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John S Giuliano

Associate Professor of Pediatrics (Critical Care); Medical Director Pediatric Intensive Care Unit, Pediatric Critical Care Medicine

Contact Information

John S Giuliano, MD, FAAP, FCCM

Mailing Address

  • Pediatric Critical Care Medicine

    PO Box 208064

    New Haven, CT 06520-8064

    United States

Research Summary

John Giuliano, Jr., M.D, has focused his research interests around inflammation and the host’s response to sepsis/acute lung injury. To this end, he has been involved in translational research projects looking at the role angiopoietins play in vascular leak in pediatric patients with severe sepsis and septic shock. Additionally, he investigates the morbidity and mortality as well as the genetic makeup of children admitted to the ICU with influenza. He has contributed to multicenter studies in patients with COVID-19 and MIS-C. Finally, he is involved with improving the morbidity and mortality associated with pediatric endotracheal intubation.

Specialized Terms: Pediatric sepsis; Acute lung injury and the inflammatory response; Pediatric transport medicine; Pediatric endotracheal intubation

Extensive Research Description

John Giuliano, Jr., M.D, has centered his research interest around our body’s inflammatory response to infection. His main interest lies in the release of vascular growth factors called angiopoietins. He has shown that ang-2 is significantly elevated when children with septic shock are admitted to the PICU and that these levels peak around day 2 of illness. This growth factor may play a role in the vascular leak phenomena seen in these patients. Along similar lines, he continues to study plasma biomarkers released when children have severe influenza infections. Since many children with severe sepsis require an advanced airway, Dr. Giuliano is also investigating ways to improve the morbidity and mortality associated with this high risk procedure.

  • Evaluating the biomarker profile of critically ill children with influenza infection
  • Understanding pediatric medication pharmacokinetics
  • Reducing tracheal intubation associated events in children
  • Improving tracheal intubation teaching using video laryngoscopy


Research Interests

Critical Care; Inflammation; Pediatrics; Extracorporeal Membrane Oxygenation; Sepsis; Acute Lung Injury

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Lung; Diseases of the Respiratory SystemsPICFLU2: Discovering the immunobiology of influenza critical illness in young people