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Guoping Cai, MD, MS

Professor of Pathology; Associate Director of Cytopathology, Pathology

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Guoping Cai, MD, MS

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Yale Medicine

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Research Summary

Molecular testing in fine needle aspiration biopsy, and biomarker studies in lung, pancreas, thyroid and bladder cancers

Extensive Research Description

Molecular testing in fine needle aspiration biopsy, and biomarker studies in lung, pancreas, thyroid and bladder cancers

Coauthors

Research Interests

Lung Neoplasms; Neoplasms; Pancreas; Respiratory Tract Diseases; Male Urogenital Diseases

Selected Publications

  • Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistryMeiklejohn K, Hrones M, Wang M, Prasad M, Cai G, Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry Cytopathology 2023 PMID: 36825365, DOI: 10.1111/cyt.13222.
  • GATA3 Expression in Primary Lung Carcinomas: Correlation with Histopathologic Features and TTF-1, Napsin A, and p40 ExpressionWang M, Chen P, Cai G. GATA3 Expression in Primary Lung Carcinomas: Correlation with Histopathologic Features and TTF-1, Napsin A, and p40 Expression Human Pathology 2023 PMID: 36702357, DOI: 10.1016/j.humpath.2023.01.007.
  • Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine CarcinomaYoon E, Cai G. Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma 2022, 75-81. DOI: 10.1007/978-3-031-14402-8_14.
  • Small-Cell Carcinoma Versus Atypical Carcinoid TumorYoon E, Zhang X, Cai G. Small-Cell Carcinoma Versus Atypical Carcinoid Tumor 2022, 83-88. DOI: 10.1007/978-3-031-14402-8_15.
  • Pleomorphic Carcinoma Versus Sarcomatoid Malignant MesotheliomaBaine M, Cai G, Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma 2022, 137-145. DOI: 10.1007/978-3-031-14402-8_23.
  • Cytological Evaluation of Upper Urinary Tract Specimens: An Institutional Retrospective Study Using The Paris System for Reporting Urine Cytology Second Edition with Histopathologic Follow UpKhajir G, Sun T, Wang H, Adeniran A, Cai G, Levi A. Cytological Evaluation of Upper Urinary Tract Specimens: An Institutional Retrospective Study Using The Paris System for Reporting Urine Cytology Second Edition with Histopathologic Follow Up Journal Of The American Society Of Cytopathology 2022, 11: s35. DOI: 10.1016/j.jasc.2022.07.065.
  • Fine-Needle Aspiration Evaluation of Pancreatic Cysts: An Institutional Experience Using the Upcoming WHO International System for Reporting Pancreaticobiliary CytopathologySardana R, Wang M, Gilani S, Sun T, Cai G. Fine-Needle Aspiration Evaluation of Pancreatic Cysts: An Institutional Experience Using the Upcoming WHO International System for Reporting Pancreaticobiliary Cytopathology Journal Of The American Society Of Cytopathology 2022, 11: s62. DOI: 10.1016/j.jasc.2022.07.113.
  • The Value of Parathyroid Hormone Immunostaining in Fine-Needle Aspiration Diagnosis of Parathyroid TissueSardana R, Abi-Raad R, Adeniran A, Cai G. The Value of Parathyroid Hormone Immunostaining in Fine-Needle Aspiration Diagnosis of Parathyroid Tissue Journal Of The American Society Of Cytopathology 2022, 11: s54. DOI: 10.1016/j.jasc.2022.07.098.
  • Cervical Cancer Screening Using Primary High-Risk HPV (hrHPV) Versus Cotesting: Implications for hrHPV-Negative Patients with High Grade Squamous Epithelial LesionManrai P, Levi A, Sun T, Wang M, Cai G, Abi-Raad R. Cervical Cancer Screening Using Primary High-Risk HPV (hrHPV) Versus Cotesting: Implications for hrHPV-Negative Patients with High Grade Squamous Epithelial Lesion Journal Of The American Society Of Cytopathology 2022, 11: s32. DOI: 10.1016/j.jasc.2022.07.060.
  • Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular featuresStendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G. Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features Cancer Cytopathology 2022, 131: 37-49. PMID: 36041224, DOI: 10.1002/cncy.22637.
  • Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratificationWang X, Abi‐Raad R, Tang H, Cai G. Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification Cancer Cytopathology 2022, 130: 974-982. PMID: 35876606, DOI: 10.1002/cncy.22630.
  • Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma.Wang M, Stendahl K, Cai G, Adeniran A, Harigopal M, Gilani SM. Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. American Journal Of Clinical Pathology 2022, 158: 416-425. PMID: 35760555, DOI: 10.1093/ajcp/aqac066.
  • Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimensRazzano D, Bouza SJ, Hernandez PV, Wang M, Robert ME, Walther Z, Cai G. Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens Cancer Cytopathology 2022, 130: 726-734. PMID: 35511415, DOI: 10.1002/cncy.22589.
  • Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective reviewSun T, Zuo T, Hui P, Cai G. Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review Cancer Cytopathology 2022, 130: 558-565. PMID: 35417072, DOI: 10.1002/cncy.22579.
  • Copy number variations identified in thyroid FNA specimens are associated with Hürthle cell cytomorphologyAbi‐Raad R, Prasad ML, Adeniran AJ, Cai G. Copy number variations identified in thyroid FNA specimens are associated with Hürthle cell cytomorphology Cancer Cytopathology 2022, 130: 415-422. PMID: 35332982, DOI: 10.1002/cncy.22569.
  • Role of Combined Endoscopic Ultrasound-Guided Fine Needle Aspiration and Fine Needle Biopsy in the Diagnosis of Upper Gastrointestinal Submucosal LesionsAhmed M, Gilani S, Muniraj T, Aslanian H, Cai G. Role of Combined Endoscopic Ultrasound-Guided Fine Needle Aspiration and Fine Needle Biopsy in the Diagnosis of Upper Gastrointestinal Submucosal Lesions Journal Of The American Society Of Cytopathology 2020, 9: s29. DOI: 10.1016/j.jasc.2020.07.061.
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas.Gilani SM, Adeniran AJ, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas. American Journal Of Clinical Pathology 2020, 154: 559-570. PMID: 32589187, DOI: 10.1093/ajcp/aqaa079.
  • KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrityGupta R, Malvi P, Parajuli KR, Janostiak R, Bugide S, Cai G, Zhu LJ, Green MR, Wajapeyee N. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 12341-12351. PMID: 32430335, PMCID: PMC7275752, DOI: 10.1073/pnas.2005156117.
  • Diagnosis and Prognostic Evaluation of Uveal Melanoma via Fine Needle Aspiration BiopsyCai G. Diagnosis and Prognostic Evaluation of Uveal Melanoma via Fine Needle Aspiration Biopsy Journal Of Optometry And Ophthalmology 2020, 22: 81-86. DOI: 10.3760/cma.j.issn.1674-845x.2020.02.001.
  • A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma.Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
  • Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expressionMalvi P, Janostiak R, Nagarajan A, Cai G, Wajapeyee N. Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression PLOS Genetics 2019, 15: e1008439. PMID: 31589613, PMCID: PMC6797230, DOI: 10.1371/journal.pgen.1008439.
  • Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective AnalysisRay AS, Li C, Murphy TE, Cai G, Araujo KLB, Bramley K, DeBiasi EM, Pisani MA, Cortopassi IO, Puchalski JT. Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis The Annals Of Thoracic Surgery 2019, 109: 894-901. PMID: 31593653, PMCID: PMC9376016, DOI: 10.1016/j.athoracsur.2019.08.106.
  • Concordance Between the TIRADS Ultrasound Scoring Criteria, Fine-Needle Aspiration Cytology, and Thyroid Final Resection DiagnosisKaseb H, Charifa A, Abi-Raad R, Cai G, Hammers L, Prasad M, Adeniran A. Concordance Between the TIRADS Ultrasound Scoring Criteria, Fine-Needle Aspiration Cytology, and Thyroid Final Resection Diagnosis American Journal Of Clinical Pathology 2019, 152: s92-s92. DOI: 10.1093/ajcp/aqz118.001.
