E Kevin Hall, MD
Research & Publications
Biography
News
Research Summary
Dr. Hall's research interests include better diagnosis and treatment of children with heart failure and cardiomyopathy. He has a particular interest in network theory and nonrelational data models and their applications for more clear understanding of deeply interrelated and nested data sets in pediatrics and pediatric cardiology.
Extensive Research Description
E. Kevin Hall, M.D. is Associate Professor of Pediatrics (Cardiology) and Medical Director of the Pediatric Heart Failure and Cardiomyopathy Program at the Yale University School of Medicine. Dr. Hall has had a life-long and active involvement with computers and information technology stretching back to the Texas Instruments TI-99/4A in the mid 1980s. He had an internship with Alliant Computer Systems in 1991/1992 and six systems engineering internships with Silicon Graphics in the later 1990s. He has significant experience with UNIX (both System V and BSD) and Linux dating back to 1991 and 1995 respectively. He is capable in C (C90), Objective-C, Swift, Ruby, Javascript (ES2015), and Clojure. He was publicly cited as a contributor to the Qt GUI framework prior to its acquisition by Nokia in 2008. He was appointed to and served on the Information Systems Steering Committee of the Cardiac Center at the Children’s Hospital of Philadelphia and University of Pennsylvania. He currently serves on the Yale University Provost’s ITS Advisory Committee (ITSAC)
Dr. Hall’s work has focused on cardiomyopathy in children and adolescents and the effects of these conditions on individuals’ qualities of life. He has been an early participant in mobile health and has a particular focus on using network and mobile technologies to study and better understand these conditions over broad geographies and age ranges. He is the principal investigator of a nationwide clinical study currently enrolling patients from 2 – 80 years of age with or at risk for these heart diseases. He is the programmer behind the Yale Cardiomyopathy Index, the iPhone-based application fronting this work. The Yale Cardiomyopathy Index was the second Apple research application released after the March 2015 announcement of ResearchKit and the first to enroll pediatric participants.
Because of this landmark work, in March of 2016 Dr. Hall was invited for five days to Fuwai Hospital in Beijing, the largest cardiovascular hospital in China, to present his findings and begin mobile health collaborations with their investigators. He is working closely with teams to build and release several large mobile health studies expected later this year.
Dr. Hall is a member of the Leadership and Steering Committee for the International Society of Pediatric Innovation, an organization of leaders in medicine from one hundred pediatric institutions around the world. He leads both the eMedicine and Communications Committees.
Dr. Hall is Principal Investigator on a new industry-sponsored heart failure pharmacologic treatment for children. He is additionally co-investigator on several other trials for cardiomyopathy and heart failure. In addition to his research activity Dr. Hall trained as a pediatric cardiologist and completed his Pediatric Cardiology fellowship at the Children’s Hospital of Philadelphia. He completed his Senior Fellowship in Pediatric Heart Failure and Transplantation at Children’s Hospital Boston. Since his arrival to Yale he has directed the Pediatric Heart Failure and Cardiomyopathy Program which manages patients with these conditions from three hundred families around Connecticut and bordering states.
Coauthors
Research Interests
Computer Communication Networks; Heart Defects, Congenital; Heart Failure; Cardiomyopathies; Myocarditis; Pediatrics; Mobile Applications
Selected Publications
- Vigorous Exercise in Patients With Hypertrophic CardiomyopathyLampert R, Ackerman M, Marino B, Burg M, Ainsworth B, Salberg L, Tome Esteban M, Ho C, Abraham R, Balaji S, Barth C, Berul C, Bos M, Cannom D, Choudhury L, Concannon M, Cooper R, Czosek R, Dubin A, Dziura J, Eidem B, Emery M, Estes N, Etheridge S, Geske J, Gray B, Hall K, Harmon K, James C, Lal A, Law I, Li F, Link M, McKenna W, Molossi S, Olshansky B, Ommen S, Saarel E, Saberi S, Simone L, Tomaselli G, Ware J, Zipes D, Day S, Abrahms D, Ashley E, Aziz P, Batra A, Cerrone M, Colan S, Erickson C, Ferhaan A, Gollob M, Johnsrude C, Kannankeril P, Kanter R, Li W, Masri A, Murphy A, Nandi D, Perez M, Perry J, Popjes E, Rao R, Rosenthal D, Sanatani S, Semsarian C, Shah M, Skinner J, Tardif J, Towbin J, Turer A, Webster G, Wever-Pinzon O, Wong T. Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy JAMA Cardiology 2023, 8: 595-605. PMID: 37195701, PMCID: PMC10193262, DOI: 10.1001/jamacardio.2023.1042.
- Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditisBarmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis Science Immunology 2023, 8: eadh3455. PMID: 37146127, DOI: 10.1126/sciimmunol.adh3455.
- Priorities to promote participant engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) NetworkSchuster A, Crossnohere N, Bachini M, Blair C, Carpten J, Claus E, Colditz G, Ding L, Drake B, Fields R, Janeway K, Kwan B, Lenz H, Ma Q, Mishra S, Paskett E, Rebbeck T, Ricker C, Stern M, Sussman A, Tiner J, Trent J, Verhaak R, Wagle N, Willman C, Bridges J, Network F. Priorities to promote participant engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network Cancer Epidemiology Biomarkers & Prevention 2023, 32: 487-495. PMID: 36791345, PMCID: PMC10068438, DOI: 10.1158/1055-9965.epi-22-0356.
- Short-Term Outcomes After Myopericarditis Related to COVID-19 VaccinationPareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O’Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.
- Short-Term Outcomes After Myopericarditis Related to COVID-19 VaccinationPareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.
- Current Practices in Treating Cardiomyopathy and Heart Failure in Duchenne Muscular Dystrophy (DMD): Understanding Care Practices in Order to Optimize DMD Heart Failure Through ACTIONVilla C, Auerbach SR, Bansal N, Birnbaum BF, Conway J, Esteso P, Gambetta K, Hall EK, Kaufman BD, Kirmani S, Lal AK, Martinez HR, Nandi D, O’Connor M, Parent JJ, Raucci FJ, Shih R, Shugh S, Soslow JH, Tunuguntla H, Wittlieb-Weber CA, Kinnett K, Cripe L. Current Practices in Treating Cardiomyopathy and Heart Failure in Duchenne Muscular Dystrophy (DMD): Understanding Care Practices in Order to Optimize DMD Heart Failure Through ACTION Pediatric Cardiology 2022, 43: 977-985. PMID: 35024902, PMCID: PMC8756173, DOI: 10.1007/s00246-021-02807-7.
- Electromagnetic interference complicating Impella® use during pediatric ablationSullivan J, Maitoza L, Brysiewicz N, Hall E, Beach C. Electromagnetic interference complicating Impella® use during pediatric ablation Annals Of Pediatric Cardiology 2022, 15: 533-535. PMID: 37152518, PMCID: PMC10158480, DOI: 10.4103/apc.apc_3_22.
- Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial.Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, VANISH Investigators., Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial. Nat Med 2021 doi: 10.1038/s41591-021-01505-4. PMID: 34556856.
- Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 VaccinationMarshall M, Ferguson ID, Lewis P, Jaggi P, Gagliardo C, Collins JS, Shaughnessy R, Caron R, Fuss C, Corbin KJE, Emuren L, Faherty E, Hall EK, Di Pentima C, Oster ME, Paintsil E, Siddiqui S, Timchak DM, Guzman-Cottrill JA. Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination Pediatrics 2021, 148: e2021052478. PMID: 34088762, DOI: 10.1542/peds.2021-052478.
- Hair and skin predict cardiomyopathies: Carvajal and erythrokeratodermia cardiomyopathy syndromesSun Q, Lee L, Hall EK, Choate KA, Elder RW. Hair and skin predict cardiomyopathies: Carvajal and erythrokeratodermia cardiomyopathy syndromes Pediatric Dermatology 2020, 38: 31-38. PMID: 33275305, DOI: 10.1111/pde.14478.
- Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 VariantsLandim-Vieira M, Johnston JR, Ji W, Mis EK, Tijerino J, Spencer-Manzon M, Jeffries L, Hall EK, Panisello-Manterola D, Khokha MK, Deniz E, Chase PB, Lakhani SA, Pinto JR. Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants Frontiers In Physiology 2020, 10: 1612. PMID: 32038292, PMCID: PMC6990120, DOI: 10.3389/fphys.2019.01612.
