2001
Replication-Competent or Attenuated, Nonpropagating Vesicular Stomatitis Viruses Expressing Respiratory Syncytial Virus (RSV) Antigens Protect Mice against RSV Challenge
Kahn J, Roberts A, Weibel C, Buonocore L, Rose J. Replication-Competent or Attenuated, Nonpropagating Vesicular Stomatitis Viruses Expressing Respiratory Syncytial Virus (RSV) Antigens Protect Mice against RSV Challenge. Journal Of Virology 2001, 75: 11079-11087. PMID: 11602747, PMCID: PMC114687, DOI: 10.1128/jvi.75.22.11079-11087.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAntigens, ViralBase SequenceCell LineCricetinaeFemaleMiceMice, Inbred BALB CMolecular Sequence DataRespiratory Syncytial Virus InfectionsVaccines, AttenuatedVaccines, SyntheticVesicular stomatitis Indiana virusViral ProteinsViral VaccinesVirus ReplicationConceptsRespiratory syncytial virusRSV challengeRecombinant vesicular stomatitis virusVesicular stomatitis virusRSV FRespiratory syncytial virus GRSV-specific antibodiesDetectable neutralizing antibodiesDetectable serum antibodiesStomatitis virusIntranasal vaccinationRSV vaccineRSV GProtective immunitySyncytial virusDetectable serumNeutralizing antibodiesSerum antibodiesMouse modelRSV proteinsComplete protectionReplication competentAntibodiesG glycoproteinVirusVesicular Stomatitis Virus Glycoprotein Containing the Entire Green Fluorescent Protein on Its Cytoplasmic Domain Is Incorporated Efficiently into Virus Particles
Dalton K, Rose J. Vesicular Stomatitis Virus Glycoprotein Containing the Entire Green Fluorescent Protein on Its Cytoplasmic Domain Is Incorporated Efficiently into Virus Particles. Virology 2001, 279: 414-421. PMID: 11162797, DOI: 10.1006/viro.2000.0736.Peer-Reviewed Original ResearchConceptsLarge cytoplasmic domainCytoplasmic domainVSV G proteinVesicular stomatitis virusGreen fluorescent proteinG proteinsGFP proteinWild-type G proteinFluorescent proteinShort cytoplasmic domainVesicular stomatitis virus glycoproteinStrong selectionVirus particlesExtra genesHeterotrimeric proteinGFP geneProtein sequencesWild-type virusFluorescent virus particlesStop codonVirus assemblyInfectious cloneGenesViral membraneAmino acids
2000
Presence of bovine viral diarrhea virus (BVDV) E2 glycoprotein in VSV recombinant particles and induction of neutralizing BVDV antibodies in mice
Grigera P, Marzocca M, Capozzo A, Buonocore L, Donis R, Rose J. Presence of bovine viral diarrhea virus (BVDV) E2 glycoprotein in VSV recombinant particles and induction of neutralizing BVDV antibodies in mice. Virus Research 2000, 69: 3-15. PMID: 10989181, DOI: 10.1016/s0168-1702(00)00164-7.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, ViralBase SequenceCattleCell LineChimeraCricetinaeDiarrhea Viruses, Bovine ViralDNA, RecombinantFemaleMembrane GlycoproteinsMiceMice, Inbred BALB CNeutralization TestsRecombinant ProteinsVaccines, SyntheticVesicular stomatitis Indiana virusViral Envelope ProteinsViral VaccinesConceptsBovine viral diarrhea virus (BVDV) E2BALB/c miceRecombinant vesicular stomatitis virusViral-induced diseasesC miceE2 antibodiesBVDV antibodiesVesicular stomatitis virusHigh avidityBVDV E2Recombinant E2Infected cellsDays post inoculationG glycoproteinE2Stomatitis virusMiceAntibodiesImmunofluorescence microscopyPost inoculationRecombinant particlesBHK21 cellsCellsSymptomsInfectionExpression of Human Immunodeficiency Virus Type 1 Gag Protein Precursor and Envelope Proteins from a Vesicular Stomatitis Virus Recombinant: High-Level Production of Virus-like Particles Containing HIV Envelope
