Joseph Akar, MD, PhD
Research & Publications
Biography
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Research Summary
I am currently an Associate Professor of Medicine in the Section of Cardiology at the Yale University School of Medicine and Director of Academic Electrophysiology and the Electrophysiology Laboratory at Yale-New Haven Hospital. During my fellowship in Cardiovascular Medicine at the University of Virginia Health Sciences Center, I completed a PhD in Molecular Physiology and Biological Physics. Following that I was Assistant Professor of Medicine at Loyola University Medical Center, Chicago and remained on faculty there for 5 years before joining Yale. I have dedicated my clinical and academic work over the past two decades to the study and treatment of atrial fibrillation (AF). I take a systems biology approach to the study of AF, from the cellular to the population science level. My PhD thesis during fellowship focused on the study of the subcellular distribution of elements during the development of electrical and structural remodeling in AF. I continue to study the role of atrial structural remodeling in AF and I have received NIH funding (R01) to examine non-invasive imaging of matrix metalloproteases in large animal models. I have collaborated closely with biomedical engineers using signal analysis techniques to quantify spatiotemporal organization in AF, and continue to utilize in silico computer modeling and non-linear dynamics methodology to study the basic mechanisms of AF. Clinically, I have expertise in intracardiac echocardiographic (ICE) atrial imaging and using it to eliminate ionizing radiation use during AF ablation. I hold special interest in device remote monitoring and outcomes research and have compiled the only device database capable of relating AF burden to clinical outcomes. I am a member of the Heart Rhythm Society expert consensus statement on Remote Interrogation and Monitoring for Cardiovascular Implantable Electronic Devices. I am also the PI of the YALE-CORE data analytic site for the national ACC/NCDR Atrial Fibrillation Ablation Registry, and I am a member of the steering Committee of the ACC/NCDR Left Atrial Appendage Occlusion Registry. My expertise in atrial remodeling and AF ablation is reflected in nominations for the writing group of the 2016 EHRA/HRS Expert Consensus Statement on Atrial Cardiomyopathies and the 2017 Heart Rhythm Society Expert Consensus Statement on AF Ablation.
Specialized Terms: Mechanisms of atrial fibrillation; Ablation of atrial fibrillation; Molecular imaging of structural remodeling; Pericardial fat and arrhythmogenesis; Effect of remote device monitoring on patient outcomes; Atrial fibrillation burden; Clinical outcomes
Extensive Research Description
I take a systems biology approach to the study of AF, from the cellular to the population science level.
1. Basic Mechanisms of Atrial Fibrillation. A major focus of pre-clinical and clinical research interest is the study of electrical and structural remodeling processes that lead to the development of AF. This has been a major theme of my academic work over the past two decades. During my fellowship training at the University of Virginia I pursued a PhD in Molecular Physiology and Biological Physics, focusing on the just recently described phenomena of electrical and structural remodeling in AF. I used animal models of AF to examine changes in the mitochondrial and subcellular distribution of different elements (Na, K, Cl, Mg) during the development of electrical remodeling. I also determined the relative contribution of atrial electrical and structural remodeling to the spatiotemporal organization of AF. I am currently the co-PI of an extramural NIH R01 grant performing non-invasive molecular imaging of activated matrix metalloproteinases as a substrate for the development of atrial structural remodeling and the precursor of fibrosis. The grant aims at developing novel techniques for early non-invasive assessment of AF vulnerability. This holds the potential for early detection and treatment of the disease before the onset of fibrosis. I have been collaborating with Dr. Lawrence Young and Dr. Fadi Akar to study the mouse model of AF induced by LKB1 deletion. My expertise in atrial remodeling has provided the opportunity to be a writing group member of the 2016 EHRA/HRS Consensus Statement on Atrial Cardiomyopathy.
a. Akar JG, Everett TH, Kok LC, Moorman JR, Haines DE. Effect of electrical and structural remodeling on spatiotemporal organization in acute and persistent atrial fibrillation. J Cardiovasc Electrophysiol 2002; 13:1027-1034.
b. Akar JG, Everett TH, Ho RH, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular chloride accumulation and subcellular elemental distribution during atrial fibrillation. Circulation 2003; 107:1810-1815.
c. Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, Desantis SM, Spinale FG, Gold MR. Plasma profiles of matrix metalloproteinases and tissue inhibitors of the metalloproteinases predict recurrence of atrial fibrillation following cardioversion. J Cardiovasc Transl Res. 2013; 6:528-35.
d. Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res 2015; 108:197-208.
2. Dynamics of Atrial Fibrillation. I have a long-standing interest in using signal analysis techniques to identify mechanisms and quantify spatiotemporal organization of AF. Given the clinical importance of objectively measuring the level of AF electrogram fractionation, I worked closely with biomedical engineers to use signal analysis techniques (Fourier transforms, entropy, cross correlations and wavelet analysis) to quantify AF organization in time and space. More recently, I have turned my attention to using the non-linear dynamics methodology of Recurrence Quantitative Analysis (RQA) to examine basic pathophysiological mechanisms of AF. Using computer modeling I am applying RQA in silico to differentiate differentiate different AF mechanisms (i.e spiral wave reentry “rotors” versus multiple wavelet reentry), and subsequently applying the RQA analysis on human AF signals obtained at the time of ablation.
a. Everett TH, Moorman JR, Kok LC, Akar JG, Haines DE. Assessment of global atrial fibrillation organization to optimize the timing of atrial defibrillation. Circulation 2001; 103:2857-2861.
b. Everett TH, Akar JG, Kok LC, Moorman JR, Haines DE. Use of global atrial fibrillation organization to optimize the success of burst pace termination. J Am Coll Cardiol 2002; 40:1831-1840.
c. Webber Jr. CL, Hu Z, Akar JG. Unstable Cardiac Singularities May Lead to Atrial Fibrillation. Int J Bifurc Chaos. 2011; 21: 1141–1151.
d. Hummel JP, Baher A, Buck B, Fanarjian M, Webber CL, Akar JG. A Method for Quantifying Recurrent Patterns of Local Wavefront Direction During Atrial Fibrillation. Comput Biology Medicine. 2017;89:497-504.
3. Reducing Ionizing Radiation During Fibrillation Ablation. I have significant expertise in the clinical use of intracardiac echocardiography (ICE) in order to eliminate ionizing radiation during AF ablation. I performed the first-in-man evaluation of the novel 3D ICE catheters and under my direction, the Yale-New Haven Hospital EP laboratory frequently hosts physicians interested in learning ICE skills and fluoroscopy reduction techniques. I am a writing group member of the 2014 Heart Rhythm Society Consensus Statement on EP Laboratory Standards, and the 2017 Heart Rhythm Society Consensus Statement on AF Ablation.
