Li Wen, MD, PhD
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Appointments
Endocrinology
Primary
Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Endocrinology
Primary
Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Endocrinology
Primary
Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
About
Titles
Professor of Medicine (Endocrinology)
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)Appointments
Endocrinology
ProfessorPrimary
Other Departments & Organizations
- Diabetes Research Center
- Discovery to Cure Internship
- Endocrinology
- Fellowship Training
- Human and Translational Immunology Program
- Internal Medicine
Education & Training
- Postdoctoral Associate and Fellow
- Yale University (1997)
- PhD
- University of London (1992)
- MD
- Capital University of Medicine (1983)
Research
Overview
Medical Subject Headings (MeSH)
Antigen-Presenting Cells; Antigens, CD20; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Hypersensitivity; Immune Tolerance; Immunity, Humoral; Immunity, Innate; Inflammasomes; Islets of Langerhans; Liver; Microbiota; Obesity; T-Lymphocytes, Regulatory; Toll-Like Receptors
ORCID
0000-0002-8805-2934
Research at a Glance
Yale Co-Authors
Frequent collaborators of Li Wen's published research.
Publications Timeline
A big-picture view of Li Wen's research output by year.
Research Interests
Research topics Li Wen is interested in exploring.
Juan Huang
Ningwen Tai, PhD
Jian Peng
Joseph Craft, MD
Xin Yang
Youjia Hu, PhD
127Publications
6,795Citations
Diabetes Mellitus, Type 1
CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Islets of Langerhans
Autoimmune Diseases
Immune Tolerance
Publications
2024
Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice.
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, e0012724. PMID: 38934542, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchConceptsGut microbiotaGut microbiota dysbiosisDysregulated gut microbiotaGut microbiota transplantationGerm-free miceVirulence factorsSmall intestinal bacteriaBile acid homeostasisMicrobiota dysbiosisDecreased diversityMicrobiota imbalanceMicrobiotaMouse model of cholestasisBile acidsMouse modelIntestinal bacteriaAcid homeostasisMicrobiota transplantationClinical management of patientsGutHepatic bile acidsLong-term effectsPre-clinical findingsModel of cholestasisManagement of patientsGut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D
Yang X, Huang J, Peng J, Wang P, Wong F, Wang R, Wang D, Wen L. Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D. Frontiers In Immunology 2024, 15: 1413177. PMID: 38903498, PMCID: PMC11187306, DOI: 10.3389/fimmu.2024.1413177.Peer-Reviewed Original ResearchAltmetricConceptsGut microbiotaGerm-free miceToll-like receptor 9Increased gut permeabilityIntestinal microbiotaGut permeabilityT1D developmentGut microbiota compositionFecal samplesTransferred to germ-free miceGut barrier integrityBreg cell differentiationMicrobiota influenceMucin degradationMicrobiota compositionBreg cellsAltered microbiotaMicrobiota impactMicrobiotaGene expressionImmune regulationDevelopment of T1DCell differentiationGutNOD miceTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl miceMulti-purposed diagnostic system for ovarian endometrioma using CNN and transformer networks in ultrasound
Li Y, Zhao B, Wen L, Huang R, Ni D. Multi-purposed diagnostic system for ovarian endometrioma using CNN and transformer networks in ultrasound. Biomedical Signal Processing And Control 2024, 91: 105923. DOI: 10.1016/j.bspc.2023.105923.Peer-Reviewed Original ResearchConceptsFirst deep learning methodDeep learning methodsAccuracy of classificationDeep learningSegmentation branchTransformer networkClassification branchPopular networksAttention mechanismDice scoreCyst segmentationLearning methodsClassification accuracyComparable performanceExperience of doctorsReader studyDiagnostic systemNetworkClassificationSpecific informationAccuracyImagesCNNCyst regionExtensive datasetGut microbiota and therapy for obesity and type 2 diabetes