Haglund K, Forman J, Kräusslich H, Rose J. Expression of Human Immunodeficiency Virus Type 1 Gag Protein Precursor and Envelope Proteins from a Vesicular Stomatitis Virus Recombinant: High-Level Production of Virus-like Particles Containing HIV Envelope. Virology 2000, 268: 112-121. PMID: 10683333, DOI: 10.1006/viro.1999.0120.Peer-Reviewed Original ResearchMeSH KeywordsAIDS VaccinesAnimalsCell LineDNA, RecombinantGene Products, gagGenetic VectorsHIV Envelope Protein gp120HIV-1HumansMembrane GlycoproteinsMicroscopy, ElectronPlasmidsProtein PrecursorsRecombinant Fusion ProteinsVaccines, AttenuatedVesicular stomatitis Indiana virusViral Envelope ProteinsVirionConceptsHIV virus-like particlesVirus-like particlesEnv proteinHIV-1HIV-1 envelope proteinAntibody-mediated immunityHigh-level productionRecombinant vesicular stomatitis virusVSV particlesHIV Env proteinEnvelope proteinEffective vaccine vectorHIV-like particlesProtein precursorHIV envelopeHigh-level expression vectorVaccine vectorHIV recombinantsVesicular stomatitis virusVirus titersVirus recombinantsVSV G proteinG proteinsStomatitis virusExpression vector
1999
Replication-Competent Rhabdoviruses with Human Immunodeficiency Virus Type 1 Coats and Green Fluorescent Protein: Entry by a pH-Independent Pathway
Boritz E, Gerlach J, Johnson J, Rose J. Replication-Competent Rhabdoviruses with Human Immunodeficiency Virus Type 1 Coats and Green Fluorescent Protein: Entry by a pH-Independent Pathway. Journal Of Virology 1999, 73: 6937-6945. PMID: 10400792, PMCID: PMC112779, DOI: 10.1128/jvi.73.8.6937-6945.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCD4-Positive T-LymphocytesCell LineCricetinaeGreen Fluorescent ProteinsHeLa CellsHIV AntibodiesHIV Envelope Protein gp160HIV-1HumansHydrogen-Ion ConcentrationLigandsLuminescent ProteinsNeutralization TestsReceptors, CCR5Receptors, CXCR4Receptors, HIVRecombination, GeneticVesicular stomatitis Indiana virusVirus ReplicationConceptsVesicular stomatitis virusHuman immunodeficiency virus type 1 (HIV-1) envelope proteinSurrogate virusesRecombinant vesicular stomatitis virusPH-independent pathwayHIV bindingHIV vaccineHIV receptor CD4Coreceptor CXCR4HIV entryCoreceptor specificitySDF-1HIVReceptor CD4Single transmembrane glycoproteinAntibodiesVirusCD4Envelope proteinStomatitis virusCXCR4InfectionTransmembrane glycoproteinGreen fluorescent proteinAdditional recombinantsAttenuated Vesicular Stomatitis Viruses as Vaccine Vectors
Roberts A, Buonocore L, Price R, Forman J, Rose J. Attenuated Vesicular Stomatitis Viruses as Vaccine Vectors. Journal Of Virology 1999, 73: 3723-3732. PMID: 10196265, PMCID: PMC104148, DOI: 10.1128/jvi.73.5.3723-3732.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell LineCricetinaeFemaleGene ExpressionGenetic VectorsHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesMembrane GlycoproteinsMiceMice, Inbred BALB COrthomyxoviridae InfectionsRecombination, GeneticTime FactorsVaccines, AttenuatedVaccines, SyntheticVesicular stomatitis Indiana virusViral Envelope ProteinsVirionConceptsVesicular stomatitis virusLethal influenza virus challengeComplete protectionInfluenza virus challengeRecombinant vesicular stomatitis virusSingle intranasal vaccinationInfluenza virus HAStomatitis virusIntranasal vaccinationLethal challengeIntranasal administrationVirus challengeMouse modelVaccine vectorVSV vectorsVirus HAInfluenza virusHemagglutinin proteinInfluenza virus hemagglutinin (HA) proteinG proteinsPathogenesisVirus hemagglutinin proteinVirusPresent studyVaccinationRecombinant Vesicular Stomatitis Virus Expressing Respiratory Syncytial Virus (RSV) Glycoproteins: RSV Fusion Protein Can Mediate Infection and Cell Fusion