  • Fine Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Imaging Guidance, Rapid Onsite Evaluation, and Ancillary TestingDolezal D, Aslanian H, Cai G. Fine Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Imaging Guidance, Rapid Onsite Evaluation, and Ancillary Testing Journal Of The American Society Of Cytopathology 2019, 8: s2. DOI: 10.1016/j.jasc.2019.08.010.
  • Potential Role of Paraoxonase 2 Expression in Enhancing Fine Needle Aspiration Diagnosis of Pancreatic Ductal AdenocarcinomasMartinez M, Yoon E, Adeniran A, Cai G, Robert M, Wajapeyee N. Potential Role of Paraoxonase 2 Expression in Enhancing Fine Needle Aspiration Diagnosis of Pancreatic Ductal Adenocarcinomas Journal Of The American Society Of Cytopathology 2019, 8: s24. DOI: 10.1016/j.jasc.2019.08.058.
  • OverviewCai G, Adeniran A. Overview 2019, 3-11. DOI: 10.1007/978-3-030-21799-0_1.
  • MediastinumAbi-Raad R, Cai G. Mediastinum 2019, 305-323. DOI: 10.1007/978-3-030-21799-0_11.
  • Lymph NodeCai G. Lymph Node 2019, 119-150. DOI: 10.1007/978-3-030-21799-0_6.
  • Economics, Regulations, and Trends in PracticeLevi A, Cai G. Economics, Regulations, and Trends in Practice 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.
  • LiverCai G. Liver 2019, 153-185. DOI: 10.1007/978-3-030-21799-0_7.
  • Facility, Equipment, Specimen Preparation, and StainsCai G. Facility, Equipment, Specimen Preparation, and Stains 2019, 13-27. DOI: 10.1007/978-3-030-21799-0_2.
  • PancreasCai G. Pancreas 2019, 327-363. DOI: 10.1007/978-3-030-21799-0_12.
  • Gastrointestinal TractAbi-Raad R, Cai G. Gastrointestinal Tract 2019, 365-384. DOI: 10.1007/978-3-030-21799-0_13.
  • Cytological Evaluation During Intraoperative ConsultationCai G. Cytological Evaluation During Intraoperative Consultation 2019, 387-405. DOI: 10.1007/978-3-030-21799-0_14.
  • LungCai G. Lung 2019, 267-304. DOI: 10.1007/978-3-030-21799-0_10.
  • Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material.Abi-Raad R, Lavik JP, Barbieri AL, Zhang X, Adeniran AJ, Cai G. Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material. American Journal Of Clinical Pathology 2019, 153: 74-81. PMID: 31415691, DOI: 10.1093/ajcp/aqz110.
  • Molecular Testing on Pleural Fluid Samples.Oh S, Ronaghi R, Cai G. Molecular Testing on Pleural Fluid Samples. Seminars In Respiratory And Critical Care Medicine 2019, 40: 340-346. PMID: 31525809, DOI: 10.1055/s-0039-1695702.
  • EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancerHastings K, Yu HA, Wei W, Sanchez-Vega F, DeVeaux M, Choi J, Rizvi H, Lisberg A, Truini A, Lydon CA, Liu Z, Henick BS, Wurtz A, Cai G, Plodkowski AJ, Long NM, Halpenny DF, Killam J, Oliva I, Schultz N, Riely GJ, Arcila ME, Ladanyi M, Zelterman D, Herbst RS, Goldberg SB, Awad MM, Garon EB, Gettinger S, Hellmann MD, Politi K. EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer Annals Of Oncology 2019, 30: 1311-1320. PMID: 31086949, PMCID: PMC6683857, DOI: 10.1093/annonc/mdz141.
  • Diagnosis of Infectious Diseases in the Lower Respiratory Tract: A Cytopathologist's PerspectiveBaldassarri RJ, Kumar D, Baldassarri S, Cai G. Diagnosis of Infectious Diseases in the Lower Respiratory Tract: A Cytopathologist's Perspective Archives Of Pathology & Laboratory Medicine 2018, 143: 683-694. PMID: 30203986, DOI: 10.5858/arpa.2017-0573-ra.
  • Abstract A09: Impaired HLA Class I antigen processing and presentation as a mechanism of acquired Rrsistance to immune checkpoint inhibitors in lung cancerHastings K, Gettinger S, Jungmin C, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick M, Schlessinger J, Goldberg S, Chiang A, Melero I, Agorreta J, Montuenga L, Lifton R, Ferrone S, Kavathas P, Rimm D, Kaech S, Schalper K, Herbst R, Politi K. Abstract A09: Impaired HLA Class I antigen processing and presentation as a mechanism of acquired Rrsistance to immune checkpoint inhibitors in lung cancer Cancer Immunology Research 2018, 6: a09-a09. DOI: 10.1158/2326-6074.tumimm17-a09.
