Florence Ida Hsu, MD
Assistant Professor of Medicine (Rheumatology, Allergy & Immunology); Training Program Director - Allergy & Immunology Fellowship, Internal Medicine
Research & Publications
Biography
News
Research Summary
Dr. Hsu's particular interests within the field of allergy and immunology include treatment of chronic urticaria (idiopathic or autoimmune hives), angioedema (particularly hereditary angioedema), and aspirin/non-steroidal antinflammatory sensitivity (AKA aspirin exacerbated respiratory disease - AERD, or aspirin-sensitive asthma with nasal polyposis, or Samter's Triad). She ws one of first allergists in the CT/metro NYC area to routinely perform aspirin desensitizations for AERD patients in the outpatient setting.
Dr. Hsu has participated over the years in a variety of clinical trials for pharmacotherapeutics in hereditary angioedema and chronic rhinosinusitis. We are currently a site for a multicenter observational trial for patients with hereditary angioedema. Dr. Hsu also collaborates with researchers around the country on other observational clinical studies in hereditary angioedema.
Coauthors
Research Interests
Angioedema; Asthma; Drug Hypersensitivity; Nasal Polyps; Rhinitis; Urticaria; Asthma, Aspirin-Induced; Hereditary Angioedema Types I and II; Rhinitis, Allergic
Selected Publications
- A safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextranBelmont A, Liao J, Hsu F, Kwah J. A safe, effective, and single-day protocol for rapid drug desensitization to intravenous iron dextran. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3242-3244.e1. PMID: 37329952, DOI: 10.1016/j.jaip.2023.06.018.
- A Safe Effective and Resource Conscientious Protocol for Iron Dextran DesensitizationLiao J, Belmont A, Hsu F, Kwah J. A Safe Effective and Resource Conscientious Protocol for Iron Dextran Desensitization. Journal Of Allergy And Clinical Immunology 2023, 151: ab60. DOI: 10.1016/j.jaci.2022.12.190.
- Considerations in the management of hereditary angioedema due to C1-INH deficiency in women of childbearing ageHsu FI, Lumry W, Riedl M, Tachdjian R. Considerations in the management of hereditary angioedema due to C1-INH deficiency in women of childbearing age. Allergy, Asthma & Clinical Immunology 2022, 18: 64. PMID: 35831891, PMCID: PMC9281160, DOI: 10.1186/s13223-022-00689-9.
- Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody DeficiencyShin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.
- Clinical profile and treatment outcomes in patients with hereditary angioedema with normal C1 esterase inhibitorJones DH, Bansal P, Bernstein JA, Fatteh S, Harper J, Hsu FI, O’Connor M, Park N, Suez D. Clinical profile and treatment outcomes in patients with hereditary angioedema with normal C1 esterase inhibitor. World Allergy Organization Journal 2022, 15: 100621. PMID: 35145604, PMCID: PMC8804245, DOI: 10.1016/j.waojou.2021.100621.
- Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiencyKuster JK, Unlu S, Makin TA, Par-Young J, Simonov M, Shafi S, Balanda M, Randolph C, Steele R, Hsu FI, Price C, Kohli-Pamnani A, Borish L, Lawrence MG, Kang I, Shin JJ. Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency. The Journal Of Allergy And Clinical Immunology In Practice 2021, 10: 633-636.e3. PMID: 34929372, PMCID: PMC8683251, DOI: 10.1016/j.jaip.2021.11.030.
- Clinical presentation of hereditary angioedema.Azmy V, Brooks JP, Hsu FI. Clinical presentation of hereditary angioedema. Allergy & Asthma Proceedings 2020, 41: s18-s21. PMID: 33109320, DOI: 10.2500/aap.2020.41.200065.
- Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control MeasureMurphy K, Chipps B, Beuther D, Wise R, McCann W, Gilbert I, Eudicone J, Gandhi H, Harding G, Coyne K, Zeiger R, Board P, Kobernick A, Mohammad A, Cherry A, Fein A, Gaines A, Ramsey A, Michaud A, Palmer A, Kim A, Smith A, White A, Ricci A, Kettelhut B, Modena B, Stone B, Rolston B, Schnapf B, Krajicek B, Kraft C, Hopkins C, Natalie C, Anderson C, Czajkowski C, Arce D, Hamlin D, Hill D, Mares D, Pham D, Liao D, Simmons D, Johnson D, Jhaveri D, Maselli D, Kerwin E, Schuman E, Sher E, Bleecker E, Rakowski E, Hsu F, Averill F, Barsanti F, Gross G, Chupp G, Head G, Nasir H, Lee H, Barjaktarevic I, Cook J, Krainson J, Pearl J, Bellak J, Perez-Fernandez J, Rehm J, Trevor J, Most J, Hanson J, Blessing-Moore J, Biller J, Gedell J, Southard J, Chancellor J, Ilowite J, Romeo J, Mercado J, Fisher J, Greiwe J, Gregory K, Nadeau K, Shenoy K, Tan L, Stefanowicz L, Humes L, Bowers L, O’Connor M, Perez M, White M, Hegewald M, Wilson M, Sikora M, Morganroth M, Smith M, Farooqui N, Lesch N, Jain N, Parikh N, Hartog N, Luthin P, Stewart P, O’Connor P, Schochet P, Goldberg P, Patel P, Chinthrajah R, Sidhu R, Ayinla R, Brown R, Stadtler R, Wachs R, Balkissoon R, Duplantier R, Puente R, Settipane R, Mustafa S, Surani S, Jawad S, Adams S, Villegas S, Al-Farra S, Subramanian S, Bains S, Kelsen S, Wise S, Estrella-Eades S, Smith S, Qureshi T, Chen T, Kelbel T, Miller T, Jain V, Soong W, Soler X, Mattar Z. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2263-2274.e5. PMID: 32387166, DOI: 10.1016/j.jaip.2020.02.042.
- Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature ReviewBrooks JP, Radojicic C, Riedl MA, Newcomer SD, Banerji A, Hsu FI. Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature Review. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 1875-1880.e3. PMID: 32251736, DOI: 10.1016/j.jaip.2020.03.009.
- Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease SpectrumShin JJ, Liauw D, Siddiqui S, Lee J, Chung EJ, Steele R, Hsu FI, Price C, Kang I. Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. Journal Of Clinical Immunology 2020, 40: 592-601. PMID: 32239366, PMCID: PMC7260109, DOI: 10.1007/s10875-020-00773-y.
- Long-term efficacy and safety of subcutaneous C1-inhibitor in women with hereditary angioedema: subgroup analysis from an open-label extension of a phase 3 trialLevy DS, Farkas H, Riedl MA, Hsu FI, Brooks JP, Cicardi M, Feuersenger H, Pragst I, Reshef A. Long-term efficacy and safety of subcutaneous C1-inhibitor in women with hereditary angioedema: subgroup analysis from an open-label extension of a phase 3 trial. Allergy, Asthma & Clinical Immunology 2020, 16: 8. PMID: 32042283, PMCID: PMC7001333, DOI: 10.1186/s13223-020-0409-3.
- Recombinant human C1 esterase inhibitor as short-term prophylaxis in patients with hereditary angioedemaValerieva A, Staevska M, Jesenak M, Hrubiskova K, Sobotkova M, Zachova R, Hakl R, Andrejevic S, Suiter T, Grivcheva-Panovska V, Karadza-Lapic L, Soteres D, Shapiro R, Rumbyrt J, Tachdjian R, Mehta V, Hsu FI, Zanichelli A. Recombinant human C1 esterase inhibitor as short-term prophylaxis in patients with hereditary angioedema. The Journal Of Allergy And Clinical Immunology In Practice 2019, 8: 799-802. PMID: 31437566, DOI: 10.1016/j.jaip.2019.08.011.
- Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivityBrooks JP, Azmy V, Thompson A, Luon D, Prozora SD, Price C, Hsu FI. Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivity. Journal Of Oncology Pharmacy Practice 2019, 26: 228-231. PMID: 30885040, DOI: 10.1177/1078155219836478.
- Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responsesRomberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu M, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. Journal Of Allergy And Clinical Immunology 2018, 143: 258-265. PMID: 29935219, PMCID: PMC6400323, DOI: 10.1016/j.jaci.2018.06.012.
- Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal AntibodiesSloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. The Journal Of Allergy And Clinical Immunology In Practice 2016, 4: 497-504. PMID: 26895621, DOI: 10.1016/j.jaip.2015.12.019.
- Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal AntibodiesBanerji A, Brennan P, Hesterberg P, Oren E, Hsu F. Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal Antibodies. 2010, 297-311. DOI: 10.1007/978-1-60327-951-2_19.
- Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatmentBrennan PJ, Bouza T, Hsu FI, Sloane DE, Castells MC. Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment. Journal Of Allergy And Clinical Immunology 2009, 124: 1259-1266. PMID: 19910036, DOI: 10.1016/j.jaci.2009.09.009.
- Chapter 19 Biology of Mast Cells and their MediatorsHsu F, Boyce J. Chapter 19 Biology of Mast Cells and their Mediators. 2009, 311-328. DOI: 10.1016/b978-0-323-05659-5.00019-x.
- Hypersensitivity reactions to chemotherapy: Outcomes and safety of rapid desensitization in 413 casesCastells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA. Hypersensitivity reactions to chemotherapy: Outcomes and safety of rapid desensitization in 413 cases. Journal Of Allergy And Clinical Immunology 2008, 122: 574-580. PMID: 18502492, DOI: 10.1016/j.jaci.2008.02.044.
- Anaphylactic and anaphylactoid reactions to chemotherapy: outcomes and safety of rapid intravenous and intraperitoneal desensitizations in 413 casesCastells M, Tennant N, Sloane D, Hsu F, Berlin S, Campos S, Matulonis U. Anaphylactic and anaphylactoid reactions to chemotherapy: outcomes and safety of rapid intravenous and intraperitoneal desensitizations in 413 cases. Journal Of Clinical Oncology 2008, 26: 5526-5526. DOI: 10.1200/jco.2008.26.15_suppl.5526.
- Successful Implementation of a Standardized Rapid Drug Desensitization Protocol for Chemotherapy and Rituximab in 413 CasesLegere H, Tennant N, Sloane D, Barrett N, Hong D, Hsu F, Laidlaw T, Nallamshetty S, Palis R, Rao J, Castells M. Successful Implementation of a Standardized Rapid Drug Desensitization Protocol for Chemotherapy and Rituximab in 413 Cases. Journal Of Allergy And Clinical Immunology 2008, 121: s68. DOI: 10.1016/j.jaci.2007.12.272.
- Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary InflammationKim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation. The Journal Of Immunology 2006, 176: 4440-4448. PMID: 16547282, DOI: 10.4049/jimmunol.176.7.4440.
- Chest wall resection for locally recurrent breast cancer: Is it worthwhile?Downey R, Rusch V, Hsu F, Leon L, Venkatraman E, Linehan D, Bains M, van Zee K, Korst R, Ginsberg R. Chest wall resection for locally recurrent breast cancer: Is it worthwhile? Journal Of Thoracic And Cardiovascular Surgery 2000, 119: 420-428. PMID: 10694599, DOI: 10.1016/s0022-5223(00)70119-x.
- Extramedullary hematopoiesis mimicking metastatic lung carcinomaHsu F, Filippa D, Castro-Malaspina H, Downey R. Extramedullary hematopoiesis mimicking metastatic lung carcinoma. The Annals Of Thoracic Surgery 1998, 66: 1411-1413. PMID: 9800847, DOI: 10.1016/s0003-4975(98)00785-1.
- Echocardiographic and surgical correlation of pericardial effusions in patients with malignant diseaseHsu F, Keefe D, Desiderio D, Downey R. Echocardiographic and surgical correlation of pericardial effusions in patients with malignant disease. Journal Of Thoracic And Cardiovascular Surgery 1998, 115: 1215-1216. PMID: 9605094, DOI: 10.1016/s0022-5223(98)70424-6.
- Morphometric Analysis of the Human Infant Brain: Effects of Intraventricular Hemorrhage and Periventricular Leukomalaciade la Monte S, Hsu F, Hedley-Whyte E, Kupsky W. Morphometric Analysis of the Human Infant Brain: Effects of Intraventricular Hemorrhage and Periventricular Leukomalacia. Journal Of Child Neurology 1990, 5: 101-110. PMID: 2345277, DOI: 10.1177/088307389000500206.