Kahn J, Schnell M, Buonocore L, Rose J. Recombinant Vesicular Stomatitis Virus Expressing Respiratory Syncytial Virus (RSV) Glycoproteins: RSV Fusion Protein Can Mediate Infection and Cell Fusion. Virology 1999, 254: 81-91. PMID: 9927576, DOI: 10.1006/viro.1998.9535.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesCell LineCricetinaeCytoplasmGene ExpressionGenetic VectorsGlycoproteinsHN ProteinHumansMembrane FusionMolecular Sequence DataRecombinant Fusion ProteinsRespiratory Syncytial Virus, HumanTumor Cells, CulturedVesicular stomatitis Indiana virusViral Envelope ProteinsViral Fusion ProteinsViral ProteinsVirionConceptsRecombinant vesicular stomatitis virusVesicular stomatitis virusRSV fusion proteinRSV F glycoproteinRSV vaccineF recombinantsRSV glycoproteinsRSV proteinsEnvelope glycoproteinVirus attachmentFusion (F) envelope glycoproteinsF glycoproteinG glycoproteinStomatitis virusLarge syncytiaGlycoproteinPH-independent pathwayCell surfaceCell fusionCytoplasmic tail sequencesVSV G.Endosomal pHFusion activityVaccineFusion protein
1998
Requirement for a non‐specific glycoprotein cytoplasmic domain sequence to drive efficient budding of vesicular stomatitis virus
Schnell M, Buonocore L, Boritz E, Ghosh H, Chernish R, Rose J. Requirement for a non‐specific glycoprotein cytoplasmic domain sequence to drive efficient budding of vesicular stomatitis virus. The EMBO Journal 1998, 17: 1289-1296. PMID: 9482726, PMCID: PMC1170477, DOI: 10.1093/emboj/17.5.1289.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD4 AntigensCell LineCell MembraneCricetinaeCytopathogenic Effect, ViralCytoplasmHumansMembrane GlycoproteinsMolecular Sequence DataMutationRecombinant Fusion ProteinsSequence DeletionSerial PassageVesicular stomatitis Indiana virusViral Envelope ProteinsViral ProteinsVirionConceptsCytoplasmic domainEfficient buddingAmino acidsCytoplasmic domain deletion mutantEfficient virus buddingShort cytoplasmic domainCytoplasmic domain sequencesDomain deletion mutantVesicular stomatitis virus glycoproteinChimeric G proteinsTransmembrane domainDeletion mutantsInternal viral componentsVirus buddingGlycoprotein arrayVesicular stomatitis virusDomain sequencesViral buddingVirion morphologyG proteinsMatrix proteinsVSV GHuman CD4 proteinForeign sequencesBudding
1997
Specific targeting to CD4+ cells of recombinant vesicular stomatitis viruses encoding human immunodeficiency virus envelope proteins
Johnson J, Schnell M, Buonocore L, Rose J. Specific targeting to CD4+ cells of recombinant vesicular stomatitis viruses encoding human immunodeficiency virus envelope proteins. Journal Of Virology 1997, 71: 5060-5068. PMID: 9188571, PMCID: PMC191739, DOI: 10.1128/jvi.71.7.5060-5068.1997.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell LineCricetinaeGene ExpressionGenetic VectorsHeLa CellsHIV Envelope Protein gp160HIV-1HumansMembrane GlycoproteinsProtein Processing, Post-TranslationalRabbitsRecombinant Fusion ProteinsRecombination, GeneticVesicular stomatitis Indiana virusViral Envelope ProteinsVirionConceptsRecombinant vesicular stomatitis virusHuman immunodeficiency virus envelope proteinHIV envelope proteinVesicular stomatitis virusHIV envelopeVirus envelope proteinEnvelope proteinHIV type 1 envelopeChimeric envelopesCD4-positive cellsReplication-competent recombinant virusesStomatitis virusHIV seraRecombinant virusesHIV vaccineSpecific infectionsPrimary isolatesHIV-1HIV gp120Chimeric envelope proteinsAlternative receptorLow titersVSV serumVSV infectivityVSV glycoprotein
1996
Replication of Primary HIV-1 Isolates Is Inhibited in PM1 Cells Expressing sCD4-KDEL
Degar S, Johnson J, Boritz E, Rose J. Replication of Primary HIV-1 Isolates Is Inhibited in PM1 Cells Expressing sCD4-KDEL. Virology 1996, 226: 424-429. PMID: 8955064, DOI: 10.1006/viro.1996.0672.Peer-Reviewed Original ResearchConceptsPrimary HIV-1 isolatesPrimary HIV-1HIV-1 isolatesPrimary isolatesHIV-1HIV-1-infected individualsCell linesSoluble CD4 moleculesHIV-1 spreadHIV-1 replicationGene therapy-based approachesHIV-1 LTRHIV-1MN strainTreatment of AIDST cell linesCell culture supernatantsCD4 moleculePM1 cellsVirus presentPM1 cell linesPrototype strainCulture supernatantsPotent inhibitorIsolatesExpressionForeign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles.
