John Giuliano
Research & Publications
Biography
News
Research Summary
John Giuliano, Jr., M.D, has focused his research interests around inflammation and the host’s response to sepsis/acute lung injury. To this end, he has been involved in translational research projects looking at the role angiopoietins play in vascular leak in pediatric patients with severe sepsis and septic shock. Additionally, he investigates the morbidity and mortality as well as the genetic makeup of children admitted to the ICU with influenza. He has contributed to multicenter studies in patients with COVID-19 and MIS-C. Finally, he is involved with improving the morbidity and mortality associated with pediatric endotracheal intubation.
Specialized Terms: Pediatric sepsis; Acute lung injury and the inflammatory response; Pediatric transport medicine; Pediatric endotracheal intubation
Extensive Research Description
John Giuliano, Jr., M.D, has centered his research interest around our body’s inflammatory response to infection. His main interest lies in the release of vascular growth factors called angiopoietins. He has shown that ang-2 is significantly elevated when children with septic shock are admitted to the PICU and that these levels peak around day 2 of illness. This growth factor may play a role in the vascular leak phenomena seen in these patients. Along similar lines, he continues to study plasma biomarkers released when children have severe influenza infections. Since many children with severe sepsis require an advanced airway, Dr. Giuliano is also investigating ways to improve the morbidity and mortality associated with this high risk procedure.
- Evaluating the biomarker profile of critically ill children with influenza infection
- Understanding pediatric medication pharmacokinetics
- Reducing tracheal intubation associated events in children
- Improving tracheal intubation teaching using video laryngoscopy
Coauthors
Research Interests
Critical Care; Inflammation; Pediatrics; Extracorporeal Membrane Oxygenation; Sepsis; Acute Lung Injury
Selected Publications
- Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescentsGeva A, Patel MM, Newhams MM, Young CC, Son MBF, Kong M, Maddux AB, Hall MW, Riggs BJ, Singh AR, Giuliano JS, Hobbs CV, Loftis LL, McLaughlin GE, Schwartz SP, Schuster JE, Babbitt CJ, Halasa NB, Gertz SJ, Doymaz S, Hume JR, Bradford TT, Irby K, Carroll CL, McGuire JK, Tarquinio KM, Rowan CM, Mack EH, Cvijanovich NZ, Fitzgerald JC, Spinella PC, Staat MA, Clouser KN, Soma VL, Dapul H, Maamari M, Bowens C, Havlin KM, Mourani PM, Heidemann SM, Horwitz SM, Feldstein LR, Tenforde MW, Newburger JW, Mandl KD, Randolph AG, Investigators O. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents EClinicalMedicine 2021, 40: 101112. PMID: 34485878, PMCID: PMC8405351, DOI: 10.1016/j.eclinm.2021.101112.
- Multisystem Inflammatory Syndrome in Children — Initial Therapy and OutcomesSon MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes New England Journal Of Medicine 2021, 385: 23-34. PMID: 34133855, PMCID: PMC8220972, DOI: 10.1056/nejmoa2102605.
- Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D’Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP, Balachandran N, Murray T, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin S, Perella D, Jones K, Marohn K, Yager P, Fernandes N, Flori H, Koncicki M, Walker K, Di Pentima M, Li S, Horwitz S, Gaur S, Coffey D, Harwayne-Gidansky I, Hymes S, Thomas N, Ackerman K, Cholette J. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2 JAMA Network Open 2021, 4: e2116420. PMID: 34110391, PMCID: PMC8193431, DOI: 10.1001/jamanetworkopen.2021.16420.
- Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory SyndromeLaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG, Last Name* F, Gaspers M, Typpo K, Sanders R, Schwarz A, Harvey H, Zinter M, Mourani P, Coates B, Bhoojhawon G, Havlin K, Montgomery V, Sullivan J, Bradford T, Bembea M, Lipton S, Graciano A, Chen S, Kucukak S, Newburger J, Carroll R, Fernandes N, Yager P, Marohn K, Heidemann S, Cullimore M, McCulloh R, Horwitz S, Li S, Walsh R, Ratner A, Soma V, Gillen J, Zackai S, Ackerman K, Cholette J, Harwayne-Gidansky I, Hymes S, Overby P, Schwartz S, Lansell A, Koncicki M, Carcillo J, Fink E, Kimura D, Bowens C, Crandall H, Smith L, Cengiz P. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome JAMA Neurology 2021, 78: 536-547. PMID: 33666649, PMCID: PMC7936352, DOI: 10.1001/jamaneurol.2021.0504.