  • Reliability of p16 in Cytology Specimens from Head and Neck Squamous Cell CarcinomaAbi-Raad R, Prasad M, Cai G, Adeniran A. Reliability of p16 in Cytology Specimens from Head and Neck Squamous Cell Carcinoma Journal Of The American Society Of Cytopathology 2018, 7: s12. DOI: 10.1016/j.jasc.2018.06.037.
  • Fine Needle Aspiration Diagnosis of Malignant Neoplasms Secondarily Involving the Thyroid: An Institutional ExperienceDolezal D, Zuo T, Adeniran A, Raad R, Cai G. Fine Needle Aspiration Diagnosis of Malignant Neoplasms Secondarily Involving the Thyroid: An Institutional Experience Journal Of The American Society Of Cytopathology 2018, 7: s23. DOI: 10.1016/j.jasc.2018.06.058.
  • EUS diagnosis of cystic pancreatic neuroendocrine tumorsLi-Geng T, Cai G, Aslanian HR. EUS diagnosis of cystic pancreatic neuroendocrine tumors VideoGIE 2018, 3: 106-108. PMID: 29916484, PMCID: PMC6004037, DOI: 10.1016/j.vgie.2017.12.007.
  • Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung CancerGettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer Cancer Discovery 2017, 7: cd-17-0593. PMID: 29025772, PMCID: PMC5718941, DOI: 10.1158/2159-8290.cd-17-0593.
  • p40 is Superior to p63 and CK5/6 for Differentiating Lung Squamous Cell Carcinoma from Adenocarcinoma in Cytological SpecimensDelgado S, Cai G. p40 is Superior to p63 and CK5/6 for Differentiating Lung Squamous Cell Carcinoma from Adenocarcinoma in Cytological Specimens Journal Of The American Society Of Cytopathology 2017, 6: s46. DOI: 10.1016/j.jasc.2017.06.115.
  • Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose TransportNagarajan A, Dogra SK, Sun L, Gandotra N, Ho T, Cai G, Cline G, Kumar P, Cowles RA, Wajapeyee N. Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport Molecular Cell 2017, 67: 685-701.e6. PMID: 28803777, PMCID: PMC5567863, DOI: 10.1016/j.molcel.2017.07.014.
  • A Semi-Quantitative Approach to Biopsy Diagnosis of Large Cell Neuroendocrine Carcinoma of the LungBaine M, Sinard J, Cai G, Homer R. A Semi-Quantitative Approach to Biopsy Diagnosis of Large Cell Neuroendocrine Carcinoma of the Lung Journal Of Thoracic Oncology 2017, 12: s1543. DOI: 10.1016/j.jtho.2017.06.051.
  • MA16.02 Mutational Landscape of TKI Naïve and Resistant EGFR Mutant Lung AdenocarcinomasHastings K, Hastings K, Choi J, Choi J, Wurtz A, Walther Z, Cai G, Oliva I, Oliva I, Zhao Z, Zhao Z, Gaffney S, Gaffney S, Iamarino A, Iamarino A, Zhao S, Zhao S, Bi M, Bi M, Goldberg S, Chiang A, Liu Z, Liu Z, Townsend J, Schlessinger J, Lifton R, Herbst R, Gettinger S, Politi K. MA16.02 Mutational Landscape of TKI Naïve and Resistant EGFR Mutant Lung Adenocarcinomas Journal Of Thoracic Oncology 2017, 12: s435. DOI: 10.1016/j.jtho.2016.11.507.
  • P3.02c-088 Acquired Resistance to Programmed Death-1 Axis Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Topic: IT BiomarkersChoi J, Sowell R, Truini A, Schalper K, Wurtz A, Cai G, Perry C, Datar I, Hastings K, Melnick M, Kaftan E, Kavathas P, Kaech S, Rimm D, Goldberg S, Chiang A, Lifton R, Chen L, Herbst R, Politi K, Gettinger S. P3.02c-088 Acquired Resistance to Programmed Death-1 Axis Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Topic: IT Biomarkers Journal Of Thoracic Oncology 2017, 12: s1331-s1332. DOI: 10.1016/j.jtho.2016.11.1884.
  • Tumor Genotyping Analysis Using Cytological Specimens of Primary and Metastatic Lung AdenocarcinomasRaad R, Walther Z, Gettinger S, Politi K, Puchalski J, Homer R, Cai G. Tumor Genotyping Analysis Using Cytological Specimens of Primary and Metastatic Lung Adenocarcinomas Journal Of The American Society Of Cytopathology 2016, 5: s53. DOI: 10.1016/j.jasc.2016.07.122.