Schnell M, Buonocore L, Kretzschmar E, Johnson E, Rose J. Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11359-11365. PMID: 8876140, PMCID: PMC38062, DOI: 10.1073/pnas.93.21.11359.Peer-Reviewed Original ResearchConceptsVSV G proteinDifferent membrane proteinsVesicular stomatitis virusG proteinsMembrane proteinsMembrane protein purificationEctodomain of CD4Virus particlesStomatitis virusWild-type virionsVirus fusion proteinExtra genesHybrid proteinCytoplasmic tailHelical nucleocapsidMammalian cellsRecombinant vesicular stomatitis virusVSV G.Fusion proteinMeasles virus fusion proteinSoluble proteinMembrane envelopeCell surfaceProtein purificationViral targetingMembrane Association of Influenza Virus Matrix Protein Does Not Require Specific Hydrophobic Domains or the Viral Glycoproteins
KRETZSCHMAR E, BUI M, ROSE J. Membrane Association of Influenza Virus Matrix Protein Does Not Require Specific Hydrophobic Domains or the Viral Glycoproteins. Virology 1996, 220: 37-45. PMID: 8659126, DOI: 10.1006/viro.1996.0283.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesCell LineCell MembraneChick EmbryoDogsHeLa CellsHemagglutinin Glycoproteins, Influenza VirusHemagglutinins, ViralHumansInfluenza A virusMolecular Sequence DataMutagenesis, Site-DirectedNeuraminidaseOligodeoxyribonucleotidesRecombinant ProteinsViral Matrix ProteinsConceptsMembrane associationSpecific hydrophobic domainsM1 proteinMatrix proteinsHydrophobic domainInfluenza virus matrix proteinVirus matrix proteinInteraction of M1Viral glycoproteinsMajor structural componentRibonucleocapsid coreCytoplasmic tailIntegral proteinsMembrane proteinsMembrane bindingSubcellular fractionationMembrane envelopeCellular membranesHeLa cellsViral proteinsHydrophobic regionProteinIsolated membranesMembraneInfluenza proteinsExpression of Additional Genes in a Vector Derived from a Minimal RNA Virus
ROLLS M, HAGLUND K, ROSE J. Expression of Additional Genes in a Vector Derived from a Minimal RNA Virus. Virology 1996, 218: 406-411. PMID: 8610469, DOI: 10.1006/viro.1996.0211.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCapsidCD4 AntigensCell LineChloramphenicol O-AcetyltransferaseCloning, MolecularCricetinaeGene ExpressionGenetic VectorsMembrane GlycoproteinsMolecular Sequence DataPromoter Regions, GeneticRecombinant Fusion ProteinsRNA, ViralSemliki forest virusVesicular stomatitis Indiana virusViral Core ProteinsViral Envelope ProteinsConceptsVSV G proteinG proteinsVSV G geneVesicular stomatitis virus glycoproteinTotal cell proteinMembrane fusion activityViral structural proteinsHost protein synthesisTissue culture cellsUnselected genesMultiple cloning siteInfectious particlesAdditional genesForeign genesPlasma membraneG RNADifferent proteinsStructural proteinsMajor proteinsRNA repliconsCell proteinsFusion activityRNA virusesProtein synthesisGenes
1995
Recombinant vesicular stomatitis viruses from DNA.
Lawson N, Stillman E, Whitt M, Rose J. Recombinant vesicular stomatitis viruses from DNA. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4477-4481. PMID: 7753828, PMCID: PMC41967, DOI: 10.1073/pnas.92.10.4477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCapsidCell LineCricetinaeDNA PrimersDNA, ViralDNA-Directed RNA PolymerasesGenome, ViralKidneyMacromolecular SubstancesMolecular Sequence DataPolymerase Chain ReactionRecombination, GeneticRestriction MappingRNA, ViralTransfectionVesicular stomatitis Indiana virusViral Core ProteinsConceptsVesicular stomatitis virusBacteriophage T7 RNA polymeraseVSV nucleocapsid proteinT7 RNA polymeraseStomatitis virusPositive-strand RNAWild-type vesicular stomatitis virusPolymerase subunitsGenetic tagsRNA polymeraseDNA clonesRecombinant vesicular stomatitis virusGenomic RNAVSV genomeGenetic analysisRestriction sitesPrototype rhabdovirusNucleocapsid proteinDNARNAVSV replicationGenomeVSV recombinantsModified virusRecovered virusReplication and amplification of novel vesicular stomatitis virus minigenomes encoding viral structural proteins
Stillman E, Rose J, Whitt M. Replication and amplification of novel vesicular stomatitis virus minigenomes encoding viral structural proteins. Journal Of Virology 1995, 69: 2946-2953. PMID: 7707520, PMCID: PMC188993, DOI: 10.1128/jvi.69.5.2946-2953.1995.Peer-Reviewed Original ResearchConceptsVesicular stomatitis virusViral structural proteinsStructural proteinsMatrix protein geneFunctional viral proteinsM proteinNorthern blot analysisEncoded proteinsInfectious particlesTranscriptional eventsFunctional mRNAProtein geneL proteinLeader regionMinigenome RNAVSV genomeIndiana serotypePolymerase proteinOwn propagationGlycoprotein geneVSV proteinsViral proteinsProteinNucleocapsid proteinMinigenome
1993
Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat.
