Harris E. Foster Jr, MD
Professor of Urology
Research & Publications
Biography
News
Research Summary
Dr. Harris Emilio Foster Jr.'s research interests revolve around neurogenic dysfunction of the lower urinary tract, incontinence, and female urology. At present, he and his group are investigating the distribution of adrenergic, muscarinic and endothelin receptors in the lower urinary tract of rats and rabbits. In addition, they are involved in determining the role nitric oxide synthase plays in the pathogenesis of lower urinary tract dysfunction. The team has found that nitric oxide synthase is high in patients with urinary tract infections; however, it is significantly lower than controls in female patients with interstitial cystitis. Dr. Foster Jr. and his colleagues hope to eventually apply this knowledge to improving both the diagnosis and treatment of interstitial cystitis. Presently, they have treated a small number of patients with oral L-ariginine, which is a substrate for nitric oxide synthase obtaining encouraging results. A randomized double-blind placebo controlled study is now in progress to further investigate these preliminary findings. Other projects include assessing the long term efficacy of surgical procedures to treat female stress urinary incontinence, and the use of non-surgical methods such as biofeedback. Finally, Dr. Foster Jr. is the principal investigator at Yale University for an NIH sponsored 7 year randomized clinical trial assessing the ability of doxazosin and/or finasteride to delay or prevent the progression of benign prostatic hyperplasia.
Specialized Terms: Benign prostatic hyperplasis clinical trials; Interstitial cystitis clinical trials; Basic science investigations into changes in receptor system in the prostate in response to treatment with standard pharmacotherapies
Coauthors
Research Interests
Urinary Bladder, Neurogenic; Prostate; Prostatic Hyperplasia; Urinary Incontinence; Urology; Cystitis, Interstitial; Nitric Oxide Synthase; Female Urogenital Diseases
Selected Publications
- Reply by Authors.Foster H, Dahm P, Kohler T, Lerner L, Parsons J, Wilt T, McVary K. Reply by Authors. Investigative Urology 2020, 203: 1219-1221. PMID: 32068490, DOI: 10.1097/ju.0000000000000802.
- Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline Amendment 2019.Foster H, Dahm P, Kohler TS, Lerner LB, Parsons JK, Wilt TJ, McVary K. Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline Amendment 2019. Investigative Urology 2019, 202: 592-598. PMID: 31059668, DOI: 10.1097/ju.0000000000000319.
- 2199 RENAL TRACT ULTRASONOGRAPHY FOR ROUTINE SURVEILLANCE IN SPINAL CORD INJURY PATIENTSEdokpolo L, Foster H. 2199 RENAL TRACT ULTRASONOGRAPHY FOR ROUTINE SURVEILLANCE IN SPINAL CORD INJURY PATIENTS. Investigative Urology 2012, 187: e886-e887. DOI: 10.1016/j.juro.2012.02.2373.
- 1744 IMPROVEMENTS IN LOWER URINARY TRACT SYMPTOM SEVERITY ARE ASSOCIATED WITH IMPROVEMENTS IN SLEEP DISTURBANCE OVER TIMEHelfand B, Sharp V, Williams O, Foster H, Naslund M, Lee J, McVary K. 1744 IMPROVEMENTS IN LOWER URINARY TRACT SYMPTOM SEVERITY ARE ASSOCIATED WITH IMPROVEMENTS IN SLEEP DISTURBANCE OVER TIME. Investigative Urology 2012, 187: e703-e704. DOI: 10.1016/j.juro.2012.02.1705.
- POD-04.06 The Effect of Increasing Doses of a Saw Palmetto Fruit Extract on Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: A Randomized TrialRoehrborn C, McVary K, Nickel J, Crawford E, Kreder K, Naslund M, Andriole G, Kaplan S, Foster H, Kusek J. POD-04.06 The Effect of Increasing Doses of a Saw Palmetto Fruit Extract on Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: A Randomized Trial. Urology 2011, 78: s14. DOI: 10.1016/j.urology.2011.07.427.
- 1035 RANDOMIZED MULTICENTER CLINICAL TRIAL SHOWS EFFICACY OF MYOFASCIAL PHYSICAL THERAPY IN WOMEN WITH INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS)Payne C, Fitzgerald M, Burks D, Nickel J, Lukacz E, Kreder K, Chai T, Hanno P, Mayer R, Yang C, Peters K, Foster H, Landis J, Cen L, Propert K, Kusek J. 1035 RANDOMIZED MULTICENTER CLINICAL TRIAL SHOWS EFFICACY OF MYOFASCIAL PHYSICAL THERAPY IN WOMEN WITH INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS). Investigative Urology 2010, 183: e402-e403. DOI: 10.1016/j.juro.2010.02.2113.
- Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tractYono M, Foster H, Yoshida M, Ueda S, Weiss R, Latifpour J. Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract. The FASEB Journal 2006, 20: a254-a254. DOI: 10.1096/fasebj.20.4.a254-a.
