Elizabeth Claus, PhD, MD
Research & Publications
Biography
News
Locations
Research Summary
Elizabeth B. Claus, MD, PhD is Professor and Director of Medical Research in the Yale University School of Public Health as well as Attending Neurosurgeon and Director of Stereotactic Radiosurgery within the Department of Neurosurgery at Brigham and Women’s Hospital in Boston. Dr. Claus' work is focused in cancer and genetic epidemiology with an emphasis on the development of risk models for breast and brain tumors. She is the overall PI of the Meningioma Consortium, the Meningioma Genome-Wide Association Study, and the Yale Acoustic Neuroma Study as well as a co-investigator of the GLIOGENE (Genes for Glioma) and International Glioma Case/Control (GICC) projects. In addition to her research activities, Dr. Claus trained as a neurosurgeon at Yale-New Haven Hospital and completed a fellowship in neurosurgical oncology at Brigham and Women’s Hospital; her clinical focus is on the treatment of meningioma, glioma, acoustic neuroma and brain metastases. In partnership with national patient brain tumor organizations including the American Brain Tumor Association (ABTA), the National Brain Tumor Society (NBTS) and the Acoustic Neuroma Association (ANA), Dr. Claus is working to develop cost- and time-efficient web- and smartphone- based recruitment strategies to be used in the study of brain tumors. She has recently received pilot funding from the ABTA and NBTS to commence development of a web-based registry for patients with low grade glioma (The International Low Grade Glioma Project at glioma@yale.edu) in an effort to advance research efforts for this group of patients.
Extensive Research Description
- The Yale Breast Study
- The DCIS and BRCA1/2 Cohort Study
- The Meningioma Consortium Project
- The Meningioma Family Study
- The Meningioma Genome-Wide Association Study
- GLIOGENE (Genes for Glioma)
- The International Glioma Case/Control Study (GICC)
- The Yale Acoustic Neuroma Study (acousticneuroma@yale.edu)
- The International Low Grade Glioma Project (glioma@yale.edu)
Coauthors
Research Interests
Astrocytoma; Breast Neoplasms; Epidemiology; Glioma; Meningioma; Neurosurgery; Oligodendroglioma; Statistics as Topic; Central Nervous System Neoplasms
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics
Research Image
Yale School of Public Health
Selected Publications
- A Molecularly Integrated Grade for MeningiomaDriver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi W. A Molecularly Integrated Grade for Meningioma Neuro-Oncology 2021, 24: noab213-. PMID: 34508644, PMCID: PMC9071299, DOI: 10.1093/neuonc/noab213.
- Environmental and sex-specific molecular signatures of glioma causationClaus EB, Cannataro VL, Gaffney SG, Townsend JP. Environmental and sex-specific molecular signatures of glioma causation Neuro-Oncology 2021, 24: noab103-. PMID: 33942853, PMCID: PMC8730771, DOI: 10.1093/neuonc/noab103.
- Brain Tumor Discussions on Twitter (#BTSM): Social Network AnalysisFeliciano JT, Salmi L, Blotner C, Hayden A, Nduom EK, Kwan BM, Katz MS, Claus EB. Brain Tumor Discussions on Twitter (#BTSM): Social Network Analysis Journal Of Medical Internet Research 2020, 22: e22005. PMID: 33030435, PMCID: PMC7582142, DOI: 10.2196/22005.
- Longitudinal molecular trajectories of diffuse glioma in adultsBarthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW. Longitudinal molecular trajectories of diffuse glioma in adults Nature 2019, 576: 112-120. PMID: 31748746, PMCID: PMC6897368, DOI: 10.1038/s41586-019-1775-1.
- Lack of association between modifiable exposures and glioma risk: A Mendelian randomisation analysisSaunders CN, Cornish AJ, Kinnersley B, Law PJ, Claus EB, Il’yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS. Lack of association between modifiable exposures and glioma risk: A Mendelian randomisation analysis Neuro-Oncology 2019, 22: 207-215. PMID: 31665421, PMCID: PMC7442418, DOI: 10.1093/neuonc/noz209.
- Social media partnerships with patient organizations for neuro-oncology patient recruitment.Claus EB, Feliciano J, Benz LS, Calvocoressi L. Social media partnerships with patient organizations for neuro-oncology patient recruitment. Neuro-Oncology Practice 2019, 7: 143-151. PMID: 32626583, PMCID: PMC7318861, DOI: 10.1093/nop/npz049.
- Glioma risk associated with extent of estimated European genetic ancestry in African Americans and HispanicsOstrom QT, Egan KM, Nabors LB, Gerke T, Thompson RC, Olson JJ, LaRocca R, Chowdhary S, Eckel‐Passow J, Armstrong G, Wiencke JK, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Houlston RS, Jenkins RB, Wrensch MR, Melin B, Amos CI, Huse JT, Barnholtz‐Sloan J, Bondy ML. Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics International Journal Of Cancer 2019, 146: 739-748. PMID: 30963577, PMCID: PMC6785354, DOI: 10.1002/ijc.32318.