Buonocore L, Rose J. Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 2695-2699. PMID: 8464877, PMCID: PMC46162, DOI: 10.1073/pnas.90.7.2695.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 productionHIV-1 infectionInfectious HIV-1HIV envelope proteinHuman T cell lineSoluble CD4 proteinT cell linesT cellsHIV-1Viral spreadSyncytium formationInfected cellsViral long terminal repeatCD4CD4 proteinEnvelope proteinIntracellular CD4Intracellular trapsGene therapyLong terminal repeatRetroviral vectorsCellsCell surfaceHIVBlockadeCell fusion by the envelope glycoproteins of persistent measles viruses which caused lethal human brain disease
Cattaneo R, Rose J. Cell fusion by the envelope glycoproteins of persistent measles viruses which caused lethal human brain disease. Journal Of Virology 1993, 67: 1493-1502. PMID: 8437226, PMCID: PMC237519, DOI: 10.1128/jvi.67.3.1493-1502.1993.Peer-Reviewed Original ResearchMeSH KeywordsAutopsyBacteriophage T7Biological TransportBrain DiseasesCell FusionCell LineCloning, MolecularDNA, ViralGlycosylationHeLa CellsHemagglutinins, ViralHumansMeaslesMeasles virusOligosaccharidesPromoter Regions, GeneticProtein ConformationProtein Processing, Post-TranslationalRecombinant ProteinsRNA, ViralViral Envelope ProteinsViral Fusion ProteinsViral InterferenceViral Matrix ProteinsVirulenceConceptsIntegral membrane proteinsH proteinCell fusionMembrane proteinsIntracellular domainViral buddingM proteinHS-protein interactionsF protein functionProtein interactionsMV genesIntracellular transportFusion proteinOligosaccharide modificationViral envelope proteinsMatrix proteinsHuman brain diseasesProteinMeasles virusReduced expressionEnvelope proteinPersistent measles virusBuddingSyncytium formationDisease development
1992
Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin
Kemble G, Bodian D, Rosé J, Wilson I, White J. Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin. Journal Of Virology 1992, 66: 4940-4950. PMID: 1629960, PMCID: PMC241339, DOI: 10.1128/jvi.66.8.4940-4950.1992.Peer-Reviewed Original ResearchAnimalsAntibodies, MonoclonalCell LineCHO CellsCricetinaeDisulfidesDithiothreitolErythrocytesFluorescent DyesHemagglutinin Glycoproteins, Influenza VirusHemagglutinins, ViralHumansHydrogen-Ion ConcentrationKineticsMacromolecular SubstancesMembrane FusionProtein ConformationRhodaminesViral Envelope ProteinsFc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.
Miettinen H, Matter K, Hunziker W, Rose J, Mellman I. Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization. Journal Of Cell Biology 1992, 116: 875-888. PMID: 1734021, PMCID: PMC2289334, DOI: 10.1083/jcb.116.4.875.Peer-Reviewed Original ResearchSorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Brown D, Rose J. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 1992, 68: 533-544. PMID: 1531449, DOI: 10.1016/0092-8674(92)90189-j.Peer-Reviewed Original ResearchConceptsBasolateral marker proteinsCertain membrane proteinsApical cell surfaceDetergent-insoluble formGlycosylphosphatidyl inositol (GPI) anchorMembrane subdomainsMembrane proteinsIntracellular associationGolgi complexMicrodomains formGolgi apparatusInositol anchorMarker proteinsCell surfaceProteinApical surfaceEpithelial cellsGPIGlycosphingolipidsComplexesVesiclesLysatesGlycolipidsSortingMembrane