  • GATA 3 is a Reliable Marker in the Detection of Metastatic Breast Cancers in Cytology Specimens from both ER-Positive and ER-Negative Breast CancersAbi-Raad R, Boto A, Lavik J, Fernandez S, Cai G, Adeniran A, Baldassarri R, Kowalski D, Harigopal M. GATA 3 is a Reliable Marker in the Detection of Metastatic Breast Cancers in Cytology Specimens from both ER-Positive and ER-Negative Breast Cancers Journal Of The American Society Of Cytopathology 2016, 5: s11. DOI: 10.1016/j.jasc.2016.07.023.
  • Clinical utility of rapid on-site cytopathologyOza VM, Cai G, Aslanian HR. Clinical utility of rapid on-site cytopathology Gastrointestinal Endoscopy 2016, 85: 261. PMID: 27562939, DOI: 10.1016/j.gie.2016.08.008.
  • Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experienceAlomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience CytoJournal 2016, 13: 1. PMID: 26955395, PMCID: PMC4763477, DOI: 10.4103/1742-6413.173585.
  • Rapid On-Site Evaluation for Endoscopic Ultrasound–Guided Fine-Needle Aspiration Diagnosis of Pancreatic LesionsCai G, Sun X, Aslanian H, Chhieng D. Rapid On-Site Evaluation for Endoscopic Ultrasound–Guided Fine-Needle Aspiration Diagnosis of Pancreatic Lesions AJSP Review And Reports 2015, 20: 164-168. DOI: 10.1097/pcr.0000000000000099.
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Ampullary MassesRoss J, Chhieng D, Aslanian H, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Ampullary Masses Journal Of The American Society Of Cytopathology 2014, 3: s71. DOI: 10.1016/j.jasc.2014.09.166.
  • Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W, Politi K. Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1 Cell Reports 2014, 7: 999-1008. PMID: 24813888, PMCID: PMC4074596, DOI: 10.1016/j.celrep.2014.04.014.
  • Abstract C90: Dependence of afatinib and cetuximab resistant lung adenocarcinomas on mTOR signaling.Pirazzoli V, Nebhan C, Song X, Walter Z, Cai G, Wurtz A, Zhao Z, Elisa de Stanchina E, Horn L, Carbone D, Stevens P, Miller V, Gettinger S, Pao W, Politi K. Abstract C90: Dependence of afatinib and cetuximab resistant lung adenocarcinomas on mTOR signaling. Molecular Cancer Therapeutics 2013, 12: c90-c90. DOI: 10.1158/1535-7163.targ-13-c90.
  • Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐upKarunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up Cancer Cytopathology 2013, 122: 23-32. PMID: 24127207, DOI: 10.1002/cncy.21350.
  • The Value of Rapid On-site Evaluation for Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Cystic and Solid Pancreatic LesionsUstun B, Bernstein J, Chen X, Aslanian H, Chhieng D, Cai G. The Value of Rapid On-site Evaluation for Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Cystic and Solid Pancreatic Lesions Journal Of The American Society Of Cytopathology 2013, 2: s23. DOI: 10.1016/j.jasc.2013.08.059.
  • Calcitonin Immunostain Performed on Thin-Prep Slide Enhances Fine Needle Aspiration Diagnosis of Medullary Thyroid CarcinomaFu L, Theoharis C, Adeniran A, Ustun B, Chhieng D, Sosa J, Roman S, Holt E, Cai G. Calcitonin Immunostain Performed on Thin-Prep Slide Enhances Fine Needle Aspiration Diagnosis of Medullary Thyroid Carcinoma Journal Of The American Society Of Cytopathology 2013, 2: s21. DOI: 10.1016/j.jasc.2013.08.054.
  • Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumorsBernstein J, Ustun B, Alomari A, Bao F, Aslanian HR, Siddiqui U, Chhieng D, Cai G. Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors CytoJournal 2013, 10: 10. PMID: 23858320, PMCID: PMC3709383, DOI: 10.4103/1742-6413.112648.
  • Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinomaCai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma Cancer Cytopathology 2013, 121: 500-507. PMID: 23495083, DOI: 10.1002/cncy.21288.