Ruisi CP, Brysiewicz N, Asnes JD, Sugeng L, Marieb M, Clancy J, Akar JG. Use of Intracardiac Echocardiography during Atrial Fibrillation Ablation. Pacing Clin Electrophysiol. 2013; 36:781-8.
a. Brysiewicz N, Mitiku T, Haleem K, Bhatt P, Al-Shaaraoui M, Clancy JF, Marieb MA, Sugeng L, Akar JG. Three-Dimensional Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation Ablation. JACC Imaging. 2014;7:97-100.
b. Haines DE, Beheiry S, Akar JG, Baker JL, Beinborn D, Beshai JF, Brysiewicz N, Chiu-Man C, Collins KK, Dare M, Fetterly K, Fisher JD, Hongo R, Irefin S, Lopez J, Miller JM, Perry JC, Slotwiner DJ, Tomassoni GF, Weiss E. Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety. Heart Rhythm. 2014 May 7, S1547-5271.
c. Yu R, Liu N, Lu J, Zhao X, Hu Y, Zhang J, Xu F, Tang R, Bai R, Akar JG, Dong J, Ma C. 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis: A Fluoroscopy-Free and Echocardiography-Free Method. JACC Cardiovasc Interv. 2020 May 25;13(10):1223-1232
d. Ortiz-Leon XA, Posada-Martinez EL, Trejo-Paredes MC, Ivey-Miranda JB, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Ugonabo I, Chen W, Houle H, Akar JG, Lin BA, McNamara RL, Lombo-Lievano B, Arias-Godinez JA, Sugeng L. Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography. Eur Heart J Cardiovasc Imaging. 2020 May 5:jeaa058. doi: 10.1093/ehjci/jeaa058
4. Registry Studies and Electrophysiology Outcomes Research. I have strong interest and expertise in registry studies examining cardiovascular outcomes. I headed the development a unique database of patients with cardiac devices by linking multiple different data sources. We used the ACC NCDR ICD Registry to derive baseline characteristics, the Boston Scientific Altitude registry to obtain a wealth of device and physiological data obtained via remote monitoring, Medicare claims to examine hospitalizations, and the social security death index to ascertain vital status. This one-of-a-kind database of ~30,000 patients allows the examination of cardiovascular outcomes associated with detailed device-, disease- and physiological device information. Our initial projects were to examine the determinants of remote monitoring and its effect on outcomes. We are now examining the relationship between device parameters (e.g. AF burden, RV pacing, etc…) on outcomes. Not only was this work presented as a Late Breaking Trial at the Heart Rhythm Society Scientific Sessions 2014, but also the registry expertise has provided me the opportunity be a writing group member of the 2015 Consensus Statement on Remote Monitoring, lead the Yale-CORE Data Analytical Site for the national ACC NCDR AF Ablation Registry, as well being a steering committee member of the ACC NCDR Left Atrial Appendage Occlusion registry.
a. Akar, JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators: insights from the Patient RElated Determinants of ICD Remote Monitoring (PREDICt RM) study. Circulation. 2013;128:2372-2378.
b. Slotwiner D, Varma N, Akar JG, Annas G, Beardsall M, Fogel RI, Galizio NO, Glotzer TV, Leahy RA, Love CJ, McLean RC, Mittal S, Morichelli L, Patton KK, Raitt MH, Pietro Ricci R, Rickard J, Schoenfeld MH, Serwer GA, Shea J, Varosy P, Verma A, Yu CM. Heart Rhythm Society Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devices. Heart Rhythm 2015;12:e69-e100.
c. Akar JG, Bao H, Jones P, Wang Y, Varosy P, Masoudi FA, Stein K, Saxon LA, Normand ST, Curtis JP. Use of Remote Monitoring Is Associated with Lower Risk of Adverse Outcomes Among Patients with Implanted Cardiac Defibrillators. Circ Arrhythm Electrophysiol 2015; 8:1173-80.
d. Al-Chekakie MO, Bao H, Jones PW, Stein KM, Marzec L, Varosy PD, Masoudi FA, Curtis JP, Akar JG. Addition of Blood Pressure and Weight Transmissions to Standard Remote Monitoring of Implantable Defibrillators and its Association with Mortality and Rehospitalization. Circulation: Cardiovas Quality Outcomes. 2017 May;10(5). pii: e003087. doi: 10.1161
Coauthors
Research Interests
Arrhythmias, Cardiac; Atrial Fibrillation; Cardiology; Catheter Ablation; Defibrillators
Research Images
Selected Publications
- In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation RegistryDarden D, Aldaas O, Du C, Munir M, Feld G, Pothineni N, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry EP Europace 2023, 25: euad124. PMID: 37184436, PMCID: PMC10228609, DOI: 10.1093/europace/euad124.
- PO-01-205 COMPUTATIONAL MODELING UNCOVERS A UNIFYING MECHANISM LINKING CONDUCTION BLOCK TO VT LOCALIZATION AND STABILITY IN ARRHYTHMOGENIC CARDIOMYOPATHYMcKay M, Akar J, Hummel J, Akar F. PO-01-205 COMPUTATIONAL MODELING UNCOVERS A UNIFYING MECHANISM LINKING CONDUCTION BLOCK TO VT LOCALIZATION AND STABILITY IN ARRHYTHMOGENIC CARDIOMYOPATHY Heart Rhythm 2023, 20: s159. DOI: 10.1016/j.hrthm.2023.03.523.
- PO-02-202 CORONARY SINUS PRESSURE FOLLOWING RETROGRADE CARDIOPLEGIA PREDICTS POSTOPERATIVE ATRIAL FIBRILLATIONKawkabani N, Farah R, Boustros O, Khoury A, Ghanem M, Khalil B, Akar J. PO-02-202 CORONARY SINUS PRESSURE FOLLOWING RETROGRADE CARDIOPLEGIA PREDICTS POSTOPERATIVE ATRIAL FIBRILLATION Heart Rhythm 2023, 20: s311-s312. DOI: 10.1016/j.hrthm.2023.03.1585.
- Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomesChui P, Lan Z, Freeman J, Enriquez A, Khera R, Akar J, Masoudi F, Ong E, Curtis J. Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes Heart Rhythm 2023 PMID: 36963741, DOI: 10.1016/j.hrthm.2023.03.022.
- Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation ProceduresHsu J, Darden D, Du C, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, Selzman K, Varosy P, Masoudi F, Freeman J, Curtis J, Akar J, Kowey P. Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures Journal Of The American College Of Cardiology 2023, 81: 867-878. PMID: 36858707, DOI: 10.1016/j.jacc.2022.11.060.
- Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote MonitoringGinder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.
- Abstract 15068: Regional Variation in Atrial Fibrillation Ablation Care for Medicare Beneficiaries Across the United StatesHanna J, Freeman J, Hummel J, Curtis J, Lin Z, Akar J, Khera R. Abstract 15068: Regional Variation in Atrial Fibrillation Ablation Care for Medicare Beneficiaries Across the United States Circulation 2022, 146: a15068-a15068. DOI: 10.1161/circ.146.suppl_1.15068.
- Abstract 15360: Characteristics and In-Hospital Outcomes of Patients Undergoing Pulmonary Vein Isolation With and Without Adjunctive Lesions: Insights From the Ncdr Afib Ablation RegistryDarden D, Aldaas O, Du C, Feld G, Pothineni K, Gopinathannair R, Lakkireddy D, Curtis J, Freeman J, Akar J, Hsu J. Abstract 15360: Characteristics and In-Hospital Outcomes of Patients Undergoing Pulmonary Vein Isolation With and Without Adjunctive Lesions: Insights From the Ncdr Afib Ablation Registry Circulation 2022, 146: a15360-a15360. DOI: 10.1161/circ.146.suppl_1.15360.
- Abstract 13258: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial FibrillationGonzalez F, perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract 13258: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation Circulation 2022, 146: a13258-a13258. DOI: 10.1161/circ.146.suppl_1.13258.
- Sex-based differences in atrial fibrillation ablation adverse eventsMszar R, Friedman D, Ong E, Du C, Wang Y, Zeitler E, Cunningham S, Akar J, Curtis J, Freeman J. Sex-based differences in atrial fibrillation ablation adverse events Heart 2022, 109: 595-605. PMID: 36104219, DOI: 10.1136/heartjnl-2022-321192.
- Abstract P1098: Atrial Deletion Of AMPK Promotes Atrial Oxidative Stress And The Formation Of Delayed Afterdepolarizations Within The Inter-atrial Pulmonary Vein JunctionCacheux M, Ma Y, Wu X, Akar J, Young L, Akar F. Abstract P1098: Atrial Deletion Of AMPK Promotes Atrial Oxidative Stress And The Formation Of Delayed Afterdepolarizations Within The Inter-atrial Pulmonary Vein Junction Circulation Research 2022, 131: ap1098-ap1098. DOI: 10.1161/res.131.suppl_1.p1098.
- PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATIONZiki M, Hummel J, Lampert R, Akar J. PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION Heart Rhythm 2022, 19: s273-s274. DOI: 10.1016/j.hrthm.2022.03.295.
- Abstract P458: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atrial Hypocontractility In Atrial FibrillationGonzalez-Gonzalez F, Perike S, Damen F, Capote A, Alsina K, Levin B, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P458: Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atrial Hypocontractility In Atrial Fibrillation Circulation Research 2021, 129: ap458-ap458. DOI: 10.1161/res.129.suppl_1.p458.
- B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIASStrauss B, Obus E, Katz M, Fargnoli A, Cacheux M, Akar J, Hummel J, Sassi Y, Akar F. B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIAS Heart Rhythm 2021, 18: s106. DOI: 10.1016/j.hrthm.2021.06.284.
- B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSEZiki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Abstract P780: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial FibrillationGonzalez-Gonzalez F, Srikanth P, Capote A, Katherina M A, Levin B, Sridhar A, Jacob G, Martin J, Akar J, Warren C, Solaro J, Darbar D, Goergen C, Wolska B, Wehrens X, McCauley M. Abstract P780: Myosin Light Chain Dephosphorylation by Ppp1r12c Promotes Atrial Hypocontractility in Atrial Fibrillation Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p780.
- Abstract 16496: Longitudinal Outcomes After Implantation of a Subcutaneous or Transvenous Implantable Cardioverter Defibrillator in Older Patients: A Report From the National Cardiovascular Data RegistryFriedman D, Parzynski C, Heist E, Russo A, Ranasinghe I, Zeitler E, Minges K, Akar J, Freeman J, Curtis J, Al-khatib S. Abstract 16496: Longitudinal Outcomes After Implantation of a Subcutaneous or Transvenous Implantable Cardioverter Defibrillator in Older Patients: A Report From the National Cardiovascular Data Registry Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16496.
- Abstract 12785: The American College of Cardiology's NCDR Afib Ablation Registry: A Summary of Initial Data Including Patient Characteristics, Procedural Characteristics, and Adverse EventsHsu J, Akar J, Marine J, Nichols S, Marcus G, Natale A, Noseworthy P, selzman K, Varosy P, Masoudi F, Du C, Freeman J, Curtis J, Kowey P. Abstract 12785: The American College of Cardiology's NCDR Afib Ablation Registry: A Summary of Initial Data Including Patient Characteristics, Procedural Characteristics, and Adverse Events Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.12785.
- Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 InfectionHummel JP, Maraj I, Taoutel R, Chamoun R, Workman VK, Tran L, Abboud JM, Afif C, Chouairi S, Delvecchio A, Howes CJ, Enriquez AD, Akar JG. Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection Circulation Arrhythmia And Electrophysiology 2020, 13: e008841-e008841. PMID: 32931318, PMCID: PMC7566294, DOI: 10.1161/circep.120.008841.
- Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID‐19: The need for pharmacogenetic insights”Hummel JP, Akar JG. Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID‐19: The need for pharmacogenetic insights” Journal Of Cardiovascular Electrophysiology 2020, 31: 2795-2795. PMID: 32864768, DOI: 10.1111/jce.14721.
- Risk of COVID-19 infection after cardiac electrophysiology proceduresWorkman V, Freeman JV, Obasare ER, Jain S, Ganeshan R, Burr A, Blitzer M, Akar J, Lampert R. Risk of COVID-19 infection after cardiac electrophysiology procedures Heart Rhythm O2 2020, 1: 239-242. PMID: 32904452, PMCID: PMC7455246, DOI: 10.1016/j.hroo.2020.08.006.
- Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycinMaraj I, Hummel JP, Taoutel R, Chamoun R, Workman V, Li C, Tran L, DelVecchio A, Howes C, Akar JG. Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin Journal Of Cardiovascular Electrophysiology 2020, 31: 1904-1907. PMID: 32485061, PMCID: PMC7300464, DOI: 10.1111/jce.14594.
- Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019Jain S, Workman V, Ganeshan R, Obasare ER, Burr A, DeBiasi RM, Freeman JV, Akar J, Lampert R, Rosenfeld LE. Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019 Heart Rhythm 2020, 17: 1417-1422. PMID: 32387247, PMCID: PMC7200355, DOI: 10.1016/j.hrthm.2020.04.047.
- Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography.Ortiz-Leon XA, Posada-Martinez EL, Trejo-Paredes MC, Ivey-Miranda JB, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Ugonabo I, Chen W, Houle H, Akar JG, Lin BA, McNamara RL, Lombo-Lievano B, Arias-Godinez JA, Sugeng L. Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography. European Heart Journal - Cardiovascular Imaging 2020, 21: 747-755. PMID: 32372089, DOI: 10.1093/ehjci/jeaa058.
- 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free MethodYu R, Liu N, Lu J, Zhao X, Hu Y, Zhang J, Xu F, Tang R, Bai R, Akar JG, Dong J, Ma C. 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free Method JACC Cardiovascular Interventions 2020, 13: 1223-1232. PMID: 32438994, DOI: 10.1016/j.jcin.2020.03.015.
- TT2 CARDIAC PERFORATION AMONG PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING ABLATION: WHAT ARE THE UNDERLYING PREDICTORS?Friedman D, Pokorney S, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar J, Freeman J, Goldstein L, Khanna R, Piccini J. TT2 CARDIAC PERFORATION AMONG PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING ABLATION: WHAT ARE THE UNDERLYING PREDICTORS? Value In Health 2020, 23: s385-s386. DOI: 10.1016/j.jval.2020.04.1502.
- Aggregating multiple real-world data sources using a patient-centered health-data-sharing platformDhruva SS, Ross JS, Akar JG, Caldwell B, Childers K, Chow W, Ciaccio L, Coplan P, Dong J, Dykhoff HJ, Johnston S, Kellogg T, Long C, Noseworthy PA, Roberts K, Saha A, Yoo A, Shah ND. Aggregating multiple real-world data sources using a patient-centered health-data-sharing platform Npj Digital Medicine 2020, 3: 60. PMID: 32352038, PMCID: PMC7170944, DOI: 10.1038/s41746-020-0265-z.
- The NCDR Left Atrial Appendage Occlusion RegistryFreeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, Kavinsky CJ, Turi ZG, Akar J, Koutras C, Curtis JP, Masoudi FA. The NCDR Left Atrial Appendage Occlusion Registry Journal Of The American College Of Cardiology 2020, 75: 1503-1518. PMID: 32238316, PMCID: PMC7205034, DOI: 10.1016/j.jacc.2019.12.040.
- Predictors of Cardiac Perforation With Catheter Ablation of Atrial FibrillationFriedman DJ, Pokorney SD, Ghanem A, Marcello S, Kalsekar I, Yadalam S, Akar JG, Freeman JV, Goldstein L, Khanna R, Piccini JP. Predictors of Cardiac Perforation With Catheter Ablation of Atrial Fibrillation JACC Clinical Electrophysiology 2020, 6: 636-645. PMID: 32553212, DOI: 10.1016/j.jacep.2020.01.011.
- TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDYOrtiz-Leon X, Posada E, Trejo M, Miranda J, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Houle H, Akar J, Lin B, McNamara R, Lombo B, Arias-Godínez J, Sugeng L. TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY Journal Of The American College Of Cardiology 2020, 75: 1706. DOI: 10.1016/s0735-1097(20)32333-0.
- CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHYOrtiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.
- IVABRADINE USE MAY BE ASSOCIATED WITH INCREASED BURDEN OF IDIOPATHIC PREMATURE CONTRACTIONSAkar J, Charif M, Dib G, Abboud J, Chouairi S. IVABRADINE USE MAY BE ASSOCIATED WITH INCREASED BURDEN OF IDIOPATHIC PREMATURE CONTRACTIONS Journal Of The American College Of Cardiology 2020, 75: 2640. DOI: 10.1016/s0735-1097(20)33267-8.
- Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillationBaher A, Buck B, Fanarjian M, Mounsey J, Gehi A, Chung E, Akar FG, Webber CL, Akar JG, Hummel JP. Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation Journal Of Cardiovascular Electrophysiology 2019, 30: 2229-2238. PMID: 31507008, DOI: 10.1111/jce.14161.
- Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM databaseHummel JP, Leipold RJ, Amorosi SL, Bao H, Deger KA, Jones PW, Kansal AR, Ott LS, Stern S, Stein K, Curtis JP, Akar JG. Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database Journal Of Cardiovascular Electrophysiology 2019, 30: 1066-1077. PMID: 30938894, PMCID: PMC6850124, DOI: 10.1111/jce.13934.
- Atrial Fibrillation Thermographic and Endoscopic Monitoring of Patients: Safety Algorithm for the EsophagusHummel JP, Kadado AJ, Baker M, Gehi AK, Mounsey JP, Sadaf MI, Enriquez AD, Freeman JV, Akar JG. Atrial Fibrillation Thermographic and Endoscopic Monitoring of Patients: Safety Algorithm for the Esophagus Circulation Arrhythmia And Electrophysiology 2018, 11: e006814. PMID: 30562101, DOI: 10.1161/circep.118.006814.
- Luminal Esophageal Temperature Monitoring to Reduce Esophageal Thermal Injury During Catheter Ablation for Atrial Fibrillation: A ReviewKadado AJ, Akar JG, Hummel JP. Luminal Esophageal Temperature Monitoring to Reduce Esophageal Thermal Injury During Catheter Ablation for Atrial Fibrillation: A Review Trends In Cardiovascular Medicine 2018, 29: 264-271. PMID: 30282588, DOI: 10.1016/j.tcm.2018.09.010.
- New skip parameter to facilitate recurrence quantification of signals comprised of multiple componentsHummel JP, Akar JG, Baher A, Webber CL. New skip parameter to facilitate recurrence quantification of signals comprised of multiple components Chaos An Interdisciplinary Journal Of Nonlinear Science 2018, 28: 085718. PMID: 30180597, DOI: 10.1063/1.5024845.
- Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter DefibrillatorFriedman DJ, Parzynski CS, Heist EK, Russo AM, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator Circulation 2018, 137: 2463-2477. PMID: 29463509, PMCID: PMC5988932, DOI: 10.1161/circulationaha.117.032167.
- Postoperative Atrial Fibrillation and Maslow’s HammerKadado AJ, Freeman J, Akar JG. Postoperative Atrial Fibrillation and Maslow’s Hammer Anesthesia & Analgesia 2018, 126: 19-20. PMID: 29252478, DOI: 10.1213/ane.0000000000002414.
