMCID: PMC1534799, DOI: 10.1111/j.1365-2249.1994.tb06585.x.
Elevation of activated γδ T cell receptor bearing T lymphocytes in patients with autoimmune chronic liver diseaseWEN L, PEAKMAN M, MIELI‐VERGANI G, VERGANI D. Elevation of activated γδ T cell receptor bearing T lymphocytes in patients with autoimmune chronic liver disease. Clinical & Experimental Immunology 2008, 89: 78-82. PMID: 1385768, PMCID: PMC1554410, DOI: 10.1111/j.1365-2249.1992.tb06881.x.
CD8+ T-cells and their interaction with other cells in damage to islet β-cellsWong F, Siew L, Wen L. CD8+ T-cells and their interaction with other cells in damage to islet β-cells. Biochemical Society Transactions 2008, 36: 316-320. PMID: 18481949, DOI: 10.1042/bst0360316.
Anti-CD20 Therapy Delays or Prevents Recurrent Type 1 Diabetes in NOD MiceHu C, Deng S, Wong S, Wen L. Anti-CD20 Therapy Delays or Prevents Recurrent Type 1 Diabetes in NOD Mice. Clinical Immunology 2008, 127: s18. DOI: 10.1016/j.clim.2008.03.044.
Functional inhibition related to structure of a highly potent insulin‐specific CD8 T cell clone using altered peptide ligandsde Marquesini L, Moustakas A, Thomas I, Wen L, Papadopoulos G, Wong F. Functional inhibition related to structure of a highly potent insulin‐specific CD8 T cell clone using altered peptide ligands. European Journal Of Immunology 2007, 38: 240-249. PMID: 18157812, PMCID: PMC2901522, DOI: 10.1002/eji.200737762.
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in miceHu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, Shlomchik MJ, Wen L. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. Journal Of Clinical Investigation 2007, 117: 3857-3867. PMID: 18060033, PMCID: PMC2096456, DOI: 10.1172/jci32405.
CD86 Has Sustained Costimulatory Effects on CD8 T CellsThomas IJ, de Marquesini L, Ravanan R, Smith RM, Guerder S, Flavell RA, Wraith DC, Wen L, Wong FS. CD86 Has Sustained Costimulatory Effects on CD8 T Cells. The Journal Of Immunology 2007, 179: 5936-5946. PMID: 17947667, PMCID: PMC2629533, DOI: 10.4049/jimmunol.179.9.5936.
Role of Fas in Autoimmune Diabetes (128.30)Mora C, Wen L, Gomis R, Green E, Chervonsky A, Wong F, García A, Flavell R. Role of Fas in Autoimmune Diabetes (128.30). The Journal Of Immunology 2007, 178: s216-s216. DOI: 10.4049/jimmunol.178.supp.128.30.
Activated Insulin-Reactive CD8 T cells in NOD mice Cause Diabetes. (129.46)Wong F, Siew L, Thomas I, Chapman S, Viret C, Wen L. Activated Insulin-Reactive CD8 T cells in NOD mice Cause Diabetes. (129.46). The Journal Of Immunology 2007, 178: s227-s227. DOI: 10.4049/jimmunol.178.supp.129.46.
Anti-CD20 Therapy in NOD Model of Type 1 Diabetes (131.26)Hu C, Rodriguez D, Du W, Ahuja A, Wong F, Shlomchik M, Wen L. Anti-CD20 Therapy in NOD Model of Type 1 Diabetes (131.26). The Journal Of Immunology 2007, 178: s242-s242. DOI: 10.4049/jimmunol.178.supp.131.26.
Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes SusceptibilityGe X, Piganelli J, Tse H, Bertera S, Mathews C, Trucco M, Wen L, Rudert W. Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility. Diabetes 2006, 55: 3455-3462. PMID: 17130492, DOI: 10.2337/db06-0680.
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 miceGebe J, Unrath K, Falk B, Ito K, Wen L, Daniels T, Lernmark Å, Nepom G. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clinical Immunology 2006, 121: 294-304. PMID: 16979383, PMCID: PMC1850983, DOI: 10.1016/j.clim.2006.08.002.
TGF-γ signaling is required for the function of insulin-reactive T regulatory cellsDu W, Wong F, Li M, Peng J, Qi H, Flavell R, Sherwin R, Wen L. TGF-γ signaling is required for the function of insulin-reactive T regulatory cells. Journal Of Clinical Investigation 2006, 116: 1738-1738. PMCID: PMC1464901, DOI: 10.1172/jci27030c1.
TGF-β signaling is required for the function of insulin-reactive T regulatory cellsDu W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-β signaling is required for the function of insulin-reactive T regulatory cells. Journal Of Clinical Investigation 2006, 116: 1360-1370. PMID: 16670772, PMCID: PMC1451206, DOI: 10.1172/jci27030.
B cells in autoimmune diabetes.Wong FS, Wen L. B cells in autoimmune diabetes. The Review Of Diabetic Studies 2005, 2: 121-35. PMID: 17491687, PMCID: PMC1783559, DOI: 10.1900/rds.2005.2.121.