- Unintentional Window Falls in Children and Adolescents.Flaherty MR, Raybould T, Savarino J, Yager P, Mooney DP, Farr BJ, Giuliano JS, Neeman E, Campbell BT, Thaker S, McKiernan C, Lewis D, Epp TK, Baertschiger RM, Jackson CA, Rideout L, Shah A, Falank C, Ontengco J, Cairo S, McLoughlin RJ, Aidlen JT, Watson-Smith D, Wills H, Masiakos PT. Unintentional Window Falls in Children and Adolescents. Academic Pediatrics 2021, 21: 497-503. PMID: 32653687, DOI: 10.1016/j.acap.2020.07.008.
- Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19 JAMA 2021, 325: 1074-1087. PMID: 33625505, PMCID: PMC7905703, DOI: 10.1001/jama.2021.2091.
- Impact of Failure of Noninvasive Ventilation on the Safety of Pediatric Tracheal Intubation.Emeriaud G, Napolitano N, Polikoff L, Giuliano J, Toedt-Pingel I, Miksa M, Li S, Bysani K, Hsing DD, Nett S, Turner DA, Sanders RC, Lee JH, Adu-Darko M, Owen EB, Gangadharan S, Parker M, Montgomery V, Craig N, Crulli B, Edwards L, Pinto M, Brunet F, Shults J, Nadkarni V, Nishisaki A. Impact of Failure of Noninvasive Ventilation on the Safety of Pediatric Tracheal Intubation. Critical Care Medicine 2020, 48: 1503-1512. PMID: 32701551, DOI: 10.1097/CCM.0000000000004500.
- The New Trainee Effect in Tracheal Intubation Procedural Safety Across PICUs in North America: A Report From National Emergency Airway Registry for Children.Branca A, Tellez D, Berkenbosch J, Rehder KJ, Giuliano JS, Gradidge E, Shults J, Turner DA, Nett S, Krawiec C, Edwards LR, Pinto M, Harwayne-Gidansky I, Bysani GK, Shenoi A, Breuer RK, Toedt-Pingel I, Parsons SJ, Orioles A, Al-Subu A, Konyk L, Panisello J, Adu-Darko M, Tarquinio K, François T, Emeriaud G, Lee A, Meyer K, Glater-Welt LB, Polikoff L, Kelly SP, Tallent S, Napolitano N, Nadkarni V, Nishisaki A. The New Trainee Effect in Tracheal Intubation Procedural Safety Across PICUs in North America: A Report From National Emergency Airway Registry for Children. Pediatric Critical Care Medicine 2020, 21: 1042-1050. PMID: 32740182, DOI: 10.1097/pcc.0000000000002480.
- Multisystem Inflammatory Syndrome in U.S. Children and AdolescentsFeldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai SP, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents New England Journal Of Medicine 2020, 383: 334-346. PMID: 32598831, PMCID: PMC7346765, DOI: 10.1056/nejmoa2021680.
- Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events.Conway JA, Kharayat P, Sanders RC, Nett S, Weiss SL, Edwards LR, Breuer R, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner DA, Shults J, Giuliano JS, Orioles A, Balkandier S, Emeriaud G, Rehder KJ, Kian Boon JL, Shenoi A, Vanderford P, Nuthall G, Lee A, Zeqo J, Parsons SJ, Furlong-Dillard J, Meyer K, Harwayne-Gidansky I, Jung P, Adu-Darko M, Bysani GK, McCarthy MA, Shlomovich M, Toedt-Pingel I, Branca A, Esperanza MC, Al-Subu AM, Pinto M, Tallent S, Shetty R, Thyagarajan S, Ikeyama T, Tarquinio KM, Skippen P, Kasagi M, Howell JD, Nadkarni VM, Nishisaki A. Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. Critical Care Medicine 2020, 48: e489-e497. PMID: 32317603, DOI: 10.1097/CCM.0000000000004314.
- Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary EndotheliumPierce RW, Shabanova V, Canarie M, Pinto M, da Silva YS, Bhandari V, Giuliano JS. Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium Shock 2019, 51: 298-305. PMID: 30286031, PMCID: PMC6375782, DOI: 10.1097/shk.0000000000001172.
- Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness.Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS, Shein SL, Moffitt K. Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2019, 68: 365-372. PMID: 29893805, PMCID: PMC6336914, DOI: 10.1093/cid/ciy495.
- Health-Related Quality of Life after Pediatric Severe Sepsis.Syngal P, Giuliano JS. Health-Related Quality of Life after Pediatric Severe Sepsis. Healthcare (Basel, Switzerland) 2018, 6 PMID: 30208619, PMCID: PMC6164000, DOI: 10.3390/healthcare6030113.
- Safety of tracheal intubation in the presence of cardiac disease in paediatric ICUs.Gradidge EA, Bakar A, Tellez D, Ruppe M, Tallent S, Bird G, Lavin N, Lee A, Nadkarni V, Adu-Darko M, Bain J, Biagas K, Branca A, Breuer RK, Brown C, Bysani K, Emeriaud G, Gangadharan S, Giuliano JS, Howell JD, Krawiec C, Lee JH, Li S, Meyer K, Miksa M, Napolitano N, Nett S, Nuthall G, Orioles A, Owen EB, Parker MM, Parsons S, Polikoff LA, Rehder K, Saito O, Sanders RC, Shenoi A, Simon DW, Skippen PW, Tarquinio K, Thompson A, Toedt-Pingel I, Walson K, Nishisaki A. Safety of tracheal intubation in the presence of cardiac disease in paediatric ICUs. Cardiology In The Young 2018, 28: 928-937. PMID: 29690950, DOI: 10.1017/S1047951118000495.
- Cricoid Pressure During Induction for Tracheal Intubation in Critically Ill Children: A Report From National Emergency Airway Registry for Children.Kojima T, Harwayne-Gidansky I, Shenoi AN, Owen EB, Napolitano N, Rehder KJ, Adu-Darko MA, Nett ST, Spear D, Meyer K, Giuliano JS, Tarquinio KM, Sanders RC, Lee JH, Simon DW, Vanderford PA, Lee AY, Brown CA, Skippen PW, Breuer RK, Toedt-Pingel I, Parsons SJ, Gradidge EA, Glater LB, Culver K, Nadkarni VM, Nishisaki A. Cricoid Pressure During Induction for Tracheal Intubation in Critically Ill Children: A Report From National Emergency Airway Registry for Children. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2018, 19: 528-537. PMID: 29863636, DOI: 10.1097/PCC.0000000000001531.
- Downward Trend in Pediatric Resident Laryngoscopy Participation in PICUs.Gabrani A, Kojima T, Sanders RC, Shenoi A, Montgomery V, Parsons SJ, Gangadharan S, Nett S, Napolitano N, Tarquinio K, Simon DW, Lee A, Emeriaud G, Adu-Darko M, Giuliano JS, Meyer K, Graciano AL, Turner DA, Krawiec C, Bakar AM, Polikoff LA, Parker M, Harwayne-Gidansky I, Crulli B, Vanderford P, Breuer RK, Gradidge E, Branca A, Grater-Welt LB, Tellez D, Wright LV, Pinto M, Nadkarni V, Nishisaki A. Downward Trend in Pediatric Resident Laryngoscopy Participation in PICUs. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2018, 19: e242-e250. PMID: 29406378, PMCID: PMC5935530, DOI: 10.1097/PCC.0000000000001470.
- Effect of Location on Tracheal Intubation Safety in Cardiac Disease-Are Cardiac ICUs Safer?Gradidge EA, Bakar A, Tellez D, Ruppe M, Tallent S, Bird G, Lavin N, Lee A, Adu-Darko M, Bain J, Biagas K, Branca A, Breuer RK, Brown C, Bysani GK, Cheifitz IM, Emeriaud G, Gangadharan S, Giuliano JS, Howell JD, Krawiec C, Lee JH, Li S, Meyer K, Miksa M, Napolitano N, Nett S, Nuthall G, Orioles A, Owen EB, Parker MM, Parsons S, Polikoff LA, Rehder K, Saito O, Sanders RC, Shenoi AN, Simon DW, Skippen PW, Tarquinio K, Thompson A, Toedt-Pingel I, Vanderford P, Walson K, Nadkarni V, Nishisaki A. Effect of Location on Tracheal Intubation Safety in Cardiac Disease-Are Cardiac ICUs Safer? Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2018, 19: 218-227. PMID: 29252865, DOI: 10.1097/PCC.0000000000001422.
- Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children.Kojima T, Laverriere EK, Owen EB, Harwayne-Gidansky I, Shenoi AN, Napolitano N, Rehder KJ, Adu-Darko MA, Nett ST, Spear D, Meyer K, Giuliano JS, Tarquinio KM, Sanders RC, Lee JH, Simon DW, Vanderford PA, Lee AY, Brown CA, Skippen PW, Breuer RK, Toedt-Pingel I, Parsons SJ, Gradidge EA, Glater LB, Culver K, Li S, Polikoff LA, Howell JD, Nuthall G, Bysani GK, Graciano AL, Emeriaud G, Saito O, Orioles A, Walson K, Jung P, Al-Subu AM, Ikeyama T, Shetty R, Yoder KM, Nadkarni VM, Nishisaki A. Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2018, 19: 106-114. PMID: 29140970, DOI: 10.1097/PCC.0000000000001373.
- End-Tidal Carbon Dioxide Use for Tracheal IntubationLanghan ML, Emerson BL, Nett S, Pinto M, Harwayne-Gidansky I, Rehder KJ, Krawiec C, Meyer K, Giuliano JS, Owen EB, Tarquinio KM, Sanders RC, Shepherd M, Bysani GK, Shenoi AN, Napolitano N, Gangadharan S, Parsons SJ, Simon DW, Nadkarni VM, Nishisaki A. End-Tidal Carbon Dioxide Use for Tracheal Intubation Pediatric Critical Care Medicine 2018, 19: 98-105. PMID: 29140968, DOI: 10.1097/pcc.0000000000001372.
- A Qualitative Study of Multidisciplinary Providers' Experiences With the Transfer Process for Injured Children and Ideas for ImprovementGawel M, Emerson B, Giuliano JS, Rosenberg A, Minges KE, Feder S, Violano P, Morrell P, Petersen J, Christison-Lagay E, Auerbach M. A Qualitative Study of Multidisciplinary Providers' Experiences With the Transfer Process for Injured Children and Ideas for Improvement Pediatric Emergency Care 2018, 34: 125-131. PMID: 29346234, PMCID: PMC5792311, DOI: 10.1097/pec.0000000000001405.
- Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs.Li S, Hsieh TC, Rehder KJ, Nett S, Kamat P, Napolitano N, Turner DA, Adu-Darko M, Jarvis JD, Krawiec C, Derbyshire AT, Meyer K, Giuliano JS, Tala J, Tarquinio K, Ruppe MD, Sanders RC, Pinto M, Howell JD, Parker MM, Nuthall G, Shepherd M, Emeriaud G, Nagai Y, Saito O, Lee JH, Simon DW, Orioles A, Walson K, Vanderford P, Shenoi A, Lee A, Bird GL, Miksa M, Graciano AL, Bain J, Skippen PW, Polikoff LA, Nadkarni V, Nishisaki A. Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2018, 19: e41-e50. PMID: 29210925, DOI: 10.1097/PCC.0000000000001384.
- Promoters and Barriers to Implementation of Tracheal Intubation Airway Safety Bundle: A Mixed-Method Analysis.Davis KF, Napolitano N, Li S, Buffman H, Rehder K, Pinto M, Nett S, Jarvis JD, Kamat P, Sanders RC, Turner DA, Sullivan JE, Bysani K, Lee A, Parker M, Adu-Darko M, Giuliano J, Biagas K, Nadkarni V, Nishisaki A. Promoters and Barriers to Implementation of Tracheal Intubation Airway Safety Bundle: A Mixed-Method Analysis. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2017, 18: 965-972. PMID: 28654550, PMCID: PMC5628113, DOI: 10.1097/PCC.0000000000001251.
- Endothelial Cell Function and Dysfunction in Critically Ill ChildrenPierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children Pediatrics 2017, 140: e20170355. PMID: 28759412, PMCID: PMC9923607, DOI: 10.1542/peds.2017-0355.
- Endothelial Cell Function and Dysfunction in Critically Ill Children.Pierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children. Pediatrics 2017 PMID: 28814621, DOI: 10.1542/peds.2017-0355.