- Abstract 20924: Threshold Based Infrared Imaging for Prevention of Esophageal Thermal Injury During Atrial Fibrillation AblationHummel J, Kadado A, Baker M, Sadaf M, Gehi A, Bhatt P, Enriquez A, Freeman J, Marieb M, Mounsey P, Akar J. Abstract 20924: Threshold Based Infrared Imaging for Prevention of Esophageal Thermal Injury During Atrial Fibrillation Ablation Circulation 2017, 136 DOI: 10.1161/circ.136.suppl_1.20924.
- Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetesKaram BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summaryCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary Journal Of Arrhythmia 2017, 33: 369-409. PMID: 29021841, PMCID: PMC5634725, DOI: 10.1016/j.joa.2017.08.001.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summaryCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Wyn Davies D, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary Journal Of Interventional Cardiac Electrophysiology 2017, 50: 1-55. PMID: 28914401, PMCID: PMC5633646, DOI: 10.1007/s10840-017-0277-z.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillationCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen J, Curtis AB, Davies DW, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T, Blomström-Lundqvist C, De Paola A, Kistler P, Lip G, Peters N, Pisani C, Raviele A, Saad E, Satomi K, Stiles M, Willems S. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation EP Europace 2017, 20: e1-e160. PMID: 29016840, PMCID: PMC5834122, DOI: 10.1093/europace/eux274.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summaryCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary EP Europace 2017, 20: 157-208. PMID: 29016841, PMCID: PMC5892164, DOI: 10.1093/europace/eux275.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summaryCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary Heart Rhythm 2017, 14: e445-e494. PMID: 31631881, DOI: 10.1016/j.hrthm.2017.07.009.
- A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillationHummel JP, Baher A, Buck B, Fanarjian M, Webber CL, Akar JG. A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillation Computers In Biology And Medicine 2017, 89: 497-504. PMID: 28889077, DOI: 10.1016/j.compbiomed.2017.08.027.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillationCalkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.07.001.
- Can machine learning complement traditional medical device surveillance? A case-study of dual-chamber implantable cardioverter–defibrillatorsRoss JS, Bates J, Parzynski CS, Akar JG, Curtis JP, Desai NR, Freeman JV, Gamble GM, Kuntz R, Li SX, Marinac-Dabic D, Masoudi FA, Normand ST, Ranasinghe I, Shaw RE, Krumholz HM. Can machine learning complement traditional medical device surveillance? A case-study of dual-chamber implantable cardioverter–defibrillators Medical Devices Evidence And Research 2017, 10: 165-188. PMID: 28860874, PMCID: PMC5566316, DOI: 10.2147/mder.s138158.
- Arrhythmias after left ventricular assist device implantation: Incidence and managementKadado AJ, Akar JG, Hummel JP. Arrhythmias after left ventricular assist device implantation: Incidence and management Trends In Cardiovascular Medicine 2017, 28: 41-50. PMID: 28734595, DOI: 10.1016/j.tcm.2017.07.002.
- P1639Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: an economic model based on the PREDICt RM databaseHummel J, Leipold R, Amorosi, Bao H, Deger K, Jones P, Stivland T, Kansal A, Ott L, Stern S, Stein K, Curtis J, Akar J. P1639Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: an economic model based on the PREDICt RM database EP Europace 2017, 19: iii353-iii353. DOI: 10.1093/ehjci/eux158.265.
- Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QTZiki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillationCalkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation Heart Rhythm 2017, 14: e275-e444. PMID: 28506916, PMCID: PMC6019327, DOI: 10.1016/j.hrthm.2017.05.012.
- Addition of Blood Pressure and Weight Transmissions to Standard Remote Monitoring of Implantable Defibrillators and its Association with Mortality and RehospitalizationAl-Chekakie MO, Bao H, Jones PW, Stein KM, Marzec L, Varosy PD, Masoudi FA, Curtis JP, Akar JG. Addition of Blood Pressure and Weight Transmissions to Standard Remote Monitoring of Implantable Defibrillators and its Association with Mortality and Rehospitalization Circulation Cardiovascular Quality And Outcomes 2017, 10: e003087. PMID: 28506978, DOI: 10.1161/circoutcomes.116.003087.
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial FibrillationCalkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d'Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation Journal Of Arrhythmia 2017 DOI: 10.1016/j.joa.2017.05.001.
- DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROMEZiki M, Seidelmann S, Smith E, Narayanan A, Atteya G, Jiang Y, Gil-Fernandez R, Marieb M, Akar J, Mani A. DELETERIOUS MUTATIONS IN SCN10A ARE ASSOCIATED WITH LONG QT SYNDROME Journal Of The American College Of Cardiology 2017, 69: 509. DOI: 10.1016/s0735-1097(17)33898-6.
- Proposed Standardized Neurological Endpoints for Cardiovascular Clinical TrialsAn Academic Research Consortium InitiativeLansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical TrialsAn Academic Research Consortium Initiative European Heart Journal 2017, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.
- Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium InitiativeLansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium Initiative Journal Of The American College Of Cardiology 2017, 69: 679-691. PMID: 28183511, DOI: 10.1016/j.jacc.2016.11.045.
- National Trends in Atrial Fibrillation Hospitalization, Readmission, and Mortality for Medicare Beneficiaries, 1999–2013Freeman JV, Wang Y, Akar J, Desai N, Krumholz H. National Trends in Atrial Fibrillation Hospitalization, Readmission, and Mortality for Medicare Beneficiaries, 1999–2013 Circulation 2017, 135: 1227-1239. PMID: 28148599, DOI: 10.1161/circulationaha.116.022388.
- Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in AdultsSeidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.
- Determinants of Time in Therapeutic Range in Patients Receiving Oral Anticoagulants (A Substudy of IMPACT)Lip GY, Waldo AL, Ip J, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen M, Halperin JL, Investigators I. Determinants of Time in Therapeutic Range in Patients Receiving Oral Anticoagulants (A Substudy of IMPACT) The American Journal Of Cardiology 2016, 118: 1680-1684. PMID: 27665206, DOI: 10.1016/j.amjcard.2016.08.047.
- A Fresh Perspective on Atrial Fibrillation∗Curtis JP, Akar JG. A Fresh Perspective on Atrial Fibrillation∗ Journal Of The American College Of Cardiology 2016, 68: 905-907. PMID: 27561763, DOI: 10.1016/j.jacc.2016.06.019.
- EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implicationGoette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim Y, Lip GY, Ma C, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Document Reviewers: Osmar A. Centurion K, Shantsila R. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication Journal Of Arrhythmia 2016, 32: 247-278. PMID: 27588148, PMCID: PMC4996910, DOI: 10.1016/j.joa.2016.05.002.
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implicationGoette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S, Centurion O, Kuck K, Patton K, Sapp J, Stiles M, Svendsen J, Upadhyay G, Shantsila A. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication EP Europace 2016, 18: 1455-1490. PMID: 27402624, PMCID: PMC6392440, DOI: 10.1093/europace/euw161.
- Editorial commentary: Virtual medicine—A better reality?Akar JG, Hummel JP. Editorial commentary: Virtual medicine—A better reality? Trends In Cardiovascular Medicine 2016, 26: 731-732. PMID: 27737760, DOI: 10.1016/j.tcm.2016.06.012.
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implicationGoette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D’Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication Heart Rhythm 2016, 14: e3-e40. PMID: 27320515, PMCID: PMC5548137, DOI: 10.1016/j.hrthm.2016.05.028.
- Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation: An Observational Cohort Study.Ranasinghe I, Parzynski CS, Freeman JV, Dreyer RP, Ross JS, Akar JG, Krumholz HM, Curtis JP. Long-Term Risk for Device-Related Complications and Reoperations After Implantable Cardioverter-Defibrillator Implantation: An Observational Cohort Study. Annals Of Internal Medicine 2016, 165: 20-29. PMID: 27135392, DOI: 10.7326/m15-2732.
- BASELINE RED CELL DISTRIBUTION WIDTH INDEPENDENTLY PREDICTS POST-OPERATIVE ATRIAL FIBRILLATIONAkar J, El-Hachem G, Ayyash B, Kadado A, Nabbout R, Lamaa N, Bao H, Khalil B. BASELINE RED CELL DISTRIBUTION WIDTH INDEPENDENTLY PREDICTS POST-OPERATIVE ATRIAL FIBRILLATION Journal Of The American College Of Cardiology 2016, 67: 729. DOI: 10.1016/s0735-1097(16)30730-6.
- LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillationKim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation Cardiovascular Research 2015, 108: 197-208. PMID: 26378152, PMCID: PMC4571838, DOI: 10.1093/cvr/cvv212.
- Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac DefibrillatorsAkar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.
- HRS Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devicesSlotwiner D, Varma N, Akar JG, Annas G, Beardsall M, Fogel RI, Galizio NO, Glotzer TV, Leahy RA, Love CJ, McLean RC, Mittal S, Morichelli L, Patton KK, Raitt MH, Ricci RP, Rickard J, Schoenfeld MH, Serwer GA, Shea J, Varosy P, Verma A, Yu CM. HRS Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devices Heart Rhythm 2015, 12: e69-e100. PMID: 25981148, DOI: 10.1016/j.hrthm.2015.05.008.
- Atrial Fibrillation and Thrombogenesis Innocent Bystander or Guilty Accomplice?∗Akar JG, Marieb MA. Atrial Fibrillation and Thrombogenesis Innocent Bystander or Guilty Accomplice?∗ JACC Clinical Electrophysiology 2015, 1: 218-219. PMID: 29759367, DOI: 10.1016/j.jacep.2015.05.003.
- Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devicesMartin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, Ip J, Holcomb R, Akar JG, Halperin JL. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices European Heart Journal 2015, 36: 1660-1668. PMID: 25908774, DOI: 10.1093/eurheartj/ehv115.
- VARIATIONS IN USE OF REMOTE MONITORING OF IMPLANTABLE DEFIBRILLATORS RELATIVE TO THE INTRODUCTION OF BILLING CODES SPECIFIC TO REMOTE MONITORINGAltaf F, Akar J, Lichtman J, Bao H, Jones P, Varosy P, Masoudi F, Stein K, Saxon L, Curtis J. VARIATIONS IN USE OF REMOTE MONITORING OF IMPLANTABLE DEFIBRILLATORS RELATIVE TO THE INTRODUCTION OF BILLING CODES SPECIFIC TO REMOTE MONITORING Journal Of The American College Of Cardiology 2015, 65: a459. DOI: 10.1016/s0735-1097(15)60459-4.
- Abstract 20158: Long-Term Device-Related Adverse Events After Implantable Cardioverter-Defibrillator TherapyRanasinghe I, Parzynski C, Freeman J, Dreyer R, Ross J, Akar J, Krumholz H, Curtis J. Abstract 20158: Long-Term Device-Related Adverse Events After Implantable Cardioverter-Defibrillator Therapy Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.20158.
- Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and SafetyHaines DE, Beheiry S, Akar JG, Baker JL, Beinborn D, Beshai JF, Brysiewicz N, Chiu-Man C, Collins KK, Dare M, Fetterly K, Fisher JD, Hongo R, Irefin S, Lopez J, Miller JM, Perry JC, Slotwiner DJ, Tomassoni GF, Weiss E. Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety Heart Rhythm 2014, 11: e9-e51. PMID: 24814989, PMCID: PMC7106221, DOI: 10.1016/j.hrthm.2014.03.042.
- 3D Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation AblationBrysiewicz N, Mitiku T, Haleem K, Bhatt P, Al-Shaaraoui M, Clancy JF, Marieb MA, Sugeng L, Akar JG. 3D Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation Ablation JACC Cardiovascular Imaging 2014, 7: 97-100. PMID: 24433712, DOI: 10.1016/j.jcmg.2013.09.018.
- Use of Remote Monitoring of Newly Implanted Cardioverter-DefibrillatorsAkar JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators Circulation 2013, 128: 2372-2383. PMID: 24043302, DOI: 10.1161/circulationaha.113.002481.
- Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following CardioversionMukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.
- Use of Intracardiac Echocardiography during Atrial Fibrillation AblationRUISI CP, BRYSIEWICZ N, ASNES JD, SUGENG L, MARIEB M, CLANCY J, AKAR JG. Use of Intracardiac Echocardiography during Atrial Fibrillation Ablation Pacing And Clinical Electrophysiology 2013, 36: 781-788. PMID: 23305194, DOI: 10.1111/pace.12030.
- Epicardial Fat and Atrial Fibrillation: A Review.Al Chekakie MO, Akar JG. Epicardial Fat and Atrial Fibrillation: A Review. Journal Of Atrial Fibrillation 2012, 4: 483. PMID: 28496734, PMCID: PMC5153200, DOI: 10.4022/jafib.483.