- 1443: Molecular Classification of Doxazosin-Induced Alterations in Rat Prostate by Gene Expression ProfilingYono M, Foster H, Shin D, Takahashi W, Latifpour J. 1443: Molecular Classification of Doxazosin-Induced Alterations in Rat Prostate by Gene Expression Profiling. Investigative Urology 2005, 173: 391. DOI: 10.1016/s0022-5347(18)35577-0.
- 1639: Development of a Nomogram to Predict Symptom Progression with or without Medical Therapy in Men with BPH Based on Data from the MTOPS TrialSlawin K, Roehrborn C, McConnell J, Kreder K, Jacobs S, McVary K, Foster H, Clarke H, Milam D, Noble W, Nyberg L, Kusek J, Kattan M. 1639: Development of a Nomogram to Predict Symptom Progression with or without Medical Therapy in Men with BPH Based on Data from the MTOPS Trial. Investigative Urology 2005, 173: 444. DOI: 10.1016/s0022-5347(18)35761-6.
- 1440: Chronic Doxazosin Treatment Differentially Alters Gene Expression of α1-Adrenoceptor Subtypes in Rat TissuesFoster H, Yono M, Shin D, Takahashi W, Latifpour J. 1440: Chronic Doxazosin Treatment Differentially Alters Gene Expression of α1-Adrenoceptor Subtypes in Rat Tissues. Investigative Urology 2005, 173: 390. DOI: 10.1016/s0022-5347(18)35574-5.
- 1316: Identification and Characterization of Endothelin Receptors in Human Prostate using Autoradiographic, Immunohistochemical and Immunoblotting TechniquesFoster H, Hemani M, Derweesh I, Pouresmail M, Sanematsu H, Yono M, Latifpour J. 1316: Identification and Characterization of Endothelin Receptors in Human Prostate using Autoradiographic, Immunohistochemical and Immunoblotting Techniques. Investigative Urology 2004, 171: 347. DOI: 10.1016/s0022-5347(18)38541-0.
- Age-related changes in gene expression of the endothelin receptor system in the rat genitourinary tractYono M, Takahashi W, Foster H, Pouresmail M, Weiss R, Latifpour J. Age-related changes in gene expression of the endothelin receptor system in the rat genitourinary tract. European Urology Open Science 2003, 2: 3. DOI: 10.1016/s1569-9056(03)90382-4.
- Chronic administration of doxazosin differentially alters gene expression of alpha-1 adrenoceptor subtypes in rat tissuesYono M, Foster H, Shin D, Takahashi W, Pouresmail M, Weiss R, Latifpour J. Chronic administration of doxazosin differentially alters gene expression of alpha-1 adrenoceptor subtypes in rat tissues. European Urology Open Science 2003, 2: 4. DOI: 10.1016/s1569-9056(03)90383-6.
- The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostateTakahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.
- SMALL BOWEL PERFORATION AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSYOLSSON L, ANDERSON K, FOSTER H. SMALL BOWEL PERFORATION AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY. Investigative Urology 2000, 164: 775. PMID: 10953147, DOI: 10.1016/s0022-5347(05)67303-x.
- SMALL BOWEL PERFORATION AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSYOLSSON L, ANDERSON K, FOSTER H. SMALL BOWEL PERFORATION AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY. Investigative Urology 2000, 164: 775. DOI: 10.1097/00005392-200009010-00038.
- Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatmentSaito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.
- EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-βIKEDA K, WADA Y, FOSTER H, WANG Z, WEISS R, LATIFPOUR J. EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β. Investigative Urology 2000, 164: 180-185. PMID: 10840456, DOI: 10.1016/s0022-5347(05)67491-5.
- EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-βIKEDA K, WADA Y, FOSTER H, WANG Z, WEISS R, LATIFPOUR J. EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β. Investigative Urology 2000, 164: 180-185. DOI: 10.1097/00005392-200007000-00057.
- Expression and localization of basic fibroblast growth factor in diabetic rat prostateWang Z, Ikeda K, Wada Y, Foster H, Weiss R, Latifpour J. Expression and localization of basic fibroblast growth factor in diabetic rat prostate. BJU International 2000, 85: 945-952. PMID: 10792180, DOI: 10.1046/j.1464-410x.2000.00597.x.
- Cystic pelvic pathology presenting as falsely elevated postvoid residual urine measured by portable ultrasound bladder scanning: report of 3 cases and review of the literatureCooperberg M, Chambers S, Rutherford T, Foster H. Cystic pelvic pathology presenting as falsely elevated postvoid residual urine measured by portable ultrasound bladder scanning: report of 3 cases and review of the literature. Urology 2000, 55: 590. PMID: 10754180, DOI: 10.1016/s0090-4295(99)00565-8.
- Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder domeSaito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.
- EXPRESSION AND LOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR IN DIABETIC RAT PROSTATEFoster H, Wang Z, Wada Y, Smith S, Saito M, Weiss R, Latifpour J. EXPRESSION AND LOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR IN DIABETIC RAT PROSTATE. Investigative Urology 1999, 161: 231.. DOI: 10.1097/00005392-199904010-00926.