- Transcriptome-wide association study identifies new candidate susceptibility genes for gliomaAtkins I, Kinnersley B, Ostrom QT, Labreche K, Il'yasova D, Armstrong GN, Eckel-Passow JE, Schoemaker MJ, Nöthen MM, Barnholtz-Sloan JS, Swerdlow AJ, Simon M, Rajaraman P, Chanock SJ, Shildkraut J, Bernstein JL, Hoffmann P, Jöckel KH, Lai RK, Claus EB, Olson SH, Johansen C, Wrensch MR, Melin B, Jenkins RB, Sanson M, Bondy ML, Houlston RS. Transcriptome-wide association study identifies new candidate susceptibility genes for glioma Cancer Research 2019, 79: canres.2888.2018. PMID: 30709929, PMCID: PMC6522343, DOI: 10.1158/0008-5472.can-18-2888.
- Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-AnalysisAmirian ES, Ostrom QT, Armstrong GN, Lai RK, Gu X, Jacobs DI, Jalali A, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut JM, Ali-Osman F, Sadetzki S, Jenkins RB, Lachance DH, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Johansen C, Houlston RS, Scheurer ME, Shete S, Amos CI, Melin B, Bondy ML. Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis Cancer Epidemiology Biomarkers & Prevention 2019, 28: cebp.0702.2018. PMID: 30482874, PMCID: PMC6401283, DOI: 10.1158/1055-9965.epi-18-0702.
- Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma riskMuskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk Journal Of Neuro-Oncology 2019, 142: 479-487. PMID: 30796745, PMCID: PMC6482066, DOI: 10.1007/s11060-019-03119-w.
- Genome-wide association analysis identifies a meningioma risk locus at 11p15.5Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston RS, Wiemels JL. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5 Neuro-Oncology 2018, 20: 1485-1493. PMID: 29762745, PMCID: PMC6176799, DOI: 10.1093/neuonc/noy077.
- A gene expression signature predicts recurrence-free survival in meningiomaOlar A, Goodman LD, Wani KM, Boehling NS, Sharma DS, Mody RR, Gumin J, Claus EB, Lang FF, Cloughesy TF, Lai A, Aldape KD, DeMonte F, Sulman EP. A gene expression signature predicts recurrence-free survival in meningioma Oncotarget 2018, 9: 16087-16098. PMID: 29662628, PMCID: PMC5882319, DOI: 10.18632/oncotarget.24498.
- Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis ConsortiumAldape K, Amin SB, Ashley DM, Barnholtz-Sloan JS, Bates AJ, Beroukhim R, Bock C, Brat DJ, Claus EB, Costello JF, de Groot JF, Finocchiaro G, French PJ, Gan HK, Griffith B, Herold-Mende CC, Horbinski C, Iavarone A, Kalkanis SN, Karabatsou K, Kim H, Kouwenhoven MCM, McDonald KL, Miletic H, Nam DH, Ng HK, Niclou SP, Noushmehr H, Ormond D, Poisson LM, Reifenberger G, Roncaroli F, Sa JK, Smitt P, Smits M, Souza CF, Tabatabai G, Van Meir EG, Verhaak RGW, Watts C, Wesseling P, Woehrer A, Yung WKA, Jungk C, Hau AC, van Dyck E, Westerman BA, Yin J, Abiola O, Zeps N, Grimmond S, Buckland M, Khasraw M, Sulman EP, Muscat AM, Stead L. Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium Neuro-Oncology 2018, 20: 873-884. PMID: 29432615, PMCID: PMC6280138, DOI: 10.1093/neuonc/noy020.
- Quality of life after surgery for intracranial meningiomaBenz LS, Wrensch MR, Schildkraut JM, Bondy ML, Warren JL, Wiemels JL, Claus EB. Quality of life after surgery for intracranial meningioma Cancer 2017, 124: 161-166. PMID: 28902404, PMCID: PMC6415762, DOI: 10.1002/cncr.30975.
- The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International ConsortiumAmirian ES, Armstrong GN, Zhou R, Lau CC, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Davis FG, Lai R, Shete S, Amos CI, Scheurer ME, Aldape K, Alafuzoff I, Brännström T, Broholm H, Collins P, Giannini C, Rosenblum M, Tihan T, Melin BS, Bondy ML. The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium American Journal Of Epidemiology 2015, 183: 85-91. PMID: 26656478, PMCID: PMC4706682, DOI: 10.1093/aje/kwv235.
- Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastomaRamkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma Neuro-Oncology 2015, 17: 1344-1355. PMID: 25754088, PMCID: PMC4578577, DOI: 10.1093/neuonc/nov015.
- Survival and low-grade glioma: the emergence of genetic information.Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M. Survival and low-grade glioma: the emergence of genetic information. Neurosurgical FOCUS 2015, 38: e6. PMID: 25552286, PMCID: PMC4361022, DOI: 10.3171/2014.10.focus12367.