- 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial DesignCalkins H, Hindricks G, Cappato R, Kim Y, Saad E, Aguinaga L, Akar J, Badhwar V, Brugada J, Camm J, Chen P, Chen S, Chung M, Nielsen J, Curtis A, Davies D, Day J, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton J, Ellenbogen K, Ellinor P, Ernst S, Fenelon G, Gerstenfeld E, Haines D, Haissaguerre M, Helm R, Hylek E, Jackman W, Jalife J, Kalman J, Kautzner J, Kottkamp H, Kuck K, Kumagai K, Lee R, Lewalter T, Lindsay B, Macle L, Mansour M, Marchlinski F, Michaud G, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds M, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao H, Verma A, Wilber D, Yamane T. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design Heart Rhythm 2012, 9: 632-696.e21. PMID: 22386883, PMCID: PMC5846182, DOI: 10.1016/j.hrthm.2011.12.016.
- Caveat Emptor: Implantable Devices in End‐Stage Renal DiseaseCLANCY JF, AKAR JG. Caveat Emptor: Implantable Devices in End‐Stage Renal Disease Journal Of Cardiovascular Electrophysiology 2011, 22: 1105-1106. PMID: 21848637, DOI: 10.1111/j.1540-8167.2011.02094.x.
- UNSTABLE CARDIAC SINGULARITIES MAY LEAD TO ATRIAL FIBRILLATIONWEBBER C, HU Z, AKAR J. UNSTABLE CARDIAC SINGULARITIES MAY LEAD TO ATRIAL FIBRILLATION International Journal Of Bifurcation And Chaos 2011, 21: 1141-1151. DOI: 10.1142/s0218127411028994.
- ReplyChekakie M, Akar J. Reply Journal Of The American College Of Cardiology 2011, 57: 1249. DOI: 10.1016/j.jacc.2010.10.032.
- Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow?AKAR JG. Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow? Journal Of Cardiovascular Electrophysiology 2010, 21: 1240-1241. PMID: 20662980, DOI: 10.1111/j.1540-8167.2010.01840.x.
- Pericardial Fat Is Independently Associated With Human Atrial FibrillationChekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.
- Induction of Nogo‐A in CardiomyopathyMartin J, Kartje W, Goldspink P, Akar J, Paul C, Sarkey J. Induction of Nogo‐A in Cardiomyopathy The FASEB Journal 2010, 24: lb563-lb563. DOI: 10.1096/fasebj.24.1_supplement.lb563.
- Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT studyIp J, Waldo AL, Lip GY, Rothwell PM, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen MS, Rohani P, Halperin JL, Investigators F. Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study American Heart Journal 2009, 158: 364-370.e1. PMID: 19699858, DOI: 10.1016/j.ahj.2009.07.002.
- Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutterSantucci PA, Varma N, Cytron J, Akar JG, Wilber DJ, Chekakie M, Brysiewicz N. Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter Heart Rhythm 2009, 6: 1586-1595. PMID: 19879536, DOI: 10.1016/j.hrthm.2009.08.010.
- Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular DysplasiaVASAIWALA SC, FINN C, DELPRIORE J, LEYA F, GAGERMEIER J, AKAR JG, SANTUCCI P, DAJANI K, BOVA D, PICKEN MM, BASSO C, MARCUS F, WILBER DJ. Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia Journal Of Cardiovascular Electrophysiology 2008, 20: 473-476. PMID: 19017339, DOI: 10.1111/j.1540-8167.2008.01351.x.
- Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapyAkar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.
- Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an OctogenarianAKAR JG, SINGH M, AUSEON AJ, WILBER DJ. Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an Octogenarian Journal Of Cardiovascular Electrophysiology 2008, 19: 1316-1318. PMID: 18631265, DOI: 10.1111/j.1540-8167.2008.01241.x.
- Prospective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated ElectrogramsPORTER M, SPEAR W, AKAR JG, HELMS R, BRYSIEWICZ N, SANTUCCI P, WILBER DJ. Prospective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated Electrograms Journal Of Cardiovascular Electrophysiology 2008, 19: 613-620. PMID: 18462320, DOI: 10.1111/j.1540-8167.2008.01189.x.
- Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial DysfunctionAkar JG, Jeske W, Wilber DJ. Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction Journal Of The American College Of Cardiology 2008, 51: 1790-1793. PMID: 18452786, DOI: 10.1016/j.jacc.2007.11.083.
- Electrogram‐Guided Approach to Ablation of Atrial FibrillationWilber D, Akar J, Santucci P, Brysiewicz N. Electrogram‐Guided Approach to Ablation of Atrial Fibrillation 2008, 240-255. DOI: 10.1002/9781444300185.ch18.
- Regulation of ion channels and arrhythmias in the ischemic heartAkar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.
- Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery diseaseJoyal D, Leya F, Al-Chekakie M, Arab D, Dieter RS, Morshedi-Meibodi A, Lewis B, Steen L, Fareed J, Hoppenstead D, Akar JG. Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease Coronary Artery Disease 2007, 18: 471-475. PMID: 17700219, DOI: 10.1097/mca.0b013e32818be79c.
- Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients?Chekakie M, Thompson D, Wang F, Ganguly J, Chawla R, Akar J, Barron J. Do Electrocardiographic Changes during Dobutamine Stress Echocardiography Help Detect Coronary Allograft Vasculopathy in Heart Transplant Recipients? Journal Of Cardiac Failure 2007, 13: s117-s118. DOI: 10.1016/j.cardfail.2007.06.459.
- The Effects of Statins and Renin‐Angiotensin System Blockers on Atrial Fibrillation Recurrence Following Antral Pulmonary Vein IsolationCHEKAKIE M, AKAR JG, WANG F, MURADI H, WU J, SANTUCCI P, VARMA N, WILBER DJ. The Effects of Statins and Renin‐Angiotensin System Blockers on Atrial Fibrillation Recurrence Following Antral Pulmonary Vein Isolation Journal Of Cardiovascular Electrophysiology 2007, 18: 942-946. PMID: 17593228, DOI: 10.1111/j.1540-8167.2007.00887.x.
- Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE ProceduresAKAR JG, AL‐CHEKAKIE M, HAI A, BRYSIEWICZ N, PORTER M, VARMA N, SANTUCCI P, WILBER DJ. Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures Journal Of Cardiovascular Electrophysiology 2007, 18: 349-355. PMID: 17394449, DOI: 10.1111/j.1540-8167.2007.00761.x.
- Mapping arrhythmias in the failing heart: from Langendorff to patientAkar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient Journal Of Electrocardiology 2006, 39: s19-s23. PMID: 16920143, DOI: 10.1016/j.jelectrocard.2006.03.011.