- Physical Activity in Individuals With the Long Qt Syndrome: Baseline Data From the Lifestyle and Exercise in Long Qt Study (live Lqts)https://doi.org/10.1161/circ.142.suppl_3.14500
- Blockchains in MedicineIntelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare 1st Edition
- Chapter 6 Other Key Concepts in Artificial IntelligenceChang A, Rhee K, Mousses S, Nahar J, Lane S, Ayalasomayajula F, Hall E, Chou T, Murickan G, Van Demark D. Chapter 6 Other Key Concepts in Artificial Intelligence 2020, 141-180. DOI: 10.1016/b978-0-12-823337-5.00006-8.
- Baseline Characteristics of the VANISH CohortAxelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Baseline Characteristics of the VANISH Cohort Circulation Heart Failure 2019, 12: e006231. PMID: 31813281, PMCID: PMC7219518, DOI: 10.1161/circheartfailure.119.006231.
- Text Messaging in Oncology: A Review of the LandscapeMougalian SS, Gross CP, Hall EK. Text Messaging in Oncology: A Review of the Landscape JCO Clinical Cancer Informatics 2018, 2: 1-9. PMID: 30652579, DOI: 10.1200/cci.17.00162.
- Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart DiseaseZahr R, Faustino EV, Carpenter T, Kirshbom P, Hall EK, Fahey JT, Kandil SB. Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease Journal Of Intensive Care Medicine 2016, 32: 508-513. PMID: 27251108, DOI: 10.1177/0885066616652077.
- Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysisMarsenic O, Anderson M, Couloures KG, Hong WS, Hall E, Dahl N. Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis Hemodialysis International 2015, 20: 277-285. PMID: 26663617, DOI: 10.1111/hdi.12384.
- Giant aneurysm of the atrial appendages in infantsLang SM, Zaidi A, Geva T, Sanders S, del Nido P, Hall E. Giant aneurysm of the atrial appendages in infants Annals Of Pediatric Cardiology 2014, 7: 130-134. PMID: 24987260, PMCID: PMC4070203, DOI: 10.4103/0974-2069.132489.
- Doppler tissue imaging in children following cardiac transplantation: A comparison to catheter derived hemodynamicsGoldberg DJ, Quartermain MD, Glatz AC, Hall EK, Davis E, Kren SA, Hanna BD, Cohen MS. Doppler tissue imaging in children following cardiac transplantation: A comparison to catheter derived hemodynamics Pediatric Transplantation 2011, 15: 488-494. PMID: 21518161, PMCID: PMC3140578, DOI: 10.1111/j.1399-3046.2011.01503.x.
- Brain‐type natriuretic peptide correlates with right heart pressures in a cross section of pediatric heart transplant patientsHall EK, Glatz AC, Quartermain MD, Ravishankar C, Kaufman B, Cohen MS, Hanna BD, Goldberg DJ. Brain‐type natriuretic peptide correlates with right heart pressures in a cross section of pediatric heart transplant patients Pediatric Transplantation 2010, 15: 70-74. PMID: 21199206, DOI: 10.1111/j.1399-3046.2010.01421.x.
- Heart FailureIn Netter’s Pediatrics. eds. Ludwig S, Werner H, Florin T. Elsevier, Burlington, MA
- A case report of rapid progressive coarctation and severe middle aortic syndrome in an infant with Williams syndrome.Hall EK, Glatz J, Kaplan P, Kaplan BS, Hellinger J, Ernst L, Gaynor JW. A case report of rapid progressive coarctation and severe middle aortic syndrome in an infant with Williams syndrome. Congenital Heart Disease 2009, 4: 373-7. PMID: 19740193, DOI: 10.1111/j.1747-0803.2009.00287.x.
- A functional magnetic resonance imaging study of paced finger tapping in children.Rivkin MJ, Vajapeyam S, Hutton C, Weiler ML, Hall EK, Wolraich DA, Yoo SS, Mulkern RV, Forbes PW, Wolff PH, Waber DP. A functional magnetic resonance imaging study of paced finger tapping in children. Pediatric Neurology 2003, 28: 89-95. PMID: 12699857, DOI: 10.1016/s0887-8994(02)00492-7.
- A fMRI study of paced finger tapping in children who are either good or poor readersNeuroImage 13(6):828-828; DOI: 10.1016/S1053-8119(01)92170-6
- The retinotopy of visual spatial attention.Tootell RB, Hadjikhani N, Hall EK, Marrett S, Vanduffel W, Vaughan JT, Dale AM. The retinotopy of visual spatial attention. Neuron 1998, 21: 1409-22. PMID: 9883733, DOI: 10.1016/s0896-6273(00)80659-5.