- Germline Mutations in Shelterin Complex Genes Are Associated With Familial GliomaBainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, Barnholtz-Sloan J, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Walsh KM, Davis FG, Lai R, Shete S, Aldape K, Amos CI, Thompson PA, Muzny DM, Gibbs RA, Melin BS, Bondy ML. Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma Journal Of The National Cancer Institute 2014, 107: 384. PMID: 25482530, PMCID: PMC4296199, DOI: 10.1093/jnci/dju384.
- Local control after fractionated stereotactic radiation therapy for brain metastasesRajakesari S, Arvold ND, Jimenez RB, Christianson LW, Horvath MC, Claus EB, Golby AJ, Johnson MD, Dunn IF, Lee EQ, Lin NU, Friesen S, Mannarino EG, Wagar M, Hacker FL, Weiss SE, Alexander BM. Local control after fractionated stereotactic radiation therapy for brain metastases Journal Of Neuro-Oncology 2014, 120: 339-346. PMID: 25059451, DOI: 10.1007/s11060-014-1556-5.
- Assessment of Autoantibodies to Meningioma in a Population-based StudyWiemels JL, Bracci PM, Wrensch M, Schildkraut J, Bondy M, Pfefferle J, Zhou M, Sison J, Calvocoressi L, Claus EB. Assessment of Autoantibodies to Meningioma in a Population-based Study American Journal Of Epidemiology 2012, 177: 75-83. PMID: 23221727, PMCID: PMC3590036, DOI: 10.1093/aje/kws221.
- Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM. Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females. Journal Of Neurosurgery 2012, 118: 649-56. PMID: 23101448, PMCID: PMC3756881, DOI: 10.3171/2012.9.jns12811.
- Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial gliomaLiu Y, Melin BS, Rajaraman P, Wang Z, Linet M, Shete S, Amos CI, Lau CC, Scheurer ME, Tsavachidis S, Armstrong GN, Houlston RS, Hosking FJ, Claus EB, Barnholtz-Sloan J, Lai R, Il’yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, LaChance D, Vick NA, Wrensch M, Davis F, McCarthy BJ, Andersson U, Thompson PA, Chanock S, The Gliogene Consortium, Bondy ML. Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma Human Genetics 2012, 131: 1507-1517. PMID: 22688887, PMCID: PMC3604903, DOI: 10.1007/s00439-012-1187-x.
- Dental x‐rays and risk of meningiomaClaus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.
- Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene ConsortiumShete S, Lau CC, Houlston RS, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, Yang P, Vick NA, Wrensch M, Davis FG, McCarthy BJ, Leung EH, Davis C, Cheng R, Hosking FJ, Armstrong GN, Liu Y, Yu RK, Henriksson R, Consortium T, Melin BS, Bondy ML. Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium Cancer Research 2011, 71: 7568-7575. PMID: 22037877, PMCID: PMC3242820, DOI: 10.1158/0008-5472.can-11-0013.
- Neurosurgical management of metastases in the central nervous systemClaus EB. Neurosurgical management of metastases in the central nervous system Nature Reviews Clinical Oncology 2011, 9: 79-86. PMID: 22143137, DOI: 10.1038/nrclinonc.2011.179.
- Family and personal medical history and risk of meningioma.Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.
- Prevalence, Complications, and Hospital Charges Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion ProceduresCahill KS, Chi JH, Day A, Claus EB. Prevalence, Complications, and Hospital Charges Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures JAMA 2009, 302: 58-66. PMID: 19567440, DOI: 10.1001/jama.2009.956.
- Specific Genes Expressed in Association with Progesterone Receptors in MeningiomaClaus EB, Park PJ, Carroll R, Chan J, Black PM. Specific Genes Expressed in Association with Progesterone Receptors in Meningioma Cancer Research 2008, 68: 314-322. PMID: 18172325, PMCID: PMC3256746, DOI: 10.1158/0008-5472.can-07-1796.
- GLIOGENE—an International Consortium to Understand Familial GliomaMalmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE—an International Consortium to Understand Familial Glioma Cancer Epidemiology Biomarkers & Prevention 2007, 16: 1730-1734. PMID: 17855690, DOI: 10.1158/1055-9965.epi-07-0081.
- Prevalence of BRCA1 and BRCA2 Mutations in Women Diagnosed With Ductal Carcinoma In SituClaus EB, Petruzella S, Matloff E, Carter D. Prevalence of BRCA1 and BRCA2 Mutations in Women Diagnosed With Ductal Carcinoma In Situ JAMA 2005, 293: 964-969. PMID: 15728167, DOI: 10.1001/jama.293.8.964.
- Genetic analysis of breast cancer in the cancer and steroid hormone study.Claus EB, Risch N, Thompson WD. Genetic analysis of breast cancer in the cancer and steroid hormone study. American Journal Of Human Genetics 1991, 48: 232-42. PMID: 1990835, PMCID: PMC1683001.