- International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study.Fink EL, Kochanek PM, Tasker RC, Beca J, Bell MJ, Clark RS, Hutchison J, Vavilala MS, Fabio A, Angus DC, Watson RS, Prevalence of Acute critical Neurological disease in children: A Global Epidemiological Assessment (PANGEA) Investigators.. International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study. Pediatr Crit Care Med 2017, 18:330-342.
- Relationship Between Adverse Tracheal Intubation Associated Events and PICU Outcomes.Parker MM, Nuthall G, Brown C, Biagas K, Napolitano N, Polikoff LA, Simon D, Miksa M, Gradidge E, Lee JH, Krishna AS, Tellez D, Bird GL, Rehder KJ, Turner DA, Adu-Darko M, Nett ST, Derbyshire AT, Meyer K, Giuliano J, Owen EB, Sullivan JE, Tarquinio K, Kamat P, Sanders RC, Pinto M, Bysani GK, Emeriaud G, Nagai Y, McCarthy MA, Walson KH, Vanderford P, Lee A, Bain J, Skippen P, Breuer R, Tallent S, Nadkarni V, Nishisaki A. Relationship Between Adverse Tracheal Intubation Associated Events and PICU Outcomes. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2017, 18: 310-318. PMID: 28198754, PMCID: PMC5554859, DOI: 10.1097/PCC.0000000000001074.
- New or progressive multiple organ dysfunction syndrome (NPMODS) in pediatric severe sepsis: a sepsis phenotype with higher morbidity and mortalityLin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Pediatr Crit Care Med 2017; 18(1): 8-16 Oct 13 [Epub ahead of print].
- Acute kidney injury in pediatric severe sepsis, an independent risk for death and new disability.Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Crit Care Med 2016 Aug 10 [Epub ahead of print].
- Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS, Hall MW, Bubeck Wardenburg J. Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children. The Journal Of Infectious Diseases 2016, 214: 1638-1646. PMID: 27651418, PMCID: PMC5144732, DOI: 10.1093/infdis/jiw441.
- Cardiac Arrests Associated With Tracheal Intubations in PICUs: A Multicenter Cohort Study.Shiima Y, Berg RA, Bogner HR, Morales KH, Nadkarni VM, Nishisaki A, for the National Emergency Airway Registry for Children and the Pediatric Acute Lung Injury and Sepsis Investigators. Crit Care Med 2016; 44(9): 1675-82. April 11 [Epub ahead of print].
- A regional cohort study of the treatment of critically ill children with bronchiolitisCarroll CL, Faustino EV, Pinto MG, Sala KA, Canarie MF, Li S, Giuliano JS, Consortium T. A regional cohort study of the treatment of critically ill children with bronchiolitis Journal Of Asthma 2016, 53: 1006-1011. PMID: 27177013, DOI: 10.1080/02770903.2016.1180697.
- Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.Giuliano JS, Markovitz BP, Brierley J, Levin R, Williams G, Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2016, 17: 522-30. PMID: 27124566, PMCID: PMC5399539, DOI: 10.1097/PCC.0000000000000760.
- The number of tracheal attempts matters! A prospective multi-institutional pediatric observational study.Lee JH, Turner DA, Kamat P, Nett S, Shults J, Nadkarni VM, Nishisaki A, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), National Emergency Airway Registry for Children (NEAR4KIDS). BMC Pediatr 2016; 16(1):58.
- Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection.Randolph AG, Agan AA, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S, Ferdinands JM, the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICUFlu Study Group. Pediatr Crit Care Med 2016;17(4):279-86.
- Family Presence During Pediatric Tracheal Intubations.Sanders RC, Nett ST, Davis KF, Parker MM, Bysani GK, Adu-Darko M, Bird GL, Cheifetz IM, Derbyshire AT, Emeriaud G, Giuliano JS, Graciano AL, Hagiwara Y, Hefley G, Ikeyama T, Jarvis JD, Kamat P, Krishna AS, Lee A, Lee JH, Li S, Meyer K, Montgomery VL, Nagai Y, Pinto M, Rehder KJ, Saito O, Shenoi AN, Taekema HC, Tarquinio KM, Thompson AE, Turner DA, Nadkarni VM, Nishisaki A. Family Presence During Pediatric Tracheal Intubations. JAMA Pediatrics 2016, 170: e154627. PMID: 26954533, DOI: 10.1001/jamapediatrics.2015.4627.