- Predicting elevated defibrillation energy requirements in heart failure with reasonable probabilityAkar JG. Predicting elevated defibrillation energy requirements in heart failure with reasonable probability Heart Rhythm 2006, 3: 1017-1018. PMID: 16945793, DOI: 10.1016/j.hrthm.2006.06.015.
- P6-84 Landmark registration versus surface registration of CT with real time map using CARTO-Merge in atrial fibrillationBrysiewicz N, Akar J, Santucci P, Varma N, Helms R, Mark M, Saba M, Porter M, Wilber D. P6-84 Landmark registration versus surface registration of CT with real time map using CARTO-Merge in atrial fibrillation Heart Rhythm 2006, 3: s329. DOI: 10.1016/j.hrthm.2006.02.985.
- P4-60 Electroanatomical substrate of ischemic cardiomyopathy with and without spontaneous ventricular tachycardiaOza S, Porter M, Akar J, Santucci P, Varma N, Lu Y, Wilber D. P4-60 Electroanatomical substrate of ischemic cardiomyopathy with and without spontaneous ventricular tachycardia Heart Rhythm 2006, 3: s238. DOI: 10.1016/j.hrthm.2006.02.715.
- AB3-4 Pathogenesis of atrial fibrillation and hypercoagulability: Potential role of inflammatory responseHoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Akar J, Fareed J. AB3-4 Pathogenesis of atrial fibrillation and hypercoagulability: Potential role of inflammatory response Heart Rhythm 2006, 3: s6. DOI: 10.1016/j.hrthm.2006.02.037.
- AB3-1 Human atrial fibrillation is associated with endothelial dysfunction and oxidative stressHoppensteadt D, Klein A, Iqbal O, Cunanan J, Wahi R, Wilber D, Fareed J, Akar J. AB3-1 Human atrial fibrillation is associated with endothelial dysfunction and oxidative stress Heart Rhythm 2006, 3: s5. DOI: 10.1016/j.hrthm.2006.02.034.
- Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of ValsalvaDaniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.
- 8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation8.8 Impact of Left Atrial Scar on the Outcome of Pulmonary Vein IsolationWilber D, Lipman E, Madsen H, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A. 8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation8.8 Impact of Left Atrial Scar on the Outcome of Pulmonary Vein Isolation EP Europace 2005, 7: s14-s14. DOI: 10.1016/j.eupc.2005.08.054.
- Chagas Myocarditis and SyncopePatel R, DiMarco J, Akar J, Voros S, Kramer C. Chagas Myocarditis and Syncope Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-688. DOI: 10.1081/jcmr-200065627.
- Rapid assessment of isthmus block in patients with atrial flutterSantucci P, Joshi S, Lin A, Akar J, Tierney S, Dasari R, Gauri A, Lipman E, Wilber D. Rapid assessment of isthmus block in patients with atrial flutter Heart Rhythm 2005, 2: s277. DOI: 10.1016/j.hrthm.2005.02.872.
- Incidence and determinants of left atrial scar in patients with paroxysmal and persistent atrial fibrillation undergoing catheter ablationLipman E, Madsen N, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A, Wilber D. Incidence and determinants of left atrial scar in patients with paroxysmal and persistent atrial fibrillation undergoing catheter ablation Heart Rhythm 2005, 2: s12. DOI: 10.1016/j.hrthm.2005.02.048.
- Safety and efficacy of catheter ablation of repetitive monomorphic ventricular tachycardia arising from the sinus of Valsalva guided by intracardiac echocardiographyLin A, Morton J, Joshi S, Dasari R, Gauri A, Lipman E, Santucci P, Akar J, Wilber D. Safety and efficacy of catheter ablation of repetitive monomorphic ventricular tachycardia arising from the sinus of Valsalva guided by intracardiac echocardiography Heart Rhythm 2005, 2: s36. DOI: 10.1016/j.hrthm.2005.02.123.
- Chagas myocarditis and syncope.Patel RA, DiMarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-8. PMID: 16136859.
- Amiodarone and the Excitable Gap:AKAR J, WILBER D. Amiodarone and the Excitable Gap: Journal Of Cardiovascular Electrophysiology 2004, 15: 1424-1425. PMID: 15610290, DOI: 10.1046/j.1540-8167.2004.04679.x.
- Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial FibrillationAkar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.
- Effect of Heating on Pulmonary Veins:KOK LC, EVERETT TH, AKAR JG, HAINES DE. Effect of Heating on Pulmonary Veins: Journal Of Cardiovascular Electrophysiology 2003, 14: 250-254. PMID: 12716105, DOI: 10.1046/j.1540-8167.2003.02490.x.
- Wavelet Analysis of Atrial Fibrillation ElectrogramsMell J, Jordan D, Xiao Y, Zheng Y, Akar J, Haines D. Wavelet Analysis of Atrial Fibrillation Electrograms 2003, 2: ii - 357-ii - 360. DOI: 10.1109/icassp.2003.1202369.
- Parameter Estimation of Spiral Waves from Atrial ElectrogramsXiao Y, Zheng Y, Jordan D, Akar J, Haines D. Parameter Estimation of Spiral Waves from Atrial Electrograms 2003, 5: v - 245-v - 248. DOI: 10.1109/icassp.2003.1199914.
- Use of global atrial fibrillation organization to optimize the success of burst pace terminationEverett TH, Akar JG, Kok LC, Moorman JR, Haines DE. Use of global atrial fibrillation organization to optimize the success of burst pace termination Journal Of The American College Of Cardiology 2002, 40: 1831-1840. PMID: 12446068, DOI: 10.1016/s0735-1097(02)02476-2.
- Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial FibrillationAKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.
- Tachycardia with Atrioventricular Dissociation after Surgery for Single VentricleAKAR J, DIMARCO J. Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle Journal Of Cardiovascular Electrophysiology 2001, 12: 1092-1093. PMID: 11573704, DOI: 10.1046/j.1540-8167.2001.01092.x.
- Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart diseaseAkar J, Kok L, Haines D, DiMarco J, Mounsey J. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease Journal Of The American College Of Cardiology 2001, 38: 377-384. PMID: 11499727, DOI: 10.1016/s0735-1097(01)01392-4.
- Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial DefibrillationEverett T, Moorman J, Kok L, Akar J, Haines D. Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation Circulation 2001, 103: 2857-2861. PMID: 11401945, DOI: 10.1161/01.cir.103.23.2857.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Cardiovascular System | The WARN Study |