  • Prognostic Significance of PAX8, Survivin, and Ki-67 Expression in Pancreatic Endocrine Neoplasms: A Tissue Microarray AnalysisBernstein J, Van Dyke A, Bao Y, Bao F, Kenney B, Prasad M, Chen G, Robert M, Cai G. Prognostic Significance of PAX8, Survivin, and Ki-67 Expression in Pancreatic Endocrine Neoplasms: A Tissue Microarray Analysis American Journal Of Clinical Pathology 2012, 138: a019-a019. DOI: 10.1093/ajcp/138.suppl2.323.
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Pancreatic Endocrine Neoplasms: An Institution's ExperienceBernstein J, Alomari A, Ustun B, Bao F, Chhieng D, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Diagnosis of Pancreatic Endocrine Neoplasms: An Institution's Experience Journal Of The American Society Of Cytopathology 2012, 1: s100. DOI: 10.1016/j.jasc.2012.08.218.
  • Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Secondary Tumors Involving the Pancreas: Review of 102 CasesAlomari A, Eltoum I, Ustun B, Chhieng D, Cai G. Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Secondary Tumors Involving the Pancreas: Review of 102 Cases Journal Of The American Society Of Cytopathology 2012, 1: s100. DOI: 10.1016/j.jasc.2012.08.217.
  • Unsatisfactory and Suboptimal Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA) Biopsies: Follow-up and Clinical ImplicationsKarunamurthy A, Cai G, Dacic S, Khalbuss W, Pantanowitz L, Monaco S. Unsatisfactory and Suboptimal Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA) Biopsies: Follow-up and Clinical Implications Journal Of The American Society Of Cytopathology 2012, 1: s81. DOI: 10.1016/j.jasc.2012.08.179.
  • Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreasLevy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas Diagnostic Cytopathology 2012, 41: 623-628. PMID: 22807461, DOI: 10.1002/dc.22893.
  • Vanishing Thyroid Nodules: A Rare Diagnostic Dilemma Induced by Ultrasound-Guided Fine-Needle AspirationEze O, Cai G, Baloch Z, Khan A, Hammers L, Udelsman R, Chhieng D, Theoharis C, Prasad M. Vanishing Thyroid Nodules: A Rare Diagnostic Dilemma Induced by Ultrasound-Guided Fine-Needle Aspiration American Journal Of Clinical Pathology 2012, 138: a206-a206. DOI: 10.1093/ajcp/138.suppl1.190.
  • Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosisCai G, Mahooti S, Lipata FM, Chhieng D, Hui P. Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis Cancer Cytopathology 2012, 120: 313-318. PMID: 22367918, DOI: 10.1002/cncy.21188.
  • The Complementary Role of CD68 Immunostaining in Diagnosing Sarcoidosis by Endobronchial UltrasounTobias L, Cai G, Puchalski J. The Complementary Role of CD68 Immunostaining in Diagnosing Sarcoidosis by Endobronchial Ultrasoun CHEST Journal 2011, 140: 864a. DOI: 10.1378/chest.1116965.
  • The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patientsMonaco SE, Khalbuss WE, Ustinova E, Liang A, Cai G. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients Diagnostic Cytopathology 2011, 40: 1062-1070. PMID: 21591276, DOI: 10.1002/dc.21733.
  • Su1383 25G Needles Provide Superior Diagnostic Yield of Malignancy With Rapid Onsite Evaluation (ROSE) in EUS-Guided FNA of Pancreatic MassesSiddiqui U, Mehra M, Cai G, Chhieng D, Aslanian H. Su1383 25G Needles Provide Superior Diagnostic Yield of Malignancy With Rapid Onsite Evaluation (ROSE) in EUS-Guided FNA of Pancreatic Masses Gastrointestinal Endoscopy 2011, 73: ab249. DOI: 10.1016/j.gie.2011.03.436.
  • Sp287: EUS Guided Confocal Laser Endomicroscopy of the PancreasAslanian H, Chhieng D, Cai G, Siddiqui U. Sp287: EUS Guided Confocal Laser Endomicroscopy of the Pancreas Gastrointestinal Endoscopy 2010, 71: ab101-ab102. DOI: 10.1016/j.gie.2010.03.1097.

Clinical Trials

ConditionsStudy Title
LungDetermining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
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