Justin Belcher
MD, PhD, FASN
Associate Professor of Medicine (Nephrology)
Research & Publications
Biography
News
Research Summary
My primary research interest lies with acute kidney injury and novel biomarkers of structural renal damage. More specifically I am interested in acute kidney injury in the setting of cirrhosis and utilizing novel biomarkers to enhance differential diagnosis and guide treatments.
Coauthors
Selected Publications
- The prognostic implications of early-stage AKI: Defining the threshold for concernWinters A, Belcher J. The prognostic implications of early-stage AKI: Defining the threshold for concern. Liver Transplantation 2023, 30: 235-236. PMID: 37903066, DOI: 10.1097/lvt.0000000000000292.
- Good Enough? Terlipressin, Hepatorenal Syndrome, and the Usage of RRTBelcher J. Good Enough? Terlipressin, Hepatorenal Syndrome, and the Usage of RRT. Kidney360 2023, 4: 1011-1013. PMID: 37651662, PMCID: PMC10484352, DOI: 10.34067/kid.0000000000000217.
- Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the USPatidar K, Belcher J, Regner K, St. Hillien S, Simonetto D, Asrani S, Neyra J, Sharma P, Velez J, Wadei H, Nadim M, Chung R, Seethapathy R, Parada X, Ouyang T, Ufere N, Robinson J, Diaz P, Wilechansky R, Przybyszewski E, Smith T, Ali A, Orman E, Schulz P, Siddiqui S, Shabbir R, Liu L, Cama-Olivares A, Flannery A, Baker M, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh R, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti A, consortium F. Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US. Journal Of Hepatology 2023, 79: 1408-1417. PMID: 37517455, PMCID: PMC10807505, DOI: 10.1016/j.jhep.2023.07.010.
- Hepatorenal Syndrome Pathophysiology, Diagnosis, and TreatmentBelcher J. Hepatorenal Syndrome Pathophysiology, Diagnosis, and Treatment. Medical Clinics Of North America 2023, 107: 781-792. PMID: 37258014, DOI: 10.1016/j.mcna.2023.03.009.
- Recent Advances in the Management of Hepatorenal Syndrome: A US PerspectivePatidar K, Piano S, Cullaro G, Belcher J, Allegretti A, Consortia H. Recent Advances in the Management of Hepatorenal Syndrome: A US Perspective. Clinical Gastroenterology And Hepatology 2023, 21: 897-901.e1. PMID: 36801201, PMCID: PMC10038893, DOI: 10.1016/j.cgh.2022.12.034.
- Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1Velez J, Karakala N, Tayebi K, Wickman T, Mohamed M, Kovacic R, Therapondos G, Kanduri S, Allegretti A, Belcher J, Regner K, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360 2023, 4: e448-e456. PMID: 36763632, PMCID: PMC10278824, DOI: 10.34067/kid.0000000000000068.
- Towards a Better Crystal Ball: Urinary C-C Motif Chemokine Ligand 14 (CCL14) and Persistent Severe AKIBelcher JM. Towards a Better Crystal Ball: Urinary C-C Motif Chemokine Ligand 14 (CCL14) and Persistent Severe AKI. Kidney360 2022, 3: 1124-1127. PMID: 35919534, PMCID: PMC9337887, DOI: 10.34067/kid.0002162022.
- Bile Acids Are Important Contributors to AKI Associated with Liver Disease: CONAllegretti AS, Belcher JM. Bile Acids Are Important Contributors to AKI Associated with Liver Disease: CON. Kidney360 2022, 3: 21-24. PMID: 35378020, PMCID: PMC8967622, DOI: 10.34067/kid.0006512020.
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story ForwardBelcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, Investigators H. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. American Journal Of Kidney Diseases 2021, 79: 737-745. PMID: 34606933, DOI: 10.1053/j.ajkd.2021.08.016.
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective StudyAllegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St. Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clinical And Translational Gastroenterology 2021, 12: e00359. PMID: 33979307, PMCID: PMC8116001, DOI: 10.14309/ctg.0000000000000359.
- The Role of Telenephrology in the Management of CKD.Belcher JM. The Role of Telenephrology in the Management of CKD. Kidney360 2020, 1: 1310-1315. PMID: 35372872, PMCID: PMC8815503, DOI: 10.34067/kid.0000802019.
- 47 Acute Kidney Injury Diagnostics and BiomarkersBelcher J, Parikh C. 47 Acute Kidney Injury Diagnostics and Biomarkers. 2019, 713-724.e5. DOI: 10.1016/b978-0-323-52978-5.00047-1.
- Acute Kidney Injury and Liver Disease: Incidence, Pathophysiology, Prevention/Treatment, and OutcomesBelcher J, Parikh C. Acute Kidney Injury and Liver Disease: Incidence, Pathophysiology, Prevention/Treatment, and Outcomes. 2018, 113-131. DOI: 10.1007/978-1-4939-8628-6_7.
- Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction MonitoringRauniyar N, Yu X, Cantley J, Voss EZ, Belcher J, Colangelo CM, Stone KL, Dahl N, Parikh C, Lam TT, Cantley LG. Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring. Proteomics Clinical Applications 2018, 12: e1700157. PMID: 29573172, PMCID: PMC6736530, DOI: 10.1002/prca.201700157.
- Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplantWilliams KR, Colangelo CM, Hou L, Chung L, Belcher JM, Abbott T, Hall IE, Zhao H, Cantley LG, Parikh CR. Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant. Proteomics Clinical Applications 2017, 11 PMID: 28261998, PMCID: PMC5549272, DOI: 10.1002/prca.201600132.