The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 MiceWong FS, Du W, Thomas IJ, Wen L. The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice. Diabetes 2005, 54: 2032-2040. PMID: 15983204, DOI: 10.2337/diabetes.54.7.2032.
Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD MouseWong FS, Wen L, Tang M, Ramanathan M, Visintin I, Daugherty J, Hannum LG, Janeway CA, Shlomchik MJ. Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse. Diabetes 2004, 53: 2581-2587. PMID: 15448087, DOI: 10.2337/diabetes.53.10.2581.
What can the HLA transgenic mouse tell us about autoimmune diabetes?Wong F, Wen L. What can the HLA transgenic mouse tell us about autoimmune diabetes? Diabetologia 2004, 47: 1476-1487. PMID: 15349728, DOI: 10.1007/s00125-004-1505-5.
Autoimmune diabetes in HLA‐DR3/DQ8 transgenic mice expressing the co‐stimulatory molecule B7‐1 in the β cells of islets of LangerhansRajagopalan G, Kudva YC, Chen L, Wen L, David CS. Autoimmune diabetes in HLA‐DR3/DQ8 transgenic mice expressing the co‐stimulatory molecule B7‐1 in the β cells of islets of Langerhans. International Immunology 2003, 15: 1035-1044. PMID: 12917255, DOI: 10.1093/intimm/dxg103.
Critical roles of CD30/CD30L interactions in murine autoimmune diabetesCHAKRABARTY S, NAGATA M, YASUDA H, WEN L, NAKAYAMA M, CHOWDHURY S, YAMADA K, JIN Z, KOTANI R, MORIYAMA H, SHIMOZATO O, YAGITA H, YOKONO K. Critical roles of CD30/CD30L interactions in murine autoimmune diabetes. Clinical & Experimental Immunology 2003, 133: 318-325. PMID: 12930356, PMCID: PMC1808783, DOI: 10.1046/j.1365-2249.2003.02223.x.
The study of HLA class II and autoimmune diabetes.Wong F, Wen L. The study of HLA class II and autoimmune diabetes. 2003, 3: 1-15. PMID: 12558070, DOI: 10.2174/1566524033361591.
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptideMoriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, Gianani R, Wong F, Eisenbarth G. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 5539-5544. PMID: 11943868, PMCID: PMC122805, DOI: 10.1073/pnas.082120099.
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2Kd that stimulates CD8 T cells in insulin-dependent diabetes mellitusWong F, Moustakas A, Wen L, Papadopoulos G, Janeway C. Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2Kd that stimulates CD8 T cells in insulin-dependent diabetes mellitus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 5551-5556. PMID: 11943852, PMCID: PMC122807, DOI: 10.1073/pnas.072037299.
Report From the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-WorkshopKaufman D, Tisch R, Sarvetnick N, Chatenoud L, Harrison L, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D. Report From the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-Workshop. Diabetes 2001, 50: 2459-2463. PMID: 11679422, DOI: 10.2337/diabetes.50.11.2459.
The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic modelWen L, Chen N, Tang J, Sherwin R, Wong F. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. Journal Of Clinical Investigation 2001, 107: 871-880. PMID: 11285306, PMCID: PMC199575, DOI: 10.1172/jci11708.
Type 1 Diabetes-Predisposing MHC Alleles Influence the Selection of Glutamic Acid Decarboxylase (GAD) 65-Specific T Cells in a Transgenic ModelAbraham R, Wen L, Marietta E, David C. Type 1 Diabetes-Predisposing MHC Alleles Influence the Selection of Glutamic Acid Decarboxylase (GAD) 65-Specific T Cells in a Transgenic Model. The Journal Of Immunology 2001, 166: 1370-1379. PMID: 11145722, DOI: 10.4049/jimmunol.166.2.1370.
In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of DiabetesWen L, Wong F, Tang J, Chen N, Altieri M, David C, Flavell R, Sherwin R. In Vivo Evidence for the Contribution of Human Histocompatibility Leukocyte Antigen (Hla)-Dq Molecules to the Development of Diabetes. Journal Of Experimental Medicine 2000, 191: 97-104. PMID: 10620608, PMCID: PMC2195792, DOI: 10.1084/jem.191.1.97.
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA libraryWong F, Karttunen J, Dumont C, Wen L, Visintin I, Pilip I, Shastri N, Pamer E, Janeway C. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nature Medicine 1999, 5: 1026-1031. PMID: 10470079, DOI: 10.1038/12465.