- Development of a Quality Improvement Bundle to Reduce Tracheal Intubation-Associated Events in Pediatric ICUs.Li S, Rehder KJ, Giuliano JS, Apkon M, Kamat P, Nadkarni VM, Napolitano N, Thompson AE, Tucker C, Nishisaki A. Development of a Quality Improvement Bundle to Reduce Tracheal Intubation-Associated Events in Pediatric ICUs. American Journal Of Medical Quality : The Official Journal Of The American College Of Medical Quality 2016, 31: 47-55. PMID: 25143411, DOI: 10.1177/1062860614547259.
- Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU.Rehder KJ, Giuliano JS, Napolitano N, Turner DA, Nuthall G, Nadkarni VM, Nishisaki A. Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU. Critical Care Medicine 2015, 43: 2668-74. PMID: 26465221, DOI: 10.1097/CCM.0000000000001313.
- Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study.Weiss SL, Fitzgerald JC, Maffei FA, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Kee SY, Bush JL, Roy JA, Thomas NJ, Nadkarni VM; for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. Crit Care. 2015; 19:325
- Global Epidemiology of Pediatric Severe Sepsis: the Sepsis PRevalence OUtcomes, and Therapies Study.Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ; for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Am J Respir Crit Care Med. 2015; 191(10):1147-57. Mar 3 [Epub ahead of print]
- Current Medication Practice and Tracheal Intubation Safety Outcomes from a Prospective Multicenter Observational Cohort Study.Tarquinio KM, Howell JD, Montgomery V, Turner DA, Hsing D, Parker M, Brown III CA, Walls RM, Nadkarni V, Nishisaki A, for the National Emergency Airway Registry for Children (NEAR4KIDS) investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Investigators. Pediatr Crit Care Med 2015; 16(3):210-8 Jan 9. [Epub ahead of print]
- Risk Factors for Failed Tracheal Intubation in Pediatric and Neonatal Critical Care Specialty Transport.Smith KA, Gothard MD, Schwartz HP, Giuliano JS, Forbes M, Bigham MT. Risk Factors for Failed Tracheal Intubation in Pediatric and Neonatal Critical Care Specialty Transport. Prehospital Emergency Care : Official Journal Of The National Association Of EMS Physicians And The National Association Of State EMS Directors 2015, 19: 17-22. PMID: 25350689, DOI: 10.3109/10903127.2014.964888.
- Incidence and associated factors of difficult tracheal intubations in pediatric ICUs: a report from National Emergency Airway Registry for Children: NEAR4KIDS.Graciano AL, Tamburro R, Thompson AE, Fiadjoe J, Nadkarni VM, Nishisaki A. [for the National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and Pediatric Acute Lung Injury and Sepsis Investigator (PALISI) Network Investigators; for the National Emergency Airway Registry for Children NEAR4KIDS Investigators and Pediatric Acute Lung Injury and Sepsis Investigator PALISI Network Investigators.] Intensive Care Med. 2014; 40(11): 1659-69
- Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe SepsisWang K, Bhandari V, Giuliano JS, O′Hern C, Shattuck MD, Kirby M. Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis PLOS ONE 2014, 9: e108461. PMID: 25255212, PMCID: PMC4178003, DOI: 10.1371/journal.pone.0108461.
- The Effect of Modified Ultrafiltration on Angiopoietins in Pediatric Cardiothoracic OperationsLang SM, Syed MA, Dziura J, Rocco E, Kirshbom P, Bhandari V, Giuliano JS. The Effect of Modified Ultrafiltration on Angiopoietins in Pediatric Cardiothoracic Operations The Annals Of Thoracic Surgery 2014, 98: 1699-1704. PMID: 25258157, PMCID: PMC4253712, DOI: 10.1016/j.athoracsur.2014.06.053.
- Effectiveness of Influenza Vaccine Against Life-threatening RT-PCR-confirmed Influenza Illness in US Children, 2010-1012.Ferdinands JM, Olsho LE, Agan AA, Bhat N, Sullivan RM, Hall M, Mourani PM, Thompson M, Randolph AG on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. J Infect Dis 2014; 210(5):674-83. Mar 26 [Epub ahead of print]
- Variability in IRBs regarding parental acceptance of passive consent.Higgerson RA, Olsho LE, Christie LM, Rehder K, Doksum T, Gedeit R, Giuliano JS, Brennan B, Wendlandt R, Randolph AG. Variability in IRBs regarding parental acceptance of passive consent. Pediatrics 2014, 134: e496-503. PMID: 25002659, DOI: 10.1542/peds.2013-4190.