- GENE EXPRESSION, LOCALIZATION, AND PHARMACOLOGICAL CHARACTERIZATION OF ENDOTHELIN RECEPTORS IN DIABETIC RAT PROSTATESaito M, Wada Y, Wang Z, Foster H, Smith S, Nishi K, Weiss R, Latifpour J. GENE EXPRESSION, LOCALIZATION, AND PHARMACOLOGICAL CHARACTERIZATION OF ENDOTHELIN RECEPTORS IN DIABETIC RAT PROSTATE. Investigative Urology 1999, 161: 350.. DOI: 10.1097/00005392-199904020-00402.
- A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITISKORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Investigative Urology 1999, 161: 558-565. PMID: 9915448, DOI: 10.1016/s0022-5347(01)61950-5.
- A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITISKORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Investigative Urology 1999, 161: 558-565.. DOI: 10.1097/00005392-199902000-00055.
- EDITORIAL COMMENTFoster H. EDITORIAL COMMENT. Investigative Urology 1999, 161: 198-199. DOI: 10.1016/s0022-5347(01)62096-2.
- THE EFFICACY OF URETHROLYSIS WITHOUT RE-SUSPENSION FOR IATROGENIC URETHRAL OBSTRUCTIONFoster H. THE EFFICACY OF URETHROLYSIS WITHOUT RE-SUSPENSION FOR IATROGENIC URETHRAL OBSTRUCTION. Investigative Urology 1999, 161: 198-199.. DOI: 10.1097/00005392-199901000-00055.
- CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRANISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Investigative Urology 1998, 160: 196-205. PMID: 9628650, DOI: 10.1016/s0022-5347(01)63090-8.
- CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRANISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Investigative Urology 1998, 160: 196-205.. DOI: 10.1097/00005392-199807000-00084.
- Recruitment strategies used in the medical therapy of prostatic symptoms (MTOPS) trialBurrows P, Kusek J, McVary K, Clarke H, Foster H, Kirkemo A, Pavlik V, Parman Z, Group M. Recruitment strategies used in the medical therapy of prostatic symptoms (MTOPS) trial. Contemporary Clinical Trials 1998, 19: s97. DOI: 10.1016/s0197-2456(98)80224-9.
- DETECTION OF URETHRAL DIVERTICULA IN WOMEN: COMPARISON OF A HIGH RESOLUTION FAST SPIN ECHO TECHNIQUE WITH DOUBLE BALLOON URETHROGRAPHYNeitlich J, Foster H, Glickman M, Smith R. DETECTION OF URETHRAL DIVERTICULA IN WOMEN: COMPARISON OF A HIGH RESOLUTION FAST SPIN ECHO TECHNIQUE WITH DOUBLE BALLOON URETHROGRAPHY. Investigative Urology 1998, 159: 408-410. PMID: 9649250, DOI: 10.1016/s0022-5347(01)63934-x.
- Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental DiabetesNishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.
- EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITISWheeler M, Smith S, Saito N, Foster H, Weiss R. EFFECT OF LONG-TERM ORAL L-ARGININE ON THE NITRIC OXIDE SYNTHASE PATHWAY IN THE URINE FROM PATIENTS WITH INTERSTITIAL CYSTITIS. Investigative Urology 1997, 158: 2045-2050. PMID: 9366309, DOI: 10.1016/s0022-5347(01)68150-3.
- Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-ArginineSmith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Investigative Urology 1997, 158: 703-708. PMID: 9258064, DOI: 10.1016/s0022-5347(01)64297-6.
- Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-ArginineSmith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Investigative Urology 1997, 158: 703-708.. DOI: 10.1097/00005392-199709000-00005.
- Erosion of Malleable Penile Prosthesis into BladderSwana H, Foster H. Erosion of Malleable Penile Prosthesis into Bladder. Investigative Urology 1997, 157: 2259-2260. PMID: 9146640, DOI: 10.1016/s0022-5347(01)64745-1.
- Erosion of Malleable Penile Prosthesis into BladderSwana H, Foster H. Erosion of Malleable Penile Prosthesis into Bladder. Investigative Urology 1997, 157: 2259-2260.. DOI: 10.1097/00005392-199706000-00078.
- Effect of experimental diabetes on rat prostate endothelin receptorsSaito M, Nishi K, Foster H, Weiss R, Latifpour J. Effect of experimental diabetes on rat prostate endothelin receptors. European Journal Of Pharmacology 1996, 310: 197-200. PMID: 8884217, DOI: 10.1016/0014-2999(96)00422-0.
- Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract InfectionsSmith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Investigative Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.
- Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract InfectionsSmith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Investigative Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Prostate | Active Surveillance in Prostate Cancer, Imaging to Detect Radiographic Progression as an Endpoint (ASPIRE) |