The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action.Barber D, Passoni L, Wen L, Geng L, Hayday A. The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action. The Journal Of Immunology 1998, 161: 11-6. PMID: 9647201, DOI: 10.4049/jimmunol.161.1.11.
The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) MiceWong F, Visintin I, Wen L, Granata J, Flavell R, Janeway C. The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice. Journal Of Experimental Medicine 1998, 187: 1985-1993. PMID: 9625758, PMCID: PMC2212360, DOI: 10.1084/jem.187.12.1985.
Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation.Wen L, Barber D, Pao W, Wong F, Owen M, Hayday A. Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. The Journal Of Immunology 1998, 160: 1965-74. PMID: 9469460, DOI: 10.4049/jimmunol.160.4.1965.
γδ T-cell help in responses to pathogens and in the development of systemic autoimmunityWen L, Hayday A. γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity. Immunologic Research 1997, 16: 229-241. PMID: 9379074, DOI: 10.1007/bf02786392.
Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouseZekzer D, Wong F, Wen L, Altieri M, Gurlo T, von Grafenstein H, Sherwin R. Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse. Diabetes 1997, 46: 1124-1132. DOI: 10.2337/diabetes.46.7.1124.
Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic MouseZekzer D, Wong F, Wen L, Altieri M, Gurlo T, von Grafenstein H, Sherwin R. Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse. Diabetes 1997, 46: 1124-1132. PMID: 9200646, DOI: 10.2337/diab.46.7.1124.
T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium.Roberts S, Smith A, West A, Wen L, Findly R, Owen M, Hayday A. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11774-11779. PMID: 8876213, PMCID: PMC38134, DOI: 10.1073/pnas.93.21.11774.
γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cellsPao W, Wen L, Smith A, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan I, Owen M, Hayday A. γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Current Biology 1996, 6: 1317-1325. PMID: 8939571, DOI: 10.1016/s0960-9822(02)70718-5.
Murine lupus in the absence of alpha beta T cells.Peng SL, Madaio MP, Hughes DP, Crispe IN, Owen MJ, Wen L, Hayday AC, Craft J. Murine lupus in the absence of alpha beta T cells. The Journal Of Immunology 1996, 156: 4041-9. PMID: 8621947, DOI: 10.4049/jimmunol.156.10.4041.
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.Wong FS, Visintin I, Wen L, Flavell RA, Janeway CA. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. Journal Of Experimental Medicine 1996, 183: 67-76. PMID: 8551245, PMCID: PMC2192404, DOI: 10.1084/jem.183.1.67.
Intestinal coccidiosis: using targeted mutagenesis to examine the role of αβ and γδ T-cells in the primary and secondary host response to EimeriaRoberts S, Smith A, Wen L, Viney J, Findly R, Owen M, West A, Hayday A. Intestinal coccidiosis: using targeted mutagenesis to examine the role of αβ and γδ T-cells in the primary and secondary host response to Eimeria. Gastroenterology 1995, 108: a904. DOI: 10.1016/0016-5085(95)27921-0.
Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells.Viney J, Dianda L, Roberts S, Wen L, Mallick C, Hayday A, Owen M. Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 11948-11952. PMID: 7991563, PMCID: PMC45353, DOI: 10.1073/pnas.91.25.11948.
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cellsWen L, Roberts S, Viney J, Wong F, Mallick C, Findly R, Peng Q, Craft J, Owen M, Mayday A. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 1994, 369: 654-658. PMID: 8208291, DOI: 10.1038/369654a0.
T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet AntigensPeakman M, Wen L, McNab G, Watkins P, Tan K, Vergani D. T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens. Autoimmunity 1994, 17: 31-39. PMID: 8025212, DOI: 10.3109/08916939409014656.
Analysis of the Peripheral T-Cell Receptor VP Repertoire in Newly Diagnosed Patients with Type I DiabetesWong S, Wen L, Hibberd M, Millward A, Demaine A. Analysis of the Peripheral T-Cell Receptor VP Repertoire in Newly Diagnosed Patients with Type I Diabetes. Autoimmunity 1994, 18: 77-83. PMID: 7999959, DOI: 10.3109/08916939409014682.