- Use of procalcitonin for the prediction and treatment of acute bacterial infection in childrenPierce R, Bigham MT, Giuliano JS. Use of procalcitonin for the prediction and treatment of acute bacterial infection in children Current Opinion In Pediatrics 2014, 26: 292-298. PMID: 24739491, DOI: 10.1097/mop.0000000000000092.
- Neonatal/infant validation study of the CAS model 740 noninvasive blood pressure monitor with the Orion/MaxIQ NIBP module.Lang SM, Giuliano JS, Carroll CL, Rosenkrantz TS, Eisenfeld L. Neonatal/infant validation study of the CAS model 740 noninvasive blood pressure monitor with the Orion/MaxIQ NIBP module. Blood Pressure Monitoring 2014, 19: 180-2. PMID: 24618916, DOI: 10.1097/MBP.0000000000000036.
- Site-Level Variance for Adverse Tracheal Intubation-Associated Events Across 15 North American PICUs: A Report From National Emergency Airway Registry for Children.Nett S, Emeriaud G, Jarvis JD, Montgomery V, Nadkarni V, Nishisaki A for the NEAR4KIDS Investigators and PALISI Network. Pediatr Crit Care Med 2014; 15(4):306-13. Mar 31. [Epub ahead of print]
- Specialty pediatric transport in primary care or urgent care settings.Joyce CN, Giuliano JS, Gothard MD, Schwartz HP, Bigham MT. Specialty pediatric transport in primary care or urgent care settings. Air Medical Journal 2014, 33: 71-5. PMID: 24589324, DOI: 10.1016/j.amj.2013.12.003.
- The extracellular stress response to pediatric cardiopulmonary bypass.Wheeler DS, Bigham MT, Lahni PM, Giuliano JS, Nelson DP, Manning PB, Wong HR. The extracellular stress response to pediatric cardiopulmonary bypass. Journal Of Pediatric Intensive Care 2014, 3: 9-16. PMID: 31214445, PMCID: PMC6530739, DOI: 10.3233/PIC-14083.
- Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model.Wong HR, Weiss SL, Giuliano JS, Wainwright MS, Cvijanovich NZ, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP, Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PloS One 2014, 9: e86242. PMID: 24489704, PMCID: PMC3906040, DOI: 10.1371/journal.pone.0086242.
- The Temporal Kinetics of Circulating Angiopoietin Levels in Children With SepsisGiuliano JS, Tran K, Li FY, Shabanova V, Tala JA, Bhandari V. The Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis Pediatric Critical Care Medicine 2014, 15: e1-e8. PMID: 24141659, PMCID: PMC3947338, DOI: 10.1097/pcc.0b013e3182a553bb.
- The temporal version of the pediatric sepsis biomarker risk model.Wong HR, Weiss SL, Giuliano JS, Wainwright MS, Cvijanovich NZ, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP, Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Harmon K, Lahni P, Lindsell CJ. The temporal version of the pediatric sepsis biomarker risk model. PloS One 2014, 9: e92121. PMID: 24626215, PMCID: PMC3953585, DOI: 10.1371/journal.pone.0092121.
- The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated childrenThompson C, Shabanova V, Giuliano JS. The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children Pediatric Anesthesia 2013, 23: 1174-1179. PMID: 24103039, PMCID: PMC3880626, DOI: 10.1111/pan.12258.
- Corticosteroid Therapy in Critically Ill Pediatric Asthmatic Patients*Giuliano JS, Faustino EV, Li S, Pinto MG, Canarie MF, Carroll CL. Corticosteroid Therapy in Critically Ill Pediatric Asthmatic Patients* Pediatric Critical Care Medicine 2013, 14: 467-470. PMID: 23628833, DOI: 10.1097/pcc.0b013e31828a7451.