- Targeting Access to Kidney Care Via Telehealth: The VA ExperienceCrowley ST, Belcher J, Choudhury D, Griffin C, Pichler R, Robey B, Rohatgi R, Mielcarek B. Targeting Access to Kidney Care Via Telehealth: The VA Experience. Advances In Kidney Disease And Health 2017, 24: 22-30. PMID: 28224939, DOI: 10.1053/j.ackd.2016.11.005.
- Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysisPuthumana J, Ariza X, Belcher JM, Graupera I, Ginès P, Parikh CR. Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2016, 15: 1003-1013.e3. PMID: 28013112, PMCID: PMC5474196, DOI: 10.1016/j.cgh.2016.11.035.
- A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney InjuryZhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.
- Development of a Targeted Urine Proteome Assay for kidney diseasesCantley LG, Colangelo CM, Stone KL, Chung L, Belcher J, Abbott T, Cantley JL, Williams KR, Parikh CR. Development of a Targeted Urine Proteome Assay for kidney diseases. Proteomics Clinical Applications 2015, 10: 58-74. PMID: 26220717, PMCID: PMC5003777, DOI: 10.1002/prca.201500020.
- Acute Kidney Injury in Liver Disease: Role of BiomarkersBelcher JM. Acute Kidney Injury in Liver Disease: Role of Biomarkers. Advances In Kidney Disease And Health 2015, 22: 368-375. PMID: 26311598, DOI: 10.1053/j.ackd.2015.06.009.
- Creatinine Change on Vasoconstrictors as Mortality Surrogate in Hepatorenal Syndrome: Systematic Review & Meta-AnalysisBelcher JM, Coca SG, Parikh CR. Creatinine Change on Vasoconstrictors as Mortality Surrogate in Hepatorenal Syndrome: Systematic Review & Meta-Analysis. PLOS ONE 2015, 10: e0135625. PMID: 26295585, PMCID: PMC4546623, DOI: 10.1371/journal.pone.0135625.
- Urinary Biomarkers and Progression of AKI in Patients with CirrhosisBelcher JM, Garcia-Tsao G, Sanyal AJ, Thiessen-Philbrook H, Peixoto AJ, Perazella MA, Ansari N, Lim J, Coca SG, Parikh CR. Urinary Biomarkers and Progression of AKI in Patients with Cirrhosis. Clinical Journal Of The American Society Of Nephrology 2014, 9: 1857-1867. PMID: 25183658, PMCID: PMC4220770, DOI: 10.2215/cjn.09430913.
- Incidence, Trends, and Diagnosis of Perioperative Acute Kidney InjuryBelcher J, Parikh C. Incidence, Trends, and Diagnosis of Perioperative Acute Kidney Injury. 2014, 3-14. DOI: 10.1007/978-1-4939-1273-5_1.
- Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injuryBelcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen‐Philbrook H, Ansari N, Coca SG, Garcia‐Tsao G, Parikh CR, Consortium F. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology 2014, 60: 622-632. PMID: 24375576, PMCID: PMC4065642, DOI: 10.1002/hep.26980.
- Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5)Williams K, Colangelo C, Stone K, Chung L, Abbott T, Belcher J, Marlier A, Cantley L, Parikh C. Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.591.5.
- Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney InjuryBelcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR. Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury. International Journal Of Nephrology 2014, 2014: 708585. PMID: 24757564, PMCID: PMC3976933, DOI: 10.1155/2014/708585.
- Is There a Role for Dialysis in Patients with Hepatorenal Syndrome Who Are Not Liver Transplant Candidates?Belcher JM. Is There a Role for Dialysis in Patients with Hepatorenal Syndrome Who Are Not Liver Transplant Candidates? Seminars In Dialysis 2014, 27: 288-291. PMID: 24620917, DOI: 10.1111/sdi.12224.
- Reconsidering a “chopped liver”: The need for improving glomular filtration rate estimation for hepatic transplantationParikh CR, Belcher JM. Reconsidering a “chopped liver”: The need for improving glomular filtration rate estimation for hepatic transplantation. Hepatology 2014, 59: 1242-1245. PMID: 24470267, DOI: 10.1002/hep.27031.
- Acute Kidney Injury in Patients With Cirrhosis: Perils and PromiseBelcher JM, Parikh CR, Garcia–Tsao G. Acute Kidney Injury in Patients With Cirrhosis: Perils and Promise. Clinical Gastroenterology And Hepatology 2013, 11: 1550-1558. PMID: 23583467, PMCID: PMC3840046, DOI: 10.1016/j.cgh.2013.03.018.
- Association of AKI With mortality and complications in hospitalized patients with cirrhosisBelcher JM, Garcia‐Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, Consortium F. Association of AKI With mortality and complications in hospitalized patients with cirrhosis. Hepatology 2012, 57: 753-762. PMID: 22454364, PMCID: PMC3390443, DOI: 10.1002/hep.25735.
- Is It Time to Evolve Past the Prerenal Azotemia versus Acute Tubular Necrosis Classification?Belcher JM, Parikh CR. Is It Time to Evolve Past the Prerenal Azotemia versus Acute Tubular Necrosis Classification? Clinical Journal Of The American Society Of Nephrology 2011, 6: 2332-2334. PMID: 21921150, PMCID: PMC3186449, DOI: 10.2215/cjn.08570811.
- Clinical Applications of Biomarkers for Acute Kidney InjuryBelcher JM, Edelstein CL, Parikh CR. Clinical Applications of Biomarkers for Acute Kidney Injury. American Journal Of Kidney Diseases 2011, 57: 930-940. PMID: 21411200, DOI: 10.1053/j.ajkd.2010.11.032.