89 IMMUNOHISTOCHEMICAL ANALYSIS OF THE T-CELL RECEPTOR (TCR) USAGE BY T LYMPHOCYTES INFILTRATING THE LIVER IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (ACAH) AND PRIMARY SCLEROSING CHOLANGITIS (PSC)Mustafa A, Wen L, Hussain M, Davies E, G M. 89 IMMUNOHISTOCHEMICAL ANALYSIS OF THE T-CELL RECEPTOR (TCR) USAGE BY T LYMPHOCYTES INFILTRATING THE LIVER IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (ACAH) AND PRIMARY SCLEROSING CHOLANGITIS (PSC). Journal Of Pediatric Gastroenterology And Nutrition 1992, 15: 355. DOI: 10.1097/00005176-199210000-00112.
γδ† T CLONES FROM LIVER BIOPSIES OF CHILDREN WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH) AND PRIMARY SCLEROSING CHOLANGITIS (aPSC) ARE CYTOTOXIC TO HUMAN LIVER TARGET CELLSWen L, Peakman M, Mowat A, Mieli-Vergani G, Vergani D. γδ† T CLONES FROM LIVER BIOPSIES OF CHILDREN WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH) AND PRIMARY SCLEROSING CHOLANGITIS (aPSC) ARE CYTOTOXIC TO HUMAN LIVER TARGET CELLS. Journal Of Pediatric Gastroenterology And Nutrition 1991, 13: 323. DOI: 10.1097/00005176-199110000-00056.
T-CELL ANTIGEN RECEPTOR V GENE USAGE OF T-CELL CLONES DERIVED FROM LIVER BIOPSIES OF CHILDREN WITH AUTOIMMUNE LIVER DISEASEWen L, Demaine A, Wong S, Hibberd M, Mowat A, Mieli-Vergani G, Vergani D. T-CELL ANTIGEN RECEPTOR V GENE USAGE OF T-CELL CLONES DERIVED FROM LIVER BIOPSIES OF CHILDREN WITH AUTOIMMUNE LIVER DISEASE. Journal Of Pediatric Gastroenterology And Nutrition 1991, 13: 322. DOI: 10.1097/00005176-199110000-00051.
Transient T and B cell activation after neonatal induction of tolerance to MHC class II or Mls alloantigens.Schurmans S, Brighouse G, Kramer G, Wen L, Izui S, Merino J, Lambert P. Transient T and B cell activation after neonatal induction of tolerance to MHC class II or Mls alloantigens. The Journal Of Immunology 1991, 146: 2152-60. PMID: 1672344, DOI: 10.4049/jimmunol.146.7.2152.
T-cell-directed hepatocyte damage in autoimmune chronic active hepatitisWen L, Peakman M, Lobo-Yeo A, Vergani D, Mowat A, Mieli-Vergani, McFarlane B. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. The Lancet 1990, 336: 1527-1530. PMID: 1979365, DOI: 10.1016/0140-6736(90)93306-a.
LIVER MEMBRANE-SPECIFIC T CEL CLONES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH)Wen L, Lobo Yeo A, Pcakman M, Mowat A, Mieli Vargant G, Vargani D. LIVER MEMBRANE-SPECIFIC T CEL CLONES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH). Pediatric Research 1989, 26: 272-272. DOI: 10.1203/00006450-198909000-00050.
Liver membrane-specific T cell clones in autoimmune chronic active hepatitis (aCAH)Wen L, Lobo-Yeo A, Peakman M, Mowat A, Mieli-Vergani G, Vergani D. Liver membrane-specific T cell clones in autoimmune chronic active hepatitis (aCAH). Journal Of Hepatology 1989, 9: p5. DOI: 10.1016/0168-8278(89)90098-6.
Quantitative Analysis of Precursors Frequency of Rheumatoid Factor (RF) Producing Human B CellsVischer T, Werner-Favre C, Wen L, Zubler R. Quantitative Analysis of Precursors Frequency of Rheumatoid Factor (RF) Producing Human B Cells. Scandinavian Journal Of Rheumatology 1988, 17: 123-126. PMID: 3266359, DOI: 10.3109/03009748809096752.
Theoretical and Practical Aspects of B‐Cell Activation: Murine and Human SystemsZubler R, Werner‐Favre C, Wen L, Sebcita K, Straub C. Theoretical and Practical Aspects of B‐Cell Activation: Murine and Human Systems. Immunological Reviews 1987, 99: 281-299. PMID: 2960608, DOI: 10.1111/j.1600-065x.1987.tb01181.x.
Limiting dilution assay for human B cells based on their activation by mutant EL4 thymoma cells: total and anti‐malaria responder B cell frequenciesWen L, Hanvanich M, Werner‐Favre C, Brouwers N, Perrin L, Zubler R. Limiting dilution assay for human B cells based on their activation by mutant EL4 thymoma cells: total and anti‐malaria responder B cell frequencies. European Journal Of Immunology 1987, 17: 887-892. PMID: 3297736, DOI: 10.1002/eji.1830170624.

Edit Profile

Contact Information

Research & Publications

Biography

News

Research Summary

Coauthors

Research Interests

Selected Publications