- The impact of postintubation chest radiograph during pediatric and neonatal critical care transport.Sanchez-Pinto N, Giuliano JS, Schwartz HP, Garrett L, Gothard MD, Kantak A, Bigham MT. The impact of postintubation chest radiograph during pediatric and neonatal critical care transport. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2013, 14: e213-7. PMID: 23439465, DOI: 10.1097/PCC.0b013e3182772e13.
- A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs.Nishisaki A, Turner DA, Brown CA 3rd, Walls RM, Nadkarni VM; National Emergency Airway Registry for Children (NEAR4KIDS); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Crit Care Med 2013; 41(3): 874-85
- Level of trainee and tracheal intubation outcomes.Sanders RC, Giuliano JS, Sullivan JE, Brown CA, Walls RM, Nadkarni V, Nishisaki A. Level of trainee and tracheal intubation outcomes. Pediatrics 2013, 131: e821-8. PMID: 23400606, DOI: 10.1542/peds.2012-2127.
- Heliox in children with croup: a strategy to hasten improvement.Kline-Krammes S, Reed C, Giuliano JS, Schwartz HP, Forbes M, Pope J, Besunder J, Gothard MD, Russell K, Bigham MT. Heliox in children with croup: a strategy to hasten improvement. Air Medical Journal 2012, 31: 131-7. PMID: 22541348, DOI: 10.1016/j.amj.2011.08.004.
- Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) ScoreKandil SB, Sanford H, Northrup V, Bigham MT, Giuliano JS. Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) Score Prehospital Emergency Care 2012, 16: 366-373. PMID: 22443350, PMCID: PMC3360797, DOI: 10.3109/10903127.2012.664246.
- Critically ill children during the 2009-2010 influenza pandemic in the United States.Randolph AG, Vaughn F, Sullivan R, Rubinson L, Thompson BT, Yoon G, Smoot E, Rice TW, Loftis LL, Helfaer M, Doctor A, Paden M, Flori H, Babbitt C, Graciano AL, Gedeit R, Sanders RC, Giuliano JS, Zimmerman J, Uyeki TM. Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics 2011, 128: e1450-8. PMID: 22065262, PMCID: PMC3387899, DOI: 10.1542/peds.2011-0774.
- Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.Giuliano JS, Lahni PM, Wong HR, Wheeler DS. Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System. The Open Inflammation Journal 2011, 4: 49-60. PMID: 24765217, PMCID: PMC3995031, DOI: 10.2174/1875041901104010049.
- The immunomodulatory effects of albumin in vitro and in vivo.Wheeler DS, Giuliano JS, Lahni PM, Denenberg A, Wong HR, Zingarelli B. The immunomodulatory effects of albumin in vitro and in vivo. Advances In Pharmacological Sciences 2011, 2011: 691928. PMID: 21603190, PMCID: PMC3096151, DOI: 10.1155/2011/691928.
- Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?Giuliano JS, Wheeler DS. Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit? Critical Care (London, England) 2009, 13: 114. PMID: 19226440, PMCID: PMC2688109, DOI: 10.1186/cc7685.
- Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass.Giuliano JS, Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR, Wheeler DS. Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Medicine 2008, 34: 1851-7. PMID: 18516587, PMCID: PMC2574898, DOI: 10.1007/s00134-008-1174-9.
- The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming.Abboud PA, Lahni PM, Page K, Giuliano JS, Harmon K, Dunsmore KE, Wong HR, Wheeler DS. The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming. Shock (Augusta, Ga.) 2008, 30: 285-92. PMID: 18323737, PMCID: PMC2771720, DOI: 10.1097/SHK.0b013e318164e2c3.
- Unilateral pulmonary edema and acute rheumatic fever.Giuliano JS, Sekar P, Dent CL, Border WL, Hirsch R, Manning PB, Wheeler DS. Unilateral pulmonary edema and acute rheumatic fever. European Journal Of Pediatrics 2008, 167: 465-7. PMID: 17450381, DOI: 10.1007/s00431-007-0491-2.
- An infant with fever and stridor.Wheeler DS, Dauplaise DJ, Giuliano JS. An infant with fever and stridor. Pediatric Emergency Care 2008, 24: 46-9. PMID: 18212612, DOI: 10.1097/pec.0b013e31815f6f7f.
- Admission angiopoietin levels in children with septic shock.Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock (Augusta, Ga.) 2007, 28: 650-654. PMID: 18092380, PMCID: PMC2754128.