Zhang L, Wang P, Huang J, Xing Y, Wong F, Suo J, Wen L. Gut microbiota and therapy for obesity and type 2 diabetes. Frontiers In Endocrinology 2024, 15: 1333778. PMID: 38596222, PMCID: PMC11002083, DOI: 10.3389/fendo.2024.1333778.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGut microbiota compositionGut microbiotaMicrobiota compositionType 2 diabetesFunction of gut microbiotaHomeostasis of gut microbiotaMicrobiota-based approachesModulating gut microbiotaBariatric surgeryEffective anti-obesity treatmentQuality of life of individualsMicrobiotaMildly obese patientsSustained weight lossAssociated with obesityDiminished quality of lifeAnti-obesity treatmentObesity management strategiesGutQuality of lifeNon-surgical interventionsIncreased medical costsPublic health crisisMusculoskeletal disordersObese patientsTLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model
Pearson J, Hu Y, Peng J, Wong F, Wen L. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers In Immunology 2024, 15: 1333967. PMID: 38482010, PMCID: PMC10935730, DOI: 10.3389/fimmu.2024.1333967.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsToll-like receptor 5Antigen-presenting cellsDendritic cellsType 1 diabetesTLR5-deficientDC developmentCytokine secretionCD4<sup>+</sup> T cell proliferationPathogenesis of type 1 diabetesT cell responsesEnhanced cytokine secretionT cell proliferationWild-type miceSusceptibility to obesitySusceptibility to T1DProinflammatory cytokine secretionGut microbiotaSpontaneous T1DNOD miceAutoimmune diabetesNon-obeseHuman T1DReceptor 5Autoimmune diseasesHyper-secretion
2023
Comparison of the diagnostic efficiency between the O-RADS US risk stratification system and doctors’ subjective judgment
Zhou S, Guo Y, Wen L, Liu J, Fu Y, Xu F, Liu M, Zhao B. Comparison of the diagnostic efficiency between the O-RADS US risk stratification system and doctors’ subjective judgment. BMC Medical Imaging 2023, 23: 190. PMID: 37986051, PMCID: PMC10662783, DOI: 10.1186/s12880-023-01153-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsNovel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice
Chen D, Kakabadse D, Fishman S, Weinstein-Marom H, Davies J, Boldison J, Thayer T, Wen L, Gross G, Wong F. Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice. Frontiers In Immunology 2023, 14: 1227133. PMID: 37731505, PMCID: PMC10507356, DOI: 10.3389/fimmu.2023.1227133.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntigen-specific CD8Islet-specific T cellsT cellsAutoimmune diabetesB cellsSCID miceMouse modelB lymphocytesNon-obese diabetic (NOD) mouse modelRegulatory B cell functionsProtective cell typesAntigen-specific CD4Pathogenic T cellsT cell cytotoxicityAntigen-presenting cellsCo-transfer experimentsDiabetic mouse modelDiabetic SCID miceType 1 diabetesAntigen-specific cellsB cell functionNovel therapeutic approachesMHC II moleculesSplenic B cellsPD-1Distinct signatures of gut microbiota and metabolites in different types of diabetes: a population-based cross-sectional study
Hu J, Ding J, Li X, Li J, Zheng T, Xie L, Li C, Tang Y, Guo K, Huang J, Liu S, Yan J, Peng W, Hou C, Wen L, Xu A, Zhou Z, Xiao Y. Distinct signatures of gut microbiota and metabolites in different types of diabetes: a population-based cross-sectional study. EClinicalMedicine 2023, 62: 102132. PMID: 37593224, PMCID: PMC10430172, DOI: 10.1016/j.eclinm.2023.102132.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAdult-onset T1DHealthy controlsGut microbiotaT1D patientsShort-chain fatty acid-producing bacteriaPopulation-based cross-sectional studyGut microbial alterationsRecent epidemiological dataType 1 diabetesCross-sectional studyT2D patientsIntestinal disturbancesDifferential diagnosisSerum metabolitesEpidemiological dataPatientsStudy subjectsT1DDiabetesSignificant differencesAcid-producing bacteriaMicrobiotaMicrobial profilesNational Key ResearchMicrobial alterationsAssessing Obstetric Anal Sphincter Injuries
Zhao B, Li Y, Tang Y, Guo Y, Yang Y, Wen L, Dietz H. Assessing Obstetric Anal Sphincter Injuries. Journal Of Ultrasound In Medicine 2023, 42: 2031-2038. PMID: 36916688, DOI: 10.1002/jum.16221.Peer-Reviewed Original ResearchCitations
Links & Media
News
- December 07, 2022
New Professors in Department of Internal Medicine (December 2022)
- September 20, 2021
Yale Endocrinology & Metabolism Publications
- September 12, 2016
How gut microbes may trigger type 1 diabetes
- September 21, 2008
‘Friendly’ Bacteria Protect Against Type 1 Diabetes, Yale Researchers Find
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